Sample records for broad iron lines

  1. Origin of the X-ray Spectral Variation and Seemingly Broad Iron Line Strucuture in the Seyfert Galaxies

    NASA Astrophysics Data System (ADS)

    Ebisawa, Ken; Naoki, Iso

    2012-07-01

    X-ray intensities and spectra of the Seyfert galaxies are known to be variable. Some of the sources have characteristic seemingly broad iron line structure, and their spectral variations are small in the iron line energy band. MCG-6-30-15 is such an archetypal source, and Miyakawa (2011) proposed a "Variable Partial Covering (VPC)" model to explain its continuum spectral variation, seemingly broad iron line structure, and small spectral variation in the iron energy band simultaneously, only due to variation of a single parameter. That single parameter is the "partial covering fraction" to describe the geometrical fraction of the X-ray emitting area covered by the ionized absorbers in the line of sight. The intrinsic X-ray luminosity is hardly variable in this model. We have applied the VPC model to the 27 Seyfert galaxies observed with Suzaku, and found that spectral variations of the 22 sources are successfully explained by this model only varying the partial covering fraction. Intrinsic X-ray luminosities of Seyfert galaxies are not variable, as opposed to what they apparently seem, and gravitationally red-shifted iron line is not necessary. Those ionized absorbing clouds are most likely to be Broad Line Region (BLR) clouds, and we will be able to constrain the BLR structure from X-ray observations.

  2. Broad line emission from iron K- and L-shell transitions in the active galaxy 1H 0707-495.

    PubMed

    Fabian, A C; Zoghbi, A; Ross, R R; Uttley, P; Gallo, L C; Brandt, W N; Blustin, A J; Boller, T; Caballero-Garcia, M D; Larsson, J; Miller, J M; Miniutti, G; Ponti, G; Reis, R C; Reynolds, C S; Tanaka, Y; Young, A J

    2009-05-28

    Since the 1995 discovery of the broad iron K-line emission from the Seyfert galaxy MCG-6-30-15 (ref. 1), broad iron K lines have been found in emission from several other Seyfert galaxies, from accreting stellar-mass black holes and even from accreting neutron stars. The iron K line is prominent in the reflection spectrum created by the hard-X-ray continuum irradiating dense accreting matter. Relativistic distortion of the line makes it sensitive to the strong gravity and spin of the black hole. The accompanying iron L-line emission should be detectable when the iron abundance is high. Here we report the presence of both iron K and iron L emission in the spectrum of the narrow-line Seyfert 1 galaxy 1H 0707-495. The bright iron L emission has enabled us to detect a reverberation lag of about 30 s between the direct X-ray continuum and its reflection from matter falling into the black hole. The observed reverberation timescale is comparable to the light-crossing time of the innermost radii around a supermassive black hole. The combination of spectral and timing data on 1H 0707-495 provides strong evidence that we are witnessing emission from matter within a gravitational radius, or a fraction of a light minute, from the event horizon of a rapidly spinning, massive black hole.

  3. Evidence for a Broad Relativistic Iron Line from the Neutron Star LMXB Ser X-1

    NASA Technical Reports Server (NTRS)

    Bhattacharyya, Sudip; Strohmayer, Tod E.

    2007-01-01

    We report on an analysis of XMM-Newton data from the neutron star low mass X-ray binary (LMXB) Serpens X-1 (Ser X-1). Spectral analysis of EPIC PN data indicates that the previously known broad iron Ka emission line in this source has a significantly skewed structure with a moderately extended red wing. The asymmetric shape of the line is well described with the laor and diskline models in XSPEC, which strongly supports an inner accretion disk origin of the line. To our knowledge this is the first strong evidence for a relativistic line in a neutron star LMXB. This finding suggests that the broad lines seen in other neutron star LMXBs likely originate from the inner disk as well. Detailed study of such lines opens up a new way to probe neutron star parameters and their strong gravitational fields. The laor model describes the line from Ser X-1 somewhat better than diskline, and suggests that the inner accretion disk radius is less than 6GM/c(exp 2). This is consistent with the weak magnetic fields of LMXBs, and may point towards a high compactness and rapid spin of the neutron star. Finally, the inferred source inclination angle in the approximate range 50-60 deg is consistent with the lack of dipping from Ser X-1.

  4. The similarity of broad iron lines in X-ray binaries and active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Walton, D. J.; Reis, R. C.; Cackett, E. M.; Fabian, A. C.; Miller, J. M.

    2012-05-01

    We have compared the 2001 XMM-Newton spectra of the stellar mass black hole binary XTE J1650-500 and the active galaxy MCG-6-30-15, focusing on the broad, excess emission features at ˜4-7 keV displayed by both sources. Such features are frequently observed in both low-mass X-ray binaries and active galactic nuclei (AGN). For the former case it is generally accepted that the excess arises due to iron emission, but there is some controversy over whether their width is partially enhanced by instrumental processes, and hence also over the intrinsic broadening mechanism. Meanwhile, in the latter case, the origin of this feature is still subject to debate; physically motivated reflection and absorption interpretations are both able to reproduce the observed spectra. In this work we make use of the contemporaneous BeppoSAX data to demonstrate that the breadth of the excess observed in XTE J1650-500 is astrophysical rather than instrumental, and proceed to highlight the similarity of the excesses present in this source and MCG-6-30-15. Both optically thick accretion discs and optically thin coronae, which in combination naturally give rise to relativistically broadened iron lines when the disc extends close to the black hole, are commonly observed in both classes of object. The simplest solution is that the broad emission features present arise from a common process, which we argue must be reflection from the inner regions of an accretion disc around a rapidly rotating black hole; for XTE J1650-500 we find spin constraints of 0.84 ≤a*≤ 0.98 at the 90 per cent confidence level. Other interpretations proposed for AGN add potentially unnecessary complexities to the theoretical framework of accretion in strong gravity.

  5. Resolving the Cygnus X-3 iron K line

    NASA Technical Reports Server (NTRS)

    Kitamoto, Shunji; Kawashima, Kenji; Negoro, Hitoshi; Miyamoto, Sigenori; White, N. E.; Nagase, Fumiaki

    1994-01-01

    An Advanced Satellite for Cosmology and Astrophysics (ASCA) observation of Cygnus X-3 on 1993 June 11, in its X-ray high intensity state, has for the first time resolved the broad iron K line emission into three components: a He-like line at 6.67 +/- 0.01 keV, a H-like line at 6.96 +/- 0.02 keV, and a neutral line at 6.37 +/- 0.03 keV. The line intensities of the 6.67 keV and 6.96 keV lines are modulated with the 4.8 hr orbital period and are maximum when the continuum intensity is minimum. There is a sharp minimum of the line intensity on the rising phase of the continuum intensity. An iron absorption edge is observed at 7.19 +/- 0.02 keV. The optical depth of the absorption edge varies from 0.3 to 0.5 and is in anti-phase with the overall X-ray continuum modulation. The observed complexity of the iron K line region is greater than that had been assumed in previous spectral modeling based on observations with lower resolution detectors.

  6. MICROLENSING OF QUASAR BROAD EMISSION LINES: CONSTRAINTS ON BROAD LINE REGION SIZE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Guerras, E.; Mediavilla, E.; Jimenez-Vicente, J.

    2013-02-20

    We measure the differential microlensing of the broad emission lines between 18 quasar image pairs in 16 gravitational lenses. We find that the broad emission lines are in general weakly microlensed. The results show, at a modest level of confidence (1.8{sigma}), that high ionization lines such as C IV are more strongly microlensed than low ionization lines such as H{beta}, indicating that the high ionization line emission regions are more compact. If we statistically model the distribution of microlensing magnifications, we obtain estimates for the broad line region size of r{sub s} = 24{sup +22} {sub -15} and r{sub s}more » = 55{sup +150} {sub -35} lt-day (90% confidence) for the high and low ionization lines, respectively. When the samples are divided into higher and lower luminosity quasars, we find that the line emission regions of more luminous quasars are larger, with a slope consistent with the expected scaling from photoionization models. Our estimates also agree well with the results from local reveberation mapping studies.« less

  7. Broad Balmer-Line Absorption in SDSS J172341.10+555340.5

    NASA Astrophysics Data System (ADS)

    Aoki, Kentaro

    2010-10-01

    We present the discovery of Balmer-line absorption from Hα to H9 in an iron low-ionizaton broad absorption line (FeLoBAL) quasar, SDSS J172341.10+555340.5, by near-infrared spectroscopy with the Cooled Infrared Spectrograph and Camera for OHS (CISCO) attached to the Subaru Telescope. The redshift of the Balmer-line absorption troughs is 2.0530±0.0003, and it is blueshifted by 5370 km s-1 from the Balmer emission lines. It is more than 4000 km s-1 blueshifted from the previously known UV absorption lines. We detected relatively strong (EWrest = 20 Å) [OIII] emission lines that are similar to those found in other broad absorption line quasars with Balmer-line absorption. We also derived the column density of neutral hydrogen of 5.2 × 1017 cm-2 by using the curve of growth and taking account of Lyα trapping. We searched for UV absorption lines that had the same redshift with Balmer-line absorption, and found Ali III and Fe III absorption lines at z = 2.053 that correspond to previously unidentified absorption lines, and the presence of other blended troughs that were difficult to identify.

  8. Extreme Variability in a Broad Absorption Line Quasar

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stern, Daniel; Jun, Hyunsung D.; Graham, Matthew J.

    CRTS J084133.15+200525.8 is an optically bright quasar at z = 2.345 that has shown extreme spectral variability over the past decade. Photometrically, the source had a visual magnitude of V ∼ 17.3 between 2002 and 2008. Then, over the following five years, the source slowly brightened by approximately one magnitude, to V ∼ 16.2. Only ∼1 in 10,000 quasars show such extreme variability, as quantified by the extreme parameters derived for this quasar assuming a damped random walk model. A combination of archival and newly acquired spectra reveal the source to be an iron low-ionization broad absorption line quasar withmore » extreme changes in its absorption spectrum. Some absorption features completely disappear over the 9 years of optical spectra, while other features remain essentially unchanged. We report the first definitive redshift for this source, based on the detection of broad H α in a Keck/MOSFIRE spectrum. Absorption systems separated by several 1000 km s{sup −1} in velocity show coordinated weakening in the depths of their troughs as the continuum flux increases. We interpret the broad absorption line variability to be due to changes in photoionization, rather than due to motion of material along our line of sight. This source highlights one sort of rare transition object that astronomy will now be finding through dedicated time-domain surveys.« less

  9. 49 CFR 192.373 - Service lines: Cast iron and ductile iron.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 3 2010-10-01 2010-10-01 false Service lines: Cast iron and ductile iron. 192.373... Regulators, and Service Lines § 192.373 Service lines: Cast iron and ductile iron. (a) Cast or ductile iron... cast iron pipe or ductile iron pipe is installed for use as a service line, the part of the service...

  10. Iron lines in model disk spectra of Galactic black hole binaries

    NASA Astrophysics Data System (ADS)

    Różańska, A.; Madej, J.; Konorski, P.; SaḐowski, A.

    2011-03-01

    Context. We present angle-dependent, broad-band intensity spectra from accretion disks around black holes of 10 M⊙. In our computations disks are assumed to be slim, which means that the radial advection is taken into account while computing the effective temperature of the disk. Aims: We attempt to reconstruct continuum and line spectra of X-ray binaries in soft state, i.e. dominated by the disk component of multitemperature shape. We follow how the iron-line complex depends on the external irradiation, an accretion rate, and a black hole spin. Methods: Full radiative transfer is solved including effects of Compton scattering, free-free and all important bound-free transitions of 10 main elements. We assume the LTE equation of state. Moreover, we include here the fundamental series of iron lines from helium-like and hydrogen-like ions, and fluorescent Kα and Kβ lines from low ionized iron. We consider two cases: nonrotating black hole, and black hole rotating with almost maximum spin a = 0.98, and obtain spectra for five accretion disks from hard X-rays to the infrared. Results: In nonirradiated disks, resonance lines from He-like and H-like iron appear mostly in absorption. Such disk spectra exhibit limb darkening in the whole energy range. External irradiation causes that iron resonance lines appear in emission. Furthermore, depending on disk effective temperature, fluorescent iron Kα and Kβ lines are present in disk emitting spectra. All models with irradiation exhibit limb brightening in their X-ray reflected continua. Conclusions: We show that the disk around stellar black hole itself is hot enough to produce strong-absorption resonance lines of iron. Emission lines can only be observed if heating by external X-rays dominates thermal processess in a hot disk atmosphere. Irradiated disks are usually brighter in X-ray continuum when seen edge on, and fainter when seen face on.

  11. Relativistic redshifts in quasar broad lines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tremaine, Scott; Shen, Yue; Liu, Xin

    2014-10-10

    The broad emission lines commonly seen in quasar spectra have velocity widths of a few percent of the speed of light, so special- and general-relativistic effects have a significant influence on the line profile. We have determined the redshift of the broadline in the quasar rest frame (determined from the core component of the [O III] line) for over 20,000 quasars from the Sloan Digital Sky Survey Data Release 7 quasar catalog. The mean redshift as a function of line width is approximately consistent with the relativistic redshift that is expected if the line originates in a randomlymore » oriented Keplerian disk that is obscured when the inclination of the disk to the line of sight exceeds ∼30°-45°, consistent with simple active galactic nucleus unification schemes. This result also implies that the net line-of-sight inflow/outflow velocities in the broad-line region are much less than the Keplerian velocity when averaged over a large sample of quasars with a given line width.« less

  12. 49 CFR 192.487 - Remedial measures: Distribution lines other than cast iron or ductile iron lines.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... STANDARDS Requirements for Corrosion Control § 192.487 Remedial measures: Distribution lines other than cast iron or ductile iron lines. (a) General corrosion. Except for cast iron or ductile iron pipe, each... engineering tests and analyses show can permanently restore the serviceability of the pipe. Corrosion pitting...

  13. 49 CFR 192.487 - Remedial measures: Distribution lines other than cast iron or ductile iron lines.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... STANDARDS Requirements for Corrosion Control § 192.487 Remedial measures: Distribution lines other than cast iron or ductile iron lines. (a) General corrosion. Except for cast iron or ductile iron pipe, each... engineering tests and analyses show can permanently restore the serviceability of the pipe. Corrosion pitting...

  14. 49 CFR 192.487 - Remedial measures: Distribution lines other than cast iron or ductile iron lines.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... STANDARDS Requirements for Corrosion Control § 192.487 Remedial measures: Distribution lines other than cast iron or ductile iron lines. (a) General corrosion. Except for cast iron or ductile iron pipe, each... engineering tests and analyses show can permanently restore the serviceability of the pipe. Corrosion pitting...

  15. 49 CFR 192.487 - Remedial measures: Distribution lines other than cast iron or ductile iron lines.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... STANDARDS Requirements for Corrosion Control § 192.487 Remedial measures: Distribution lines other than cast iron or ductile iron lines. (a) General corrosion. Except for cast iron or ductile iron pipe, each... engineering tests and analyses show can permanently restore the serviceability of the pipe. Corrosion pitting...

  16. Constraints on Black Hole Spin in a Sample of Broad Iron Line AGN

    NASA Technical Reports Server (NTRS)

    Brenneman, Laura W.; Reynolds, Christopher S.

    2008-01-01

    We present a uniform X-ray spectral analysis of nine type-1 active galactic nuclei (AGN) that have been previously found to harbor relativistically broadened iron emission lines. We show that the need for relativistic effects in the spectrum is robust even when one includes continuum "reflection" from the accretion disk. We then proceed to model these relativistic effects in order to constrain the spin of the supermassive black holes in these AGN. Our principal assumption, supported by recent simulations of geometrically-thin accretion disks, is that no iron line emission (or any associated Xray reflection features) can originate from the disk within the innermost stable circular orbit. Under this assumption, which tends to lead to constraints in the form of lower limits on the spin parameter, we obtain non-trivial spin constraints on five AGN. The spin parameters of these sources range from moderate (a approximates 0.6) to high (a > 0.96). Our results allow, for the first time, an observational constraint on the spin distribution function of local supermassive black holes. Parameterizing this as a power-law in dimensionless spin parameter (f(a) varies as absolute value of (a) exp zeta), we present the probability distribution for zeta implied by our results. Our results suggest 90% and 95% confidence limits of zeta > -0.09 and zeta > -0.3 respectively.

  17. A short review of relativistic iron lines from stellar-mass black holes

    NASA Astrophysics Data System (ADS)

    Miller, J. M.

    2006-12-01

    % In this contribution, I briefly review recent progress in detecting and measuring the properties of relativistic iron lines observed in stellar-mass black hole systems, and the aspects of these lines that are most relevant to studies of similar lines in Seyfert-1 AGN. In particular, the lines observed in stellar-mass black holes are not complicated by complex low-energy absorption or partial-covering of the central engine, and strong lines are largely independent of the model used to fit the underlying broad-band continuum flux. Indeed, relativistic iron lines are the most robust diagnostic of black hole spin that is presently available to observers, with specific advantages over the systematics-plagued disk continuum. If accretion onto stellar-mass black holes simply scales with mass, then the widespread nature of lines in stellar-mass black holes may indicate that lines should be common in Seyfert-1 AGN, though perhaps harder to detect.

  18. X-ray spectra of Hercules X-1. 1: Iron line fluorescence from a subrelativistic shell

    NASA Technical Reports Server (NTRS)

    Pravdo, S. H.; Becker, R. H.; Boldt, E. A.; Holt, S. S.; Serlemitsos, P. J.; Swank, J. H.

    1977-01-01

    The X-ray spectrum of Hercules X-1 was observed in the energy range 2-24 keV from August 29 to September 3, 1975. A broad iron line feature is observed in the normal high state spectrum. The line equivalent width is given along with its full-width-half-maximum energy. Iron line fluorescence from an opaque, cool shell of material at the Alfven surface provides the necessary luminosity in this feature. The line energy width can be due to Doppler broadening if the shell is forced to corotate with the pulsar at a radius 800 million cm. Implications of this model regarding physical conditions near Her X-1 are discussed.

  19. Evidence for active galactic nucleus feedback in the broad absorption lines and reddening of MRK 231 {sup ,}

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leighly, Karen M.; Baron, Eddie; Lucy, Adrian B.

    2014-06-20

    We present the first J-band spectrum of Mrk 231, which reveals a large He I* λ10830 broad absorption line with a profile similar to that of the well-known Na I broad absorption line. Combining this spectrum with optical and UV spectra from the literature, we show that the unusual reddening noted by Veilleux et al. is explained by a reddening curve like those previously used to explain low values of total-to-selective extinction in Type Ia supernovae. The nuclear starburst may be the origin and location of the dust. Spatially resolved emission in the broad absorption line trough suggests nearly fullmore » coverage of the continuum emission region. The broad absorption lines reveal higher velocities in the He I* lines (produced in the quasar-photoionized H II region) compared with the Na I and Ca II lines (produced in the corresponding partially ionized zone). Cloudy simulations show that a density increase is required between the H II and partially ionized zones to produce ionic column densities consistent with the optical and IR absorption line measurements and limits, and that the absorber lies ∼100 pc from the central engine. These results suggest that the He I* lines are produced in an ordinary quasar BAL wind that impacts upon, compresses, and accelerates the nuclear starburst's dusty effluent (feedback in action), and the Ca II and Na I lines are produced in this dusty accelerated gas. This unusual circumstance explains the rarity of Na I absorption lines; without the compression along our line of sight, Mrk 231 would appear as an ordinary iron low-ionization, broad absorption line quasar.« less

  20. Thin Line, Broad Shadows

    NASA Image and Video Library

    2011-02-21

    Saturn rings appear as only a thin line seen edge-on in the middle of this view from NASA Cassini spacecraft, but the rings cast broad shadows on the southern hemisphere of the planet in the lower left of the image.

  1. On the origin of the broad, relativistic iron line of MCG-6-30-15 observed by XMM-Newton

    NASA Astrophysics Data System (ADS)

    Martocchia, A.; Matt, G.; Karas, V.

    2002-03-01

    The relativistic iron line profile recently observed by XMM-Newton in the spectrum of the Seyfert 1 galaxy MCG-6-30-15 (Wilms et al. \\cite{Wilms01}) is discussed in the framework of the lamp-post model. It is shown that the steep disc emissivity, the large line equivalent width and the amount of Compton reflection can be self-consistently reproduced in this scenario.

  2. Iron Low-ionization Broad Absorption Line quasars - the missing link in galaxy evolution?

    NASA Astrophysics Data System (ADS)

    Lawther, Daniel Peter; Vestergaard, Marianne; Fan, Xiaohui

    2015-08-01

    A peculiar and rare type of quasar with strong low-ionization iron absorption lines - known as FeLoBAL quasars - may be the missing link between star forming (or starbursting) galaxies and quasars. They are hypothesized to be quasars breaking out of their dense birth blanket of gas and dust. In that case they are expected to have high rates of star formation in their galaxies. With the aim of addressing and settling this issue we have studied deep Hubble Space Telescope restframe UV and optical imaging of a subset of such quasars in order to characterize the host galaxy properties of these quasars. We present the results of this study along with simulations to characterize the uncertainties and robustness of our results.

  3. Broad absorption line symbiotic stars: highly ionized species in the fast outflow from MWC 560

    NASA Astrophysics Data System (ADS)

    Lucy, Adrian B.; Knigge, Christian; Sokoloski, J. L.

    2018-07-01

    In symbiotic binaries, jets and disc winds may be integral to the physics of accretion on to white dwarfs from cool giants. The persistent outflow from symbiotic star MWC 560 (≡V694 Mon) is known to manifest as broad absorption lines (BALs), most prominently at the Balmer transitions. We report the detection of high-ionization BALs from C IV, Si IV, N V, and He II in International Ultraviolet Explorer spectra obtained on 1990 April 29-30, when an optical outburst temporarily erased the obscuring `iron curtain' of absorption troughs from Fe II and similar ions. The C IV and Si IV BALs reached maximum radial velocities at least 1000 km s-1 higher than contemporaneous Mg II and He II BALs; the same behaviours occur in the winds of quasars and cataclysmic variables. An iron curtain lifts to unveil high-ionization BALs during the P Cygni phase observed in some novae, suggesting by analogy a temporary switch in MWC 560 from persistent outflow to discrete mass ejection. At least three more symbiotic stars exhibit broad absorption with blue edges faster than 1500 km s-1; high-ionization BALs have been reported in AS 304 (≡V4018 Sgr), while transient Balmer BALs have been reported in Z And and CH Cyg. These BAL-producing fast outflows can have wider opening angles than has been previously supposed. BAL symbiotics are short-time-scale laboratories for their giga-scale analogues, broad absorption line quasars (BALQSOs), which display a similarly wide range of ionization states in their winds.

  4. Broad absorption line symbiotic stars: highly ionized species in the fast outflow from MWC 560

    NASA Astrophysics Data System (ADS)

    Lucy, Adrian B.; Knigge, Christian; Sokoloski, J. L.

    2018-04-01

    In symbiotic binaries, jets and disk winds may be integral to the physics of accretion onto white dwarfs from cool giants. The persistent outflow from symbiotic star MWC 560 (≡V694 Mon) is known to manifest as broad absorption lines (BALs), most prominently at the Balmer transitions. We report the detection of high-ionization BALs from C IV, Si IV, N V, and He II in International Ultraviolet Explorer spectra obtained on 1990 April 29 - 30, when an optical outburst temporarily erased the obscuring `iron curtain' of absorption troughs from Fe II and similar ions. The C IV and Si IV BALs reached maximum radial velocities at least 1000 km s-1 higher than contemporaneous Mg II and He II BALs; the same behaviors occur in the winds of quasars and cataclysmic variables. An iron curtain lifts to unveil high-ionization BALs during the P Cygni phase observed in some novae, suggesting by analogy a temporary switch in MWC 560 from persistent outflow to discrete mass ejection. At least three more symbiotic stars exhibit broad absorption with blue edges faster than 1500 km s-1; high-ionization BALs have been reported in AS 304 (≡V4018 Sgr), while transient Balmer BALs have been reported in Z And and CH Cyg. These BAL-producing fast outflows can have wider opening angles than has been previously supposed. BAL symbiotics are short-timescale laboratories for their giga-scale analogs, broad absorption line quasars (BALQSOs), which display a similarly wide range of ionization states in their winds.

  5. DISCOVERY OF THE TRANSITION OF A MINI-BROAD ABSORPTION LINE INTO A BROAD ABSORPTION LINE IN THE SDSS QUASAR J115122.14+020426.3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hidalgo, Paola Rodriguez; Eracleous, Michael; Charlton, Jane

    We present the detection of a rare case of dramatic strengthening in the UV absorption profiles in the spectrum of the quasar J115122.14+020426.3 between observations {approx}2.86 yr apart in the quasar rest frame. A spectrum obtained in 2001 by the Sloan Digital Sky Survey shows a C IV ''mini-broad'' absorption line (FWHM = 1220 km s{sup -1}) with a maximum blueshift velocity of {approx}9520 km s{sup -1}, while a later spectrum from the Very Large Telescope shows a significantly broader and stronger absorption line, with a maximum blueshift velocity of {approx}12, 240 km s{sup -1} that qualifies as a broadmore » absorption line. A similar variability pattern is observed in two additional systems at lower blueshifted velocities and in the Ly{alpha} and N V transitions as well. One of the absorption systems appears to be resolved and shows evidence for partial covering of the quasar continuum source (C{sub f} {approx} 0.65), indicating a transverse absorber size of, at least, {approx}6 Multiplication-Sign 10{sup 16} cm. In contrast, a cluster of narrower C IV lines appears to originate in gas that fully covers the continuum and broad emission line sources. There is no evidence for changes in the centroid velocity of the absorption troughs. This case suggests that at least some of the absorbers that produce ''mini-broad'' and broad absorption lines in quasar spectra do not belong to intrinsically separate classes. Here, the ''mini-broad'' absorption line is most likely interpreted as an intermediate phase before the appearance of a broad absorption line due to their similar velocities. While the current observations do not provide enough constraints to discern among the possible causes for this variability, future monitoring of multiple transitions at high resolution will help achieve this goal.« less

  6. Photoionization Modelling of the Giant Broad-Line Region in NGC 3998.

    NASA Astrophysics Data System (ADS)

    Devereux, Nicholas

    2018-01-01

    Prior high angular resolution spectroscopic observations of the low-ionization nuclear emission-line region in NGC 3998 obtained with the Space Telescope Imaging Spectrograph aboard the Hubble Space Telescope revealed a rich UV-visible spectrum consisting of broad permitted and broad forbidden emission lines. The photoionization code XSTAR is employed together with reddening-insensitive emission line diagnostics to constrain a dynamical model for the broad-line region (BLR) in NGC 3998. The BLR is modelled as a large H+ region ~ 7 pc in radius consisting of dust-free, low density ~ 104 cm-3, low metallicity ~ 0.01 Z/Z⊙ gas. Modelling the shape of the broad Hα emission line significantly discriminates between two independent measures of the black hole mass, favouring the estimate of de Francesco (2006). Interpreting the broad Hα emission line in terms of a steady-state spherically symmetric inflow leads to a mass inflow rate of 1.4 x 10-2 M⊙/yr, well within the present uncertainty of calculations that attempt to explain the observed X-ray emission in terms of an advection-dominated accretion flow (ADAF). Collectively, the model provides an explanation for the shape of the Hα emission line, the relative intensities and luminosities for the H Balmer, [OIII], and potentially several of the broad UV emission lines, as well as refining the initial conditions needed for future modelling of the ADAF.

  7. An Extreme, Blueshifted Iron Line in the Narrow Line Seyfert 1 PG 1402+261

    NASA Technical Reports Server (NTRS)

    Reeves, J. N.; Porquet, D.; Turner, T. J.

    2004-01-01

    We report on a short, XMM-Newton observation of the radio-quiet Narrow Line Seyfert 1 PG 1402+261. The EPIC X-ray spectrum of PG 1402+261 shows a strong excess of counts between 6 - 9 keV in the rest frame. This feature can be modeled by an unusually strong (equivalent width 2 keV) and very broad energy at 7.3 keV appears blue-shifted with respect to the iron Kalpha emission band between 6.4 - 6.97 keV, whilst the blue-wing of the line extends to 9 keV in the quasar rest frame. The line profile can be fitted by reflection from the inner accretion disk, but an inclination angle of greater than 60 degrees is required to model the extreme blue-wing of the line. Furthermore the extreme strength of the line requires a geometry whereby the hard X-ray emission from PG1402+261 above 2 keV is dominated by the pure-reflection component from the disk, whilst little or none of the direct hard power-law is observed. Alternatively the spectrum above 2 keV may instead be explained by an ionized absorber, if the column density is sufficiently high (NH greater than 3 x 10(exp 23) per square centimeter) and if the matter is ionized enough to produce a deep (tau approximately equal to 1) iron K-shell absorption edge at 9 keV. This absorber could originate in a large column density, high velocity outflow, perhaps similar to those which appear to be observed in several other high accretion rate AGN. Further observations, especially at higher spectral resolution, are required to distinguish between the accretion disk reflection or outflow scenarios.

  8. The XMM-Newton Iron Line Profile of NGC 3783

    NASA Technical Reports Server (NTRS)

    Reeves, J. N.; Nandra, K.; George, I. M.; Pounds, K. A.; Turner, T. J.; Yaqoob, T.

    2003-01-01

    We report on observations of the iron K line in the nearby Seyfert 1 galaxy, NGC 3783, obtained in a long, 2 orbit (approx. 240 ks) XMM-Newton observation. The line profile obtained exhibits two strong narrow peaks at 6.4 keV and at 7.0 keV, with measured line equivalent widths of 120 and 35 eV respectively. The 6.4 keV emission is the K(alpha) line from near neutral Fe, whilst the 7.0 keV feature probably originates from a blend of the neutral Fe K(beta) line and the Hydrogen-like line of Fe at 6.97 keV. The relatively narrow velocity width of the K(alpha) line (approx. less than 5000 km/s), its lack of response to the continuum emission on short timescales and the detection of a neutral Compton reflection component are all consistent with a distant origin in Compton-thick matter such as the putative molecular torus. A strong absorption line from highly ionized iron (at 6.67 keV) is detected in the time-averaged iron line profile, whilst the depth of the feature appears to vary with time, being strongest when the continuum flux is higher. The iron absorption line probably arises from the highest ionization component of the known warm absorber in NGC 3783, with an ionization of log xi approx 3 and column density of N(sub H) approx. 5 x 10(exp 22)/sq cm and may originate from within 0.1 pc of the nucleus. A weak red-wing to the iron K line profile is also detected below 6.4 keV. However when the effect of the highly ionized warm absorber on the underlying continuum is taken into account, the requirement for a relativistic iron line component from the inner disk is reduced.

  9. Photoionization modelling of the giant broad-line region in NGC 3998

    NASA Astrophysics Data System (ADS)

    Devereux, Nick

    2018-01-01

    Prior high angular resolution spectroscopic observations of the Low-ionization nuclear emission-line region (Liner) in NGC 3998 obtained with the Space Telescope Imaging Spectrograph (STIS) aboard the Hubble Space Telescope (HST) revealed a rich UV-visible spectrum consisting of broad permitted and broad forbidden emission lines. The photoionization code XSTAR is employed together with reddening-insensitive emission line diagnostics to constrain a dynamical model for the broad-line region (BLR) in NGC 3998. The BLR is modelled as a large H+ region ∼ 7 pc in radius consisting of dust-free, low-density ∼ 104 cm-3, low-metallicity ∼ 0.01 Z/Z⊙ gas. Modelling the shape of the broad H α emission line significantly discriminates between two independent measures of the black hole (BH) mass, favouring the estimate of de Francesco, Capetti & Marconi (2006). Interpreting the broad H α emission line in terms of a steady-state spherically symmetric inflow leads to a mass inflow rate of 1.4 × 10-2 M⊙ yr-1, well within the present uncertainty of calculations that attempt to explain the observed X-ray emission in terms of an advection-dominated accretion flow (ADAF). Collectively, the model provides an explanation for the shape of the H α emission line, the relative intensities and luminosities for the H Balmer, [O III], and potentially several of the broad UV emission lines, as well as refining the initial conditions needed for future modelling of the ADAF.

  10. X-Ray Iron Line Constraints on the Inner Accretion Disk and Black Hole Spin

    NASA Technical Reports Server (NTRS)

    Reynolds, C. S.

    2000-01-01

    The broad iron line, seen in the X-ray spectra of many AGN, is thought to originate from the inner regions of the black hole accretion disk. I will summarize recent developments in using this line to probe the accretion disk structure, as well as the mass and spin of black holes n Seyfert galaxies. In particular, I will present observational evidence suggesting that the inner regions of the accretion disks in low-luminosity AGN (LLAGN) are distinctly different from those in higher-luminosity AGN. This tentative result lends support models of LLAGN based upon advective accretion disks.

  11. The Iron Abundance of IOTA Herculis From Ultraviolet Iron Lines

    NASA Astrophysics Data System (ADS)

    Grigsby, J.; Mulliss, C.; Baer, G.

    1995-03-01

    We have obtained (Adelman 1992, 1993, private comunication) coadded, high-resolution IUE spectra of Iota Herculis (B3 IV) in both short wavelength (SWP) and long wavelength (LWP) regions. The spectra span the ultraviolet spectrum from 110 - 300 nm and have a SNR of roughly 30 -50; they are described in Adelman et. al. (1993, ApJ 419, 276). Abundance indicators were 54 lines of Fe II and 26 lines of Fe III whose atomic parameters have been measured in the laboratory. LTE synthetic spectra for comparison with observations were produced with the Kurucz model atmosphere and spectral synthesis codes ATLAS9/SYNTHE (Kurucz 1979, ApJS 40,1; Kurucz and Avrett 1981, SAO Special Report 391). Model parameters were chosen from the literature: effective temperature = 17500 K, log g =3.75, v sin i= 11 km/s, and turbulent velocity = 0 km/s. (Peters and Polidan 1985, in IAU Symposium 111, ed. D. S. Hayes et al. (Dordrecht: Reidel), 417). We determined the equivalent widths of the chosen lines by fitting gaussian profiles to the lines and by measuring the equivalent widths of the gaussians. We derived abundances by fitting a straight line to a plot of observed equivalent widths vs. synthetic equivalent widths; we adjusted the iron abundance of the models until a slope of unity was achieved. The abundances derived from the different ionization stages are in agreement: Fe II lines indicate an iron abundance that is 34 +15/-10% the solar value([Fe/H]=-0.47 +0.16-0.15dex), while from Fe III lines we obtain 34 +/- 10% ([Fe/H]=-0.47 +0.11/-0.15 dex). A search of the literature suggests that no previous investigations of this star's iron abundance have found agreement between the different ionization stages. We thank Saul Adelman for his generous assistance, and the Faculty Research Fund Board of Wittenberg University for support of this research.

  12. Hints of correlation between broad-line and radio variations for 3C 120

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, H. T.; Bai, J. M.; Li, S. K.

    2014-01-01

    In this paper, we investigate the correlation between broad-line and radio variations for the broad-line radio galaxy 3C 120. By the z-transformed discrete correlation function method and the model-independent flux randomization/random subset selection (FR/RSS) Monte Carlo method, we find that broadline variations lead the 15 GHz variations. The FR/RSS method shows that the Hβ line variations lead the radio variations by a factor of τ{sub ob} = 0.34 ± 0.01 yr. This time lag can be used to locate the position of the emitting region of radio outbursts in the jet, on the order of ∼5 lt-yr frommore » the central engine. This distance is much larger than the size of the broad-line region. The large separation of the radio outburst emitting region from the broad-line region will observably influence the gamma-ray emission in 3C 120.« less

  13. Broad absorption-line time variability in the QSO CSO 203

    NASA Technical Reports Server (NTRS)

    Barlow, Thomas A.; Junkkarinen, Vesa T.; Burbidge, E. M.; Weymann, Ray J.; Morris, Simon L.; Korista, Kirk T.

    1992-01-01

    We present spectroscopy of the BALQSO CSO 203 during four epochs over a 17-month time span. These data show three distinct levels in the broad absorption lines (BALs) of Si IV 1397A and C IV 1549A. We also note possible variations in the N V 1240A and Al III 1857A absorption troughs. A broad-band monitoring effort during this period shows that the continuum level remained constant to within 10 percent. We argue that the triggering mechanism for the absorption-line changes is most likely synchronous with the continuum source photons; however, no correlation with the central source has yet been found. The observed variations are consistent with changes in the ionization level in the broad absorption-line region (BALR). We discuss possible mechanisms for these changes and the implications for the structure of the BALR.

  14. Broad-line Type Ic supernova SN 2014ad

    NASA Astrophysics Data System (ADS)

    Sahu, D. K.; Anupama, G. C.; Chakradhari, N. K.; Srivastav, S.; Tanaka, Masaomi; Maeda, Keiichi; Nomoto, Ken'ichi

    2018-04-01

    We present optical and ultraviolet photometry and low-resolution optical spectroscopy of the broad-line Type Ic supernova SN 2014ad in the galaxy PGC 37625 (Mrk 1309), covering the evolution of the supernova during -5 to +87 d with respect to the date of maximum in the B band. A late-phase spectrum obtained at +340 d is also presented. With an absolute V-band magnitude at peak of MV = -18.86 ± 0.23 mag, SN 2014ad is fainter than supernovae associated with gamma ray bursts (GRBs), and brighter than most of the normal and broad-line Type Ic supernovae without an associated GRB. The spectral evolution indicates that the expansion velocity of the ejecta, as measured using the Si II line, is as high as ˜33 500 km s-1 around maximum, while during the post-maximum phase it settles at ˜15 000 km s-1. The expansion velocity of SN 2014ad is higher than that of all other well-observed broad-line Type Ic supernovae except for the GRB-associated SN 2010bh. The explosion parameters, determined by applying Arnett's analytical light-curve model to the observed bolometric light-curve, indicate that it was an energetic explosion with a kinetic energy of ˜(1 ± 0.3) × 1052 erg and a total ejected mass of ˜(3.3 ± 0.8) M⊙, and that ˜0.24 M⊙ of 56Ni was synthesized in the explosion. The metallicity of the host galaxy near the supernova region is estimated to be ˜0.5 Z⊙.

  15. Correlation between the line width and the line flux of the double-peaked broad Hα of 3C390.3

    NASA Astrophysics Data System (ADS)

    Zhang, Xue-Guang

    2013-03-01

    In this paper, we carefully check the correlation between the line width (second moment) and the line flux of the double-peaked broad Hα of the well-known mapped active galactic nucleus (AGN) 3C390.3 in order to show some further distinctions between double-peaked emitters and normal broad-line AGN. Based on the virialization assumption MBH ∝ RBLR × V2(BLR) and the empirical relation RBLR ∝ L˜0.5, one strong negative correlation between the line width and the line flux of the double-peaked broad lines should be expected for 3C390.3, such as the negative correlation confirmed for the mapped broad-line object NGC 5548, RBLR × V2(BLR) ∝ L˜0.5 × σ2 = constant. Moreover, based on the public spectra around 1995 from the AGN WATCH project for 3C390.3, one reliable positive correlation is found between the line width and the line flux of the double-peaked broad Hα. In the context of the proposed theoretical accretion disc model for double-peaked emitters, the unexpected positive correlation can be naturally explained, due to different time delays for the inner and outer parts of the disc-like broad-line region (BLR) of 3C390.3. Moreover, the virialization assumption is checked and found to be still available for 3C390.3. However, the time-varying size of the BLR of 3C390.3 cannot be expected by the empirical relation RBLR ∝ L˜0.5. In other words, the mean size of the BLR of 3C390.3 can be estimated by the continuum luminosity (line luminosity), while the continuum emission strengthening leads to the size of BLR decreasing (not increasing) in different moments for 3C390.3. Then, we compared our results of 3C390.3 with the previous results reported in the literature for the other double-peaked emitters, and found that before to clearly correct the effects from disc physical parameters varying (such as the effects of disc precession) for long-term observed line spectra, it is not so meaningful to discuss the correlation of the line parameters of double

  16. Optical Variability of Narrow-line and Broad-line Seyfert 1 Galaxies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rakshit, Suvendu; Stalin, C. S., E-mail: suvenduat@gmail.com

    We studied the optical variability (OV) of a large sample of narrow-line Seyfert 1 (NLSy1) and broad-line Seyfert 1 (BLSy1) galaxies with z < 0.8 to investigate any differences in their OV properties. Using archival optical V -band light curves from the Catalina Real Time Transient Survey that span 5–9 years and modeling them using damped random walk, we estimated the amplitude of variability. We found that NLSy1 galaxies as a class show lower amplitude of variability than their broad-line counterparts. In the sample of both NLSy1 and BLSy1 galaxies, radio-loud sources are found to have higher variability amplitude thanmore » radio-quiet sources. Considering only sources that are detected in the X-ray band, NLSy1 galaxies are less optically variable than BLSy1 galaxies. The amplitude of variability in the sample of both NLSy1 and BLSy1 galaxies is found to be anti-correlated with Fe ii strength but correlated with the width of the H β line. The well-known anti-correlation of variability–luminosity and the variability–Eddington ratio is present in our data. Among the radio-loud sample, variability amplitude is found to be correlated with radio-loudness and radio-power, suggesting that jets also play an important role in the OV in radio-loud objects, in addition to the Eddington ratio, which is the main driving factor of OV in radio-quiet sources.« less

  17. Optical Variability of Narrow-line and Broad-line Seyfert 1 Galaxies

    NASA Astrophysics Data System (ADS)

    Rakshit, Suvendu; Stalin, C. S.

    2017-06-01

    We studied the optical variability (OV) of a large sample of narrow-line Seyfert 1 (NLSy1) and broad-line Seyfert 1 (BLSy1) galaxies with z < 0.8 to investigate any differences in their OV properties. Using archival optical V-band light curves from the Catalina Real Time Transient Survey that span 5-9 years and modeling them using damped random walk, we estimated the amplitude of variability. We found that NLSy1 galaxies as a class show lower amplitude of variability than their broad-line counterparts. In the sample of both NLSy1 and BLSy1 galaxies, radio-loud sources are found to have higher variability amplitude than radio-quiet sources. Considering only sources that are detected in the X-ray band, NLSy1 galaxies are less optically variable than BLSy1 galaxies. The amplitude of variability in the sample of both NLSy1 and BLSy1 galaxies is found to be anti-correlated with Fe II strength but correlated with the width of the Hβ line. The well-known anti-correlation of variability-luminosity and the variability-Eddington ratio is present in our data. Among the radio-loud sample, variability amplitude is found to be correlated with radio-loudness and radio-power, suggesting that jets also play an important role in the OV in radio-loud objects, in addition to the Eddington ratio, which is the main driving factor of OV in radio-quiet sources.

  18. Photoionization Modeling and the K Lines of Iron

    NASA Technical Reports Server (NTRS)

    Kallman, T. R.; Palmeri, P.; Bautista, M. A.; Mendoza, C.; Krolik, J. H.

    2004-01-01

    We calculate the efficiency of iron K line emission and iron K absorption in photoionized models using a new set of atomic data. These data are more comprehensive than those previously applied to the modeling of iron K lines from photoionized gases, and allow us to systematically examine the behavior of the properties of line emission and absorption as a function of the ionization parameter, density and column density of model constant density clouds. We show that, for example, the net fluorescence yield for the highly charged ions is sensitive to the level population distribution produced by photoionization, and these yields are generally smaller than those predicted assuming the population is according to statistical weight. We demonstrate that the effects of the many strongly damped resonances below the K ionization thresholds conspire to smear the edge, thereby potentially affecting the astrophysical interpretation of absorption features in the 7-9 keV energy band. We show that the centroid of the ensemble of K(alpha) lines, the K(beta) energy, and the ratio of the K(alpha(sub 1)) to K(alpha(sub 2)) components are all diagnostics of the ionization parameter of our model slabs.

  19. Consequences of hot gas in the broad line region of active galactic nuclei

    NASA Technical Reports Server (NTRS)

    Kallman, T.; Mushotzky, R.

    1985-01-01

    Models for hot gas in the broad line region of active galactic nuclei are discussed. The results of the two phase equilibrium models for confinement of broad line clouds by Compton heated gas are used to show that high luminosity quasars are expected to show Fe XXVI L alpha line absorption which will be observed with spectrometers such as those planned for the future X-ray spectroscopy experiments. Two phase equilibrium models also predict that the gas in the broad line clouds and the confining medium may be Compton thick. It is shown that the combined effects of Comptonization and photoabsorption can suppress both the broad emission lines and X-rays in the Einstein and HEAO-1 energy bands. The observed properties of such Compton thick active galaxies are expected to be similar to those of Seyfert 2 nuclei. The implications for polarization and variability are also discussed.

  20. Double-peaked broad line emission from the LINER nucleus of NGC 1097

    NASA Technical Reports Server (NTRS)

    Storchi-Bergmann, Thaisa; Baldwin, Jack A.; Wilson, Andrew S.

    1993-01-01

    We report the recent appearance of a very broad component in the H-alpha and H-beta emission lines of the weakly active nucleus of the Sersic-Pastoriza galaxy NGC 1097. The FWZI of the broad component is about 21,000 km/s, and its profile is double-peaked; the presence of a blue, featureless continuum in the nucleus is also suggested. The broad component was first observed in H-alpha in November 2, 1991, and confirmed 11 months later. The H-alpha profile and flux did not change in this time interval. Comparison with previously published spectral data indicates that the broad lines have only recently appeared. Together with the relatively high X-ray luminosity and the compact nuclear radio source, our results characterize the presence of a Seyfert 1 nucleus in a galaxy which had previously shown only LINER characteristics. Obscuring material along our line of sight to the nucleus appears to have recently cleared, permitting a direct view of the active nucleus. We discuss two possible structures for the broad line region, biconical outflow and an accretion disk, that could give rise to the observed profile.

  1. QSO Broad Emission Line Asymmetries: Evidence of Gravitational Redshift?

    NASA Astrophysics Data System (ADS)

    Corbin, Michael R.

    1995-07-01

    The broad optical and ultraviolet emission lines of QSOs and active galactic nuclei (AGNs) display both redward and blueward asymmetries. This result is particularly well established for Hβ and C IV λ1549, and it has been found that Hβ becomes increasingly redward asymmetric with increasing soft X-ray luminosity. Two models for the origin of these asymmetries are investigated: (1) Anisotropic line emission from an ensemble of radially moving clouds, and (2) Two-component profiles consisting of a core of intermediate (˜1000-4000 km s-1) velocity width and a very broad (˜5000-20,000 km s-1) base, in which the asymmetries arise due to a velocity difference between the centroids of the components. The second model is motivated by the evidence that the traditional broad-line region is actually composed of an intermediate-line region (ILR) of optically thick clouds and a very broad line region (VBLR) of optically thin clouds lying closer to the central continuum source. Line profiles produced by model (1) are found to be inconsistent with those observed, being asymmetric mainly in their cores, whereas the asymmetries of actual profiles arise mainly from excess emission in their wings. By contrast, numerical fitting to actual Hβ and C IV λ1549 line profiles reveals that the majority can be accurately modeled by two components, either two Gaussians or the combination of a Gaussian base and a logarithmic core. The profile asymmetries in Hβ can be interpreted as arising from a shift of the base component over a range ˜6300 km s-1 relative to systemic velocity as defined by the position of the [O III] λ5007 line. A similar model appears to apply to C IV λ1549. The correlation between Hβ asymmetry and X-ray luminosity may thus be interpreted as a progressive red- shift of the VBLR velocity centroid relative to systemic velocity with increasing X-ray luminosity. This in turn suggests that the underlying effect is gravitational red shift, as soft X-ray emission

  2. An Atlas of Computed Equivalent Widths of Quasar Broad Emission Lines

    NASA Astrophysics Data System (ADS)

    Korista, Kirk; Baldwin, Jack; Ferland, Gary; Verner, Dima

    We present graphically the results of several thousand photoionization calculations of broad emission-line clouds in quasars, spanning 7 orders of magnitude in hydrogen ionizing flux and particle density. The equivalent widths of 42 quasar emission lines are presented as contours in the particle density-ionizing flux plane for a typical incident continuum shape, solar chemical abundances, and cloud column density of N(H) = 1023 cm-2. Results are similarly given for a small subset of emission lines for two other column densities (1022 and 1024 cm-2), five other incident continuum shapes, and a gas metallicity of 5 Z⊙. These graphs should prove useful in the analysis of quasar emission-line data and in the detailed modeling of quasar broad emission-line regions. The digital results of these emission-line grids and many more are available over the Internet.

  3. Broad Redshifted Line as a Signature of Outflow

    NASA Astrophysics Data System (ADS)

    Titarchuk, Lev; Kazanas, Demos; Becker, Peter A.

    2003-11-01

    We formulate and solve the diffusion problem of line photon propagation in a bulk outflow from a compact object (black hole or neutron star) using a generic assumption regarding the distribution of line photons within the outflow. Thomson scattering of the line photons within the expanding flow leads to a decrease of their energy which is of first order in v/c, where v is the outflow velocity and c is the speed of light. We demonstrate that the emergent line profile is closely related to the time distribution of photons diffusing through the flow (the light curve) and consists of a broad redshifted feature. We analyzed the line profiles for the general case of outflow density distribution. We emphasize that the redshifted lines are intrinsic properties of the powerful outflow that are supposed to be in many compact objects.

  4. Iron K Lines from Gamma Ray Bursts

    NASA Technical Reports Server (NTRS)

    Kallman, T. R.; Meszaros, P.; Rees, M. J.

    2003-01-01

    We present models for reprocessing of an intense flux of X-rays and gamma rays expected in the vicinity of gamma ray burst sources. We consider the transfer and reprocessing of the energetic photons into observable features in the X-ray band, notably the K lines of iron. Our models are based on the assumption that the gas is sufficiently dense to allow the microphysical processes to be in a steady state, thus allowing efficient line emission with modest reprocessing mass and elemental abundances ranging from solar to moderately enriched. We show that the reprocessing is enhanced by down-Comptonization of photons whose energy would otherwise be too high to absorb on iron, and that pair production can have an effect on enhancing the line production. Both "distant" reprocessors such as supernova or wind remnants and "nearby" reprocessors such as outer stellar envelopes can reproduce the observed line fluxes with Fe abundances 30-100 times above solar, depending on the incidence angle. The high incidence angles required arise naturally only in nearby models, which for plausible values can reach Fe line to continuum ratios close to the reported values.

  5. Significant contribution of the Cerenkov line-like radiation to the broad emission lines of quasars

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, D. B.; You, J. H.; Chen, W. P.

    2014-01-01

    The Cerenkov line-like radiation in a dense gas (N {sub H} > 10{sup 13} cm{sup –3}) is potentially important in the exploration of the optical broad emission lines of quasars and Seyfert 1 galaxies. With this quasi-line emission mechanism, some long standing puzzles in the study of quasars could be resolved. In this paper, we calculate the power of the Cerenkov line-like radiation in dense gas and compare with the powers of other radiation mechanisms by a fast electron to confirm its importance. From the observed gamma-ray luminosity of 3C 279, we show that the total number of fast electronsmore » is sufficiently high to allow effective operation of the quasi-line emission. We present a model calculation for the luminosity of the Cerenkov Lyα line of 3C 279, which is high enough to compare with observations. We therefore conclude that the broad line of quasars may be a blend of the Cerenkov emission line with the real line produced by the bound-bound transition. A new approach to the absorption of the Cerenkov line is presented with the method of escape probability, which markedly simplifies the computation in the optically thick case. The revised set of formulae for the Cerenkov line-like radiation is more convenient in applications.« less

  6. Spectrophotometry of six broad absorption line QSOs

    NASA Technical Reports Server (NTRS)

    Junkkarinen, Vesa T.; Burbidge, E. Margaret; Smith, Harding E.

    1987-01-01

    Spectrophotometric observations of six broad absorption-line QSOs (BALQSOs) are presented. The continua and emission lines are compared with those in the spectra of QSOs without BALs. A statistically significant difference is found in the emission-line intensity ratio for (N V 1240-A)/(C IV 1549-A). The median value of (N V)/(C IV) for the BALQSOs is two to three times the median for QSOs without BALs. The absorption features of the BALQSOs are described, and the column densities and limits on the ionization structure of the BAL region are discussed. If the dominant ionization mechanism is photoionization, then it is likely that either the ionizing spectrum is steep or the abundances are considerably different from solar. Collisional ionization may be a significant factor, but it cannot totally dominate the ionization rate.

  7. Chandra Detection of a Parsec Scale Wind in the Broad Line Radio Galaxy 3C 382

    NASA Technical Reports Server (NTRS)

    Reeves, J. N.; Sambruna, R. M.; Braito, V.; Eracleous, Michael

    2009-01-01

    We present unambiguous evidence for a parsec scale wind in the Broad-Line Radio Galaxy (BLRG) 3C 382, the first radio-loud AGN whereby an outflow has been measured with X-ray grating spectroscopy. A 118 ks Chandra grating (HETG) observation of 3C 382 has revealed the presence of several high ionization absorption lines in the soft X-ray band, from Fe, Ne, Mg and Si. The absorption lines are blue-shifted with respect to the systemic velocity of 3C 382 by -840+/-60 km/s and are resolved by Chandra with a velocity width of sigma = 340+/-70 km/s. The outflow appears to originate from a single zone of gas of column density N(sub H) = 1.3 x 10(exp 21)/sq cm and ionization parameter log(E/erg/cm/s) = 2.45. From the above measurements we calculate that the outflow is observed on parsec scales, within the likely range from 10-1000 pc, i.e., consistent with an origin in the Narrow Line Region. Finally we also discuss the possibility of a much faster (0.1c) outflow component, based on a blue-shifted iron K(alpha) emission line in the Suzaku observation of 3C 382, which could have an origin in an accretion disk wind.

  8. The discovery of pulsed iron line emission from Centaurus X-3

    NASA Technical Reports Server (NTRS)

    Day, C. S. R.; Nagase, F.; Asai, K.; Takeshima, T.

    1993-01-01

    We present the first discovery of pulsed iron line emission from an X-ray binary, namely Cen X-3. Compared with the continuum pulsations, the iron line pulsations are shallow (50 percent change in amplitude), smeared (the profile is a single-peaked sinusoid) and phase-shifted (by about half a cycle). We also discuss the constraints on the origin of the line imposed by this discovery and by other observations.

  9. Testing the Kerr metric with the iron line and the KRZ parametrization

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ni, Yueying; Jiang, Jiachen; Bambi, Cosimo, E-mail: yyni13@fudan.edu.cn, E-mail: jcjiang12@fudan.edu.cn, E-mail: bambi@fudan.edu.cn

    The spacetime geometry around astrophysical black holes is supposed to be well approximated by the Kerr metric, but deviations from the Kerr solution are predicted in a number of scenarios involving new physics. Broad ironlines are commonly observed in the X-ray spectrum of black holes and originate by X-ray fluorescence of the inner accretion disk. The profile of the iron line is sensitively affected by the spacetime geometry in the strong gravity region and can be used to test the Kerr black hole hypothesis. In this paper, we extend previous work in the literature. In particular: i )more » as test-metric, we employ the parametrization recently proposed by Konoplya, Rezzolla, and Zhidenko, which has a number of subtle advantages with respect to the existing approaches; ii ) we perform simulations with specific X-ray missions, and we consider NuSTAR as a prototype of current observational facilities and eXTP as an example of the next generation of X-ray observatories. We find a significant difference between the constraining power of NuSTAR and eXTP. With NuSTAR, it is difficult or impossible to constrain deviations from the Kerr metric. With eXTP, in most cases we can obtain quite stringent constraints (modulo we have the correct astrophysical model).« less

  10. Broad Red-Shifted Lines as a Signature of Outflow

    NASA Astrophysics Data System (ADS)

    Kazanas, Demosthenes; Titarchuk, Lev; Becker, Peter A.

    2004-07-01

    We formulate and solve the diffusion problem of line photon propagation in a bulk outflow from a compact object (black hole or neutron star) using a generic assumption regarding the distribution of line photons within the outflow. Thomson scattering of the line photons within the expanding flow leads to a decrease of their energy which is of first order in v/c, where v is the outflow velocity and c the speed of light. We demonstrate that the emergent line profile is closely related to the time distribution of photons diffusing through the flow (the light curve) and consists of a broad redshifted feature. We analyzed the line profiles for the general case of outflow density distribution. We emphasize that the redshifted lines are intrinsic properties of the powerful outflow that are supposed to be in many compact objects.

  11. Broad Red-Shifted Lines as a Signature of Outflows

    NASA Astrophysics Data System (ADS)

    Titarchuck, Lev; Kazanas, Demos; Becker, Peter A.

    2006-02-01

    We formulate and solve the diffusion problem of line photon propagation in a bulk outflow from a compact object (black hole or neutron star) using a generic assumption regarding the distribution of line photons within the outflow. Thomson scattering of the line photons within the expanding flow leads to a decrease of their energy which is of first order in υ/c, where υ the outflow velocity and c is the speed of light. We demonstrate that the emergent line profile is closely related to the time distribution of photons diffusing through the flow (the light curve) and consists of a broad redshifted feature. We analyzed the line profiles for the general case of outflow density distribution. We emphasize that the redshifted lines are intrinsic properties of the powerful outflow that are supposed to be in many compact objects.

  12. Iron line spectroscopy with Einstein-dilaton-Gauss-Bonnet black holes

    NASA Astrophysics Data System (ADS)

    Nampalliwar, Sourabh; Bambi, Cosimo; Kokkotas, Kostas D.; Konoplya, Roman A.

    2018-06-01

    Einstein-dilaton-Gauss-Bonnet gravity is a well-motivated alternative theory of gravity that emerges naturally from string theory. While black hole solutions have been known in this theory in numerical form for a while, an approximate analytical metric was obtained recently by some of us, which allows for faster and more detailed analysis. Here we test the accuracy of the analytical metric in the context of X-ray reflection spectroscopy. We analyze innermost stable circular orbits (ISCO) and relativistically broadened iron lines and find that both the ISCO and iron lines are determined sufficiently accurately up to the limit of the approximation. We also find that, though the ISCO increases by about 7% as dilaton coupling increases from zero to extremal values, the redshift at ISCO changes by less than 1%. Consequently, the shape of the iron line is much less sensitive to the dilaton charge than expected.

  13. Constraints on the outer radius of the broad emission line region of active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Landt, Hermine; Ward, Martin J.; Elvis, Martin; Karovska, Margarita

    2014-03-01

    Here we present observational evidence that the broad emission line region (BELR) of active galactic nuclei (AGN) generally has an outer boundary. This was already clear for sources with an obvious transition between the broad and narrow components of their emission lines. We show that the narrow component of the higher-order Paschen lines is absent in all sources, revealing a broad emission line profile with a broad, flat top. This indicates that the BELR is kinematically separate from the narrow emission line region. We use the virial theorem to estimate the BELR outer radius from the flat top width of the unblended profiles of the strongest Paschen lines, Paα and Paβ, and find that it scales with the ionizing continuum luminosity roughly as expected from photoionization theory. The value of the incident continuum photon flux resulting from this relationship corresponds to that required for dust sublimation. A flat-topped broad emission line profile is produced by both a spherical gas distribution in orbital motion and an accretion disc wind if the ratio between the BELR outer and inner radius is assumed to be less than ˜100-200. On the other hand, a pure Keplerian disc can be largely excluded, since for most orientations and radial extents of the disc the emission line profile is double-horned.

  14. Broad Absorption Lines in Qsos: Observations and Implications for Models.

    NASA Astrophysics Data System (ADS)

    Turnshek, David Alvin

    Spectroscopic observations of fourteen broad absorption line (BAL) QSOs are presented and analyzed. Other observations are summarized. The following major conclusions are reached. Broad absorption lines (BALs) are probably present in 3 to 10 percent of the spectra of moderate to high redshift QSOs. The BALs exhibit a variety of velocity structures, from seemingly smooth, continuous absorption to complexes of individual absorption lines. Outflow velocities up to 40,000 km s(' -1) are observed. The level of ionization is high. The minimum total absorption column densities are 10('20) to 10('22) cm('-2). The emission line properties of BAL QSOs appear to be different from those of non-BAL QSOs. For example, N V emission is generally stronger in BAL QSOs and the emission near C III} (lamda)1909 is generally broader in BAL QSOs. The distribution of multiplicities for isolated absorption troughs suggests that the large -scale spatial distribution of BAL clouds is non-random, possibly described by a disk geometry. The BAL clouds are incapable of accounting for all of the observed broad emission lines, particularly C III} (lamda)1909 and Mg II (lamda)2798. Therefore, if the BAL clouds give rise to observable emission, the generally adopted (optically thick, single component) model for the emission line region must be incorrect. Also, photoionization models, which utilize solar abundances and take the ionizing continuum to be a simple power law, are incapable of explaining the level of ionization in the BAL clouds. By considering the observed percentage of QSOs with BALs and resonance line scattering models, it is found that the absorption covering factor in BAL QSOs is between 3 and 20 percent. This suggests that possibly all, but not less than 15 percent, of the QSOs have BAL clouds associated with them. The amount of observable emission and polarization expected to be produced by the BAL clouds from resonance line scattering and collisional excitation is considered in

  15. Does the Iron K and Alpha: Line of Active Galactic Nuclei Arise from the Cerenkov Line-like Radiation?

    NASA Technical Reports Server (NTRS)

    You, J. H.; Liu, D. B.; Chen, W. P.; Chen, L.; Zhang, S. N.

    2003-01-01

    When thermal relativistic electrons with isotropic distribution of velocities move in a gas region or impinge upon the surface of a cloud that consists of a dense gas or doped dusts, the Cerenkov effect produces peculiar atomic or ionic emission lines, which is known as the Cerenkov line - like radiation. This newly recognized emission mechanism may find wide applications in high-energy astrophysics. In this paper we tentatively adopt this new line emission mechanism to discuss the origin of the iron Kα feature of active galactic nuclei (AGNs). The motivation of this research is to attempt a solution to a problem encountered by the "disk fluorescence line" model, i.e. , the lack of temporal response of the observed ironline flux to the changes of the X-ray continuum flux. If the Cerenkov line emission is indeed responsible significant ly for the iron Kα feature, the conventional scenario around the central supermassive black holes of AGNs would need to be modified to accomodate more energetic, more violent, and much denser environments than previously thought.

  16. Distance determination to Broad Line Absorbers in AGN

    NASA Astrophysics Data System (ADS)

    Bautista, Manuel; Arav, N.; Dunn, J.; Edmonds, D.; Korista, K. T.; Moe, M.; Benn, C.; Ignacio, G.

    2009-01-01

    We present various techniques for the determination of the physical conditions (density, temperature, total hydrogen column density, and ionization structure), chemical composition, and distances of Broad Line Absorbers (BAL) to the central engine in AGN. We start by discussing various density diagnostics from absorption lines from species such as C II, Si II, and Fe III. On the other hand, lines from metastable levels Fe II are often affected by Bowen fluorescence by scattered C IV photons. Lines from metastable levels of Ni II are usually excited by continuum fluorescence and mostly sensitive to the strength of the radiation field shortward of the Lyman continuum and as such they cam be used as direct distance indicators. Further, we show how the total hydrogen density of the absorber, its ionization parameter and distance can be determined through photoionization modeling of the absorber. Finally, we present our results for outflows of three different quasars: QSO 2359-1241 and SDSS J0318-0600.

  17. Unusual broad-line Mg II emitters among luminous galaxies in the baryon oscillation spectroscopic survey

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Roig, Benjamin; Blanton, Michael R.; Ross, Nicholas P.

    2014-02-01

    Many classes of active galactic nuclei (AGNs) have been observed and recorded since the discovery of Seyfert galaxies. In this paper, we examine the sample of luminous galaxies in the Baryon Oscillation Spectroscopic Survey. We find a potentially new observational class of AGNs, one with strong and broad Mg II λ2799 line emission, but very weak emission in other normal indicators of AGN activity, such as the broad-line Hα, Hβ, and the near-ultraviolet AGN continuum, leading to an extreme ratio of broad Hα/Mg II flux relative to normal quasars. Meanwhile, these objects' narrow-line flux ratios reveal AGN narrow-line regions withmore » levels of activity consistent with the Mg II fluxes and in agreement with that of normal quasars. These AGN may represent an extreme case of the Baldwin effect, with very low continuum and high equivalent width relative to typical quasars, but their ratio of broad Mg II to broad Balmer emission remains very unusual. They may also be representative of a class of AGN where the central engine is observed indirectly with scattered light. These galaxies represent a small fraction of the total population of luminous galaxies (≅ 0.1%), but are more likely (about 3.5 times) to have AGN-like nuclear line emission properties than other luminous galaxies. Because Mg II is usually inaccessible for the population of nearby galaxies, there may exist a related population of broad-line Mg II emitters in the local universe which is currently classified as narrow-line emitters (Seyfert 2 galaxies) or low ionization nuclear emission-line regions.« less

  18. Broad Hβ Emission-line Variability in a Sample of 102 Local Active Galaxies

    NASA Astrophysics Data System (ADS)

    Runco, Jordan N.; Cosens, Maren; Bennert, Vardha N.; Scott, Bryan; Komossa, S.; Malkan, Matthew A.; Lazarova, Mariana S.; Auger, Matthew W.; Treu, Tommaso; Park, Daeseong

    2016-04-01

    A sample of 102 local (0.02 ≤ z ≤ 0.1) Seyfert galaxies with black hole masses MBH > 107M⊙ was selected from the Sloan Digital Sky Survey (SDSS) and observed using the Keck 10 m telescope to study the scaling relations between MBH and host galaxy properties. We study profile changes of the broad Hβ emission line within the three to nine year time frame between the two sets of spectra. The variability of the broad Hβ emission line is of particular interest, not only because it is used to estimate MBH, but also because its strength and width are used to classify Seyfert galaxies into different types. At least some form of broad-line variability (in either width or flux) is observed in the majority (∼66%) of the objects, resulting in a Seyfert-type change for ∼38% of the objects, likely driven by variable accretion and/or obscuration. The broadline virtually disappears in 3/102 (∼3%) extreme cases. We discuss potential causes for these changing look active galactic nuclei. While similar dramatic transitions have previously been reported in the literature, either on a case-by-case basis or in larger samples focusing on quasars at higher redshifts, our study provides statistical information on the frequency of Hβ line variability in a sample of low-redshift Seyfert galaxies.

  19. WPVS 007: Dramatic Broad Absorption Line Variability in a Narrow-line Seyfert 1

    NASA Astrophysics Data System (ADS)

    Cooper, Erin M.; Leighly, K.; Hamann, F. W.; Grupe, D.; Dietrich, M.

    2014-01-01

    Blue-shifted broad absorption lines are the manifestation of gaseous outflows in astrophysical phenomena. In active galaxies, these outflowing winds may play a key role in the central engine physics by removing angular momentum and in influencing host galaxy evolution by imparting energy and chemically enriched gas to the surrounding medium. AGN wind variability affords us a valuable tool to study this still poorly understood phenomenon. The existence of a high velocity broad line outflow in WPVS007 is especially extraordinary, as Seyfert-luminosity active galaxies are unexpected to produce them. With its lower luminosity and compact size, the NLS1 galaxy WPVS007 (M_V=-19.7, z=0.02882) provides us the ability to study even colossal variability on merely human timescales. Since its 1996 FOS observation, displaying miniBALs but no true broad absorption lines, WPVS007 has experienced a short but rich history of UV BAL variability. By the 2003 FUSE observation, WPVS007 had developed a BAL with v_max ~ 6000km/s, indicating an optically thick, high velocity outflow. We present the 2010 and 2013 June and December HST COS spectra. Between 2003 and 2010, both the maximum and minimum outflow velocity had increased substantially. As of 2013 June, the continuum emission has since dimmed by a factor of ~2 and the BALs have appeared to weaken, with both decreased maximum and minimum velocities. Such dramatic shifts in BAL velocity are unprecedented, as BAL variability is typically confined to changes in optical depth. What is the nature of the variability in this BAL wind? The upcoming (as of the writing of this abstract) December observation should give us more insight into tackling that question, whether it be the transient response of a continuous flow to a fluctuating continuum or perhaps the continued decline of a discrete outflow event.

  20. BROAD Hβ EMISSION-LINE VARIABILITY IN A SAMPLE OF 102 LOCAL ACTIVE GALAXIES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Runco, Jordan N.; Cosens, Maren; Bennert, Vardha N.

    2016-04-10

    A sample of 102 local (0.02 ≤ z ≤ 0.1) Seyfert galaxies with black hole masses M{sub BH} > 10{sup 7}M{sub ⊙} was selected from the Sloan Digital Sky Survey (SDSS) and observed using the Keck 10 m telescope to study the scaling relations between M{sub BH} and host galaxy properties. We study profile changes of the broad Hβ emission line within the three to nine year time frame between the two sets of spectra. The variability of the broad Hβ emission line is of particular interest, not only because it is used to estimate M{sub BH}, but also because its strengthmore » and width are used to classify Seyfert galaxies into different types. At least some form of broad-line variability (in either width or flux) is observed in the majority (∼66%) of the objects, resulting in a Seyfert-type change for ∼38% of the objects, likely driven by variable accretion and/or obscuration. The broadline virtually disappears in 3/102 (∼3%) extreme cases. We discuss potential causes for these changing look active galactic nuclei. While similar dramatic transitions have previously been reported in the literature, either on a case-by-case basis or in larger samples focusing on quasars at higher redshifts, our study provides statistical information on the frequency of Hβ line variability in a sample of low-redshift Seyfert galaxies.« less

  1. VARIABLE REDDENING AND BROAD ABSORPTION LINES IN THE NARROW-LINE SEYFERT 1 GALAXY WPVS 007: AN ORIGIN IN THE TORUS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leighly, Karen M.; Cooper, Erin; Grupe, Dirk

    2015-08-10

    We report the discovery of an occultation event in the low-luminosity narrow-line Seyfert 1 galaxy WPVS 007 in 2015 February and March. In concert with longer timescale variability, these observations place strong constraints on the nature and location of the absorbing material. Swift monitoring has revealed a secular decrease since ∼2010 accompanied by flattening of the optical and UV photometry that suggests variable reddening. Analysis of four Hubble Space Telescope COS observations since 2010, including a Director’s Discretionary time observation during the occultation, shows that the broad-absorption-line velocity offset and the C iv emission-line width both decrease as the reddeningmore » increases. The occultation dynamical timescale, the BAL variability dynamical timescale, and the density of the BAL gas show that both the reddening material and the broad-absorption-line gas are consistent with an origin in the torus. These observations can be explained by a scenario in which the torus is clumpy with variable scale height, and the BAL gas is blown from the torus material like spray from the crest of a wave. As the obscuring material passes into our line of sight, we alternately see high-velocity broad absorption lines and a clear view to the central engine, or low-velocity broad absorption lines and strong reddening. WPVS 007 has a small black hole mass, and correspondingly short timescales, and so we may be observing behavior that is common in BALQSOs, but is not typically observable.« less

  2. On the origin of gamma-rays in Fermi blazars: beyondthe broad-line region

    NASA Astrophysics Data System (ADS)

    Costamante, L.; Cutini, S.; Tosti, G.; Antolini, E.; Tramacere, A.

    2018-07-01

    The gamma-ray emission in broad-line blazars is generally explained as inverse Compton (IC) radiation of relativistic electrons in the jet scattering optical-UV photons from the broad-line region (BLR), the so-called BLR external Compton (EC) scenario. We test this scenario on the Fermi gamma-ray spectra of 106 broad-line blazars detected with the highest significance or largest BLR, by looking for cut-off signatures at high energies compatible with γ-γ interactions with BLR photons. We do not find evidence for the expected BLR absorption. For 2/3 of the sources, we can exclude any significant absorption (τmax < 1), while for the remaining 1/3 the possible absorption is constrained to be 1.5-2 orders of magnitude lower than expected. This result holds also dividing the spectra in high- and low-flux states, and for powerful blazars with large BLR. Only 1 object out of 10 seems compatible with substantial attenuation (τmax > 5). We conclude that for 9 out of 10 objects, the jet does not interact with BLR photons. Gamma-rays seem either produced outside the BLR most of the time, or the BLR is ˜100 × larger than given by reverberation mapping. This means that (i) EC on BLR photons is disfavoured as the main gamma-ray mechanism, versus IC on IR photons from the torus or synchrotron self-Compton; (ii) the Fermi gamma-ray spectrum is mostly intrinsic, determined by the interaction of the particle distribution with the seed-photon spectrum; and (iii) without suppression by the BLR, broad-line blazars can become copious emitters above 100 GeV, as demonstrated by 3C 454.3. We expect the CTA sky to be much richer of broad-line blazars than previously thought.

  3. EVIDENCE FOR PHOTOIONIZATION-DRIVEN BROAD ABSORPTION LINE VARIABILITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Tinggui; Yang, Chenwei; Wang, Huiyuan

    2015-12-01

    We present a qualitative analysis of the variability of quasar broad absorption lines using the large multi-epoch spectroscopic data set of the Sloan Digital Sky Survey Data Release 10. We confirm that variations of absorption lines are highly coordinated among different components of the same ion or the same absorption component of different ions for C iv, Si iv, and N v. Furthermore, we show that the equivalent widths (EWs) of the lines decrease or increase statistically when the continuum brightens or dims. This is further supported by the synchronized variations of emission and absorption-line EWs when the well-established intrinsicmore » Baldwin effect for emission lines is taken into account. We find that the emergence of an absorption component is usually accompanied by the dimming of the continuum while the disappearance of an absorption-line component is accompanied by the brightening of the continuum. This suggests that the emergence or disappearance of a C iv absorption component is only the extreme case, when the ionic column density is very sensitive to continuum variations or the continuum variability the amplitude is larger. These results support the idea that absorption-line variability is driven mainly by changes in the gas ionization in response to continuum variations, that the line-absorbing gas is highly ionized, and in some extreme cases, too highly ionized to be detected in UV absorption lines. Due to uncertainties in the spectroscopic flux calibration, we cannot quantify the fraction of quasars with asynchronized continuum and absorption-line variations.« less

  4. Using iron line reverberation and spectroscopy to distinguish Kerr and non-Kerr black holes

    NASA Astrophysics Data System (ADS)

    Jiang, Jiachen; Bambi, Cosimo; Steiner, James F.

    2015-05-01

    The ironline commonly observed in the X-ray spectrum of both stellar-mass and supermassive black hole candidates is produced by the illumination of a cold accretion disk by a hot corona. In this framework, the activation of a new flaring region in the hot corona imprints a time variation on the iron line spectrum. Future X-ray facilities with high time resolution and large effective areas may be able to measure the so-called 2-dimensional transfer function; that is, the iron line profile detected by a distant observer as a function of time in response to an instantaneous flare from the X-ray primary source. This work is a preliminary study to determine if and how such a technique can provide more information about the spacetime geometry around the compact object than the already possible measurements of the time-integrated iron line profile. Within our simplified model, we find that a measurement of iron line reverberation can improve constraints appreciably given a sufficiently strong signal, though that most of the information is present in the time-integrated spectrum. Our aim is to test the Kerr metric. We find that current X-ray facilities and data are unable to provide strong tests of the Kerr nature of supermassive black hole candidates. We consider an optimistic case of 105 iron line photons from a next-generation data set. With such data, the reverberation model improves upon the spectral constraint by an order of magnitude.

  5. Photoionisation modelling of the broad line region

    NASA Astrophysics Data System (ADS)

    King, Anthea

    2016-08-01

    Two of the most fundamental questions regarding the broad line region (BLR) are "what is its structure?" and "how is it moving?" Baldwin et al. (1995) showed that by summing over an ensemble of clouds at differing densities and distances from the ionising source we can easily and naturally produce a spectrum similar to what is observed for AGN. This approach is called the `locally optimally emitting clouds' (LOC) model. This approach can also explain the well-observed stratification of emission lines in the BLR (e.g. Clavel et al. 1991, Peterson et al. 1991, Kollatschny et al. 2001) and `breathing' of BLR with changes in the continuum luminosity (Netzer & Mor 1990, Peterson et al. 2014) and is therefore a generally accepted model of the BLR. However, LOC predictions require some assumptions to be made about the distribution of the clouds within the BLR. By comparing photoionization predictions, for a distribution of cloud properties, with observed spectra we can infer something about the structure of the BLR and distribution of clouds. I use existing reverberation mapping data to constrain the structure of the BLR by observing how individual line strengths and ratios of different lines change in high and low luminosity states. I will present my initial constraints and discuss the challenges associated with the method.

  6. Constraints on the broad-line region properties and extinction in local Seyferts

    NASA Astrophysics Data System (ADS)

    Schnorr-Müller, Allan; Davies, R. I.; Korista, K. T.; Burtscher, L.; Rosario, D.; Storchi-Bergmann, T.; Contursi, A.; Genzel, R.; Graciá-Carpio, J.; Hicks, E. K. S.; Janssen, A.; Koss, M.; Lin, M.-Y.; Lutz, D.; Maciejewski, W.; Müller-Sánchez, F.; Orban de Xivry, G.; Riffel, R.; Riffel, Rogemar A.; Schartmann, M.; Sternberg, A.; Sturm, E.; Tacconi, L.; Veilleux, S.; Ulrich, O. A.

    2016-11-01

    We use high-spectral resolution (R > 8000) data covering 3800-13 000 Å to study the physical conditions of the broad-line region (BLR) of nine nearby Seyfert 1 galaxies. Up to six broad H I lines are present in each spectrum. A comparison - for the first time using simultaneous optical to near-infrared observations - to photoionization calculations with our devised simple scheme yields the extinction to the BLR at the same time as determining the density and photon flux, and hence distance from the nucleus, of the emitting gas. This points to a typical density for the H I emitting gas of 1011 cm-3 and shows that a significant amount of this gas lies at regions near the dust sublimation radius, consistent with theoretical predictions. We also confirm that in many objects, the line ratios are far from case B, the best-fitting intrinsic broad-line Hα/H β ratios being in the range 2.5-6.6 as derived with our photoionization modelling scheme. The extinction to the BLR, based on independent estimates from H I and He II lines, is AV ≤ 3 for Seyfert 1-1.5s, while Seyfert 1.8-1.9s have AV in the range 4-8. A comparison of the extinction towards the BLR and narrow-line region (NLR) indicates that the structure obscuring the BLR exists on scales smaller than the NLR. This could be the dusty torus, but dusty nuclear spirals or filaments could also be responsible. The ratios between the X-ray absorbing column NH and the extinction to the BLR are consistent with the Galactic gas-to-dust ratio if NH variations are considered.

  7. The case for inflow of the broad-line region of active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Gaskell, C. Martin; Goosmann, René W.

    2016-02-01

    The high-ionization lines of the broad-line region (BLR) of thermal active galactic nuclei (AGNs) show blueshifts of a few hundred km/s to several thousand km/sec with respect to the low-ionization lines. This has long been thought to be due to the high-ionization lines of the BLR arising in a wind of which the far side of the outflow is blocked from our view by the accretion disc. Evidence for and against the disc-wind model is discussed. The biggest problem for the model is that velocity-resolved reverberation mapping repeatedly fails to show the expected kinematic signature of outflow of the BLR. The disc-wind model also cannot readily reproduce the red side of the line profiles of high-ionization lines. The rapidly falling density in an outflow makes it difficult to obtain high equivalent widths. We point out a number of major problems with associating the BLR with the outflows producing broad absorption lines. An explanation which avoids all these problems and satisfies the constraints of both the line profiles and velocity-resolved reverberation-mapping is a model in which the blueshifting is due to scattering off material spiraling inwards with an inflow velocity of half the velocity of the blueshifting. We discuss how recent reverberation mapping results are consistent with the scattering-plus-inflow model but do not support a disc-wind model. We propose that the anti-correlation of the apparent redshifting of Hβ with the blueshifting of C iv is a consequence of contamination of the red wings of Hβ by the broad wings of [O iii].

  8. Iron homeostasis and eye disease

    PubMed Central

    Loh, Allison; Hadziahmetovic, Majda; Dunaief, Joshua L.

    2009-01-01

    Summary Iron is necessary for life, but excess iron can be toxic to tissues. Iron is thought to damage tissues primarily by generating oxygen free radicals through the Fenton reaction. We present an overview of the evidence supporting iron's potential contribution to a broad range of eye disease using an anatomical approach. Firstly, iron can be visualized in the cornea as iron lines in the normal aging cornea as well as in diseases like keratoconus and pterygium. In the lens, we present the evidence for the role of oxidative damage in cataractogenesis. Also, we review the evidence that iron may play a role in the pathogenesis of the retinal disease age-related macular degeneration. Although currently there is no direct link between excess iron and development of optic neuropathies, ferrous iron's ability to form highly reactive oxygen species may play a role in optic nerve pathology. Lastly, we discuss recent advances in prevention and therapeutics for eye disease with antioxidants and iron chelators,. PMID:19059309

  9. The Suzaku Observation of NGC 3516: Complex Absorption and the Broad and Narrow Fe K Lines

    NASA Technical Reports Server (NTRS)

    Markowitz, Alex; Reeves, James N.; Miniutti, Giovanni; Serlemitsos, Peter; Kunieda, Hideyo; Taqoob, Tahir; Fabian, Andrew C.; Fukazawa, Yasushi; Mushotzky, Richard; Okajima, Takashi; hide

    2007-01-01

    We present results from a 150 ksec Suzaku observation of the Seyfert 1 NGC 3516 in October 2005. The source was in a relatively highly absorbed state. Our best-fit model is consistent with partial covering by a lowly-ionized absorber with a column density near 5x10(exp 22) cm(exp -2) and with a covering fraction 96-100 percent. Narrow K-shell absorption features due to He- and H-like Fe confirm the presence of a high-ionization absorbing component as well. A broad Fe K(alpha) diskline is required in all fits, even after the complex absorption is taken into account; an additional partial-covering component is an inadequate substitute for the continuum curvature associated with the broad line. The narrow Fe Ka line at 6.4 keV is resolved, yielding a velocity width commensurate with the optical Broad Line Region. The strength of the Compton reflection hump suggests a contribution mainly from the broad Fe line origin. We include in our model soft band emission lines from He- and H-like ions and radiative recombination lines, consistent with photo-ionization, though a small contribution from collisional ionization is possible.

  10. Extreme Ultraviolet Emission Lines of Iron Fe XI-XIII

    NASA Astrophysics Data System (ADS)

    Lepson, Jaan; Beiersdorfer, P.; Brown, G. V.; Liedahl, D. A.; Brickhouse, N. S.; Dupree, A. K.

    2013-04-01

    The extreme ultraviolet (EUV) spectral region (ca. 20--300 Å) is rich in emission lines from low- to mid-Z ions, particularly from the middle charge states of iron. Many of these emission lines are important diagnostics for astrophysical plasmas, providing information on properties such as elemental abundance, temperature, density, and even magnetic field strength. In recent years, strides have been made to understand the complexity of the atomic levels of the ions that emit the lines that contribute to the richness of the EUV region. Laboratory measurements have been made to verify and benchmark the lines. Here, we present laboratory measurements of Fe XI, Fe XII, and Fe XIII between 40-140 Å. The measurements were made at the Lawrence Livermore electron beam ion trap (EBIT) facility, which has been optimized for laboratory astrophysics, and which allows us to select specific charge states of iron to help line identification. We also present new calculations by the Hebrew University - Lawrence Livermore Atomic Code (HULLAC), which we also utilized for line identification. We found that HULLAC does a creditable job of reproducing the forest of lines we observed in the EBIT spectra, although line positions are in need of adjustment, and line intensities often differed from those observed. We identify or confirm a number of new lines for these charge states. This work was supported by the NASA Solar and Heliospheric Program under Contract NNH10AN31I and the DOE General Plasma Science program. Work was performed in part under the auspices of the Department of Energy by Lawrence Livermore National Laboratory under Contract DEAC52-07NA27344.

  11. CHEMICAL EVOLUTION OF THE UNIVERSE AT 0.7 < z < 1.6 DERIVED FROM ABUNDANCE DIAGNOSTICS OF THE BROAD-LINE REGION OF QUASARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Sameshima, H.; Yoshii, Y.; Kawara, K., E-mail: sameshima@cc.kyoto-su.ac.jp

    2017-01-10

    We present an analysis of Mg ii λ 2798 and Fe ii UV emission lines for archival Sloan Digital Sky Survey (SDSS) quasars to explore the diagnostics of the magnesium-to-iron abundance ratio in a broad-line region cloud. Our sample consists of 17,432 quasars selected from the SDSS Data Release 7 with a redshift range of 0.72 <  z  < 1.63. A strong anticorrelation between the Mg ii equivalent width (EW) and the Eddington ratio is found, while only a weak positive correlation is found between the Fe ii EW and the Eddington ratio. To investigate the origin of these differing behaviors ofmore » Mg ii and Fe ii emission lines, we perform photoionization calculations using the Cloudy code, where constraints from recent reverberation mapping studies are considered. We find from calculations that (1) Mg ii and Fe ii emission lines are created at different regions in a photoionized cloud, and (2) their EW correlations with the Eddington ratio can be explained by just changing the cloud gas density. These results indicate that the Mg ii/Fe ii flux ratio, which has been used as a first-order proxy for the Mg/Fe abundance ratio in chemical evolution studies with quasar emission lines, depends largely on the cloud gas density. By correcting this density dependence, we propose new diagnostics of the Mg/Fe abundance ratio for a broad-line region cloud. In comparing the derived Mg/Fe abundance ratios with chemical evolution models, we suggest that α -enrichment by mass loss from metal-poor intermediate-mass stars occurred at z  ∼ 2 or earlier.« less

  12. On the origin of gamma rays in Fermi blazars: beyond the broad line region.

    NASA Astrophysics Data System (ADS)

    Costamante, L.; Cutini, S.; Tosti, G.; Antolini, E.; Tramacere, A.

    2018-05-01

    The gamma-ray emission in broad-line blazars is generally explained as inverse Compton (IC) radiation of relativistic electrons in the jet scattering optical-UV photons from the Broad Line Region (BLR), the so-called BLR External Compton scenario. We test this scenario on the Fermi gamma-ray spectra of 106 broad-line blazars detected with the highest significance or largest BLR, by looking for cut-off signatures at high energies compatible with γ-γ interactions with BLR photons. We do not find evidence for the expected BLR absorption. For 2/3 of the sources, we can exclude any significant absorption (τmax < 1), while for the remaining 1/3 the possible absorption is constrained to be 1.5-2 orders of magnitude lower than expected. This result holds also dividing the spectra in high and low-flux states, and for powerful blazars with large BLR. Only 1 object out of 10 seems compatible with substantial attenuation (τmax > 5). We conclude that for 9 out of 10 objects, the jet does not interact with BLR photons. Gamma-rays seem either produced outside the BLR most of the time, or the BLR is ˜100 × larger than given by reverberation mapping. This means that i) External Compton on BLR photons is disfavoured as the main gamma-ray mechanism, vs IC on IR photons from the torus or synchrotron self-Compton; ii) the Fermi gamma-ray spectrum is mostly intrinsic, determined by the interaction of the particle distribution with the seed-photons spectrum; iii) without suppression by the BLR, broad-line blazars can become copious emitters above 100 GeV, as demonstrated by 3C 454.3. We expect the CTA sky to be much richer of broad-line blazars than previously thought.

  13. Variability of the broad absorption lines in the QSO UM 232

    NASA Technical Reports Server (NTRS)

    Barlow, Thomas A.; Junkkarinen, Vesa T.; Burbidge, E. Margaret

    1989-01-01

    Low-resolution spectra of UM 232 taken in 1978, 1979, and 1988 at Lick Observatory are presented. Large changes in the Si IV lambda 1397, CIV lambda 1549, and Al III lambda 1857 broad absorption lines are apparent. The decrease in column density in all three ions and an observed brightening of the QSO suggests that these changes are due to an increase in the ionization level driven by an increase in the central source luminosity. This mechanism has been proposed by Smith and Penston to explain small changes in the absorption spectrum of the QSO 1246-057. The spectra of UM 232 show that the fractional decrease in optical depth is smaller at higher outflow velocies. The structure of the broad absorption-line region (BALR) is investigted by estimating an ionization parameter for each ion species as a function of velocity.

  14. DISENTANGLING THE CIRCUMNUCLEAR ENVIRONS OF CENTAURUS A. II. ON THE NATURE OF THE BROAD ABSORPTION LINE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Espada, D.; Matsushita, S.; Sakamoto, K.

    2010-09-01

    We report on atomic gas (H I) and molecular gas (as traced by CO(2-1)) redshifted absorption features toward the nuclear regions of the closest powerful radio galaxy, Centaurus A (NGC 5128). Our H I observations using the Very Long Baseline Array allow us to discern with unprecedented sub-parsec resolution H I absorption profiles toward different positions along the 21 cm continuum jet in the inner 0.''3 (or 5.4 pc). In addition, our CO(2-1) data obtained with the Submillimeter Array probe the bulk of the absorbing molecular gas with little contamination by emission, which was not possible with previous CO single-dishmore » observations. We shed light on the physical properties of the gas in the line of sight with these data, emphasizing the still open debate about the nature of the gas that produces the broad absorption line ({approx}55 km s{sup -1}). First, the broad H I line is more prominent toward the central and brightest 21 cm continuum component than toward a region along the jet at a distance {approx}20 mas (or 0.4 pc) further from the nucleus. This indicates that the broad absorption line arises from gas located close to the nucleus, rather than from diffuse and more distant gas. Second, the different velocity components detected in the CO(2-1) absorption spectrum match well with other molecular lines, such as those of HCO{sup +}(1-0), except the broad absorption line that is detected in HCO{sup +}(1-0) (and most likely related to that of the H I). Dissociation of molecular hydrogen due to the active galactic nucleus seems to be efficient at distances r {approx}< 10 pc, which might contribute to the depth of the broad H I and molecular lines.« less

  15. Steps Toward Unveiling the True Population of AGN: Photometric Selection of Broad-Line AGN

    NASA Astrophysics Data System (ADS)

    Schneider, Evan; Impey, C.

    2012-01-01

    We present an AGN selection technique that enables identification of broad-line AGN using only photometric data. An extension of infrared selection techniques, our method involves fitting a given spectral energy distribution with a model consisting of three physically motivated components: infrared power law emission, optical accretion disk emission, and host galaxy emission. Each component can be varied in intensity, and a reduced chi-square minimization routine is used to determine the optimum parameters for each object. Using this model, both broad- and narrow-line AGN are seen to fall within discrete ranges of parameter space that have plausible bounds, allowing physical trends with luminosity and redshift to be determined. Based on a fiducial sample of AGN from the catalog of Trump et al. (2009), we find the region occupied by broad-line AGN to be distinct from that of quiescent or star-bursting galaxies. Because this technique relies only on photometry, it will allow us to find AGN at fainter magnitudes than are accessible in spectroscopic surveys, and thus probe a population of less luminous and/or higher redshift objects. With the vast availability of photometric data in large surveys, this technique should have broad applicability and result in large samples that will complement X-ray AGN catalogs.

  16. Broad Absorption Line Quasar catalogues with Supervised Neural Networks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scaringi, Simone; Knigge, Christian; Cottis, Christopher E.

    2008-12-05

    We have applied a Learning Vector Quantization (LVQ) algorithm to SDSS DR5 quasar spectra in order to create a large catalogue of broad absorption line quasars (BALQSOs). We first discuss the problems with BALQSO catalogues constructed using the conventional balnicity and/or absorption indices (BI and AI), and then describe the supervised LVQ network we have trained to recognise BALQSOs. The resulting BALQSO catalogue should be substantially more robust and complete than BI-or AI-based ones.

  17. Using the Properties of Broad Absorption Line Quasars to Illuminate Quasar Structure

    NASA Astrophysics Data System (ADS)

    Yong, Suk Yee; King, Anthea L.; Webster, Rachel L.; Bate, Nicholas F.; O'Dowd, Matthew J.; Labrie, Kathleen

    2018-06-01

    A key to understanding quasar unification paradigms is the emission properties of broad absorption line quasars (BALQs). The fact that only a small fraction of quasar spectra exhibit deep absorption troughs blueward of the broad permitted emission lines provides a crucial clue to the structure of quasar emitting regions. To learn whether it is possible to discriminate between the BALQ and non-BALQ populations given the observed spectral properties of a quasar, we employ two approaches: one based on statistical methods and the other supervised machine learning classification, applied to quasar samples from the Sloan Digital Sky Survey. The features explored include continuum and emission line properties, in particular the absolute magnitude, redshift, spectral index, line width, asymmetry, strength, and relative velocity offsets of high-ionisation C IV λ1549 and low-ionisation Mg II λ2798 lines. We consider a complete population of quasars, and assume that the statistical distributions of properties represent all angles where the quasar is viewed without obscuration. The distributions of the BALQ and non-BALQ sample properties show few significant differences. None of the observed continuum and emission line features are capable of differentiating between the two samples. Most published narrow disk-wind models are inconsistent with these observations, and an alternative disk-wind model is proposed. The key feature of the proposed model is a disk-wind filling a wide opening angle with multiple radial streams of dense clumps.

  18. Iron K lines from low-mass X-ray binaries

    NASA Technical Reports Server (NTRS)

    Kallman, T.; White, N. E.

    1989-01-01

    Models are presented for the 6-7 keV iron line emission from low-mass X-ray binaries. A simplified model for an accretion disk corona is used to examine the dependence of the observable line properties, line width and mean energy, on the radial distance of the emission region from the X-ray source, and on the fraction of the X-rays from the source which reach the disk surface. The effects of blending of multiple line components and of Comptonization of the line profile are included in numerical calculations of the emitted profile shape. The results of these calculations, when compared with the line properties observed from several low-mass X-ray binaries, suggest that the broadening is dominated either by rotation or by Compton scattering through a greater optical depth than is expected from an accretion disk corona.

  19. Broad Low-Intensity Wings in the Emission-Line Profiles of Four Wolf-Rayet Galaxies

    NASA Astrophysics Data System (ADS)

    Méndez, David I.; Esteban, César

    1997-10-01

    High-resolution spectroscopic observations have been obtained for the Wolf-Rayet galaxies He 2-10, II Zw 40, POX 4, and Tol 35. Several subregions have been selected in each slit position in order to investigate possible spatial variations in the line profiles, radial velocities, and ionization conditions of the gas. The most remarkable feature of the spectra is the presence of asymmetric broad low-intensity wings in the profiles of the brightest emission lines. These spectral features are detected farther out from the star-forming knots, showing linear dimensions between 300 pc and 4.1 kpc. The maximum expansion velocity measured for this gas is between 120 and 340 km s-1 and appears to be quite constant along the slit for all the objects. Additional general properties of the spectra are (1) the quoted emission-line ratios are similar in the narrow and broad components, (2) no systematic differences of the behavior of the broad and narrow components have been found along the major and minor axis of the galaxies, and (3) the spatial distribution of the ionized gas is peaked centrally. Different mechanisms capable of producing the observed broad spectral features are discussed: cloud-cloud collisions in virialized gas, ``academic'' superbubbles, champagne flows, and superbubble blowout. It is concluded that superbubble blowout expanding over a cloudy medium can explain the observational properties in a reasonable manner.

  20. A Census of Broad-line Active Galactic Nuclei in Nearby Galaxies: Coeval Star Formation and Rapid Black Hole Growth

    NASA Astrophysics Data System (ADS)

    Trump, Jonathan R.; Hsu, Alexander D.; Fang, Jerome J.; Faber, S. M.; Koo, David C.; Kocevski, Dale D.

    2013-02-01

    We present the first quantified, statistical map of broad-line active galactic nucleus (AGN) frequency with host galaxy color and stellar mass in nearby (0.01 < z < 0.11) galaxies. Aperture photometry and z-band concentration measurements from the Sloan Digital Sky Survey are used to disentangle AGN and galaxy emission, resulting in estimates of uncontaminated galaxy rest-frame color, luminosity, and stellar mass. Broad-line AGNs are distributed throughout the blue cloud and green valley at a given stellar mass, and are much rarer in quiescent (red sequence) galaxies. This is in contrast to the published host galaxy properties of weaker narrow-line AGNs, indicating that broad-line AGNs occur during a different phase in galaxy evolution. More luminous broad-line AGNs have bluer host galaxies, even at fixed mass, suggesting that the same processes that fuel nuclear activity also efficiently form stars. The data favor processes that simultaneously fuel both star formation activity and rapid supermassive black hole accretion. If AGNs cause feedback on their host galaxies in the nearby universe, the evidence of galaxy-wide quenching must be delayed until after the broad-line AGN phase.

  1. Diagnosing the Kinematics of the Tori in Active Galactic Nuclei with the Velocity-resolved Reverberation Mapping of the Narrow Iron K α Line

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu Yuan; Li Xiaobo, E-mail: liuyuan@ihep.ac.cn, E-mail: lixb@ihep.ac.cn

    The properties of the dusty tori in active galactic nuclei (AGNs) have been investigated in detail, mainly focusing on the geometry and components; however, the kinematics of the torus are still not clear. The narrow iron K α line at 6.4 keV is thought to be produced by the X-ray reflection from the torus. Thus, the velocity-resolved reverberation mapping of it is able to constrain the kinematics of the torus. Such effort is limited by the spectral resolution of current charged coupled device (CCD) detectors and should be possible with the microcalorimeter on the next generation X-ray satellite. In thismore » paper, we first construct the response functions of the torus under a uniform inflow, a Keplerian rotation, and a uniform outflow. Then the energy-dependent light curve of the narrow iron K α line is simulated according to the performance of the X-ray Integral Field Unit in Athena. Finally, the energy-dependent cross-correlation function is calculated to reveal the kinematic signal. According to our results, 100 observations with 5 ks exposure of each are sufficient to distinguish the above three velocity fields. Although the real geometry and velocity field of the torus could be more complex than we assumed, the present result proves the feasibility of the velocity-resolved reverberation mapping of the narrow iron K α line. The combination of the dynamics of the torus with those of the broad-line region and the host galaxy is instructive for the understanding of the feeding and feedback process of AGNs.« less

  2. The Sloan Digital Sky Survey Reverberation Mapping Project: Ensemble Spectroscopic Variability of Quasar Broad Emission Lines

    NASA Astrophysics Data System (ADS)

    Sun, Mouyuan; Trump, Jonathan R.; Shen, Yue; Brandt, W. N.; Dawson, Kyle; Denney, Kelly D.; Hall, Patrick B.; Ho, Luis C.; Horne, Keith; Jiang, Linhua; Richards, Gordon T.; Schneider, Donald P.; Bizyaev, Dmitry; Kinemuchi, Karen; Oravetz, Daniel; Pan, Kaike; Simmons, Audrey

    2015-09-01

    We explore the variability of quasars in the Mg ii and {{H}}β broad emission lines and ultraviolet/optical continuum emission using the Sloan Digital Sky Survey Reverberation Mapping project (SDSS-RM). This is the largest spectroscopic study of quasar variability to date: our study includes 29 spectroscopic epochs from SDSS-RM over 6 months, containing 357 quasars with Mg ii and 41 quasars with {{H}}β . On longer timescales, the study is also supplemented with two-epoch data from SDSS-I/II. The SDSS-I/II data include an additional 2854 quasars with Mg ii and 572 quasars with {{H}}β . The Mg ii emission line is significantly variable ({{Δ }}f/f∼ 10% on ∼100-day timescales), a necessary prerequisite for its use for reverberation mapping studies. The data also confirm that continuum variability increases with timescale and decreases with luminosity, and the continuum light curves are consistent with a damped random-walk model on rest-frame timescales of ≳ 5 days. We compare the emission-line and continuum variability to investigate the structure of the broad-line region. Broad-line variability shows a shallower increase with timescale compared to the continuum emission, demonstrating that the broad-line transfer function is not a δ-function. {{H}}β is more variable than Mg ii (roughly by a factor of ∼1.5), suggesting different excitation mechanisms, optical depths and/or geometrical configuration for each emission line. The ensemble spectroscopic variability measurements enabled by the SDSS-RM project have important consequences for future studies of reverberation mapping and black hole mass estimation of 1\\lt z\\lt 2 quasars.

  3. A Catalog of Broad Absorption Line Quasars from the Sloan Digital Sky Survey Third Data Release

    NASA Astrophysics Data System (ADS)

    Trump, Jonathan R.; Hall, Patrick B.; Reichard, Timothy A.; Richards, Gordon T.; Schneider, Donald P.; Vanden Berk, Daniel E.; Knapp, Gillian R.; Anderson, Scott F.; Fan, Xiaohui; Brinkman, J.; Kleinman, S. J.; Nitta, Atsuko

    2006-07-01

    We present a total of 4784 unique broad absorption line quasars from the Sloan Digital Sky Survey Third Data Release. An automated algorithm was used to match a continuum to each quasar and to identify regions of flux at least 10% below the continuum over a velocity range of at least 1000 km s-1 in the C IV and Mg II absorption regions. The model continuum was selected as the best-fit match from a set of template quasar spectra binned in luminosity, emission line width, and redshift, with the power-law spectral index and amount of dust reddening as additional free parameters. We characterize our sample through the traditional ``balnicity'' index and a revised absorption index, as well as through parameters such as the width, outflow velocity, fractional depth, and number of troughs. From a sample of 16,883 quasars at 1.7<=z<=4.38, we identify 4386 (26.0%) quasars with broad C IV absorption, of which 1756 (10.4%) satisfy traditional selection criteria. From a sample of 34,973 quasars at 0.5<=z<=2.15, we identify 457 (1.31%) quasars with broad Mg II absorption, 191 (0.55%) of which satisfy traditional selection criteria. We also provide a supplementary list of 39 visually identified z>4.38 quasars with broad C IV absorption. We find that broad absorption line quasars may have broader emission lines on average than other quasars.

  4. Exploring possible relations between optical variability time scales and broad emission line shapes in AGN

    NASA Astrophysics Data System (ADS)

    Bon, Edi; Jovanović, Predrag; Marziani, Paola; Bon, Nataša; Otašević, Aleksandar

    2018-06-01

    Here we investigate the connection of broad emission line shapes and continuum light curve variability time scales of type-1 Active Galactic Nuclei (AGN). We developed a new model to describe optical broad emission lines as an accretion disk model of a line profile with additional ring emission. We connect ring radii with orbital time scales derived from optical light curves, and using Kepler's third law, we calculate mass of central supermassive black hole (SMBH). The obtained results for central black hole masses are in a good agreement with other methods. This indicates that the variability time scales of AGN may not be stochastic, but rather connected to the orbital time scales which depend on the central SMBH mass.

  5. Disc origin of broad optical emission lines of the TDE candidate PTF09djl

    NASA Astrophysics Data System (ADS)

    Liu, F. K.; Zhou, Z. Q.; Cao, R.; Ho, L. C.; Komossa, S.

    2017-11-01

    An otherwise dormant supermassive black hole (SMBH) in a galactic nucleus flares up when it tidally disrupts a star passing by. Most of the tidal disruption events (TDEs) and candidates discovered in the optical/UV have broad optical emission lines with complex and diverse profiles of puzzling origin. In this Letter, we show that the double-peaked broad H α line of the TDE candidate PTF09djl can be well modelled with a relativistic elliptical accretion disc and the peculiar substructures with one peak at the line rest wavelength and the other redshifted to about 3.5 × 104 km s-1 are mainly due to the orbital motion of the emitting matter within the disc plane of large inclination 88° and pericentre orientation nearly vertical to the observer. The accretion disc has an extreme eccentricity 0.966 and semimajor axis of 340 BH Schwarzschild radii. The viewing angle effects of large disc inclination lead to significant attenuation of He emission lines originally produced at large electron scattering optical depth and to the absence/weakness of He emission lines in the spectra of PTF09djl. Our results suggest that the diversities of line intensity ratios among the line species in optical TDEs are probably due to the differences of disc inclinations.

  6. Investigating the Fraction of Radio-Loud Quasars with High Velocity Broad Emission LInes

    NASA Astrophysics Data System (ADS)

    Bhattacharjee, Anirban; Gilbert, Miranda; Brotherton, Michael S.

    2018-06-01

    Quasars show a bimodal distribution in their radio emission, with some having powerful radio-emitting jets (radio-loud), and most having weak or no jets (radio-quiet). Surveys have shown around 10% of of quasars have detectable radio emissions. These quasars are called radio-loud. Several multiwavelength studies have shown that radio-loud quasars have different properties than radio-quiet quasars. This fraction of radio-loud quasars to radio-quiet quasars has been assumed to be constant across all parameter space. In this study, we breakdown the parameter space with respect to the increasing velocity dispersion of broad emission lines. Our sample has been drawn from 2011 Shen et al. catalog of more than 100,000 quasars. In this study, we demonstrate that this fraction varies with respect to the increasing velocity dispersion (FWHM) of broad emission lines. We compare three different emission lines: H-Beta, MgII, and CIV. We observe with increasing FWHM of these three emission lines, fraction of radio-loud quasars within the subset increases. This poster presents our initial results into investigating whether the fraction of RL quasars remains 10% in different parameter space.

  7. Broad Absorption Line Quasars with Polar Outflows

    NASA Astrophysics Data System (ADS)

    Wang, Junxian

    2005-10-01

    It is widely accepted that the broad absorption line (BAL) outflow exists in most (if not all) quasars with a small covering factor. Various evidences show that equatorial outflows are responsible for the BALs in most BAL QSOs. By searching for radio variable quasars in SDSS, we built the first sample of 6 BAL QSOs with polar BAL outflows. It is very likely that polar outflows are associated with relativistic jets, and their origins should be different from the equatorial outflows in the majority of BAL QSOs. We propose an XMM snapshot survey to a) check whether strong X-ray absorption, one of the most prominent characteristics of most BAL QSOs, also exist in the polar outflows b) check whether face-on BAL QSOs are otherwise X-ray normal c) provide a baseline for future extensive X-ray studies.

  8. SUZAKU MONITORING OF THE IRON K EMISSION LINE IN THE TYPE 1 ACTIVE GALACTIC NUCLEUS NGC 5548

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu Yuan; Elvis, Martin; Wilkes, Belinda J.

    2010-02-20

    We present seven sequential weekly observations of NGC 5548 conducted in 2007 with the Suzaku X-ray Imaging Spectrometer (XIS) in the 0.2-12 keV band and Hard X-ray Detector (HXD) in the 10-600 keV band. The iron Kalpha line is well detected in all seven observations and Kbeta line is also detected in four observations. In this paper, we investigate the origin of the Fe K lines using both the width of the line and the reverberation mapping method. With the co-added XIS and HXD spectra, we identify Fe Kalpha and Kbeta line at 6.396{sup +0.009}{sub -0.007} keV and 7.08{sup +0.05}{submore » -0.05} keV, respectively. The width of line obtained from the co-added spectra is 38{sup +16}{sub -18} eV (FWHM = 4200{sup +1800}{sub -2000} km s{sup -1}) which corresponds to a radius of 20{sup +50}{sub -10} light days, for the virial production of 1.220 x 10{sup 7} M{sub sun} in NGC 5548. To quantitatively investigate the origin of the narrow Fe line by the reverberation mapping method, we compare the observed light curves of Fe Kalpha line with the predicted ones, which are obtained by convolving the continuum light curve with the transfer functions in a thin shell and an inclined disk. The best-fit result is given by the disk case with i = 30 deg. which is better than a fit to a constant flux of the Fe K line at the 92.7% level (F-test). However, the results with other geometries are also acceptable (P>50%). We find that the emitting radius obtained from the light curve is 25-37 light days, which is consistent with the radius derived from the Fe K line width. Combining the results of the line width and variation, the most likely site for the origin of the narrow iron lines is 20-40 light days away from the central engine, though other possibilities are not completely ruled out. This radius is larger than the Hbeta emitting parts of the broad-line region at 6-10 light days (obtained by the simultaneous optical observation), and smaller than the inner radius of the hot dust in

  9. Variable broad lines and outflow in the weak blazar PBC J2333.9-2343

    NASA Astrophysics Data System (ADS)

    Hernández-García, L.; Vietri, G.; Panessa, F.; Piconcelli, E.; Chavushyan, V.; Jiménez-Andrade, E. F.; Bassani, L.; Bazzano, A.; Cazzoli, S.; Malizia, A.; Masetti, N.; Monaco, L.; Pović, M.; Saviane, I.; Ubertini, P.

    2018-05-01

    PBC J2333.9-2343 is a peculiar active nucleus with two giant radio lobes and a weak blazar-like nucleus at their center. In the present work we show new optical, UV, and X-ray data taken from the San Pedro Mártir telescope, the New Technology Telescope, NTT/EFOSC2, and the Swift/XRT satellite. The source is highly variable at all frequencies, in particular the strongest variations are found in the broad Hα component with a flux increase of 61±4 per cent between 2009 and 2016, following the X-ray flux increase of 62±6 per cent between 2010 and 2016. We also detected a broad Hβ component in 2016, making the optical classification change from type 1.9 to type 1.8 in one year. We have also detected a broad component of the [OIII]λ5007 line, which is blue-shifted and of high velocity, suggesting an origin from a highly disturbed medium, possibly an outflow. The line flux variability and broad widths are indicative of a jet that is, at least in part, responsible for the ionization of the BLR and NLR.

  10. The high-energy view of the broad-line radio galaxy 3C 111

    NASA Astrophysics Data System (ADS)

    Ballo, L.; Braito, V.; Reeves, J. N.; Sambruna, R. M.; Tombesi, F.

    2011-12-01

    We present the analysis of Suzaku and XMM-Newton observations of the broad-line radio galaxy (BLRG) 3C 111. Its high-energy emission shows variability, a harder continuum with respect to the radio-quiet active galactic nucleus population, and weak reflection features. Suzaku found the source in a minimum flux level; a comparison with the XMM-Newton data implies an increase of a factor of 2.5 in the 0.5-10 keV flux, in the 6 months separating the two observations. The iron K complex is detected in both data sets, with rather low equivalent width(s). The intensity of the iron K complex does not respond to the change in continuum flux. An ultrafast, high-ionization outflowing gas is clearly detected in the Suzaku/X-ray Imaging Spectrometer data; the absorber is most likely unstable. Indeed, during the XMM-Newton observation, which was 6 months after, the absorber was not detected. No clear rollover in the hard X-ray emission is detected, probably due to the emergence of the jet as a dominant component in the hard X-ray band, as suggested by the detection above ˜100 keV with the GSO onboard Suzaku, although the present data do not allow us to firmly constrain the relative contribution of the different components. The fluxes observed by the γ-ray satellites CGRO and Fermi would be compatible with the putative jet component if peaking at energies E˜ 100 MeV. In the X-ray band, the jet contribution to the continuum starts to be significant only above 10 keV. If the detection of the jet component in 3C 111 is confirmed, then its relative importance in the X-ray energy band could explain the different observed properties in the high-energy emission of BLRGs, which are otherwise similar in their other multiwavelength properties. Comparison between X-ray and γ-ray data taken at different epochs suggests that the strong variability observed for 3C 111 is probably driven by a change in the primary continuum.

  11. Investigating broad absorption line quasars with SDSS and UKIDSS .

    NASA Astrophysics Data System (ADS)

    Maddox, Natasha; Hewett, P. C.

    The SDSS contains the largest set of spectroscopically confirmed broad line quasars ever compiled. Upon its completion, the UKIDSS LAS will provide a near-infrared counterpart to the SDSS, reaching 3 magnitudes deeper than 2MASS over a 4000 square degree area within the SDSS footprint. Combining the SDSS optical and UKIDSS near-infrared data, allows a new insight into the photometric and spectroscopic properties of broad absorption line quasars (BALQSOs) relative to the quasar population as a whole. An accurate estimate of the intrinsic BALQSO fraction is essential for determining the BAL cloud covering fraction and the implications for the co-evolution of accreting supermassive black holes and their host galaxies. Defining a K-band limited sample of quasars makes clear the significantly redder distribution of i-K colours of the BALQSOs. The BALQSO i-K colour distribution enables us to estimate a lower limit to the intrinsic BALQSO fraction, computed to be ˜ 30 percent, significantly larger than the optical fraction of 15-20 percent found by several authors. We combined the high-quality SDSS spectra of the quasar sample to make several composite spectra based on i-K colour, and the properties of these composites are compared to a composite spectrum of unreddened quasars. If the origin of the wavelength dependent differences between the red and unreddened objects is ascribed to attenuation by dust, we find that the extinction curve of the material is intermediate in form between the steep SMC-like extinction curve and the recent, empirically determined, extinction curve presented by Gaskell & Benker (2007).

  12. A Broad-band Spectral and Timing Study of the X-Ray Binary System Centaurus X-3

    NASA Technical Reports Server (NTRS)

    Audley, Michael Damian

    1998-01-01

    This dissertation describes a multi-mission investigation of the high mass X-ray binary pulsar Centaurus X-3. Cen X-3 was observed with the Broad Band X-Ray Telescope (BBXRT) in December 1990. This was the first high-resolution solid state X-ray spectrometer to cover the iron K fluorescence region. The Fe K emission feature was resolved into two components for the first time. A broad 6.7 keV feature was found to be a blend of lines from Fe XXI-Fe XXVI with energies ranging from 6.6 to 6.9 keV due to photoionization of the companion's stellar wind. A narrow line at 6.4 keV due to fluorescence of iron in relatively low ionization states was also found. The quasi-periodic oscillations (QPO) at about 40 mHz were used to estimate the surface magnetic field of Cen X-3 as approx. 2.6 x 10(exp 12) G and to predict that there should be a cyclotron scattering resonance absorption feature (CSRF) near 30 keV. In order to further resolve the iron line complex and to investigate the pulse-phase dependence of the iron line intensities, Cen X-3 was observed with the Advanced Satellite for Cosmology and Astrophysics (ASCA). Using ASCA's state-of-the-art non-dispersive X-ray spectrometers the 6.4 keV fluorescent iron line was found to be pulsing while the intensities of the 6.7 and 6.9 keV recombination lines do not vary with pulse phase. This confirms that the 6.4 keV line is due to reflection by relatively neutral matter close to the neutron star while the recombination lines originate in the extended stellar wind. The continuum spectrum was found to be modified by reflection from matter close to the neutron star. Observations with the EXOSAT GSPC were used to search for a CSRF. The EXOSAT spectra were consistent with the presence of a CSRF but an unambiguous detection was not possible because of a lack of sensitivity at energies higher than the cyclotron energy. Cen X-3 was then observed with the Rossi X-Ray Timing Explorer (RXTE) and evidence for a CSRF at 25.1 +/- 0.3 keV was

  13. On the origin of the iron fluorescent line emission from the Galactic Ridge

    NASA Astrophysics Data System (ADS)

    Eze, R. N. C.

    2015-04-01

    The Galactic Ridge X-ray Emission (GRXE) spectrum has strong iron emission lines at 6.4, 6.7, and 7.0 keV, each corresponding to the neutral (or low-ionized), He-like, and H-like iron ions. The 6.4 keV fluorescence line is due to irradiation of neutral (or low ionized) material (iron) by hard X-ray sources, indicating uniform presence of the cold matter in the Galactic plane. In order to resolve the origin of the cold fluorescent matter, we examined the contribution of the 6.4 keV line emission from white dwarf surfaces in the hard X-ray emitting symbiotic stars (hSSs) and magnetic cataclysmic variables (mCVs) to the GRXE. In our spectral analysis of 4 hSSs and 19 mCVs observed with Suzaku, we were able to resolve the three iron emission lines. We found that the equivalent-widths (EWs) of the 6.4 keV lines of hSSs are systematically higher than those of mCVs, such that the EWs of the merged hSSs and mCVs are 179-11+46 eV and 93-3+20 eV, respectively. The EW of hSSs compares favorably with the typical EWs of the 6.4 keV line in the GRXE of 90-300 eV depending on Galactic positions. Average 6.4 keV line luminosities of the hSSs and mCVs are 9.2 ×1039 and 1.6 ×1039 photons s-1, respectively, indicating that hSSs are intrinsically more efficient 6.4 keV line emitters than mCVs. We estimated required space densities of hSSs and mCVs to account for all the GRXE 6.4 keV line emission flux to be 2 ×10-7 pc-3 and 1 ×10-6 pc-3, respectively. We also estimated the actual 6.4 keV line contribution from the mCVs with a known space density, which is as much as 20% of the observed GRXE flux, and for the hSSs, for which only five hSSs are known, we noted that they could contribute a significant percentage to the observed GRXE flux since we believe there is still more hSSs yet to be discovered in the Galaxy. We therefore conclude that the GRXE 6.4 keV line flux could be significantly explained by hSSs and mCVs 6.4 keV line flux.

  14. Missing Fe: hydrogenated iron nanoparticles

    NASA Astrophysics Data System (ADS)

    Bilalbegović, G.; Maksimović, A.; Mohaček-Grošev, V.

    2017-03-01

    Although it was found that the FeH lines exist in the spectra of some stars, none of the spectral features in the interstellar medium (ISM) have been assigned to this molecule. We suggest that iron atoms interact with hydrogen and produce Fe-H nanoparticles which sometimes contain many H atoms. We calculate infrared spectra of hydrogenated iron nanoparticles using density functional theory methods and find broad, overlapping bands. Desorption of H2 could induce spinning of these small Fe-H dust grains. Some of hydrogenated iron nanoparticles possess magnetic and electric moments and should interact with electromagnetic fields in the ISM. FenHm nanoparticles could contribute to the polarization of the ISM and the anomalous microwave emission. We discuss the conditions required to form FeH and FenHm in the ISM.

  15. Microlensing and Intrinsic Variability of the Broad Emission Lines of Lensed Quasars

    NASA Astrophysics Data System (ADS)

    Fian, C.; Guerras, Eduardo; Mediavilla, E.; Jiménez-Vicente, J.; Muñoz, J. A.; Falco, E. E.; Motta, V.; Hanslmeier, A.

    2018-05-01

    We study the broad emission lines in a sample of 11 gravitationally lensed quasars with at least two epochs of observation to identify intrinsic variability and to disentangle it from microlensing. To improve our statistical significance and emphasize trends, we also include 15 lens systems with single-epoch spectra. Mg II and C III] emission lines are only weakly affected by microlensing, but C IV shows strong microlensing in some cases, even for regions of the line core, presumably associated with small projected velocities. However, excluding the strongly microlensed cases, there is a strikingly good match, on average, between the red wings of the C IV and C III] profiles. Analysis of these results supports the existence of two regions in the broad-line region (BLR), one that is insensitive to microlensing (of size ≳50 lt-day and kinematics not confined to a plane) and another that shows up only when it is magnified by microlensing (of size of a few light-days, comparable to the accretion disk). Both regions can contribute in different proportions to the emission lines of different species and, within each line profile, to different velocity bins, all of which complicates detailed studies of the BLR based on microlensing size estimates. The strength of the microlensing indicates that some spectral features that make up the pseudo-continuum, such as the shelf-like feature at λ1610 or several Fe III blends, may in part arise from an inner region of the accretion disk. In the case of Fe II, microlensing is strong in some blends but not in others. This opens up interesting possibilities to study quasar accretion disk kinematics. Intrinsic variability seems to affect the same features prone to microlensing, with similar frequency and amplitude, but does not induce outstanding profile asymmetries. We measure intrinsic variability (≲20%) of the wings with respect to the cores in the C IV, C III], and Mg II lines consistent with reverberation mapping studies.

  16. Narrow vs. Broad line Seyfert 1 galaxies: X-ray, optical and mid-infrared AGN characteristics

    NASA Astrophysics Data System (ADS)

    Lakićević, Maša; Popović, Luka Č.; Kovačević-Dojčinović, Jelena

    2018-05-01

    We investigated narrow line Seyfert 1 galaxies (NLS1s) at optical, mid-infrared (MIR) and X-ray wavelengths, comparing them to the broad line active galactic nuclei (BLAGNs). We found that black hole mass, coronal line luminosities, X-ray hardness ratio and X-ray, optical and MIR luminosities are higher for the BLAGNs than for NLS1s, while policyclic aromatic hydrocarbon (PAH) contribution and the accretion rates are higher for the NLS1s. Furthermore, we found some trends among spectral parameters that NLS1s have and BLAGNs do not have. The evolution of FWHM(Hβ) with the luminosities of MIR and coronal lines, continuum luminosities, PAH contribution, Hβ broad line luminosity, FWHM[O III] and EW(HβNLR), are important trends found for NLS1s. That may contribute to the insight that NLS1s are developing AGNs, growing their black holes, while their luminosities and FWHM(Hβ) consequently grow, and that BLAGNs are mature, larger objects of slower and/or different evolution. Black hole mass is related to PAH contribution only for NLS1s, which may suggest that PAHs are more efficiently destroyed in NLS1s.

  17. A Falling Corona Model for the Anomalous Behavior of the Broad Emission Lines in NGC 5548

    NASA Astrophysics Data System (ADS)

    Sun, Mouyuan; Xue, Yongquan; Cai, Zhenyi; Guo, Hengxiao

    2018-04-01

    NGC 5548 has been intensively monitored by the AGN Space Telescope and Optical Reverberation Mapping collaboration. Approximately after half of the light curves, the correlation between the broad emission lines and the lag-corrected ultraviolet (UV) continua becomes weak. This anomalous behavior is accompanied by an increase of soft X-ray emission. We propose a simple model to understand this anomalous behavior, i.e., the corona might fall down, thereby increasing the covering fraction of the inner disk. Therefore, X-ray and extreme-UV emission suffer from spectral variations. The UV continua variations are driven by both X-ray and extreme-UV variations. Consequently, the spectral variability induced by the falling corona would dilute the correlation between the broad emission lines and the UV continua. Our model can explain many additional observational facts, including the dependence of the anomalous behavior on velocity and ionization energy. We also show that the time lag and correlation between the X-ray and the UV variations change as NGC 5548 displays the anomalous behavior. The time lag is dramatically longer than the expectation from disk reprocessing if the anomalous behavior is properly excluded. During the anomalous state, the time lag approaches the light-travel timescale of disk reprocessing albeit with a much weaker correlation. We speculate that the time lag in the normal state is caused by reprocessing of the broad line region gas. As NGC 5548 enters the abnormal state, the contribution of the broad line region gas is smaller; the time lag reflects disk reprocessing. We also discuss alternative scenarios.

  18. Reverberation Mapping of the Broad Line Region: Application to a Hydrodynamical Line-driven Disk Wind Solution

    NASA Astrophysics Data System (ADS)

    Waters, Tim; Kashi, Amit; Proga, Daniel; Eracleous, Michael; Barth, Aaron J.; Greene, Jenny

    2016-08-01

    The latest analysis efforts in reverberation mapping are beginning to allow reconstruction of echo images (or velocity-delay maps) that encode information about the structure and kinematics of the broad line region (BLR) in active galactic nuclei (AGNs). Such maps can constrain sophisticated physical models for the BLR. The physical picture of the BLR is often theorized to be a photoionized wind launched from the AGN accretion disk. Previously we showed that the line-driven disk wind solution found in an earlier simulation by Proga and Kallman is virialized over a large distance from the disk. This finding implies that, according to this model, black hole masses can be reliably estimated through reverberation mapping techniques. However, predictions of echo images expected from line-driven disk winds are not available. Here, after presenting the necessary radiative transfer methodology, we carry out the first calculations of such predictions. We find that the echo images are quite similar to other virialized BLR models such as randomly orbiting clouds and thin Keplerian disks. We conduct a parameter survey exploring how echo images, line profiles, and transfer functions depend on both the inclination angle and the line opacity. We find that the line profiles are almost always single peaked, while transfer functions tend to have tails extending to large time delays. The outflow, despite being primarily equatorially directed, causes an appreciable blueshifted excess on both the echo image and line profile when seen from lower inclinations (I≲ 45^\\circ ). This effect may be observable in low ionization lines such as {{H}}β .

  19. THE SLOAN DIGITAL SKY SURVEY REVERBERATION MAPPING PROJECT: RAPID C iv BROAD ABSORPTION LINE VARIABILITY

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grier, C. J.; Brandt, W. N.; Trump, J. R.

    2015-06-10

    We report the discovery of rapid variations of a high-velocity C iv broad absorption line trough in the quasar SDSS J141007.74+541203.3. This object was intensively observed in 2014 as a part of the Sloan Digital Sky Survey Reverberation Mapping Project, during which 32 epochs of spectroscopy were obtained with the Baryon Oscillation Spectroscopic Survey spectrograph. We observe significant (>4σ) variability in the equivalent width (EW) of the broad (∼4000 km s{sup −1} wide) C iv trough on rest-frame timescales as short as 1.20 days (∼29 hr), the shortest broad absorption line variability timescale yet reported. The EW varied by ∼10%more » on these short timescales, and by about a factor of two over the duration of the campaign. We evaluate several potential causes of the variability, concluding that the most likely cause is a rapid response to changes in the incident ionizing continuum. If the outflow is at a radius where the recombination rate is higher than the ionization rate, the timescale of variability places a lower limit on the density of the absorbing gas of n{sub e} ≳ 3.9 × 10{sup 5} cm{sup −3}. The broad absorption line variability characteristics of this quasar are consistent with those observed in previous studies of quasars, indicating that such short-term variability may in fact be common and thus can be used to learn about outflow characteristics and contributions to quasar/host-galaxy feedback scenarios.« less

  20. The different origins of high- and low-ionization broad emission lines revealed by gravitational microlensing in the Einstein cross

    NASA Astrophysics Data System (ADS)

    Braibant, L.; Hutsemékers, D.; Sluse, D.; Anguita, T.

    2016-07-01

    We investigate the kinematics and ionization structure of the broad emission line region of the gravitationally lensed quasar QSO2237+0305 (the Einstein cross) using differential microlensing in the high- and low-ionization broad emission lines. We combine visible and near-infrared spectra of the four images of the lensed quasar and detect a large-amplitude microlensing effect distorting the high-ionization CIV and low-ionization Hα line profiles in image A. While microlensing only magnifies the red wing of the Balmer line, it symmetrically magnifies the wings of the CIV emission line. Given that the same microlensing pattern magnifies both the high- and low-ionization broad emission line regions, these dissimilar distortions of the line profiles suggest that the high- and low-ionization regions are governed by different kinematics. Since this quasar is likely viewed at intermediate inclination, we argue that the differential magnification of the blue and red wings of Hα favors a flattened, virialized, low-ionization region whereas the symmetric microlensing effect measured in CIV can be reproduced by an emission line formed in a polar wind, without the need of fine-tuned caustic configurations. Based on observations made with the ESO-VLT, Paranal, Chile; Proposals 076.B-0197 and 076.B-0607 (PI: Courbin).

  1. Study of transmission line attenuation in broad band millimeter wave frequency range.

    PubMed

    Pandya, Hitesh Kumar B; Austin, M E; Ellis, R F

    2013-10-01

    Broad band millimeter wave transmission lines are used in fusion plasma diagnostics such as electron cyclotron emission (ECE), electron cyclotron absorption, reflectometry and interferometry systems. In particular, the ECE diagnostic for ITER will require efficient transmission over an ultra wide band, 100 to 1000 GHz. A circular corrugated waveguide transmission line is a prospective candidate to transmit such wide band with low attenuation. To evaluate this system, experiments of transmission line attenuation were performed and compared with theoretical loss calculations. A millimeter wave Michelson interferometer and a liquid nitrogen black body source are used to perform all the experiments. Atmospheric water vapor lines and continuum absorption within this band are reported. Ohmic attenuation in corrugated waveguide is very low; however, there is Bragg scattering and higher order mode conversion that can cause significant attenuation in this transmission line. The attenuation due to miter bends, gaps, joints, and curvature are estimated. The measured attenuation of 15 m length with seven miter bends and eighteen joints is 1 dB at low frequency (300 GHz) and 10 dB at high frequency (900 GHz), respectively.

  2. Hidden Broad-line Regions in Seyfert 2 Galaxies: From the Spectropolarimetric Perspective

    NASA Astrophysics Data System (ADS)

    Du, Pu; Wang, Jian-Min; Zhang, Zhi-Xiang

    2017-05-01

    The hidden broad-line regions (BLRs) in Seyfert 2 galaxies, which display broad emission lines (BELs) in their polarized spectra, are a key piece of evidence in support of the unified model for active galactic nuclei (AGNs). However, the detailed kinematics and geometry of hidden BLRs are still not fully understood. The virial factor obtained from reverberation mapping of type 1 AGNs may be a useful diagnostic of the nature of hidden BLRs in type 2 objects. In order to understand the hidden BLRs, we compile six type 2 objects from the literature with polarized BELs and dynamical measurements of black hole masses. All of them contain pseudobulges. We estimate their virial factors, and find the average value is 0.60 and the standard deviation is 0.69, which agree well with the value of type 1 AGNs with pseudobulges. This study demonstrates that (1) the geometry and kinematics of BLR are similar in type 1 and type 2 AGNs of the same bulge type (pseudobulges), and (2) the small values of virial factors in Seyfert 2 galaxies suggest that, similar to type 1 AGNs, BLRs tend to be very thick disks in type 2 objects.

  3. The Broad Iron K-alpha line of Cygnus X-1 as Seen by XMM-Newton in the EPIC-pn Modified Timing Mode

    NASA Technical Reports Server (NTRS)

    Duro, Refiz; Dauser, Thomas; Wilms, Jorn; Pottschmidt, Katja; Nowak, Michael A.; Fritz, Sonja; Kendziorra, Eckhard; Kirsch, Marcus G. F.; Reynolds, Christopher S.; Staubert, Rudiger

    2011-01-01

    We present the analysis of the broadened, flourescent iron K(alpha) line in simultaneous XMM-Newton and RXTE data from the black hole Cygnus X-I. The XMM-Newton data were taken in a modified version of the Timing Mode of the EPIC-pn camera. In this mode the lower energy threshold of the instrument is increased to 2.8 keV to avoid telemetry drop outs due to the brightness of the source, while at the same time preserving the signal to noise ratio in the Fe K(alpha) band. We find that the best-fit spectrum consists of the sum of an exponentially cut-off power-law and relativistically smeared, ionized reflection. The shape of the broadened Fe K(alpha) feature is due to strong Compton broadening combined with relativistic broadening. Assuming a standard, thin accretion disk, the black hole is close to maximally rotating. Key words. X-rays: binaries - black hole physics - gravitation

  4. The link between quasar broad-line region and galaxy-scale outflows and accurate CIV-based black hole masses

    NASA Astrophysics Data System (ADS)

    Coatman, Liam; Hewett, Paul C.; Banerji, Manda; Richards, Gordon T.; Hennawi, Joseph F.; Prochaska, Jason X.

    2017-01-01

    Accurate black-hole (BH) mass estimates for high-redshift (z>2) quasars are essential for better understanding the relationship between super-massive BH accretion and star formation. Progress is currently limited by the large systematic errors in virial BH-masses derived from the CIV broad emission line, which is often significantly blueshifted relative to systemic, most likely due to outflowing gas in the quasar broad-line region. We have assembled Balmer-line based BH masses for a large sample of 230 high-luminosity (1045.5-1048 ergs-1), redshift 1.5line-based masses by almost an order of magnitude at the most extreme blueshifts (˜5000 kms-1). An empirical correction to the CIV BH-masses is derived, which depends only on the properties of the CIV line itself (i.e. blueshift and FWHM). We show that this new correction now enables the derivation of un-biased CIV-based virial BH masses for the majority of high-luminosity, high-redshift quasars.In the same high-luminosity quasar sample, we find the narrow [OIII] emission to be weaker and more asymmetric than is generally found in lower-luminosity AGN and that a significant fraction of our quasars have exceptionally broad (FWHM > 3000 kms-1), blueshifted [OIII] emission. We find a strong correlation between the CIV and [OIII] blueshifts. This correlation holds even for quasars at fixed luminosity and suggests that broad line region outflows in quasars are connected to galaxy-scale winds.

  5. Discovery of an X-ray Violently Variable Broad Absorption Line Quasar

    NASA Technical Reports Server (NTRS)

    Ghosh, Kajal K.; Gutierrez, Carlos M.; Punsly, Brian; Chevallier, Loic; Goncalves, Anabela C.

    2006-01-01

    In this letter, we report on a quasar that is violently variable in the X-rays, XVV. It is also a broad absorption line quasar (BALQSO) that exhibits both high ionization and low ionization UV absorption lines (LoBALQSO). It is very luminous in the X-rays (approximately 10(exp 46) ergs s(sup -l) over the entire X-ray band). Surprisingly, this does not over ionize the LoBAL outflow. The X-rays vary by a factor of two within minutes in the quasar rest frame, which is shorter than 1/30 of the light travel time across a scale length equal to the black hole radius. We concluded that the X-rays are produced in a relativistic jet beamed toward earth in which variations in the Doppler enhancement produce the XVV behavior.

  6. X-Ray Absorbed, Broad-Lined, Red AGN and the Cosmic X-Ray Background

    NASA Technical Reports Server (NTRS)

    Mushotzky, Richard (Technical Monitor); Wilkes, Belinda

    2005-01-01

    We have obtained XMM spectra for five red, 2MASS AGN, selected from a sample observed by Chandra to be X-ray bright and to cover a range of hardness ratios. Our results confirm the presence of substantial absorbing material in three sources which have optical classifications ranging from Type 1 to Type 2, with an intrinsically flat (hard) power law continuum indicated in the other two. The presence of both X-ray absorption and broad optical emission lines with the usual strength suggests either a small (nuclear) absorber or a favored viewing angle so as to cover the X-ray source but not the broad emission line region (BELR). A soft excess is detected in all three Type 1 sources. We speculate that this soft X-ray emission may arise in an extended region of ionized gas, perhaps linked with the polarized (scattered) light which is a feature of these sources. The spectral complexity revealed by XMM emphasizes the limitations of the low S/N Chandra data. Overall, the new XMM results strengthen our conclusions (Wilkes et al. 2002) that the observed X-ray continua of red AGN are unusually hard at energies greater than 2 keV. Whether due to substantial line-of-sight absorption or to an intrinsically hard or reflection-dominated spectrum, these 'red' AGN have an observed spectral form consistent with contributing significantly to the missing had absorbed population of the Cosmic X-ray Background (CXRB). When absorption and or reflection is taken into account, all these AGN have power law slopes typical of broad-line (Type 1) AGN (Gamma approximately 1.9). This appears to resolve the spectral paradox which for so long has existed between the CXRB and the AGN thought to be the dominant contributors. It also suggests two scenarios whereby Type 1 AGN/QSOs may be responsible for a significant fraction of the CXRB at energies above 2 keV: 1) X-ray absorbed AGN/QSOs with visible broad emission lines; 2) AGN/QSOs with complex spectra whose hardness greater than 2 keV is not

  7. Iron line emission from a high temperature plasma in Cas A

    NASA Technical Reports Server (NTRS)

    Pravdo, S. H.; Becker, R. H.; Boldt, E. A.; Holt, S. S.; Rothschild, R. E.; Serlemitsos, P. J.; Swank, J. H.

    1976-01-01

    The X-ray spectrum of Cassiopeia A was observed for several days by the proportional counter experiment on board OSO-8. The high energy ( 5 keV) data are fit well by a thermal spectrum. A narrow iron line which is predicted by the thermal model is also observed. The low energy (2-5 keV) data show an excess over the high temperature component which is consistent with the presence of an additional low temperature thermal component. Iron abundance in the source relative to normal cosmic abundance is discussed, as in the relation of this observation to shock wave and multi-component thermal models for supernova remnants.

  8. Radiation Pressure-Driven Magnetic Disk Winds in Broad Absorption Line Quasi-Stellar Objects

    NASA Technical Reports Server (NTRS)

    DeKool, Martin; Begelman, Mitchell C.

    1995-01-01

    We explore a model in which QSO broad absorption lines (BALS) are formed in a radiation pressure-driven wind emerging from a magnetized accretion disk. The magnetic field threading the disk material is dragged by the flow and is compressed by the radiation pressure until it is dynamically important and strong enough to contribute to the confinement of the BAL clouds. We construct a simple self-similar model for such radiatively driven magnetized disk winds, in order to explore their properties. It is found that solutions exist for which the entire magnetized flow is confined to a thin wedge over the surface of the disk. For reasonable values of the mass-loss rate, a typical magnetic field strength such that the magnetic pressure is comparable to the inferred gas pressure in BAL clouds, and a moderate amount of internal soft X-ray absorption, we find that the opening angle of the flow is approximately 0.1 rad, in good agreement with the observed covering factor of the broad absorption line region.

  9. Stability and broad-sense heritability of mineral content in potato: Iron

    USDA-ARS?s Scientific Manuscript database

    Iron deficiency in humans occurs in all regions of the world. Potatoes are a modest source of iron. The purpose of this study was to determine if genetic variation for potato tuber iron content exists. Iron content in potato was measured in 33 clones, including varieties and advanced breeding sele...

  10. Discovery of the Red-Skewed K-alpha Iron Line in Cyg X-2 with Suzaku

    NASA Technical Reports Server (NTRS)

    Shaposhnikov, Nikolai; Titarchuk, Lev; Laurent, Philippe

    2008-01-01

    We report on the Suzaku observation of neutron star low-mass X-ray binary Cygnus X-2 which reveals strong iron K-alpha emission line. The line profile shows a prominent red wing extending down to 4 keV. This discovery increases the number of neutron star sources where red-skewed iron lines were observed and strongly suggests that this phenomenon is common not only in black holes but also in other types of compact objects. We examine the line profile by fitting it with the model which attributes its production to the relativistic effects due to disk reflection of X-ray radiation. We also apply an alternative model where the red wing is a result of down-scattering effect of the first order with respect to electron velocity in the wind outflow. Both models describe adequately the observed line profile. However, the X-ray variability in a state similar to that in the Suzaku observation which we establish by analysing RXTE observation favors the wind origin of the line formation.

  11. The Physical Nature of Polar Broad Absorption Line Quasars

    NASA Technical Reports Server (NTRS)

    Ghost, Kajal; Punsly, Brian

    2007-01-01

    It has been shown based on radio variability arguments that some BALQSOs (broad absorption line quasars) are viewed along the polar axis (o rthogonal to accretion disk) in the recent article of Zhou et a. Thes e arguments are based on the brightness temperature, T(sub b) exceedi ng 10(exp 12) K which leads to the well-known inverse Compton catastr ophe unless the radio jet is relativistic and is viewed along its axi s. In this letter, we expand the Zhou et al sample of polar BALQSOs u sing their techniques applied to SDSS DR5. In the process, we clarify a mistake in their calculation of brightness temperature. The expanded sample of high T(sub b) BALQSOS, has an inordinately large fraction of LoBALQSOs (low ionization BALQSOs). We consider this an important clue to understanding the nature of the polar BALQSOs. This is expec ted in the polar BALQSO analytical/numerical models of Punsly that pr edicted that LoBALQSOs occur when the line of sight is very close to the polar axis, where the outflow density is the highest.

  12. A study for testing the Kerr metric with AGN iron line eclipses

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cárdenas-Avendaño, Alejandro; Jiang, Jiachen; Bambi, Cosimo, E-mail: alejandro.cardenasa@konradlorenz.edu.co, E-mail: jcjiang12@fudan.edu.cn, E-mail: bambi@fudan.edu.cn

    2016-04-01

    Recently, two of us have studied iron line reverberation mapping to test black hole candidates, showing that the time information in reverberation mapping can better constrain the Kerr metric than the time-integrated approach. Motivated by this finding, here we explore the constraining power of another time-dependent measurement: an AGN iron line eclipse. An obscuring cloud passes between the AGN and the distant observer, covering different parts of the accretion disk at different times. Similar to the reverberation measurement, an eclipse might help to better identify the relativistic effects affecting the X-ray photons. However, this is not what we find. Inmore » our study, we employ the Johannsen-Psaltis parametrisation, but we argue that our conclusions hold in a large class of non-Kerr metrics. We explain our results pointing out an important difference between reverberation and eclipse measurements.« less

  13. Study of transmission line attenuation in broad band millimeter wave frequency range

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pandya, Hitesh Kumar B.; Austin, M. E.; Ellis, R. F.

    2013-10-15

    Broad band millimeter wave transmission lines are used in fusion plasma diagnostics such as electron cyclotron emission (ECE), electron cyclotron absorption, reflectometry and interferometry systems. In particular, the ECE diagnostic for ITER will require efficient transmission over an ultra wide band, 100 to 1000 GHz. A circular corrugated waveguide transmission line is a prospective candidate to transmit such wide band with low attenuation. To evaluate this system, experiments of transmission line attenuation were performed and compared with theoretical loss calculations. A millimeter wave Michelson interferometer and a liquid nitrogen black body source are used to perform all the experiments. Atmosphericmore » water vapor lines and continuum absorption within this band are reported. Ohmic attenuation in corrugated waveguide is very low; however, there is Bragg scattering and higher order mode conversion that can cause significant attenuation in this transmission line. The attenuation due to miter bends, gaps, joints, and curvature are estimated. The measured attenuation of 15 m length with seven miter bends and eighteen joints is 1 dB at low frequency (300 GHz) and 10 dB at high frequency (900 GHz), respectively.« less

  14. Hidden Broad-line Regions in Seyfert 2 Galaxies: From the Spectropolarimetric Perspective

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Du, Pu; Wang, Jian-Min; Zhang, Zhi-Xiang, E-mail: dupu@ihep.ac.cn

    2017-05-01

    The hidden broad-line regions (BLRs) in Seyfert 2 galaxies, which display broad emission lines (BELs) in their polarized spectra, are a key piece of evidence in support of the unified model for active galactic nuclei (AGNs). However, the detailed kinematics and geometry of hidden BLRs are still not fully understood. The virial factor obtained from reverberation mapping of type 1 AGNs may be a useful diagnostic of the nature of hidden BLRs in type 2 objects. In order to understand the hidden BLRs, we compile six type 2 objects from the literature with polarized BELs and dynamical measurements of blackmore » hole masses. All of them contain pseudobulges. We estimate their virial factors, and find the average value is 0.60 and the standard deviation is 0.69, which agree well with the value of type 1 AGNs with pseudobulges. This study demonstrates that (1) the geometry and kinematics of BLR are similar in type 1 and type 2 AGNs of the same bulge type (pseudobulges), and (2) the small values of virial factors in Seyfert 2 galaxies suggest that, similar to type 1 AGNs, BLRs tend to be very thick disks in type 2 objects.« less

  15. Why do we see Broad Lines in X-ray Absorbed, Red AGN?

    NASA Astrophysics Data System (ADS)

    Wilkes, B. J.; Ghosh, Himel; Cutri, R.; Hines, D.; Nelson, B.; Schmidt, G. D.; Smith, P. S.

    2003-05-01

    The Two Micron All-Sky Survey (2MASS) red AGN catalog has revealed a previously unknown population whose number density rivals that of optically-selected AGN as found in the many, relatively shallow surveys (e.g. PG, Hamburg). The Chandra X-ray spectra of these red, mostly broad-line AGN are hard. This, combined with their unusually high optical polarization, suggests substantial obscuration (log NH = 21-23 cm-2) toward the nuclear energy source, despite a clear view of the broad emission line region. We have expanded our Chandra-observed sub-sample to include 20 more 2MASS AGN yielding a set of 46 which includes all available optical classes. This sample is thus pre-selected for complex absorption and sufficient to study the relative X-ray and optical obscuration for each AGN class. Those observed to date continue the lack of a relation between the X-ray hardness ratio and optical class noted in our earlier sample. Combining this with X-ray spectral fits where we have sufficient counts and with our multi-wavelength data, we compare the spectral energy distributions with those of normal and other red AGN and investigate possible scenarios for the absorbing material. We gratefully ackowledge the financial support of NASA grant: GO1-2112A

  16. Radio/X-ray monitoring of the broad-line radio galaxy 3C 382. High-energy view with XMM-Newtonand NuSTAR

    NASA Astrophysics Data System (ADS)

    Ursini, F.; Petrucci, P.-O.; Matt, G.; Bianchi, S.; Cappi, M.; Dadina, M.; Grandi, P.; Torresi, E.; Ballantyne, D. R.; De Marco, B.; De Rosa, A.; Giroletti, M.; Malzac, J.; Marinucci, A.; Middei, R.; Ponti, G.; Tortosa, A.

    2018-05-01

    We present the analysis of five joint XMM-Newton/NuSTARobservations, 20 ks each and separated by 12 days, of the broad-line radio galaxy 3C 382. The data were obtained as part of a campaign performed in September-October 2016 simultaneously with VLBA. The radio data and their relation with the X-ray ones will be discussed in a following paper. The source exhibits a moderate flux variability in the UV/X-ray bands, and a limited spectral variability especially in the soft X-ray band. In agreement with past observations, we find the presence of a warm absorber, an ironline with no associated Compton reflection hump, and a variable soft excess well described by a thermal Comptonization component. The data are consistent with a "two-corona" scenario, in which the UV emission and soft excess are produced by a warm (kT ≃ 0.6 keV), optically thick (τ ≃ 20) corona consistent with being a slab fully covering a nearly passive accretion disc, while the hard X-ray emission is due to a hot corona intercepting roughly 10% of the soft emission. These results are remarkably similar to those generally found in radio-quiet Seyferts, thus suggesting a common accretion mechanism.

  17. Evidence for a Neutral Iron Line Generated by MeV Protons from Supernova Remnants Interacting with Molecular Clouds

    NASA Astrophysics Data System (ADS)

    Nobukawa, Kumiko K.; Nobukawa, Masayoshi; Koyama, Katsuji; Yamauchi, Shigeo; Uchiyama, Hideki; Okon, Hiromichi; Tanaka, Takaaki; Uchida, Hiroyuki; Tsuru, Takeshi G.

    2018-02-01

    Supernova remnants (SNRs) have been prime candidates for Galactic cosmic-ray accelerators. When low-energy cosmic-ray protons (LECRp) collide with interstellar gas, they ionize neutral iron atoms and emit the neutral iron line (Fe I Kα) at 6.40 keV. We search for the iron K-shell line in seven SNRs from the Suzaku archive data of the Galactic plane in the 6^\\circ ≲ l≲ 40^\\circ ,| b| < 1^\\circ region. All of these SNRs interact with molecular clouds. We discover Fe I Kα line emissions from five SNRs (W28, Kes 67, Kes 69, Kes 78, and W44). The spectra and morphologies suggest that the Fe I Kα line is produced by interactions between LECRp and the adjacent cold gas. The proton energy density is estimated to be ≳10–100 eV cm‑3, which is more than 10 times higher than that in the ambient interstellar medium.

  18. SimBAL: A Spectral Synthesis Approach to Analyzing Broad Absorption Line Quasar Spectra

    NASA Astrophysics Data System (ADS)

    Terndrup, Donald M.; Leighly, Karen; Gallagher, Sarah; Richards, Gordon T.

    2017-01-01

    Broad Absorption Line quasars (BALQSOs) show blueshifted absorption lines in their rest-UV spectra, indicating powerful winds emerging from the central engine. These winds are essential part of quasars: they can carry away angular momentum and thus facilitate accretion through a disk, they can distribute chemically-enriched gas through the intergalactic medium, and they may inject kinetic energy to the host galaxy, influencing its evolution. The traditional method of analyzing BALQSO spectra involves measuring myriad absorption lines, computing the inferred ionic column densities in each feature, and comparing with the output of photonionization models. This method is inefficient and does not handle line blending well. We introduce SimBAL, a spectral synthesis fitting method for BALQSOs, which compares synthetic spectra created from photoionization model results with continuum-normalized observed spectra using Bayesian model calibration. We find that we can obtain an excellent fit to the UV to near-IR spectrum of the low-redshift BALQSO SDSS J0850+4451, including lines from diverse ionization states such as PV, CIII*, SIII, Lyalpha, NV, SiIV, CIV, MgII, and HeI*.

  19. EMISSION SIGNATURES FROM SUB-PARSEC BINARY SUPERMASSIVE BLACK HOLES. I. DIAGNOSTIC POWER OF BROAD EMISSION LINES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nguyen, Khai; Bogdanović, Tamara

    Motivated by advances in observational searches for sub-parsec supermassive black hole binaries (SBHBs) made in the past few years, we develop a semi-analytic model to describe spectral emission-line signatures of these systems. The goal of this study is to aid the interpretation of spectroscopic searches for binaries and to help test one of the leading models of binary accretion flows in the literature: SBHB in a circumbinary disk. In this work, we present the methodology and a comparison of the preliminary model with the data. We model SBHB accretion flows as a set of three accretion disks: two mini-disks thatmore » are gravitationally bound to the individual black holes and a circumbinary disk. Given a physically motivated parameter space occupied by sub-parsec SBHBs, we calculate a synthetic database of nearly 15 million broad optical emission-line profiles and explore the dependence of the profile shapes on characteristic properties of SBHBs. We find that the modeled profiles show distinct statistical properties as a function of the semimajor axis, mass ratio, eccentricity of the binary, and the degree of alignment of the triple disk system. This suggests that the broad emission-line profiles from SBHB systems can in principle be used to infer the distribution of these parameters and as such merit further investigation. Calculated profiles are more morphologically heterogeneous than the broad emission lines in observed SBHB candidates and we discuss improved treatment of radiative transfer effects, which will allow a direct statistical comparison of the two groups.« less

  20. Radio Observations of a Sample of Broad-Line Type IC Supernovae Discovered by PTF/IPTF: A Search for Relativistic Explosions

    DOE PAGES

    Corsi, Alessandra; Gal-Yam, A.; Kulkarni, S. R.; ...

    2016-10-10

    Long duration γ-ray bursts are a rare subclass of stripped-envelope core-collapse supernovae (SNe) that launch collimated relativistic outflows (jets). All γ-ray-burst-associated SNe are spectroscopically Type Ic, with broad-lines, but the fraction of broad-lined SNe Ic harboring low-luminosity γ-ray bursts remains largely unconstrained. Some SNe should be accompanied by off-axis γ-ray burst jets that initially remain invisible, but then emerge as strong radio sources (as the jets decelerate). However, this critical prediction of the jet model for γ-ray bursts has yet to be verified observationally. Here, we present K. G. Jansky Very Large Array observations of 15 broad-lined SNe of Type Ic discovered by the Palomar Transient Factory in an untargeted manner. Most of the SNe in our sample exclude radio emission observationally similar to that of the radio-loud, relativistic SN 1998bw. We constrain the fraction of 1998bw-like broad-lined SNe Ic to bemore » $$\\lesssim 41 \\% $$ (99.865% confidence). Most of the events in our sample also exclude off-axis jets similar to GRB 031203 and GRB 030329, but we cannot rule out off-axis γ-ray bursts expanding in a low-density wind environment. Three SNe in our sample are detected in the radio. PTF11qcj and PTF14dby show late-time radio emission with average ejecta speeds of ≈0.3–0.4 c, on the dividing line between relativistic and "ordinary" SNe. The speed of PTF11cmh radio ejecta is poorly constrained. We estimate that $$\\lesssim 85 \\% $$ (99.865% confidence) of the broad-lined SNe Ic in our sample may harbor off-axis γ-ray bursts expanding in media with densities in the range probed by this study.« less

  1. Narrow absorption lines complex I: one form of broad absorption line

    NASA Astrophysics Data System (ADS)

    Lu, Wei-Jian; Lin, Ying-Ru

    2018-03-01

    We discover that some of the broad absorption lines (BALs) are actually a complex of narrow absorption lines (NALs). As a pilot study of this type of BAL, we show this discovery through a typical example in this paper. Utilizing the two-epoch observations of J002710.06-094435.3 (hereafter J0027-0944) from the Sloan Digital Sky Survey (SDSS), we find that each of the C IV and Si IV BAL troughs contains at least four NAL doublets. By resolving the Si IV BAL into multiple NALs, we present the following main results and conclusions. First, all these NALs show coordinated variations between the two-epoch SDSS observations, suggesting that they all originate in the quasar outflow, and that their variations are due to global changes in the ionization condition of the absorbing gas. Secondly, a BAL consisting of a number of NAL components indicates that this type of BAL is basically the same as the intrinsic NAL, which tends to support the inclination model rather than the evolution model. Thirdly, although both the C IV and Si IV BALs originate from the same clumpy substructures of the outflow, they show different profile shapes: multiple absorption troughs for the Si IV BAL in a wider velocity range, while P-Cygni for the C IV BAL in a narrower velocity range. This can be interpreted by the substantial differences in fine structure and oscillator strength between the Si IVλλ1393, 1402 and C IVλλ1548, 1551 doublets. Based on the above conclusions, we consider that the decomposition of a BAL into NALs can serve as a way to resolve the clumpy structure for outflows, and it can be used to learn more about characteristics of the clumpy structure and to test the outflow model, when utilizing high-resolution spectra and photoionization model.

  2. CHANDRA Detects Relativistic Broad Absorption Lines from APM 08279+5255

    NASA Astrophysics Data System (ADS)

    Chartas, G.; Brandt, W. N.; Gallagher, S. C.; Garmire, G. P.

    2002-11-01

    We report the discovery of X-ray broad absorption lines (BALs) from the BAL quasar APM 08279+5255 originating from material moving at relativistic velocities with respect to the central source. The large flux magnification by a factor of ~100 provided by the gravitational lens effect combined with the large redshift (z=3.91) of the quasar have facilitated the acquisition of the first high signal-to-noise X-ray spectrum of a quasar containing X-ray BALs. Our analysis of the X-ray spectrum of APM 08279+5255 places the rest-frame energies of the two observed absorption lines at 8.1 and 9.8 keV. The detection of each of these lines is significant at a greater than 99.9% confidence level based on the F-test. Assuming that the absorption lines are from Fe XXV Kα, the implied bulk velocities of the X-ray BALs are ~0.2c and ~0.4c, respectively. The observed high bulk velocities of the X-ray BALs combined with the relatively short recombination timescales of the X-ray-absorbing gas imply that the absorbers responsible for the X-ray BALs are located at radii of <~2×1017 cm, within the expected location of the UV absorber. With this implied geometry, the X-ray gas could provide the necessary shielding to prevent the UV absorber from being completely ionized by the central X-ray source, consistent with hydrodynamical simulations of line-driven disk winds. Estimated mass-outflow rates for the gas creating the X-ray BALs are typically less than a solar mass per year. Our spectral analysis also indicates that the continuum X-ray emission of APM 08279+5255 is consistent with that of a typical radio-quiet quasar with a spectral slope of Γ=1.72+0.06-0.05.

  3. Constraining sub-parsec binary supermassive black holes in quasars with multi-epoch spectroscopy. II. The population with kinematically offset broad Balmer emission lines

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Xin; Shen, Yue; Bian, Fuyan

    2014-07-10

    A small fraction of quasars have long been known to show bulk velocity offsets (of a few hundred to thousands of km s{sup –1}) in the broad Balmer lines with respect to the systemic redshift of the host galaxy. Models to explain these offsets usually invoke broad-line region gas kinematics/asymmetry around single black holes (BHs), orbital motion of massive (∼sub-parsec (sub-pc)) binary black holes (BBHs), or recoil BHs, but single-epoch spectra are unable to distinguish between these scenarios. The line-of-sight (LOS) radial velocity (RV) shifts from long-term spectroscopic monitoring can be used to test the BBH hypothesis. We have selectedmore » a sample of 399 quasars with kinematically offset broadlines from the Sloan Digital Sky Survey (SDSS) Seventh Data Release quasar catalog, and have conducted second-epoch optical spectroscopy for 50 of them. Combined with the existing SDSS spectra, the new observations enable us to constrain the LOS RV shifts of broadlines with a rest-frame baseline of a few years to nearly a decade. While previous work focused on objects with extreme velocity offset (>10{sup 3} km s{sup –1}), we explore the parameter space with smaller (a few hundred km s{sup –1}) yet significant offsets (99.7% confidence). Using cross-correlation analysis, we detect significant (99% confidence) radial accelerations in the broadlines in 24 of the 50 objects, of ∼10-200 km s{sup –1} yr{sup –1} with a median measurement uncertainty of ∼10 km s{sup –1} yr{sup –1}, implying a high fraction of variability of the broad-line velocity on multi-year timescales. We suggest that 9 of the 24 detections are sub-pc BBH candidates, which show consistent velocity shifts independently measured from a second broad line (either Hα or Mg II) without significant changes in the broad-line profiles. Combining the results on the general quasar population studied in Paper I, we find a tentative anti-correlation between the velocity offset in

  4. Mineralogical, Physical and Geochemical Factors that Drive Microbial Reduction of Iron Oxides and Diagenesis under Broad Environmental Conditions

    NASA Astrophysics Data System (ADS)

    Dong, Y.; Sanford, R. A.; Boyanov, M.; Kemner, K. M.; Flynn, T. M.; O'Loughlin, E. J.; George, S.; Fouke, K.; Fouke, B. W.

    2016-12-01

    precipitation dynamics, adsorption of Fe(II), and subsequent transformation (dissolution and reprecipitation). This study establishes the first mechanistic understanding of biomineralization of Fe(II) bearing minerals during microbial iron reduction under a broad range of environmental conditions.

  5. Structure and kinematics of the broad-line regions in active galaxies from IUE variability data

    NASA Technical Reports Server (NTRS)

    Koratkar, Anuradha P.; Gaskell, C. Martin

    1991-01-01

    IUE archival data are used here to investigate the structure nad kinematics of the broad-line regions (BLRs) in nine AGN. It is found that the centroid of the line-continuum cross-correlation functions (CCFs) can be determined with reasonable reliability. The errors in BLR size estimates from CCFs for irregularly sampled light curves are fairly well understood. BLRs are found to have small luminosity-weighted radii, and lines of high ionization tend to be emitted closer to the central source than lines of low ionization, especially for low-luminosity objects. The motion of the gas is gravity-dominated with both pure inflow and pure outflow of high-velocity gas being excluded at a high confidence level for certain geometries.

  6. X-Ray Continua of Broad Absorption Line Quasars

    NASA Technical Reports Server (NTRS)

    Mathur, S.

    1999-01-01

    The targets for this program, PG1416-129 and LBQS 2212-1759 were known to be Broad Absorption Line Quasars (BALQSOs). BALQSOs are highly absorbed in soft X-rays. Good high energy response of Rossi-XTE made them ideal targets for observation. We observed LBQS 2212-1759 with PCA. We have now analyzed the data and found that the source was not detected. Since our target was expected to be faint, reliable estimate of background was very important. With the release of new FTOOLS (version 4.1) we were able to do so. We also analyzed a well known bright object and verified our results with the published data. This gave us confidence in the non-detection of our target LBQS 2212-1759. We are currently investigating the implications of this non-detection. Due to some scheduling problems, our second target PG1416-129 was not observed in A01. It was observed on 06/26/98. This target was detected with RXTE. We are now working on the spectral analysis with XSPEC.

  7. The Case for Optically Thick High-Velocity Broad-Line Region Gas in Active Galactic Nuclei

    NASA Astrophysics Data System (ADS)

    Snedden, Stephanie A.; Gaskell, C. Martin

    2007-11-01

    A combined analysis of the profiles of the main broad quasar emission lines in both Hubble Space Telescope and optical spectra shows that while the profiles of the strong UV lines are quite similar, there is frequently a strong increase in the Lyα/Hα ratio in the high-velocity gas. We show that the suggestion that the high-velocity gas is optically thin presents many problems. We show that the relative strengths of the high-velocity wings arise naturally in an optically thick BLR component. An optically thick model successfully explains the equivalent widths of the lines, the Lyα/Hα ratios and flatter Balmer decrements in the line wings, the strengths of C III] and the λ1400 blend, and the strong variability in flux of high-velocity, high-ionization lines (especially He II and He I).

  8. Relativistic iron lines in accretion disks: the contribution of higher order images in the strong deflection limit

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Aldi, Giulio Francesco; Bozza, Valerio, E-mail: giuliofrancesco.aldi@sa.infn.it, E-mail: valboz@sa.infn.it

    The shapes of relativistic iron lines observed in spectra of candidate black holes carry the signatures of the strong gravitational fields in which the accretion disks lie. These lines result from the sum of the contributions of all images of the disk created by gravitational lensing, with the direct and first-order images largely dominating the overall shapes. Higher order images created by photons tightly winding around the black holes are often neglected in the modeling of these lines, since they require a substantially higher computational effort. With the help of the strong deflection limit, we present the most accurate semi-analyticalmore » calculation of these higher order contributions to the iron lines for Schwarzschild black holes. We show that two regimes exist depending on the inclination of the disk with respect to the line of sight. Many useful analytical formulae can be also derived in this framework.« less

  9. The solar flare iron line to continuum ratio and the coronal abundances of iron and helium

    NASA Technical Reports Server (NTRS)

    Mckenzie, D. L.

    1975-01-01

    Narrow band Ross filter measurements of the Fe 25 line flux around 0.185 nm and simultaneous broadband measurements during a solar flare were used to determine the relationship between the solar coronal abundances of iron and helium. The Fe 25 ion population was also determined as a function of time. The proportional counter and the Ross filter on OSO-7 were utilized. The data were analyzed under the separate assumptions that (1) the electron density was high enough that a single temperature could characterize the continuum spectrum and the ionization equilibrium, and that (2) the electron density was low so that the ion populations trailed the electron temperature in time. It was found that the density was at least 5x10 to the 9th power, and that the high density assumption was valid. It was also found that the iron abundance is 0.000011 for a helium abundance of 0.2, relative to hydrogen.

  10. BLACK HOLE MASS AND EDDINGTON RATIO DISTRIBUTION FUNCTIONS OF X-RAY-SELECTED BROAD-LINE AGNs AT z {approx} 1.4 IN THE SUBARU XMM-NEWTON DEEP FIELD

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nobuta, K.; Akiyama, M.; Ueda, Y.

    2012-12-20

    In order to investigate the growth of supermassive black holes (SMBHs), we construct the black hole mass function (BHMF) and Eddington ratio distribution function (ERDF) of X-ray-selected broad-line active galactic nuclei (AGNs) at z {approx} 1.4 in the Subaru XMM-Newton Deep Survey (SXDS) field. A significant part of the accretion growth of SMBHs is thought to take place in this redshift range. Black hole masses of X-ray-selected broad-line AGNs are estimated using the width of the broad Mg II line and 3000 A monochromatic luminosity. We supplement the Mg II FWHM values with the H{alpha} FWHM obtained from our NIRmore » spectroscopic survey. Using the black hole masses of broad-line AGNs at redshifts between 1.18 and 1.68, the binned broad-line AGN BHMFs and ERDFs are calculated using the V{sub max} method. To properly account for selection effects that impact the binned estimates, we derive the corrected broad-line AGN BHMFs and ERDFs by applying the maximum likelihood method, assuming that the ERDF is constant regardless of the black hole mass. We do not correct for the non-negligible uncertainties in virial BH mass estimates. If we compare the corrected broad-line AGN BHMF with that in the local universe, then the corrected BHMF at z = 1.4 has a higher number density above 10{sup 8} M{sub Sun} but a lower number density below that mass range. The evolution may be indicative of a downsizing trend of accretion activity among the SMBH population. The evolution of broad-line AGN ERDFs from z = 1.4 to 0 indicates that the fraction of broad-line AGNs with accretion rates close to the Eddington limit is higher at higher redshifts.« less

  11. Iron regulatory protein 1 is not required for the modulation of ferritin and transferrin receptor expression by iron in a murine pro-B lymphocyte cell line

    PubMed Central

    Schalinske, Kevin L.; Blemings, Kenneth P.; Steffen, Daniel W.; Chen, Opal S.; Eisenstein, Richard S.

    1997-01-01

    Iron regulatory proteins (IRPs) are cytoplasmic RNA binding proteins that are central components of a sensory and regulatory network that modulates vertebrate iron homeostasis. IRPs regulate iron metabolism by binding to iron responsive element(s) (IREs) in the 5′ or 3′ untranslated region of ferritin or transferrin receptor (TfR) mRNAs. Two IRPs, IRP1 and IRP2, have been identified previously. IRP1 exhibits two mutually exclusive functions as an RNA binding protein or as the cytosolic isoform of aconitase. We demonstrate that the Ba/F3 family of murine pro-B lymphocytes represents the first example of a mammalian cell line that fails to express IRP1 protein or mRNA. First, all of the IRE binding activity in Ba/F3-gp55 cells is attributable to IRP2. Second, synthesis of IRP2, but not of IRP1, is detectable in Ba/F3-gp55 cells. Third, the Ba/F3 family of cells express IRP2 mRNA at a level similar to other murine cell lines, but IRP1 mRNA is not detectable. In the Ba/F3 family of cells, alterations in iron status modulated ferritin biosynthesis and TfR mRNA level over as much as a 20- and 14-fold range, respectively. We conclude that IRP1 is not essential for regulation of ferritin or TfR expression by iron and that IRP2 can act as the sole IRE-dependent mediator of cellular iron homeostasis. PMID:9380695

  12. Chandra High Resolution Spectroscopy of the Circumnuclear Matter in the Broad Line Radio Galaxy, 3C 445

    NASA Technical Reports Server (NTRS)

    Reeves, J. N.; Gofford, J.; Braito, V.; Sambruna, R.

    2010-01-01

    We present evidence for X-ray line emitting and absorbing gas in the nucleus of the Broad-Line Radio Galaxy (BLRG), 3C445. A 200 ks Chandra LETG observation of 3C 445 reveals the presence of several highly ionized emission lines in the soft X-ray spectrum, primarily from the He and H-like ions of O, Ne, Mg and Si. Radiative recombination emission is detected from O VII and O VIII, indicating that the emitting gas is photoionized. The He-like emission appears to be resolved into forbidden and intercombination line components, which implies a high density of greater than 10(sup 10) cm(sup -3), while the lines are velocity broadened with a mean width of 2600 km s(sup -1). The density and widths of the ionized lines indicate an origin of the gas on sub-parsec scales in the Broad Line Region (BLR). The X-ray continuum of 3C 445 is heavily obscured by a photoionized absorber of column density N(sub H) = 2 x 10(sup 23) cm(sup -2) and ionization parameter log xi = 1.4 erg cm s(sup -1). However the view of the X-ray line emission is unobscured, which requires the absorber to be located at radii well within any parsec scale molecular torus. Instead we suggest that the X-ray absorber in 3C 445 may be associated with an outflowing, but clumpy accretion disk wind, with an observed outflow velocity of approximately 10000 km s(sup -1).

  13. Constraining the geometry and kinematics of the quasar broad emission line region using gravitational microlensing. I. Models and simulations

    NASA Astrophysics Data System (ADS)

    Braibant, L.; Hutsemékers, D.; Sluse, D.; Goosmann, R.

    2017-11-01

    Recent studies have shown that line profile distortions are commonly observed in gravitationally lensed quasar spectra. Often attributed to microlensing differential magnification, line profile distortions can provide information on the geometry and kinematics of the broad emission line region (BLR) in quasars. We investigate the effect of gravitational microlensing on quasar broad emission line profiles and their underlying continuum, combining the emission from simple representative BLR models with generic microlensing magnification maps. Specifically, we considered Keplerian disk, polar, and equatorial wind BLR models of various sizes. The effect of microlensing has been quantified with four observables: μBLR, the total magnification of the broad emission line; μcont, the magnification of the underlying continuum; as well as red/blue, RBI and wings/core, WCI, indices that characterize the line profile distortions. The simulations showed that distortions of line profiles, such as those recently observed in lensed quasars, can indeed be reproduced and attributed to the differential effect of microlensing on spatially separated regions of the BLR. While the magnification of the emission line μBLR sets an upper limit on the BLR size and, similarly, the magnification of the continuum μcont sets an upper limit on the size of the continuum source, the line profile distortions mainly depend on the BLR geometry and kinematics. We thus built (WCI,RBI) diagrams that can serve as diagnostic diagrams to discriminate between the various BLR models on the basis of quantitative measurements. It appears that a strong microlensing effect puts important constraints on the size of the BLR and on its distance to the high-magnification caustic. In that case, BLR models with different geometries and kinematics are more prone to produce distinctive line profile distortions for a limited number of caustic configurations, which facilitates their discrimination. When the microlensing

  14. WISE J233237.05-505643.5: A Double-Peaked Broad-Lined AGN with Spiral-Shaped Radio Morphology

    NASA Technical Reports Server (NTRS)

    Tsai, Chao Wei; Jarrett, Thomas H.; Stern, Daniel; Emonts, Bjorn; Barrows, R. Scott; Assef, Roberto J.; Norris, Ray P.; Eisenhardt, Peter R. M.; Lonsdale, Carol; Blain, Andrew W.; hide

    2013-01-01

    We present radio continuum mapping, optical imaging and spectroscopy of the newly discovered double-peaked broad-lined AGN WISE J233237.05-505643.5 at redshift z = 0.3447. This source exhibits an FR-I and FR-II hybrid-morphology, characterized by bright core, jet, and Doppler-boosted lobe structures in ATCA continuum maps at 1.5, 5.6, and 9 GHz. Unlike most FR-II objects, W2332-5056 is hosted by a disk-like galaxy. The core has a projected 5" linear radio feature that is perpendicular to the curved primary jet, hinting at unusual and complex activity within the inner 25 kpc. The multi-epoch optical-near-IR photometric measurements indicate significant variability over a 3-20 year baseline from the AGN component. Gemini-South optical data shows an unusual double-peaked emission-line features: the centroids of the broad-lined components of H-alpha and H-beta are blueshifted with respect to the narrow lines and host galaxy by approximately 3800 km/s. We examine possible cases which involve single or double supermassive black holes in the system, and discuss required future investigations to disentangle the mystery nature of this system.

  15. ORIGIN OF THE GALACTIC DIFFUSE X-RAY EMISSION: IRON K-SHELL LINE DIAGNOSTICS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nobukawa, Masayoshi; Uchiyama, Hideki; Nobukawa, Kumiko K.

    This paper reports detailed K-shell line profiles of iron (Fe) and nickel (Ni) of the Galactic Center X-ray Emission (GCXE), Galactic Bulge X-ray Emission (GBXE), Galactic Ridge X-ray Emission (GRXE), magnetic Cataclysmic Variables (mCVs), non-magnetic Cataclysmic Variables (non-mCVs), and coronally Active Binaries (ABs). For the study of the origin of the GCXE, GBXE, and GRXE, the spectral analysis is focused on equivalent widths of the Fe i-K α , Fe xxv-He α , and Fe xxvi-Ly α  lines. The global spectrum of the GBXE is reproduced by a combination of the mCVs, non-mCVs, and ABs spectra. On the other hand,more » the GRXE spectrum shows significant data excesses at the Fe i-K α and Fe xxv-He α  line energies. This means that additional components other than mCVs, non-mCVs, and ABs are required, which have symbiotic phenomena of cold gas and very high-temperature plasma. The GCXE spectrum shows larger excesses than those found in the GRXE spectrum at all the K-shell lines of iron and nickel. Among them the largest ones are the Fe i-K α , Fe xxv-He α , Fe xxvi-Ly α , and Fe xxvi-Ly β  lines. Together with the fact that the scale heights of the Fe i-K α , Fe xxv-He α , and Fe xxvi-Ly α lines are similar to that of the central molecular zone (CMZ), the excess components would be related to high-energy activity in the extreme envelopment of the CMZ.« less

  16. Neon-like Iron Ion Lines Measured in NIFS/Large Helical Device (LHD) and Hinode /EUV Imaging Spectrometer (EIS)

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Watanabe, Tetsuya; Hara, Hirohisa; Murakami, Izumi

    2017-06-10

    Line intensities emerging from the Ne-sequence iron ion (Fe xvii) are measured in the laboratory, by the Large Helical Device at the National Institute for Fusion Science, and in the solar corona by the EUV Imaging Spectrometer (EIS) on board the Hinode mission. The intensity ratios of Fe xvii λ 204.6/ λ 254.8 are derived in the laboratory by unblending the contributions of the Fe xiii and xii line intensities. They are consistent with theoretical predictions and solar observations, the latter of which endorses the in-flight radiometric calibrations of the EIS instrument. The still remaining temperature-dependent behavior of the linemore » ratio suggests the contamination of lower-temperature iron lines that are blended with the λ 204.6 line.« less

  17. Ironline of Kerr black holes with scalar hair

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ni, Yueying; Zhou, Menglei; Bambi, Cosimo

    Recently, a family of hairy black holes in 4-dimensional Einstein gravity minimally coupled to a complex, massive scalar field was discovered [1]. Besides the mass M and spin angular momentum J , these objects are characterized by a Noether charge Q , measuring the amount of scalar hair, which is not associated to a Gauss law and cannot be measured at spatial infinity. Introducing a dimensionless scalar hair parameter q , ranging from 0 to 1, we recover (a subset of) Kerr black holes for q = 0 and a family of rotating boson stars for q = 1. Inmore » the present paper, we explore the possibility of measuring q for astrophysical black holes with current and future X-ray missions. We study the ironline expected in the reflection spectrum of such hairy black holes and we simulate observations with Suzaku and eXTP. As a proof of concept, we point out, by analyzing a sample of hairy black holes, that current observations can already constrain the scalar hair parameter q , because black holes with q close to 1 would have iron lines definitively different from those we observe in the available data. We conclude that a detailed scanning of the full space of solutions, together with data from the future X-ray missions, like eXTP, will be able to put relevant constraints on the astrophysical realization of Kerr black holes with scalar hair.« less

  18. The metallicities of the broad emission line regions in the nitrogen-loudest quasars

    NASA Astrophysics Data System (ADS)

    Batra, Neelam Dhanda; Baldwin, Jack A.

    2014-03-01

    We measured the metallicity Z in the broad emission-line regions (BELRs) of 43 Sloan Digital Sky Survey (SDSS) quasars with the strongest N IV] and N III] emission lines. These N-loud quasi-stellar objects (QSOs) have unusually low-black-hole masses. We used the intensity ratio of N lines to collisionally excited emission lines of other heavy elements to find metallicities in their BELR regions. We found that seven of the eight line-intensity ratios that we employed give roughly consistent metallicities as measured, but that for each individual QSO their differences from the mean of all metallicity measurements depend on the ionization potential of the ions that form the emission lines. After correcting for this effect, the different line-intensity ratios give metallicities that generally agree to within the 0.24 dex uncertainty in the measurements of the line-intensity ratios. The metallicities are very high, with mean log Z for the whole sample of 5.5 Z⊙ and a maximum of 18 Z⊙. Our results argue against the possibility that the strong N lines represent an overabundance only of N but not of all heavy elements. They are compatible with either that (1) the BELR gas has been chemically enriched by the general stellar population in the central bulge of the host galaxy, but the locally optimally emitting cloud model used in the analysis needs some fine tuning or (2) that instead this gas has been enriched by intense star formation on the very local scale of the active nucleus that has resulted in an abundance gradient within the BELR.

  19. REVERBERATION AND PHOTOIONIZATION ESTIMATES OF THE BROAD-LINE REGION RADIUS IN LOW-z QUASARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Negrete, C. Alenka; Dultzin, Deborah; Marziani, Paola

    2013-07-01

    Black hole mass estimation in quasars, especially at high redshift, involves the use of single-epoch spectra with signal-to-noise ratio and resolution that permit accurate measurement of the width of a broad line assumed to be a reliable virial estimator. Coupled with an estimate of the radius of the broad-line region (BLR) this yields the black hole mass M{sub BH}. The radius of the BLR may be inferred from an extrapolation of the correlation between source luminosity and reverberation-derived r{sub BLR} measures (the so-called Kaspi relation involving about 60 low-z sources). We are exploring a different method for estimating r{sub BLR}more » directly from inferred physical conditions in the BLR of each source. We report here on a comparison of r{sub BLR} estimates that come from our method and from reverberation mapping. Our ''photoionization'' method employs diagnostic line intensity ratios in the rest-frame range 1400-2000 A (Al III {lambda}1860/Si III] {lambda}1892, C IV {lambda}1549/Al III {lambda}1860) that enable derivation of the product of density and ionization parameter with the BLR distance derived from the definition of the ionization parameter. We find good agreement between our estimates of the density, ionization parameter, and r{sub BLR} and those from reverberation mapping. We suggest empirical corrections to improve the agreement between individual photoionization-derived r{sub BLR} values and those obtained from reverberation mapping. The results in this paper can be exploited to estimate M{sub BH} for large samples of high-z quasars using an appropriate virial broadening estimator. We show that the width of the UV intermediate emission lines are consistent with the width of H{beta}, thereby providing a reliable virial broadening estimator that can be measured in large samples of high-z quasars.« less

  20. Excitation Anisotropy in Laser-Induced-Fluorescence Spectroscopy —High-Intensity, Broad-Line Excitation

    NASA Astrophysics Data System (ADS)

    Hirabayashi, Atsumu; Nambu, Yoshihiro; Fujimoto, Takashi

    1986-10-01

    The problem of excitation anisotropy in laser-induced-fluorescence spectroscopy (LIFS) was investigated for the intense excitation case under the broad-line condition. The depolarization coefficient for the fluorescence light was derived in the intense-excitation limit (linearly-polarized or unpolarized light excitation) and the results are presented in tables. In the region of intermediate intensity, between the weak and intense-excitation limits, the master equation was solved for a specific example of atomic transitions and its result is compared with experimental results.

  1. The Seyfert 2 Galaxy NGC 2110: Hard X-Ray Emission Observed by NuStar and Variability of the Iron K-Alpha Line

    NASA Technical Reports Server (NTRS)

    Marinucci, A.; Matt, G.; Bianchi, S.; Lu, T. N.; Arevalo, P.; Balokovic, M.; Ballantyne, D.; Bauer, F. E.; Boggs, S. E.; Stern, D.; hide

    2014-01-01

    We present NuSTAR observations of the bright Seyfert 2 galaxy NGC 2110 obtained in 2012, when the source was at the highest flux level ever observed, and in 2013, when the source was at a more typical flux level. We include archival observations from other X-ray satellites, namely XMM-Newton, Suzaku, BeppoSAX, Chandra and Swift. Simultaneous NuSTAR and Swift broad band spectra (in the 3-80 keV range) indicate a cutoff energy E(sub c) greater than 210 keV, with no detectable contribution from Compton reflection. NGC 2110 is one of the very few sources where no evidence for distant Compton thick scattering is found and, by using temporal information collected over more than a decade, we investigate variations of the iron K(alpha) line on time scales of years. The Fe K alpha line is likely the sum of two components: one constant (originating from distant Compton-thick material) and the other one variable and linearly correlated with the source flux (possibly arising from Compton-thin material much closer to the black hole).

  2. Hidden Broad-Line Seyfert 2 Galaxies in the CFA and 12 μM Samples

    NASA Astrophysics Data System (ADS)

    Tran, Hien D.

    2001-06-01

    We report the results of a spectropolarimetric survey of the CfA and 12 μm samples of Seyfert 2 (S2) galaxies. Polarized (hidden) broad-line regions (HBLRs) are confirmed in a number of galaxies, and several new cases (F02581-1136, MCG -3-58-7, NGC 5995, NGC 6552, NGC 7682) are reported. The 12 μm S2 galaxy sample shows a significantly higher incidence of HBLRs (50%) than its CfA counterpart (30%), suggesting that the latter may be incomplete in hidden active galactic nuclei. Compared to the non-HBLR S2 galaxies, the HBLR S2 galaxies display distinctly higher radio power relative to their far-infrared output and hotter dust temperature as indicated by the f25/f60 color. However, the level of obscuration is indistinguishable between the two types of S2 galaxies. These results strongly support the existence of two intrinsically different populations of S2 galaxies: one harboring an energetic, hidden S1 nucleus with a broad-line region and the other a ``pure'' S2 galaxy, with a weak or absent S1 nucleus and a strong, perhaps dominating starburst component. Thus, the simple purely orientation-based unification model is not applicable to all Seyfert galaxies.

  3. Organic acids influence iron uptake in the human epithelial cell line Caco-2.

    PubMed

    Salovaara, Susan; Sandberg, Ann-Sofie; Andlid, Thomas

    2002-10-09

    It has previously been suggested that organic acids enhance iron absorption. We have studied the effect of nine organic acids on the absorption of Fe(II) and Fe(III) in the human epithelial cell line Caco-2. The effect obtained was dose-dependent, and the greatest increase (43-fold) was observed for tartaric acid (4 mmol/L) on Fe(III) (10 micromol/L). Tartaric, malic, succinic, and fumaric acids enhanced Fe(II) and Fe(III) uptake. Citric and oxalic acid, on the other hand, inhibited Fe(II) uptake but enhanced Fe(III) uptake. Propionic and acetic acid increased the Fe(II) uptake, but had no effect on Fe(III) uptake. Our results show a correlation between absorption pattern and chemical structure; e.g. hydroxyl groups, in addition to carboxyls, were connected with a positive influence. The results may be important for elucidating factors affecting iron bioavailability in the small intestine and for the development of foods with improved iron bioavailability.

  4. REVERBERATION MAPPING WITH INTERMEDIATE-BAND PHOTOMETRY: DETECTION OF BROAD-LINE Hα TIME LAGS FOR QUASARS AT 0.2 < z < 0.4

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jiang, Linhua; Shen, Yue; McGreer, Ian D.

    2016-02-20

    We present a reverberation mapping (RM) experiment that combines broad- and intermediate-band photometry; it is the first such attempt targeting 13 quasars at 0.2 < z < 0.9. The quasars were selected to have strong Hα or Hβ emission lines that are located in one of three intermediate bands (with FWHM around 200 Å) centered at 8045, 8505, and 9171 Å. The imaging observations were carried out in the intermediate bands and the broad i and z bands using the prime-focus imager 90Prime on the 2.3 m Bok telescope. Because of the large (∼1 deg{sup 2}) field of view (FOV) of 90Prime, we includedmore » the 13 quasars within only five telescope pointings or fields. The five fields were repeatedly observed over 20–30 epochs that were unevenly distributed over a duration of 5–6 months. The combination of the broad- and intermediate-band photometry allows us to derive accurate light curves for both optical continuum emission (from the accretion disk) and line emission (from the broad-line region, or BLR). We detect Hα time lags between the continuum and line emission in six quasars. These quasars are at relatively low redshifts 0.2 < z < 0.4. The measured lags are consistent with the current BLR size–luminosity relation for Hβ at z < 0.3. While this experiment appears successful in detecting lags of the bright Hα line, further investigation is required to see if it can also be applied to the fainter Hβ line for quasars at higher redshifts. Finally we demonstrate that, by using a small telescope with a large FOV, intermediate-band photometric RM can be efficiently executed for a large sample of quasars at z > 0.2.« less

  5. Space Telescope and Optical Reverberation Mapping Project: Unraveling the Broad Line Region and the Intrinsic Absorption in NGC 5548

    NASA Astrophysics Data System (ADS)

    Kriss, G.; Storm Team

    2015-07-01

    The Space Telescope and Optical Reverberation Mapping (STORM) project monitored the Seyfert 1 galaxy NGC 5548 over a six-month period, obtaining 171 far-ultraviolet HST/COS spectra at approximately daily intervals. We find significant correlated variability in the continuum and broad emission lines, with amplitudes ranging from a factor of two in the emission lines to a factor of three in the continuum. The variations of all the strong emission lines lag behind those of the continuum, with He II lagging by ˜ 2.5 days and Ly&alpha,; C IV, and Si IV lagging by 5 to 6 days. The broad UV absorption lines discovered by Kaastra et al. (2014) and associated with the new soft X-ray obscurer are continuously present in the STORM campaign COS spectra. Their strength varies with the degree of soft X-ray obscuration as revealed by the Swift X-ray spectra. The narrow absorption lines associated with the historical warm absorber varied in response to the changing UV flux on a daily basis with lags of 3 to 8 days. The ionization response allows precise determinations of the locations, mass flux, and kinetic luminosities of the absorbers.

  6. Marketing the `Broad Line': Invitations to STEM education in a Swedish recruitment campaign

    NASA Astrophysics Data System (ADS)

    Andrée, Maria; Hansson, Lena

    2013-01-01

    In many Western societies, there is a concern about the tendency of young people not choosing Science, Technology, Engineering, and Mathematics (STEM) education and occupations. In response, different initiatives have been launched. If one believes that science should have a place in more young people's lives, an important question is to what extent recruitment campaigns communicate messages that open up for STEM education to become relevant in young people's identity formation. Here, we analyse a Swedish government-initiated, primarily Internet-based recruitment attempt ('The Broad Line Campaign') aimed at increasing the number of young people choosing the natural science programme in upper secondary school. The campaign is based on marketing principles and deliberately draws on identity issues. The data analysed consists of campaign films and written resources describing the campaign. Data are analysed by use of the constant comparative approach in order to produce categories describing different messages about why to engage in STEM education. These messages are then analysed from an identity perspective using the concept of subjective values. Our results show that the messages communicated in the Broad Line campaign emphasise utility value, attainment value and relative cost rather than interest-enjoyment. The campaign communicates that the natural science programme is to be associated with a high attainment value without establishing relations to the field of science. Finally, potential consequences of the communicated messages in the campaign are discussed in light of previous research.

  7. C IV absorption-line variability in X-ray-bright broad absorption-line quasi-stellar objects

    NASA Astrophysics Data System (ADS)

    Joshi, Ravi; Chand, Hum; Srianand, Raghunathan; Majumdar, Jhilik

    2014-07-01

    We report the kinematic shift and strength variability of the C IV broad absorption-line (BAL) trough in two high-ionization X-ray-bright quasi-stellar objects (QSOs): SDSS J085551+375752 (at zem ˜ 1.936) and SDSS J091127+055054 (at zem ˜ 2.793). Both these QSOs have shown a combination of profile shifts and the appearance and disappearance of absorption components belonging to a single BAL trough. The observed average kinematic shift of the whole BAL profile resulted in an average deceleration of ˜-0.7 ± 0.1, -2.0 ± 0.1 cm s-2 over rest-frame time-spans of 3.11 and 2.34 yr for SDSS J085551+375752 and SDSS J091127+055054, respectively. To our knowledge, these are the largest kinematic shifts known, exceeding by factors of about 2.8 and 7.8 the highest deceleration reported in the literature; this makes both objects potential candidates to investigate outflows using multiwavelength monitoring of their line and continuum variability. We explore various possible mechanisms to understand the observed profile variations. Outflow models involving many small self-shielded clouds, probably moving in a curved path, provide the simplest explanation for the C IV BAL strength and velocity variations, along with the X-ray-bright nature of these sources.

  8. Self-shadowing effects of slim accretion disks in active galactic nuclei: the diverse appearance of the broad-line region

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wang, Jian-Min; Qiu, Jie; Du, Pu

    2014-12-10

    Supermassive black holes in active galactic nuclei (AGNs) undergo a wide range of accretion rates, which lead to diversity of appearance. We consider the effects of anisotropic radiation from accretion disks on the broad-line region (BLR) from the Shakura-Sunyaev regime to slim disks with super-Eddington accretion rates. The geometrically thick funnel of the inner region of slim disks produces strong self-shadowing effects that lead to very strong anisotropy of the radiation field. We demonstrate that the degree of anisotropy of the radiation fields grows with increasing accretion rate. As a result of this anisotropy, BLR clouds receive different spectral energymore » distributions depending on their location relative to the disk, resulting in the diverse observational appearance of the BLR. We show that the self-shadowing of the inner parts of the disk naturally produces two dynamically distinct regions of the BLR, depending on accretion rate. These two regions manifest themselves as kinematically distinct components of the broadline profile with different line widths and fluxes, which jointly account for the Lorentzian profile generally observed in narrow-line Seyfert 1 galaxies. In the time domain, these two components are expected to reverberate with different time lags with respect to the varying ionizing continuum, depending on the accretion rate and the viewing angle of the observer. The diverse appearance of the BLR due to the anisotropic ionizing energy source can be tested by reverberation mapping of Hβ and other broad emission lines (e.g., Fe II), providing a new tool to diagnose the structure and dynamics of the BLR. Other observational consequences of our model are also explored.« less

  9. Discovery of Hα Absorption in the Unusual Broad Absorption Line Quasar SDSS J083942.11+380526.3

    NASA Astrophysics Data System (ADS)

    Aoki, Kentaro; Iwata, Ikuru; Ohta, Kouji; Ando, Masataka; Akiyama, Masayuki; Tamura, Naoyuki

    2006-11-01

    We discovered Hα absorption in the broad Hα emission line of an unusual broad absorption line quasar, SDSS J083942.11+380526.3, at z=2.318, through near-infrared spectroscopy with the Cooled Infrared Spectrograph and Camera for OHS (CISCO) on the Subaru telescope. The presence of nonstellar Hα absorption is known only in the Seyfert galaxy NGC 4151 to date; thus, our discovery is the first case for quasars. The Hα absorption line is blueshifted by 520 km s-1 relative to the Hα emission line, and its redshift almost coincides with those of UV low-ionization metal absorption lines. The width of the Hα absorption (~340 km s-1) is similar to those of the UV low-ionization absorption lines. These facts suggest that the Hα and low-ionization metal absorption lines are produced by the same low-ionization gas, which has a substantial amount of neutral gas. The column density of the neutral hydrogen is estimated to be ~1018 cm-2 by assuming a gas temperature of 10,000 K from the analysis of the curve of growth. The continuum spectrum is reproduced by a reddened [E(B-V)~0.15 mag for the SMC-like reddening law] composite quasar spectrum. Furthermore, the UV spectrum of SDSS J083942.11+380526.3 shows a remarkable similarity to that of NGC 4151 in its low state, suggesting that the physical condition of the absorber in SDSS J083942.11+380526.3 is similar to that of NGC 4151 in the low state. As proposed for NGC 4151, SDSS J083942.11+380526.3 may also be seen through the edge of the obscuring torus. Based in part on data collected at Subaru Telescope, which is operated by the National Astronomical Observatory of Japan.

  10. A quasi-periodic modulation of the iron line centroid energy in the black hole binary H1743-322

    NASA Astrophysics Data System (ADS)

    Ingram, Adam; van der Klis, Michiel; Middleton, Matthew; Done, Chris; Altamirano, Diego; Heil, Lucy; Uttley, Phil; Axelsson, Magnus

    2016-09-01

    Accreting stellar-mass black holes often show a `Type-C' quasi-periodic oscillation (QPO) in their X-ray flux and an iron emission line in their X-ray spectrum. The iron line is generated through continuum photons reflecting off the accretion disc, and its shape is distorted by relativistic motion of the orbiting plasma and the gravitational pull of the black hole. The physical origin of the QPO has long been debated, but is often attributed to Lense-Thirring precession, a General Relativistic effect causing the inner flow to precess as the spinning black hole twists up the surrounding space-time. This predicts a characteristic rocking of the iron line between red- and blueshift as the receding and approaching sides of the disc are respectively illuminated. Here we report on XMM-Newton and NuSTAR observations of the black hole binary H1743-322 in which the line energy varies systematically over the ˜4 s QPO cycle (3.70σ significance), as predicted. This provides strong evidence that the QPO is produced by Lense-Thirring precession, constituting the first detection of this effect in the strong gravitation regime. There are however elements of our results harder to explain, with one section of data behaving differently than all the others. Our result enables the future application of tomographic techniques to map the inner regions of black hole accretion discs.

  11. A RADIAL VELOCITY TEST FOR SUPERMASSIVE BLACK HOLE BINARIES AS AN EXPLANATION FOR BROAD, DOUBLE-PEAKED EMISSION LINES IN ACTIVE GALACTIC NUCLEI

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Liu, Jia; Halpern, Jules P.; Eracleous, Michael

    2016-01-20

    One of the proposed explanations for the broad, double-peaked Balmer emission lines observed in the spectra of some active galactic nuclei (AGNs) is that they are associated with sub-parsec supermassive black hole (SMBH) binaries. Here, we test the binary broad-line region hypothesis through several decades of monitoring of the velocity structure of double-peaked Hα emission lines in 13 low-redshift, mostly radio-loud AGNs. This is a much larger set of objects compared to an earlier test by Eracleous et al. and we use much longer time series for the three objects studied in that paper. Although systematic changes in radial velocitymore » can be traced in many of their lines, they are demonstrably not like those of a spectroscopic binary in a circular orbit. Any spectroscopic binary period must therefore be much longer than the span of the monitoring (assuming a circular orbit), which in turn would require black hole masses that exceed by 1–2 orders of magnitude the values obtained for these objects using techniques such as reverberation mapping and stellar velocity dispersion. Moreover, the response of the double-peaked Balmer line profiles to fluctuations of the ionizing continuum and the shape of the Lyα profiles are incompatible with an SMBH binary. The binary broad-line region hypothesis is therefore disfavored. Other processes evidently shape these line profiles and cause the long-term velocity variations of the double peaks.« less

  12. DISCOVERY OF BROAD MOLECULAR LINES AND OF SHOCKED MOLECULAR HYDROGEN FROM THE SUPERNOVA REMNANT G357.7+0.3: HHSMT, APEX, SPITZER , AND SOFIA OBSERVATIONS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rho, J.; Hewitt, J. W.; Bieging, J.

    We report a discovery of shocked gas from the supernova remnant (SNR) G357.7+0.3. Our millimeter and submillimeter observations reveal broad molecular lines of CO(2-1), CO(3-2), CO(4-3), {sup 13}CO (2-1), and {sup 13}CO (3-2), HCO{sup +}, and HCN using the Heinrich Hertz Submillimeter Telescope, the Arizona 12 m Telescope, APEX, and the MOPRA Telescope. The widths of the broad lines are 15–30 km s{sup −1}, and the detection of such broad lines is unambiguous, dynamic evidence showing that the SNR G357.7+0.3 is interacting with molecular clouds. The broad lines appear in extended regions (>4.′5 × 5′). We also present the detectionmore » of shocked H{sub 2} emission in the mid-infrared but lacking ionic lines using Spitzer /IRS observations to map a few-arcminute area. The H{sub 2} excitation diagram shows a best fit with a two-temperature local thermal equilibrium model with the temperatures of ∼200 and 660 K. We observed [C ii] at 158 μ m and high- J CO(11-10) with the German Receiver for Astronomy at Terahertz Frequencies (GREAT) on the Stratospheric Observatory for Infrared Astronomy. The GREAT spectrum of [C ii], a 3 σ detection, shows a broad line profile with a width of 15.7 km{sup −1} that is similar to those of broad CO molecular lines. The line width of [C ii] implies that ionic lines can come from a low-velocity C-shock. Comparison of H{sub 2} emission with shock models shows that a combination of two C-shock models is favored over a combination of C- and J-shocks or a single shock. We estimate the CO density, column density, and temperature using a RADEX model. The best-fit model with n (H{sub 2}) = 1.7 × 10{sup 4} cm{sup −3}, N(CO) = 5.6 × 10{sup 16} cm{sup −2}, and T  = 75 K can reproduce the observed millimeter CO brightnesses.« less

  13. AGN Space Telescope and Optical Reverberation Mapping Project. IV. Velocity-Delay Mapping of Broad Emission Lines in NGC 5548

    NASA Astrophysics Data System (ADS)

    Horne, Keith D.; Agn Storm Team

    2015-01-01

    Two-dimensional velocity-delay maps of AGN broad emission line regions can be recovered by modelling observations of reverberating emission-line profiles on the assumption that the line profile variations are driven by changes in ionising radiation from a compact source near the black hole. The observable light travel time delay resolves spatial structure on iso-delay paraboloids, while the doppler shift resolves kinematic structure along the observer's line-of-sight. Velocity-delay maps will be presented and briefly discussed for the Lyman alpha, CIV and Hbeta line profiles based on the HST and ground-based spectrophotometric monitoring of NGC 5548 during the 2014 AGN STORM campaign.

  14. Composite Spectra of Broad Absorption Line Quasars in SDSS-III BOSS

    NASA Astrophysics Data System (ADS)

    Herbst, Hanna; Hamann, Fred; Paris, Isabelle; Capellupo, Daniel M.

    2017-01-01

    We present preliminary results from a study of broad absorption line (BAL) quasars in the SDSS-III BOSS survey. We’re particularly interested in BALs because they arise from quasar outflows, which may be a source of feedback to the host galaxy. We analyze median composite spectra for BOSS QSOs in the redshift range 2.1 to 3.4 sorted by the strength of the BAL absorption troughs, parameterized by the Balnicity Index (BI), to study trends in the emission and absorption properties of BAL quasars. The wavelength coverage and high number of quasars observed in the BOSS survey allow us to examine BALs in the Lyman forest. Our main preliminary results when sorting the quasars by BI are 1) doublet absorption lines such as P V 1128A show a 1:1 ratio across all BI, indicating large column densities at all BI. This suggests that weaker BAL troughs result from smaller covering fractions rather than lower column densities. 2) The He II emission line, which is a measure of the far-UV/near-UV hardness of the ionizing continuum, is weaker in the larger BI composite spectra, indicating a far-UV spectral softening correlated with BI. This is consistent with the radiatively-driven BAL outflows being helped by intrinsically weaker ionizing continuum shapes (e.g., Baskin, Laor, and Hamann 2013). We also find a trend for slightly redder continuum slopes in the larger BI composite spectra, suggesting that the slope differences in the near-UV are also intrinsic.

  15. Simultaneous detection and analysis of optical and ultraviolet broad emission lines in quasars at z 2.2

    NASA Astrophysics Data System (ADS)

    Bisogni, S.; di Serego Alighieri, S.; Goldoni, P.; Ho, L. C.; Marconi, A.; Ponti, G.; Risaliti, G.

    2017-06-01

    We studied the spectra of six z 2.2 quasars obtained with the X-shooter spectrograph at the Very Large Telescope. The redshift of these sources and the X-shooter's spectral coverage allow us to cover the rest of the spectral range 1200-7000 Å for the simultaneous detection of optical and ultraviolet lines emitted by the broad-line region. Simultaneous measurements, avoiding issues related to quasars variability, help us understand the connection between the different broad-line region line profiles generally used as virial estimators of black hole masses in quasars. The goal of this work is to compare the different emission lines for each object to check on the reliability of Hα, Mg II and C iv with respect to Hβ. Hα and Mg II linewidths correlate well with Hβ, while C iv shows a poorer correlation, due to the presence of strong blueshifts and asymmetries in the profile. We compared our sample with the only other two whose spectra were taken with the same instrument and for all examined lines our results are in agreement with the ones obtained with X-shooter at z 1.5-1.7. We finally evaluate C III] as a possible substitute of C iv in the same spectral range and find that its behaviour is more coherent with those of the other lines: we believe that, when a high quality spectrum such as the ones we present is available and a proper modelization with the Fe II and Fe III emissions is performed, it is more appropriate to use this line than that of C iv if not corrected for the contamination by non-virialized components. Based on observations collected at the European Organisation for Astronomical Research in the Southern Hemisphere, Chile, under programme 086.B-0320(A).The reduced spectra (FITS files) are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (http://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/603/A1

  16. NGC 5506 unmasked as a Narrow Line Seyfert 1:. A direct view of the broad line region using near-IR spectroscopy

    NASA Astrophysics Data System (ADS)

    Nagar, N. M.; Oliva, E.; Marconi, A.; Maiolino, R.

    2002-08-01

    This letter presents incontrovertible evidence that NGC 5506 is a Narrow Line Seyfert 1 (NLSy1). Our new 0.9-1.4 mu m spectrum of its nucleus clearly shows the permitted O I lambda 1.1287 mu m line (with full width at half maximum <2000 km s-1) and the ``1 micron Fe II lines''. These lines can only originate in the optically-thick broad line region (BLR) and, among Seyfert nuclei the latter series of lines are seen only in NLSy1s. The obscuration to the BLR, derived from a rough estimate of the O I lambda 1.1287 mu m/O I lambda 8446 ratio and from the reddening of the near-IR Paschen lines, is AV > 5. Together, these results make NGC 5506 the first identified case of an optically-obscured NLSy1. This new classification helps explain its radio to X-ray properties, which until now were considered highly anomalous. However, interesting new concerns are raised: e.g., NGC 5506 is unusual in hosting both a ``type 1'' AGN and a nuclear water vapor megamaser. As the brightest known NLSy1, NGC 5506 is highly suitable for study at wavebands less affected by obscuration. Based on observations made with the Italian Telescopio Nazionale Galileo (TNG) operated on the island of La Palma by the Centro Galileo Galilei of the INAF (Istituto Nazionale di Astrofisica) at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofisica de Canarias.

  17. Surprises from a Deep ASCA Spectrum of the Broad Absorption Line Quasar PHL 5200

    NASA Technical Reports Server (NTRS)

    Mathur, Smita; Matt, G.; Green, P. J.; Elvis, M.; Singh, K. P.

    2002-01-01

    We present a deep (approx. 85 ks) ASCA observation of the prototype broad absorption line quasar (BALQSO) PHL 5200. This is the best X-ray spectrum of a BALQSO yet. We find the following: (1) The source is not intrinsically X-ray weak. (2) The line-of-sight absorption is very strong, with N(sub H) = 5 x 10(exp 23)/sq cm. (3) The absorber does not cover the source completely; the covering fraction is approx. 90%. This is consistent with the large optical polarization observed in this source, implying multiple lines of sight. The most surprising result of this observation is that (4) the spectrum of this BALQSO is not exactly similar to other radio-quiet quasars. The hard X-ray spectrum of PHL 5200 is steep, with the power-law spectral index alpha approx. 1.5. This is similar to the steepest hard X-ray slopes observed so far. At low redshifts, such steep slopes are observed in narrow-line Seyfert 1 (NLS1) galaxies, believed to be accreting at a high Eddington rate. This observation strengthens the analogy between BALQSOs and NLS1 galaxies and supports the hypothesis that BALQSOs represent an early evolutionary state of quasars. It is well accepted that the orientation to the line of sight determines the appearance of a quasar: age seems to play a significant role as well.

  18. Stellar Contrails in Quasi-stellar Objects: The Origin of Broad Absorption Lines

    NASA Astrophysics Data System (ADS)

    Scoville, Nick; Norman, Colin

    1995-10-01

    Active galactic nuclei (AGNs) and quasars often exhibit infrared excesses at λ = 2-10 microns attributable to thermal dust emission. In this paper we propose that this hot dust is supplied by circumstellar mass loss from evolved stars in the nuclear star cluster. The physics of the mass-loss dust, specifically the evaporation temperature, is a critical parameter in determining the accretion rate of mass-loss material onto the central AGN. For standard interstellar dust grains with an evaporation temperature of 1800 K the dust is destroyed inside a radius of 1 pc from a central luminosity source of 5 × 10 Lsun. The mass-loss material inside 1 pc will therefore have a lower radiation pressure efficiency and accrete inward. Outside this critical radius, dust may survive, and the mass loss is accelerated outward owing to the high radiation pressure efficiency of the dust mixed with the gas. The outflowing material will consist of discrete trails of debris shed by the individual mass-loss stars, and we suggest that these trails produce the broad absorption lines (BALs) seen in 5%-10% of QSOs. The model accounts naturally for the maximum outflow velocities seen in the BALs (˜30,000 km s-1 and varying as L¼) since this maximum terminal velocity occurs for matter originating at the inner edge of the radiative equilibrium dust survival zone. Although the radiation pressure acts on the dust, individual grains will be highly charged (Z ˜ 103+), and the grains are therefore strongly coupled to the gas through the ambient magnetic fields. Numerical hydrodynamic calculations were done to follow the evolution of mass-loss material. As the orbiting debris is driven outward by radiation pressure, the trail forms a spiral with initially high pitch angle (˜85°). The trails are compressed into thin ribbons in the radial direction initially by the radiation pressure gradients due to absorption within the trail. After reaching > 104 km s-1 radial velocity, the compression can be

  19. C IV broad absorption line variability in QSO spectra from SDSS surveys

    NASA Astrophysics Data System (ADS)

    De Cicco, Demetra; Brandt, William N.; Grier, Catherine J.; Paolillo, Maurizio

    2017-12-01

    Broad absorption lines (BALs) in the spectra of quasi-stellar objects (QSOs) are thought to arise from outflowing winds along our line of sight; winds, in turn, are thought to originate from the accretion disk, in the very surroundings of the central supermassive black hole (SMBH), and they likely affect the accretion process onto the SMBH, as well as galaxy evolution. BALs can exhibit variability on timescales typically ranging from months to years. We analyze such variability and, in particular, BAL disappearance, with the aim of investigating QSO physics and structure. We search for disappearing C IV BALs in the spectra of 1319 QSOs from different programs from the Sloan Digital Sky Survey (SDSS); the analyzed time span covers 0.28-4.9 yr (rest frame), and the source redshifts are in the range 1.68-4.27. This is to date the largest sample ever used for such a study. We find 67 sources (5.1_{-0.6}^{+0.7}% of the sample) with 73 disappearing BALs in total (3.9_{-0.5}^{+0.5}% of the total number of C IV BALs detected; some sources have more than one BAL that disappears). We compare the sample of disappearing BALs to the whole sample of BALs, and investigate the correlation in the variability of multiple troughs in the same spectrum. We also derive estimates of the average lifetime of a BAL trough and of the BAL phase along our line of sight.

  20. THE VIEWING ANGLES OF BROAD ABSORPTION LINE VERSUS UNABSORBED QUASARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    DiPompeo, M. A.; Brotherton, M. S.; De Breuck, C.

    2012-06-10

    It was recently shown that there is a significant difference in the radio spectral index distributions of broad absorption line (BAL) quasars and unabsorbed quasars, with an overabundance of BAL quasars with steeper radio spectra. This result suggests that source orientation does play into the presence or absence of BAL features. In this paper, we provide more quantitative analysis of this result based on Monte Carlo simulations. While the relationship between viewing angle and spectral index does indeed contain a lot of scatter, the spectral index distributions are different enough to overcome that intrinsic variation. Utilizing two different models ofmore » the relationship between spectral index and viewing angle, the simulations indicate that the difference in spectral index distributions can be explained by allowing BAL quasar viewing angles to extend about 10 Degree-Sign farther from the radio jet axis than non-BAL sources, though both can be seen at small angles. These results show that orientation cannot be the only factor determining whether BAL features are present, but it does play a role.« less

  1. OUTFLOW AND METALLICITY IN THE BROAD-LINE REGION OF LOW-REDSHIFT ACTIVE GALACTIC NUCLEI

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shin, Jaejin; Woo, Jong-Hak; Nagao, Tohru

    2017-01-20

    Outflows in active galactic nuclei (AGNs) are crucial to understand in investigating the co-evolution of supermassive black holes (SMBHs) and their host galaxies since outflows may play an important role as an AGN feedback mechanism. Based on archival UV spectra obtained with the Hubble Space Telescope and IUE , we investigate outflows in the broad-line region (BLR) in low-redshift AGNs ( z < 0.4) through detailed analysis of the velocity profile of the C iv emission line. We find a dependence of the outflow strength on the Eddington ratio and the BLR metallicity in our low-redshift AGN sample, which ismore » consistent with earlier results obtained for high-redshift quasars. These results suggest that BLR outflows, gas accretion onto SMBHs, and past star formation activity in host galaxies are physically related in low-redshift AGNs as in powerful high-redshift quasars.« less

  2. Broad [C II] Line Wings as Tracer of Molecular and Multi-phase Outflows in Infrared Bright Galaxies

    NASA Astrophysics Data System (ADS)

    Janssen, A. W.; Christopher, N.; Sturm, E.; Veilleux, S.; Contursi, A.; González-Alfonso, E.; Fischer, J.; Davies, R.; Verma, A.; Graciá-Carpio, J.; Genzel, R.; Lutz, D.; Sternberg, A.; Tacconi, L.; Burtscher, L.; Poglitsch, A.

    2016-05-01

    We report a tentative correlation between the outflow characteristics derived from OH absorption at 119 μm and [C II] emission at 158 μm in a sample of 22 local and bright ultraluminous infrared galaxies (ULIRGs). For this sample, we investigate whether [C II] broad wings are a good tracer of molecular outflows, and how the two tracers are connected. Fourteen objects in our sample have a broad wing component as traced by [C II], and all of these also show OH119 absorption indicative of an outflow (in one case an inflow). The other eight cases, where no broad [C II] component was found, are predominantly objects with no OH outflow or a low-velocity (≤100 km s-1) OH outflow. The FWHM of the broad [C II] component shows a trend with the OH119 blueshifted velocity, although with significant scatter. Moreover, and despite large uncertainties, the outflow masses derived from OH and broad [C II] show a 1:1 relation. The main conclusion is therefore that broad [C II] wings can be used to trace molecular outflows. This may be particularly relevant at high redshift, where the usual tracers of molecular gas (like low-J CO lines) become hard to observe. Additionally, observations of blueshifted Na I D λλ 5890, 5896 absorption are available for 10 of our sources. Outflow velocities of Na I D show a trend with OH velocity and broad [C II] FWHM. These observations suggest that the atomic and molecular gas phases of the outflow are connected.

  3. When galaxies collide: understanding the broad absorption-line radio galaxy 4C +72.26

    NASA Astrophysics Data System (ADS)

    Smith, D. J. B.; Simpson, C.; Swinbank, A. M.; Rawlings, S.; Jarvis, M. J.

    2010-05-01

    We present a range of new observations of the `broad absorption-line radio galaxy' 4C +72.26 (z ~ 3.5), including sensitive rest-frame ultraviolet integral field spectroscopy using the Gemini/GMOS-N instrument and Subaru/CISCO K-band imaging and spectroscopy. We show that 4C +72.26 is a system of two vigorously star-forming galaxies superimposed along the line of sight separated by ~1300 +/- 200 km s-1 in velocity, with each demonstrating spectroscopically resolved absorption lines. The most active star-forming galaxy also hosts the accreting supermassive black hole which powers the extended radio source. We conclude that the star formation is unlikely to have been induced by a shock caused by the passage of the radio jet, and instead propose that a collision is a more probable trigger for the star formation. Despite the massive starburst, the ultraviolet-mid-infrared spectral energy distribution suggests that the pre-existing stellar population comprises ~1012Msolar of stellar mass, with the current burst only contributing a further ~2 per cent, suggesting that 4C +72.26 has already assembled most of its final stellar mass.

  4. EDDINGTON RATIO DISTRIBUTION OF X-RAY-SELECTED BROAD-LINE AGNs AT 1.0 < z < 2.2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Suh, Hyewon; Hasinger, Günther; Steinhardt, Charles

    2015-12-20

    We investigate the Eddington ratio distribution of X-ray-selected broad-line active galactic nuclei (AGNs) in the redshift range 1.0 < z < 2.2, where the number density of AGNs peaks. Combining the optical and Subaru/Fiber Multi Object Spectrograph near-infrared spectroscopy, we estimate black hole masses for broad-line AGNs in the Chandra Deep Field South (CDF-S), Extended Chandra Deep Field South (E-CDF-S), and the XMM-Newton Lockman Hole (XMM-LH) surveys. AGNs with similar black hole masses show a broad range of AGN bolometric luminosities, which are calculated from X-ray luminosities, indicating that the accretion rate of black holes is widely distributed. We find a substantial fraction ofmore » massive black holes accreting significantly below the Eddington limit at z ≲ 2, in contrast to what is generally found for luminous AGNs at high redshift. Our analysis of observational selection biases indicates that the “AGN cosmic downsizing” phenomenon can be simply explained by the strong evolution of the comoving number density at the bright end of the AGN luminosity function, together with the corresponding selection effects. However, one might need to consider a correlation between the AGN luminosity and the accretion rate of black holes, in which luminous AGNs have higher Eddington ratios than low-luminosity AGNs, in order to understand the relatively small fraction of low-luminosity AGNs with high accretion rates in this epoch. Therefore, the observed downsizing trend could be interpreted as massive black holes with low accretion rates, which are relatively fainter than less-massive black holes with efficient accretion.« less

  5. Glial cell ceruloplasmin and hepcidin differentially regulate iron efflux from brain microvascular endothelial cells.

    PubMed

    McCarthy, Ryan C; Kosman, Daniel J

    2014-01-01

    We have used an in vitro model system to probe the iron transport pathway across the brain microvascular endothelial cells (BMVEC) of the blood-brain barrier (BBB). This model consists of human BMVEC (hBMVEC) and C6 glioma cells (as an astrocytic cell line) grown in a transwell, a cell culture system commonly used to quantify metabolite flux across a cell-derived barrier. We found that iron efflux from hBMVEC through the ferrous iron permease ferroportin (Fpn) was stimulated by secretion of the soluble form of the multi-copper ferroxidase, ceruloplasmin (sCp) from the co-cultured C6 cells. Reciprocally, expression of sCp mRNA in the C6 cells was increased by neighboring hBMVEC. In addition, data indicate that C6 cell-secreted hepcidin stimulates internalization of hBMVEC Fpn but only when the end-feet projections characteristic of this glia-derived cell line are proximal to the endothelial cells. This hepcidin-dependent loss of Fpn correlated with knock-down of iron efflux from the hBMVEC; this result was consistent with the mechanism by which hepcidin regulates iron efflux in mammalian cells. In summary, the data support a model of iron trafficking across the BBB in which the capillary endothelium induce the underlying astrocytes to produce the ferroxidase activity needed to support Fpn-mediated iron efflux. Reciprocally, astrocyte proximity modulates the effective concentration of hepcidin at the endothelial cell membrane and thus the surface expression of hBMVEC Fpn. These results are independent of the source of hBMVEC iron (transferrin or non-transferrin bound) indicating that the model developed here is broadly applicable to brain iron homeostasis.

  6. Altered expression of CD1d molecules and lipid accumulation in the human hepatoma cell line HepG2 after iron loading.

    PubMed

    Cabrita, Marisa; Pereira, Carlos F; Rodrigues, Pedro; Cardoso, Elsa M; Arosa, Fernando A

    2005-01-01

    Iron overload in the liver may occur in clinical conditions such as hemochromatosis and nonalcoholic steatohepatitis, and may lead to the deterioration of the normal liver architecture by mechanisms not well understood. Although a relationship between the expression of ICAM-1, and classical major histocompatibility complex (MHC) class I molecules, and iron overload has been reported, no relationship has been identified between iron overload and the expression of unconventional MHC class I molecules. Herein, we report that parameters of iron metabolism were regulated in a coordinated-fashion in a human hepatoma cell line (HepG2 cells) after iron loading, leading to increased cellular oxidative stress and growth retardation. Iron loading of HepG2 cells resulted in increased expression of Nor3.2-reactive CD1d molecules at the plasma membrane. Expression of classical MHC class I and II molecules, ICAM-1 and the epithelial CD8 ligand, gp180 was not significantly affected by iron. Considering that intracellular lipids regulate expression of CD1d at the cell surface, we examined parameters of lipid metabolism in iron-loaded HepG2 cells. Interestingly, increased expression of CD1d molecules by iron-loaded HepG2 cells was associated with increased phosphatidylserine expression in the outer leaflet of the plasma membrane and the presence of many intracellular lipid droplets. These data describe a new relationship between iron loading, lipid accumulation and altered expression of CD1d, an unconventional MHC class I molecule reported to monitor intracellular and plasma membrane lipid metabolism, in the human hepatoma cell line HepG2.

  7. Neutrino-heated stars and broad-line emission from active galactic nuclei

    NASA Technical Reports Server (NTRS)

    Macdonald, James; Stanev, Todor; Biermann, Peter L.

    1991-01-01

    Nonthermal radiation from active galactic nuclei indicates the presence of highly relativistic particles. The interaction of these high-energy particles with matter and photons gives rise to a flux of high-energy neutrinos. In this paper, the influence of the expected high neutrino fluxes on the structure and evolution of single, main-sequence stars is investigated. Sequences of models of neutrino-heated stars in thermal equilibrium are presented for masses 0.25, 0.5, 0.8, and 1.0 solar mass. In addition, a set of evolutionary sequences for mass 0.5 solar mass have been computed for different assumed values for the incident neutrino energy flux. It is found that winds driven by the heating due to high-energy particles and hard electromagnetic radiation of the outer layers of neutrino-bloated stars may satisfy the requirements of the model of Kazanas (1989) for the broad-line emission clouds in active galactic nuclei.

  8. 5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation

    PubMed Central

    Aik, WeiShen; Che, Ka Hing; Li, Xuan Shirley; Kristensen, Jan B. L.; King, Oliver N. F.; Chan, Mun Chiang; Yeoh, Kar Kheng; Choi, Hwanho; Walport, Louise J.; Thinnes, Cyrille C.; Bush, Jacob T.; Lejeune, Clarisse; Rydzik, Anna M.; Rose, Nathan R.; Bagg, Eleanor A.; McDonough, Michael A.; Krojer, Tobias; Yue, Wyatt W.; Ng, Stanley S.; Olsen, Lars; Brennan, Paul E.; Oppermann, Udo; Muller-Knapp, Susanne; Klose, Robert J.; Ratcliffe, Peter J.; Schofield, Christopher J.; Kawamura, Akane

    2015-01-01

    2-Oxoglutarate and iron dependent oxygenases are therapeutic targets for human diseases. Using a representative 2OG oxygenase panel, we compare the inhibitory activities of 5-carboxy-8-hydroxyquinoline (IOX1) and 4-carboxy-8-hydroxyquinoline (4C8HQ) with that of two other commonly used 2OG oxygenase inhibitors, N-oxalylglycine (NOG) and 2,4-pyridinedicarboxylic acid (2,4-PDCA). The results reveal that IOX1 has a broad spectrum of activity, as demonstrated by the inhibition of transcription factor hydroxylases, representatives of all 2OG dependent histone demethylase subfamilies, nucleic acid demethylases and γ-butyrobetaine hydroxylase. Cellular assays show that, unlike NOG and 2,4-PDCA, IOX1 is active against both cytosolic and nuclear 2OG oxygenases without ester derivatisation. Unexpectedly, crystallographic studies on these oxygenases demonstrate that IOX1, but not 4C8HQ, can cause translocation of the active site metal, revealing a rare example of protein ligand-induced metal movement PMID:26682036

  9. Probing the accretion flow and emission-line regions of M81, the nearest broad-lined low-luminosity AGN

    NASA Astrophysics Data System (ADS)

    Barth, Aaron

    2017-08-01

    The nucleus of M81 is an object of singular importance as a template for low-luminosity accretion flows onto supermassive black holes. We propose to obtain a complete, small-aperture, high S/N STIS UV/optical spectrum of the M81 nucleus and multi-filter WFC3 imaging covering the UV through near-IR. Such data have never previously been obtained with HST; the only prior archival UV/optical spectra of M81 have low S/N, incomplete wavelength coverage, and are strongly contaminated by starlight. Combined with new Chandra X-ray data, our proposed observations will comprise the definitive reference dataset on the spectral energy distribution of this benchmark low-luminosity AGN. These data will provide unique new constraints on the possible contribution of a truncated thin accretion disk to the AGN emission spectrum, clarifying a fundamental property of low-luminosity accretion flows. The data will additionally provide new insights into broad-line region structure and black hole mass scaling relationships at the lowest AGN luminosities, and spatially resolved diagnostics of narrow-line region excitation conditions at unprecedented spatial resolution to assess the impact of the AGN on the ionization state of the gas in the host galaxy bulge.

  10. THE COMPLEX CIRCUMNUCLEAR ENVIRONMENT OF THE BROAD-LINE RADIO GALAXY 3C 390.3 REVEALED BY CHANDRA HETG

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tombesi, F.; Kallman, T.; Leutenegger, M. A.

    2016-10-20

    We present the first high spectral resolution X-ray observation of the broad-line radio galaxy 3C 390.3 obtained with the high-energy transmission grating spectrometer on board the Chandra X-ray Observatory . The spectrum shows complex emission and absorption features in both the soft X-rays and Fe K band. We detect emission and absorption lines in the energy range E = 700–1000 eV associated with ionized Fe L transitions (Fe XVII–XX). An emission line at the energy of E ≃ 6.4 keV consistent with the Fe K α is also observed. Our best-fit model requires at least three different components: (i) amore » hot emission component likely associated with the hot interstellar medium in this elliptical galaxy with temperature kT = 0.5 ± 0.1 keV; (ii) a warm absorber with ionization parameter log ξ = 2.3 ± 0.5 erg s{sup −1} cm, column density log N {sub H} = 20.7 ± 0.1 cm{sup −2}, and outflow velocity v {sub out} < 150 km s{sup −1}; and (iii) a lowly ionized reflection component in the Fe K band likely associated with the optical broad-line region or the outer accretion disk. These evidences suggest the possibility that we are looking directly down the ionization cone of this active galaxy and that the central X-ray source only photoionizes along the unobscured cone. This is overall consistent with the angle-dependent unified picture of active galactic nuclei.« less

  11. The Complex Circumnuclear Environment of the Broad-Line Radio Galaxy 3C 390.3 Revealed by Chandra HETG

    NASA Technical Reports Server (NTRS)

    Tombesi, F.; Reeves, J. N.; Kallman, Timothy R.; Reynolds, C. S.; Mushotzky, R. F.; Braito, V.; Behar, E.; Leutenegger, Maurice A.; Cappi, M.

    2016-01-01

    We present the first high spectral resolution X-ray observation of the broad-line radio galaxy 3C 390.3 obtained with the high-energy transmission grating spectrometer on board the Chandra X-ray Observatory. The spectrum shows complex emission and absorption features in both the soft X-rays and Fe K band. We detect emission and absorption lines in the energy range E = 700-1000 eV associated with ionized Fe L transitions (Fe XVIIXX). An emission line at the energy of E approximately equal to 6.4 keV consistent with the Fe K alpha is also observed. Our best-fit model requires at least three different components: (i) a hot emission component likely associated with the hot interstellar medium in this elliptical galaxy with temperature kT = 0.5 +/- 0.1 keV; (ii) a warm absorber with ionization parameter log Epislon = 2.3 +/- 0.5 erg s(exp 1) cm, column density logN(sub H) = 20.7 +/- 0.1 cm(exp -2), and outflow velocity v(sub out) less than 150 km s(exp -1); and (iii) a lowly ionized reflection component in the Fe K band likely associated with the optical broad-line region or the outer accretion disk. These evidences suggest the possibility that we are looking directly down the ionization cone of this active galaxy and that the central X-ray source only photoionizes along the unobscured cone. This is overall consistent with the angle-dependent unified picture of active galactic nuclei.

  12. Constraining UV Continuum Slopes of Active Galactic Nuclei with CLOUDY Models of Broad-line Region Extreme-ultraviolet Emission Lines

    NASA Astrophysics Data System (ADS)

    Moloney, Joshua; Shull, J. Michael

    2014-10-01

    Understanding the composition and structure of the broad-line region (BLR) of active galactic nuclei (AGNs) is important for answering many outstanding questions in supermassive black hole evolution, galaxy evolution, and ionization of the intergalactic medium. We used single-epoch UV spectra from the Cosmic Origins Spectrograph (COS) on the Hubble Space Telescope to measure EUV emission-line fluxes from four individual AGNs with 0.49 <= z <= 0.64, two AGNs with 0.32 <= z <= 0.40, and a composite of 159 AGNs. With the CLOUDY photoionization code, we calculated emission-line fluxes from BLR clouds with a range of density, hydrogen ionizing flux, and incident continuum spectral indices. The photoionization grids were fit to the observations using single-component and locally optimally emitting cloud (LOC) models. The LOC models provide good fits to the measured fluxes, while the single-component models do not. The UV spectral indices preferred by our LOC models are consistent with those measured from COS spectra. EUV emission lines such as N IV λ765, O II λ833, and O III λ834 originate primarily from gas with electron temperatures between 37,000 K and 55,000 K. This gas is found in BLR clouds with high hydrogen densities (n H >= 1012 cm-3) and hydrogen ionizing photon fluxes (ΦH >= 1022 cm-2 s-1). Based on observations made with the NASA/ESA Hubble Space Telescope, obtained from the data archive at the Space Telescope Science Institute. STScI is operated by the Association of Universities for Research in Astronomy, Inc. under NASA contract NAS5-26555.

  13. Collision-induced stimulated photon echo generated at transition 0-1 on broad spectral line conditions

    NASA Astrophysics Data System (ADS)

    Rubtsova, N. N.; Gol'dort, V. G.; Ishchenko, V. N.; Khvorostov, E. B.; Kochubei, S. A.; Borisov, G. M.; Ledovskikh, D. V.; Reshetov, V. A.

    2018-04-01

    For the first time, the collision induced stimulated photon echo generated at transition 1S0 → 3 P1 of 174Yb (type 0-1) in the mixture of gases Yb  +  Xe was investigated in the presence of weak longitudinal magnetic field, with experimental parameters corresponding to broad spectral line conditions. Comparison of the experimental echo amplitude versus magnetic field strength dependence with the theoretical curve shows a very good agreement, giving rise to an improved estimate for the difference between alignment and orientation decay rates.

  14. Relativistic Iron K Emission and Absorption in the Seyfert 1.9 Galaxy MCG-05-23-16

    NASA Technical Reports Server (NTRS)

    Braito, V.; Reeves, J. N.; Dewangan, G. C.; George, I.; Griffiths, R.; Markowitz, A.; Nandra, K.; Porquet, D.; Ptak, A.; Turner, T. J.; hide

    2007-01-01

    We present the results of the simultaneous deep XMM-Newton and Chandra observations of the bright Seyfert 1.9 galaxy MCG-5-23-16, which is thought to have one of the best known examples of a relativistically broadened iron Kalpha line. We detected a narrow sporadic absorption line at 7.7 keV which appears to be variable on a time-scale of 20 ksec. If associated with FeXXVI this absorption is indicative of a possible variable high ionization, high velocity outflow. The time averaged spectral analysis shows that the iron K-shell complex is best modeled with an unresolved narrow emission component (FWHM less than 5000 kilometers per second, EW approx. 60 eV) plus a broad component. This latter component has FWHM approx. 44000 kilometers per second, an EW approx. 50 eV and its profile is well described with an emission line originating from the accretion disk viewed with an inclination angle approx. 40 deg. and with the emission arising from within a few tens of gravitational radii of the central black hole. The time-resolved spectral analysis of the XMM-Newton EPIC-pn spectrum shows that both the narrow and broad components of the Fe K emission line appear to be constant within the errors. The analysis of the XMM-Newton/RGS spectrum reveals that the soft X-ray emission of MCG-5-23-16 is likely dominated by several emission lines superimposed on an unabsorbed scattered power-law continuum. The lack of strong Fe L shell emission together with the detection of a strong forbidden line in the O VII triplet supports a scenario where the soft X ray emission lines are produced in a plasma photoionized by the nuclear emission.

  15. The pathophysiology of transfusional iron overload.

    PubMed

    Porter, John B; Garbowski, Maciej

    2014-08-01

    The pathophysiologic consequences of transfusional iron overload (TIO) as well as the benefits of iron chelation therapy are best described in thalassemia major, although TIO is increasingly seen in other clinical settings. These consequences broadly reflect the levels and distribution of excess storage iron in the heart, endocrine tissues, and liver. TIO also increases the risk of infection, due to increased availability of labile iron to microorganisms. The authors suggest that extrahepatic iron distribution, and hence toxicity, is influenced by balance between generation of nontransferrin-bound iron from red cell catabolism and the utilization of transferrin iron by the erythron. Copyright © 2014 Elsevier Inc. All rights reserved.

  16. THE DIFFERENCES IN THE TORUS GEOMETRY BETWEEN HIDDEN AND NON-HIDDEN BROAD LINE ACTIVE GALACTIC NUCLEI

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ichikawa, Kohei; Ueda, Yoshihiro; Packham, Christopher

    2015-04-20

    We present results from the fitting of infrared (IR) spectral energy distributions of 21 active galactic nuclei (AGNs) with clumpy torus models. We compiled high spatial resolution (∼0.3–0.7 arcsec) mid-IR (MIR) N-band spectroscopy, Q-band imaging, and nuclear near- and MIR photometry from the literature. Combining these nuclear near- and MIR observations, far-IR photometry, and clumpy torus models enables us to put constraints on the torus properties and geometry. We divide the sample into three types according to the broad line region (BLR) properties: type-1s, type-2s with scattered or hidden broad line region (HBLR) previously observed, and type-2s without any publishedmore » HBLR signature (NHBLR). Comparing the torus model parameters gives us the first quantitative torus geometrical view for each subgroup. We find that NHBLR AGNs have smaller torus opening angles and larger covering factors than HBLR AGNs. This suggests that the chance to observe scattered (polarized) flux from the BLR in NHBLR could be reduced by the dual effects of (a) less scattering medium due to the reduced scattering volume given the small torus opening angle and (b) the increased torus obscuration between the observer and the scattering region. These effects give a reasonable explanation for the lack of observed HBLR in some type-2 AGNs.« less

  17. 1E 0104.2 + 3153 - A broad absorption-line QSO viewed through a giant elliptical galaxy

    NASA Technical Reports Server (NTRS)

    Stocke, J. T.; Liebert, J.; Schild, R.; Gioia, I. M.; Maccacaro, T.

    1984-01-01

    The optical identification of the X-ray source 1E 0104.2 + 3153 is complicated by the close projection of a broad absorption-line (BAL) QSO (z = 2.027) 10 arcsec from a giant elliptical galaxy (z = 0.111) at the center of a compact group of galaxies. At only 1.2 de Vaucouleur radii (16 kpc for H sub 0 = 100 km/s Mpc) this QSO-galaxy projection is the closest yet discovered. Based upon current observations, the source of the X-ray emission cannot be conclusively determined. Present in the BAL QSO spectrum are extremely strong Ca II H and K absorption lines due to the intervening galaxy, the first optical detection of the cold interstellar medium in an elliptical galaxy. The strength of these lines (EW = 2 and 1 A) requires observation through several interstellar clouds in the line of sight to the QSO. By its proximity to the central regions of the elliptical galaxy and the relative distances of the galaxy and QSO, this QSO is a particularly good candidate for observing dramatic transient gravitational lensing phenomena due to halo stars in the foreground galaxy.

  18. Evidence for Doppler-Shifted Iron Emission Lines in Black Hole Candidate 4U 1630-47

    NASA Technical Reports Server (NTRS)

    Cui, Wei; Chen, Wan; Zhang, Shuang Nan

    2000-01-01

    We report the first detection of a pair of correlated the X-ray spectrum of black hole candidate 4U 1630-47 outburst, based on Rossi X-Ray Timing Explorer (RXTE) emission lines in during its 1996 observations of the source. At the peak plateau of the outburst, the emission lines are detected, centered mostly at approx. 5.7 and approx. 7.7 keV, respectively, while the line energies exhibit random variability approx. 5%. Interestingly, the lines move in a concerted manner to keep their separation roughly constant. The lines also vary greatly in strength, but with the lower energy line always much stronger than the higher energy one. The measured equivalent width ranges from approx. 50 to approx. 270 eV for the former, and from insignificant detection to approx. 140 eV for the latter; the two are reasonably correlated. The correlation between the lines implies a causal connection; perhaps they share a common origin. Both lines may arise from a single K & alpha; line of highly ionized iron that is Doppler shifted either in a Keplerian accretion disk or in a bipolar outflow or even both. In both scenarios, a change in the line energy might simply reflect a change in the ionization state of line-emitting matter. We discuss the implication of the results and also raise some questions about such interpretations.

  19. Solar coronal temperature diagnostics using emission line from multiple stages of ionization of iron

    NASA Technical Reports Server (NTRS)

    Brosius, Jeffrey W.; Davila, Joseph M.; Thomas, Roger J.; Thompson, William T.

    1994-01-01

    We obtained spatially resolved extreme-ultraviolet (EUV) spectra of AR 6615 on 1991 May 7 with NASA/ Goddard Space Flight Center's Solar EUV Rocket Telescope and Spectrograph (SERTS). Included are emission lines from four different stages of ionization of iron: Fe(+15) lambda 335 A, Fe(+14) lambda 327 A, Fe(+13) lambda 334 A, and Fe(+12) lambda 348 A. Using intensity ratios from among these lines, we have calculated the active region coronal temperature along the Solar Extreme Ultraviolet Telescope and Spectrograph (SERTS) slit. Temperatures derived from line ratios which incorporate adjacent stages of ionization are most sensitive to measurement uncertainties and yield the largest scatter. Temperatures derived from line ratios which incorporate nonadjacent stages of ionization are less sensitive to measurement uncertainties and yield little scatter. The active region temperature derived from these latter ratios has an average value of 2.54 x 10(exp 6) K, with a standard deviation approximately 0.12 x 10(exp 6) K, and shows no significant variation with position along the slit.

  20. A TEST OF THE FORMATION MECHANISM OF THE BROAD LINE REGION IN ACTIVE GALACTIC NUCLEI

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Czerny, Bozena; Du, Pu; Wang, Jian-Min

    2016-11-20

    The origin of the broad line region (BLR) in active galaxies remains unknown. It seems to be related to the underlying accretion disk, but an efficient mechanism is required to raise the material from the disk surface without giving signatures of the outflow that are too strong in the case of the low ionization lines. We discuss in detail two proposed mechanisms: (1) radiation pressure acting on dust in the disk atmosphere creating a failed wind and (2) the gravitational instability of the underlying disk. We compare the predicted location of the inner radius of the BLR in those two scenarios withmore » the observed position obtained from the reverberation studies of several active galaxies. The failed dusty outflow model well represents the observational data while the predictions of the self-gravitational instability are not consistent with observations. The issue that remains is why do we not see any imprints of the underlying disk instability in the BLR properties.« less

  1. Structural model of FeoB, the iron transporter from Pseudomonas aeruginosa, predicts a cysteine lined, GTP-gated pore

    PubMed Central

    Seyedmohammad, Saeed; Fuentealba, Natalia Alveal; Marriott, Robert A.J.; Goetze, Tom A.; Edwardson, J. Michael; Barrera, Nelson P.; Venter, Henrietta

    2016-01-01

    Iron is essential for the survival and virulence of pathogenic bacteria. The FeoB transporter allows the bacterial cell to acquire ferrous iron from its environment, making it an excellent drug target in intractable pathogens. The protein consists of an N-terminal GTP-binding domain and a C-terminal membrane domain. Despite the availability of X-ray crystal structures of the N-terminal domain, many aspects of the structure and function of FeoB remain unclear, such as the structure of the membrane domain, the oligomeric state of the protein, the molecular mechanism of iron transport, and how this is coupled to GTP hydrolysis at the N-terminal domain. In the present study, we describe the first homology model of FeoB. Due to the lack of sequence homology between FeoB and other transporters, the structures of four different proteins were used as templates to generate the homology model of full-length FeoB, which predicts a trimeric structure. We confirmed this trimeric structure by both blue-native-PAGE (BN-PAGE) and AFM. According to our model, the membrane domain of the trimeric protein forms a central pore lined by highly conserved cysteine residues. This pore aligns with a central pore in the N-terminal GTPase domain (G-domain) lined by aspartate residues. Biochemical analysis of FeoB from Pseudomonas aeruginosa further reveals a putative iron sensor domain that could connect GTP binding/hydrolysis to the opening of the pore. These results indicate that FeoB might not act as a transporter, but rather as a GTP-gated channel. PMID:26934982

  2. The influence of magnetic and dielectric loss on the noise absorption of iron particles-rubber composites attached to a microstrip line

    NASA Astrophysics Data System (ADS)

    Kim, Sun-Tae; Park, Yong-Gwon; Kim, Sung-Soo

    2008-04-01

    Magnetic and dielectric loss are systematically controlled by using iron flake powders with various initial sizes (7 μm and 70 μm) as the absorbent fillers in the rubber matrix, and their noise absorbing characteristics have been investigated as a function of frequency and sheet thickness. Flake iron particles were prepared by the mechanical forging of spherical powders using an attrition mill. Composite sheets (thickness=0.2 mm-1.0 mm) were prepared with a mixture of iron particles and silicone rubber. Attaching the composite sheets to a microstrip line of 50 Ω, a network analyzer was used to measure the reflection and transmission parameters (S11 and S21, respectively). A nearly constant value of S11 (about -10 dB) was observed, irrespective of particle size. However, S21 is strongly dependent upon initial particle size. For the composites of 7 μm particles (with high magnetic loss), S21 is reduced below -20 dB in the frequency range of 1 GHz to 10 GHz, and the corresponding bandwidth of noise absorption is not so greatly diminished by reducing the sheet thickness as low as 0.2 mm. For the composites of 70 μm particles (with high dielectric loss), however, the bandwidth is greatly reduced with a decrease in sheet thickness. It is concluded that the attenuation of conduction noise through the microstrip line is primarily controlled by the magnetic loss of the iron particles due to strong magnetic field around the microstrip line.

  3. Single-epoch black hole mass estimators for broad-line active galactic nuclei: recalibrating Hβ with a new approach

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Feng, Hua; Li, Hong; Shen, Yue

    2014-10-10

    Based on an updated Hβ reverberation mapping (RM) sample of 44 nearby active galactic nuclei (AGNs), we propose a novel approach for black hole (BH) mass estimation using two filtered luminosities computed from single-epoch (SE) AGN spectra around the Hβ region. We found that the two optimal-filter luminosities extract virial information (size and virial velocity of the broad-line region, BLR) from the spectra, justifying their usage in this empirical BH mass estimator. The major advantages of this new recipe over traditional SE BH mass estimators utilizing continuum luminosity and broad-line width are (1) it has a smaller intrinsic scatter ofmore » 0.28 dex calibrated against RM masses, (2) it is extremely simple to use in practice, without any need to decompose the spectrum, and (3) it produces unambiguous and highly repeatable results even with low signal-to-noise spectra. The combination of the two luminosities can also cancel out, to some extent, systematic luminosity errors potentially introduced by uncertainties in distance or flux calibration. In addition, we recalibrated the traditional SE mass estimators using broad Hβ FWHM and monochromatic continuum luminosity at 5100 Å (L {sub 5100}). We found that using the best-fit slopes on FWHM and L {sub 5100} (derived from fitting the BLR radius-luminosity relation and the correlation between rms line dispersion and SE FWHM, respectively) rather than simple assumptions (e.g., 0.5 for L {sub 5100} and 2 for FWHM) leads to more precise SE mass estimates, improving the intrinsic scatter from 0.41 dex to 0.36 dex with respect to the RM masses. We compared different estimators and discussed their applications to the Sloan Digital Sky Survey quasar sample. Due to the limitations of the current RM sample, application of any SE recipe calibrated against RM masses to distant quasars should be treated with caution.« less

  4. Tracking the Ironline and the Ultra Fast Outflow in NGC 2992 at different accretion states

    NASA Astrophysics Data System (ADS)

    Marinucci, A.; Bianchi, S.; Braito, V.; Matt, G.; Nardini, E.; Reeves, J.

    2018-06-01

    The Seyfert 2 galaxy NGC 2992 has been monitored eight times by XMM-Newton in 2010 and then observed again in 2013, while in 2015 it was simultaneously targeted by Swift and NuSTAR. XMM-Newton always caught the source in a faint state (2-10 keV fluxes ranging from 0.3 to 1.6× 10-11 erg cm-2 s-1) but NuSTAR showed an increase in the 2-10 keV flux up to 6× 10-11 erg cm-2 s-1. We find possible evidence of an Ultra Fast Outflow with velocity v1 = 0.21 ± 0.01c (detected at about 99% confidence level) in such a flux state. The UFO in NGC 2992 is consistent with being ejected at a few tens of gravitational radii only at accretion rates greater than 2% of the Eddington luminosity. The analysis of the low flux 2010/2013 XMM data allowed us to determine that the Iron Kα emission line complex in this object is likely the sum of three distinct components: a constant, narrow one due to reflection from cold, distant material (likely the molecular torus); a narrow, but variable one which is more intense in brighter observations and a broad relativistic one emitted in the innermost regions of the accretion disk, which has been detected only in the 2003 XMM observation.

  5. C IV BROAD ABSORPTION LINE ACCELERATION IN SLOAN DIGITAL SKY SURVEY QUASARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grier, C. J.; Brandt, W. N.; Trump, J. R.

    2016-06-20

    We present results from the largest systematic investigation of broad absorption line (BAL) acceleration to date. We use spectra of 140 quasars from three Sloan Digital Sky Survey programs to search for global velocity offsets in BALs over timescales of ≈2.5–5.5 years in the quasar rest frame. We carefully select acceleration candidates by requiring monolithic velocity shifts over the entire BAL trough, avoiding BALs with velocity shifts that might be caused by profile variability. The C iv BALs of two quasars show velocity shifts consistent with the expected signatures of BAL acceleration, and the BAL of one quasar shows amore » velocity-shift signature of deceleration. In our two acceleration candidates, we see evidence that the magnitude of the acceleration is not constant over time; the magnitudes of the change in acceleration for both acceleration candidates are difficult to produce with a standard disk-wind model or via geometric projection effects. We measure upper limits to acceleration and deceleration for 76 additional BAL troughs and find that the majority of BALs are stable to within about 3% of their mean velocities. The lack of widespread acceleration/deceleration could indicate that the gas producing most BALs is located at large radii from the central black hole and/or is not currently strongly interacting with ambient material within the host galaxy along our line of sight.« less

  6. The case for cases B and C: intrinsic hydrogen line ratios of the broad-line region of active galactic nuclei, reddenings, and accretion disc sizes

    NASA Astrophysics Data System (ADS)

    Gaskell, C. Martin

    2017-05-01

    Low-redshift active galactic nuclei (AGNs) with extremely blue optical spectral indices are shown to have a mean, velocity-averaged, broad-line Hα/Hβ ratio of ≈2.72 ± 0.04, consistent with a Baker-Menzel Case B value. Comparison of a wide range of properties of the very bluest AGNs with those of a luminosity-matched subset of the Dong et al. blue AGN sample indicates that the only difference is the internal reddening. Ultraviolet fluxes are brighter for the bluest AGNs by an amount consistent with the flat AGN reddening curve of Gaskell et al. The lack of a significant difference in the GALEX (far-ultraviolet-near-ultraviolet) colour index strongly rules out a steep Small Magellanic Cloud-like reddening curve and also argues against an intrinsically harder spectrum for the bluest AGNs. For very blue AGNs, the Ly α/Hβ ratio is also consistent with being the Case B value. The Case B ratios provide strong support for the self-shielded broad-line model of Gaskell, Klimek & Nazarova. It is proposed that the greatly enhanced Ly α/Hβ ratio at very high velocities is a consequence of continuum fluorescence in the Lyman lines (Case C). Reddenings of AGNs mean that the far-UV luminosity is often underestimated by up to an order of magnitude. This is a major factor causing the discrepancies between measured accretion disc sizes and the predictions of simple accretion disc theory. Dust covering fractions for most AGNs are lower than has been estimated. The total mass in lower mass supermassive black holes must be greater than hitherto estimated.

  7. Thomson Thick X-Ray Absorption in a Broad Absorption Line Quasar, PG 0946+301.

    PubMed

    Mathur; Green; Arav; Brotherton; Crenshaw; deKool; Elvis; Goodrich; Hamann; Hines; Kashyap; Korista; Peterson; Shields; Shlosman; van Breugel W; Voit

    2000-04-20

    We present a deep ASCA observation of a broad absorption line quasar (BALQSO) PG 0946+301. The source was clearly detected in one of the gas imaging spectrometers, but not in any other detector. If BALQSOs have intrinsic X-ray spectra similar to normal radio-quiet quasars, our observations imply that there is Thomson thick X-ray absorption (NH greater, similar1024 cm-2) toward PG 0946+301. This is the largest column density estimated so far toward a BALQSO. The absorber must be at least partially ionized and may be responsible for attenuation in the optical and UV. If the Thomson optical depth toward BALQSOs is close to 1, as inferred here, then spectroscopy in hard X-rays with large telescopes like XMM would be feasible.

  8. Quantification of body iron and iron absorption in the REDS-II Donor Iron Status Evaluation (RISE) study.

    PubMed

    Kiss, Joseph E; Birch, Rebecca J; Steele, Whitney R; Wright, David J; Cable, Ritchard G

    2017-07-01

    Repeated blood donation alters the iron balance of blood donors. We quantified these effects by analyzing changes in body iron as well as calculating iron absorbed per day for donors enrolled in a prospective study. For 1308 donors who completed a final study visit, we calculated total body iron at the enrollment and final visits and the change in total body iron over the course of the study. Taking into account iron lost from blood donations during the study and obligate losses, we also calculated the average amount of iron absorbed per day. First-time/reactivated donors at enrollment had iron stores comparable to previous general population estimates. Repeat donors had greater donation intensity and greater mean iron losses than first-time/reactivated donors, yet they had little change in total body iron over the study period, whereas first-time/reactivated donors had an average 35% drop. There was higher estimated iron absorption in the repeat donors (men: 4.49 mg/day [95% confidence interval [CI], 4.41-4.58 mg/day]; women: 3.75 mg/day [95% CI, 3.67-3.84 mg/day]) compared with estimated iron absorption in first-time/reactivated donors (men: 2.89 mg/day [95% CI, 2.75-3.04 mg/day]; women: 2.76 mg/day [95% CI, 2.64-2.87 mg/day]). The threshold for negative estimated iron stores (below "0" mg/kg stores) was correlated with the development of anemia at a plasma ferritin value of 10 ng/mL. These analyses provide quantitative data on changes in estimated total body iron for a broad spectrum of blood donors. In contrast to using ferritin alone, this model allows assessment of the iron content of red blood cells and the degree of both iron surplus and depletion over time. © 2017 AABB.

  9. Compacted graphite iron: Cast iron makes a comeback

    NASA Astrophysics Data System (ADS)

    Dawson, S.

    1994-08-01

    Although compacted graphite iron has been known for more than four decades, the absence of a reliable mass-production technique has resulted in relatively little effort to exploit its operational benefits. However, a proven on-line process control technology developed by SinterCast allows for series production of complex components in high-quality CGI. The improved mechanical properties of compacted graphite iron relative to conventional gray iron allow for substantial weight reduction in gasoline and diesel engines or substantial increases in horsepower, or an optimal combination of both. Concurrent with these primary benefits, CGI also provides significant emissions and fuel efficiency benefits allowing automakers to meet legislated performance standards. The operational and environmental benefits of compacted graphite iron together with its low cost and recyclability reinforce cast iron as a prime engineering material for the future.

  10. Partial dust obscuration in active galactic nuclei as a cause of broad-line profile and lag variability, and apparent accretion disc inhomogeneities

    NASA Astrophysics Data System (ADS)

    Gaskell, C. Martin; Harrington, Peter Z.

    2018-04-01

    The profiles of the broad emission lines of active galactic nuclei (AGNs) and the time delays in their response to changes in the ionizing continuum ("lags") give information about the structure and kinematics of the inner regions of AGNs. Line profiles are also our main way of estimating the masses of the supermassive black holes (SMBHs). However, the profiles often show ill-understood, asymmetric structure and velocity-dependent lags vary with time. Here we show that partial obscuration of the broad-line region (BLR) by outflowing, compact, dusty clumps produces asymmetries and velocity-dependent lags similar to those observed. Our model explains previously inexplicable changes in the ratios of the hydrogen lines with time and velocity, the lack of correlation of changes in line profiles with variability of the central engine, the velocity dependence of lags, and the change of lags with time. We propose that changes on timescales longer than the light-crossing time do not come from dynamical changes in the BLR, but are a natural result of the effect of outflowing dusty clumps driven by radiation pressure acting on the dust. The motion of these clumps offers an explanation of long-term changes in polarization. The effects of the dust complicate the study of the structure and kinematics of the BLR and the search for sub-parsec SMBH binaries. Partial obscuration of the accretion disc can also provide the local fluctuations in luminosity that can explain sizes deduced from microlensing.

  11. Evidence for a Circum-Nuclear and Ionised Absorber in the X-ray Obscured Broad Line Radio Galaxy 3C 445

    NASA Technical Reports Server (NTRS)

    Braito, V.; Reeves, J. N.; Sambruna, R. M.; Gofford, J.

    2012-01-01

    Here we present the results of a Suzaku observation of the Broad Line Radio Galaxy 3C 445. We confirm the results obtained with the previous X-ray observations which unveiled the presence of several soft X-ray emission lines and an overall X-ray emission which strongly resembles a typical Seyfert 2 despite of the optical classification as an unobscured AGN. The broad band spectrum allowed us to measure for the first time the amount of reflection (R approximately 0.9) which together with the relatively strong neutral Fe Ka emission line (EW approximately 100 eV) strongly supports a scenario where a Compton-thick mirror is present. The primary X ray continuum is strongly obscured by an absorber with a column density of NH = 2 - 3 x 10(exp 23) per square centimeter. Two possible scenarios are proposed for the absorber: a neutral partial covering or a mildly ionised absorber with an ionisation parameter log xi approximately 1.0 erg centimeter per second. A comparison with the past and more recent X-ray observations of 3C 445 performed with XMM-Newton and Chandra is presented, which provided tentative evidence that the ionised and outflowing absorber varied. We argue that the absorber is probably associated with an equatorial diskwind located within the parsec scale molecular torus.

  12. Simultaneous NuSTAR and XMM-Newton 0.5-80 KeV Spectroscopy of the Narrow-Line Seyfert 1 Galaxy SWIFT J2127.4+5654

    NASA Technical Reports Server (NTRS)

    Marinucci, A.; Matt, G.; Kara, E.; Miniutti, G.; Elvis, M.; Arevalo, P.; Ballantyne, D. R.; Balokovic, M.; Bauer, F.; Brenneman, L.; hide

    2014-01-01

    We present a broad-band spectral analysis of the joint XMM-Newton and Nuclear Spectroscopic Telescope Array observational campaign of the narrow-line Seyfert 1 SWIFT J2127.4+5654, consisting of 300 kiloseconds performed during three XMM-Newton orbits. We detect a relativistic broadened iron K-alpha line originating from the innermost regions of the accretion disc surrounding the central black hole, from which we infer an intermediate spin of a = 0.58 (sup +0.11) (sub -0.17). The intrinsic spectrum is steep (gamma = 2.08 plus or minus 0.01) as commonly found in narrow-line Seyfert 1 galaxies, while the cutoff energy (E (sub c) = 108 (sup +11) (sub -10) kiloelectronvolts) falls within the range observed in broad-line Seyfert 1 galaxies. We measure a low-frequency lag that increases steadily with energy, while at high frequencies, there is a clear lag following the shape of the broad Fe K emission line. Interestingly, the observed Fe K lag in SWIFT J2127.4+5654 is not as broad as in other sources that have maximally spinning black holes. The lag amplitude suggests a continuum-to-reprocessor distance of about 10-20 radius of gyration. These timing results independently support an intermediate black hole spin and a compact corona.

  13. Broad-Band Continuum and Line Emission of the gamma-Ray Blazar PKS 0537-441

    NASA Technical Reports Server (NTRS)

    Pian, E.; Falomo, R.; Hartman, R. C.; Maraschi, L.; Tavecchio, F.; Tornikoski, M.; Treves, A.; Urry, C. M.; Ballo, L.; Mukherjee, R.; hide

    2002-01-01

    PKS 0537-441, a bright gamma ray emitting blazar was observed at radio, optical, UV and X-ray frequencies during various EGRET paintings, often quasi-simultaneously. In 1995 the object was found in an intense emission state at all wavelengths. BeppoSAX observations made in 1998, non-simultaneously with exposures at other frequencies, allow us to characterize precisely the spectral shape of the high energy blazer component, which we attribute to inverse Compton scatter in The optical-to-gamma-ray spectral energy distributions at the different epochs show that the gamma-ray luminosity dominates the barometric output. This, together with the presence of optical and UV line emission, suggests that, besides the synchrotron self-Compton mechanism, the Compton upscattering of photons external to the jet (e.g., in the broad line region) may have a significant role for high energy radiation. The multiwavelength variability can be reproduced by changes of the plasma bulk Lorentz factor. The spectrum secured by ICE in 1995 appears to be partially absorbed shortward of approximately 1700 Angstroms. However, this signature is not detected in the HST spectrum taker during a lower state of the source. The presence of intervening absorbers is not supported by optical imaging and spectroscopy of the field.

  14. What Drives the Outflows in Broad Absorption Line QSOs?

    NASA Technical Reports Server (NTRS)

    Begelman, Mitchell C.

    1997-01-01

    We have made progress in the areas related to the propulsion and confinement of gas responsible for broad absorption troughts in QSOs: Radiative Acceleration in BALQSOs; The "Ghost" of Lyman (alpha); and Magnetic Confinement of Absorbing Gas.

  15. Analysis of high iron rice lines reveals new miRNAs that target iron transporters in roots

    PubMed Central

    Paul, Soumitra; Gayen, Dipak; Datta, Swapan K.; Datta, Karabi

    2016-01-01

    The present study highlights the molecular regulation of iron transport in soyFER1-overexpressing transgenic rice. Accumulation of iron in three different seed developmental stages, milk, dough, and mature, has been examined. The transgenic seeds of the milk stage showed significant augmentation of iron and zinc levels compared with wild-type seeds, and similar results were observed throughout the dough and mature stages. To investigate the regulation of iron transport, the role of miRNAs was studied in roots of transgenic rice. Sequencing of small RNA libraries revealed 153 known and 41 novel miRNAs in roots. Among them, 59 known and 14 novel miRNAs were found to be significantly expressed. miR166, miR399, and miR408 were identified as playing a vital role in iron uptake in roots of transgenic plants . Most importantly, four putative novel miRNAs, namely miR11, miR26, miR30, and miR31, were found to be down-regulated in roots of transgenic plants. For all these four novel miRNAs, natural resistance-associated macrophage protein 4 (NRAMP4), encoding a metal transporter, was predicted as a target gene. It is hypothesized that the NRAMP4 transporter is activated in roots of transgenic plants due to the lower abundance of its corresponding putative novel miRNAs. The relative transcript level of the NRAMP4 transcript was increased from 0.107 in the wild type to 65.24 and 55.39 in transgenic plants, which demonstrates the elevated amount of iron transport in transgenic plants. In addition, up-regulation of OsYSL15, OsFRO2, and OsIRT1 in roots also facilitates iron loading in transgenic seeds. PMID:27729476

  16. Electron Spin Relaxation Rates for High-Spin Fe(III) in Iron Transferrin Carbonate and Iron Transferrin Oxalate

    PubMed Central

    Gaffney, Betty Jean; Eaton, Gareth R.; Eaton*, Sandra S.

    2005-01-01

    To optimize simulations of CW EPR spectra for high-spin Fe(III) with zero-field splitting comparable to the EPR quantum, information is needed on the factors that contribute to the line shapes and line widths. Continuous wave electron paramagnetic resonance (EPR) spectra obtained for iron transferrin carbonate from 4 to 150 K and for iron transferrin oxalate from 4 to 100 K did not exhibit significant temperature dependence of the line shape, which suggested that the line shapes were not relaxation determined. To obtain direct information concerning the electron spin relaxation rates, electron spin echo and inversion recovery EPR were used to measure T1 and Tm for the high-spin Fe(III) in iron transferrin carbonate and iron transferrin oxalate between 5 and 20–30 K. For comparison with the data for the transferrin complexes, relaxation times were obtained for tris(oxalato)ferrate(III). The relaxation rates are similar for the three complexes and do not exhibit a strong dependence on position in the spectrum. Extrapolation of the observed temperature dependence of the relaxation rates to higher temperatures gives values consistent with the conclusion that the CW line shapes are not relaxation determined up to 150 K. PMID:16429607

  17. Application of the spine-layer jet radiation model to outbursts in the broad-line radio galaxy 3C 120

    NASA Astrophysics Data System (ADS)

    Janiak, M.; Sikora, M.; Moderski, R.

    2016-05-01

    We present a detailed Fermi/LAT data analysis for the broad-line radio galaxy 3C 120. This source has recently entered into a state of increased γ-ray activity which manifested itself in two major flares detected by Fermi/LAT in 2014 September and 2015 April with no significant flux changes reported in other wavelengths. We analyse available data focusing our attention on aforementioned outbursts. We find very fast variability time-scale during flares (of the order of hours) together with a significant γ-ray flux increase. We show that the ˜6.8 yr averaged γ-ray emission of 3C 120 is likely a sum of the external radiation Compton and the synchrotron self-Compton radiative components. To address the problem of violent γ-ray flares and fast variability we model the jet radiation dividing the jet structure into two components: the wide and relatively slow outer layer and the fast, narrow spine. We show that with the addition of the fast spine occasionally bent towards the observer we are able to explain observed spectral energy distribution of 3C 120 during flares with the Compton upscattered broad-line region and dusty torus photons as main γ-rays emission mechanism.

  18. Genetic analysis of a novel broad-spectrum powdery mildew resistance gene from the wheat-Agropyron cristatum introgression line Pubing 74.

    PubMed

    Lu, Yuqing; Yao, Miaomiao; Zhang, Jinpeng; Song, Liqiang; Liu, Weihua; Yang, Xinming; Li, Xiuquan; Li, Lihui

    2016-09-01

    A novel broad-spectrum powdery mildew resistance gene PmPB74 was identified in wheat- Agropyron cristatum introgression line Pubing 74. Development of wheat cultivars with broad-spectrum, durable resistance to powdery mildew has been restricted by lack of superior genetic resources. In this study, a wheat-A. cristatum introgression line Pubing 74, originally selected from a wide cross between the common wheat cultivar Fukuhokomugi (Fukuho) and Agropyron cristatum (L.) Gaertn (2n = 4x = 28; genome PPPP), displayed resistance to powdery mildew at both the seedling and adult stages. The putative alien chromosomal fragment in Pubing 74 was below the detection limit of genomic in situ hybridization (GISH), but evidence for other non-GISH-detectable introgressions was provided by the presence of three STS markers specific to A. cristatum. Genetic analysis indicated that Pubing 74 carried a single dominant gene for powdery mildew resistance, temporarily designated PmPB74. Molecular mapping showed that PmPB74 was located on wheat chromosome arm 5DS, and flanked by markers Xcfd81 and HRM02 at genetic distances of 2.5 and 1.7 cM, respectively. Compared with other lines with powdery mildew resistance gene(s) on wheat chromosome arm 5DS, Pubing 74 was resistant to all 28 Blumeria graminis f. sp tritici (Bgt) isolates from different wheat-producing regions of northern China. Allelism tests indicated that PmPB74 was not allelic to PmPB3558 or Pm2. Our work showed that PmPB74 is a novel gene with broad resistance to powdery mildew, and hence will be helpful in broadening the genetic basis of powdery mildew resistance in wheat.

  19. Broad-Band Spectroscopy of Hercules X-1 with Suzaku

    NASA Technical Reports Server (NTRS)

    Asami, Fumi; Enoto, Teruaki; Iwakiri, Wataru; Yamada, Shin'ya; Tamagawa, Toru; Mihara, Tatehiro; Nagase, Fumiaki

    2014-01-01

    Hercules X-1 was observed with Suzaku in the main-on state from 2005 to 2010. The 0.4- 100 keV wide-band spectra obtained in four observations showed a broad hump around 4-9 keV in addition to narrow Fe lines at 6.4 and 6.7 keV. The hump was seen in all the four observations regardless of the selection of the continuum models. Thus it is considered a stable and intrinsic spectral feature in Her X-1. The broad hump lacked a sharp structure like an absorption edge. Thus it was represented by two different spectral models: an ionized partial covering or an additional broad line at 6.5 keV. The former required a persistently existing ionized absorber, whose origin was unclear. In the latter case, the Gaussian fitting of the 6.5-keV line needs a large width of sigma = 1.0-1.5 keV and a large equivalent width of 400-900 eV. If the broad line originates from Fe fluorescence of accreting matter, its large width may be explained by the Doppler broadening in the accretion flow. However, the large equivalent width may be inconsistent with a simple accretion geometry.

  20. The corona of the broad-line radio galaxy 3C 390.3

    DOE PAGES

    Lohfink, A. M.; Ogle, P.; Tombesi, F.; ...

    2015-11-13

    We present the results from a joint Suzaku/NuSTAR broadband spectral analysis of 3C 390.3. The high quality data enables us to clearly separate the primary continuum from the reprocessed components allowing us to detect a high energy spectral cut-off (more » $${E}_{\\mathrm{cut}}={117}_{-14}^{+18}$$ keV), and to place constraints on the Comptonization parameters of the primary continuum for the first time. The hard over soft compactness is $${69}_{-24}^{+124}$$ and the optical depth is $${4.1}_{-3.6}^{+0.5},$$ this leads to an electron temperature of $${30}_{-8}^{+32}$$ keV. Expanding our study of the Comptonization spectrum to the optical/UV by studying the simultaneous Swift-UVOT data, we find indications that the compactness of the corona allows only a small fraction of the total UV/optical flux to be Comptonized. Our analysis of the reprocessed emission show that 3C 390.3 only has a small amount of reflection (R ~ 0.3), and of that the vast majority is from distant neutral matter. Furthermore, we also discover a soft-X-ray excess in the source, which can be described by a weak ionized reflection component from the inner parts of the accretion disk. In addition to the backscattered emission, we also detect the highly ionized iron emission lines Fe xxv and Fe xxvi.« less

  1. SN 2010ay Is a Luminous and Broad-Lined Type Ic Supernova Within a Low-Metallicity Host Galaxy

    NASA Technical Reports Server (NTRS)

    Sanders, N. E.; Soderberg, A. M.; Valenti, S.; Foley, R. J.; Chornock, R.; Chomiuk, L.; Berger, E.; Smartt, S.; Hurley, K.; Barthelmy, S. D.; hide

    2012-01-01

    We report on our serendipitous pre-discovery detection and follow-up observations of the broad-lined Type Ic supernova (SN Ic) 2010ay at z = 0.067 imaged by the Pan-STARRS1 3pi survey just approximately 4 days after explosion. The supernova (SN) had a peak luminosity, MR approx. -20.2 mag, significantly more luminous than known GRB-SNe and one of the most luminous SNe Ib/c ever discovered. The absorption velocity of SN 2010ay is v Si (is) approx. 19×10(exp 3) km s-1 at approximately 40 days after explosion, 2-5 times higher than other broad-lined SNe and similar to the GRB-SN 2010bh at comparable epochs. Moreover, the velocity declines approximately 2 times slower than other SNe Ic-BL and GRB-SNe. Assuming that the optical emission is powered by radioactive decay, the peak magnitude implies the synthesis of an unusually large mass of 56Ni, MNi = 0.9 solar mass. Applying scaling relations to the light curve, we estimate a total ejecta mass, Mej (is) approx. 4.7 solar mass, and total kinetic energy, EK (is) approx. 11 × 10(exp 51) erg. The ratio of MNi to Mej is approximately 2 times as large for SN 2010ay as typical GRB-SNe and may suggest an additional energy reservoir. The metallicity (log(O/H)PP04 + 12 = 8.19) of the explosion site within the host galaxy places SN 2010ay in the low-metallicity regime populated by GRB-SNe, and (is) approximately 0.5(0.2) dex lower than that typically measured for the host environments of normal (broad-lined) SNe Ic. We constrain any gamma-ray emission with E(gamma) (is) approximately less than 6 × 10(exp 48) erg (25-150 keV), and our deep radio follow-up observations with the Expanded Very Large Array rule out relativistic ejecta with energy E (is) approximately greater than 10(exp 48) erg. We therefore rule out the association of a relativistic outflow like those that accompanied SN 1998bw and traditional long-duration gamma-ray bursts (GRBs), but we place less-stringent constraints on a weak afterglow like that seen from XRF

  2. Suzaku Observation of Strong Fluorescent Iron Line Emission from the Young Stellar Object V1647 Ori during Its New X-ray Outburst

    NASA Technical Reports Server (NTRS)

    Hamaguchi, Kenji; Grosso, Nicolas; Kastner, Joel H.; Weintraub, David A.; Richmond, Michael

    2009-01-01

    The Suzaku X-ray satellite observed the young stellar object V1647 Ori on 2008 October 8 during the new mass accretion outburst reported in August 2008. During the 87 ksec observation with a net exposure of 40 ks, V1647 Ori showed a. high level of X-ray emission with a gradual decrease in flux by a factor of 5 and then displayed an abrupt flux increase by an order of magnitude. Such enhanced X-ray variability was also seen in XMM-Newton observations in 2004 and 2005 during the 2003-2005 outburst, but has rarely been observed for other young stellar objects. The spectrum clearly displays emission from Helium-like iron, which is a signature of hot plasma (kT approx.5 keV). It also shows a fluorescent iron Ka line with a remarkably large equivalent width of approx. 600 eV. Such a, large equivalent width indicates that a part of the incident X-ray emission that irradiates the circumstellar material and/or the stellar surface is hidden from our line of sight. XMM-Newton spectra during the 2003-2005 outburst did not show a strong fluorescent iron Ka line ; so that the structure of the circumstellar gas very close to the stellar core that absorbs and re-emits X-ray emission from the central object may have changed in between 2005 and 2008. This phenomenon may be related to changes in the infrared morphology of McNeil's nebula between 2004 and 2008.

  3. Discovery of Ultra-fast Outflows in a Sample of Broad-line Radio Galaxies Observed with Suzaku

    NASA Astrophysics Data System (ADS)

    Tombesi, F.; Sambruna, R. M.; Reeves, J. N.; Braito, V.; Ballo, L.; Gofford, J.; Cappi, M.; Mushotzky, R. F.

    2010-08-01

    We present the results of a uniform and systematic search for blueshifted Fe K absorption lines in the X-ray spectra of five bright broad-line radio galaxies observed with Suzaku. We detect, for the first time in radio-loud active galactic nuclei (AGNs) at X-rays, several absorption lines at energies greater than 7 keV in three out of five sources, namely, 3C 111, 3C 120, and 3C 390.3. The lines are detected with high significance according to both the F-test and extensive Monte Carlo simulations. Their likely interpretation as blueshifted Fe XXV and Fe XXVI K-shell resonance lines implies an origin from highly ionized gas outflowing with mildly relativistic velocities, in the range v ~= 0.04-0.15c. A fit with specific photoionization models gives ionization parameters in the range log ξ ~= 4-5.6 erg s-1 cm and column densities of N H ~= 1022-1023 cm-2. These characteristics are very similar to those of the ultra-fast outflows (UFOs) previously observed in radio-quiet AGNs. Their estimated location within ~0.01-0.3 pc of the central super-massive black hole suggests a likely origin related with accretion disk winds/outflows. Depending on the absorber covering fraction, the mass outflow rate of these UFOs can be comparable to the accretion rate and their kinetic power can correspond to a significant fraction of the bolometric luminosity and is comparable to their typical jet power. Therefore, these UFOs can play a significant role in the expected feedback from the AGN to the surrounding environment and can give us further clues on the relation between the accretion disk and the formation of winds/jets in both radio-quiet and radio-loud AGNs.

  4. X-RAYS FROM A RADIO-LOUD COMPACT BROAD ABSORPTION LINE QUASAR 1045+352 AND THE NATURE OF OUTFLOWS IN RADIO-LOUD BROAD ABSORPTION LINE QUASARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Kunert-Bajraszewska, Magdalena; Katarzynski, Krzysztof; Siemiginowska, Aneta

    2009-11-10

    We present new results on X-ray properties of radio-loud broad absorption line (BAL) quasars and focus on broadband spectral properties of a high-ionization BAL (HiBAL) compact steep spectrum (CSS) radio-loud quasar 1045+352. This HiBAL quasar has a very complex radio morphology indicating either strong interactions between a radio jet and the surrounding interstellar medium or a possible re-start of the jet activity. We detected 1045+352 quasar in a short 5 ksec Chandra ACIS-S observation. We applied theoretical models to explain spectral energy distribution of 1045+352 and argue that non-thermal, inverse-Compton (IC) emission from the innermost parts of the radio jetmore » can account for a large fraction of the observed X-ray emission. In our analysis, we also consider a scenario in which the observed X-ray emission from radio-loud BAL quasars can be a sum of IC jet X-ray emission and optically thin corona X-ray emission. We compiled a sample of radio-loud BAL quasars that were observed in X-rays to date and report no correlation between their X-ray and radio luminosity. However, the radio-loud BAL quasars show a large range of X-ray luminosities and absorption columns. This is consistent with the results obtained earlier for radio-quiet BAL quasars and may indicate an orientation effect in BAL quasars or more complex dependence between X-ray emission, radio emission, and an orientation based on the radio morphology.« less

  5. THE LICK AGN MONITORING PROJECT: BROAD-LINE REGION RADII AND BLACK HOLE MASSES FROM REVERBERATION MAPPING OF Hbeta

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bentz, Misty C.; Walsh, Jonelle L.; Barth, Aaron J.

    2009-11-01

    We have recently completed a 64-night spectroscopic monitoring campaign at the Lick Observatory 3-m Shane telescope with the aim of measuring the masses of the black holes in 12 nearby (z < 0.05) Seyfert 1 galaxies with expected masses in the range approx10{sup 6}-10{sup 7} M {sub sun} and also the well-studied nearby active galactic nucleus (AGN) NGC 5548. Nine of the objects in the sample (including NGC 5548) showed optical variability of sufficient strength during the monitoring campaign to allow for a time lag to be measured between the continuum fluctuations and the response to these fluctuations in themore » broad Hbeta emission. We present here the light curves for all the objects in this sample and the subsequent Hbeta time lags for the nine objects where these measurements were possible. The Hbeta lag time is directly related to the size of the broad-line region (BLR) in AGNs, and by combining the Hbeta lag time with the measured width of the Hbeta emission line in the variable part of the spectrum, we determine the virial mass of the central supermassive black hole in these nine AGNs. The absolute calibration of the black hole masses is based on the normalization derived by Onken et al., which brings the masses determined by reverberation mapping into agreement with the local M {sub BH}-sigma{sub *}relationship for quiescent galaxies. We also examine the time lag response as a function of velocity across the Hbeta line profile for six of the AGNs. The analysis of four leads to rather ambiguous results with relatively flat time lags as a function of velocity. However, SBS 1116+583A exhibits a symmetric time lag response around the line center reminiscent of simple models for circularly orbiting BLR clouds, and Arp 151 shows an asymmetric profile that is most easily explained by a simple gravitational infall model. Further investigation will be necessary to fully understand the constraints placed on the physical models of the BLR by the velocity

  6. DETECTION OF THE INTERMEDIATE-WIDTH EMISSION LINE REGION IN QUASAR OI 287 WITH THE BROAD EMISSION LINE REGION OBSCURED BY THE DUSTY TORUS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Li, Zhenzhen; Zhou, Hongyan; Wang, Huiyuan

    2015-10-20

    The existence of intermediate-width emission line regions (IELRs) in active galactic nuclei has been discussed for over two decades. A consensus, however, is yet to be arrived at due to the lack of convincing evidence for their detection. We present a detailed analysis of the broadband spectrophotometry of the partially obscured quasar OI 287. The ultraviolet intermediate-width emission lines (IELs) are very prominent, in high contrast to the corresponding broad emission lines (BELs) which are heavily suppressed by dust reddening. Assuming that the IELR is virialized, we estimated its distance to the central black hole to be ∼2.9 pc, similarmore » to the dust sublimation radius of ∼1.3 pc. Photo-ionization calculations suggest that the IELR has a hydrogen density of ∼10{sup 8.8}–10{sup 9.4} cm{sup −3}, within the range of values quoted for the dusty torus near the sublimation radius. Both its inferred location and physical conditions suggest that the IELR originates from the inner surface of the dusty torus. In the spectrum of this quasar, we identified only one narrow absorption-line system associated with the dusty material. With the aid of photo-ionization model calculations, we found that the obscuring material might originate from an outer region of the dusty torus. We speculate that the dusty torus, which is exposed to the central ionizing source, may produce IELs through photo-ionization processes, as well as obscure BELs as a natural “coronagraph.” Such a “coronagraph” could be found in a large number of partially obscured quasars and may be a useful tool to study IELRs.« less

  7. Facilitated citrate-dependent iron translocation increases rice endosperm iron and zinc concentrations.

    PubMed

    Wu, Ting-Ying; Gruissem, Wilhelm; Bhullar, Navreet K

    2018-05-01

    Iron deficiency affects one third of the world population. Most iron biofortification strategies have focused on genes involved in iron uptake and storage but facilitating internal long-distance iron translocation has been understudied for increasing grain iron concentrations. Citrate is a primary iron chelator, and the transporter FERRIC REDUCTASE DEFECTIVE 3 (FRD3) loads citrate into the xylem. We have expressed AtFRD3 in combination with AtNAS1 (NICOTIANAMINE SYNTHASE 1) and PvFER (FERRITIN) or with PvFER alone to facilitate long-distance iron transport together with efficient iron uptake and storage in the rice endosperm. The citrate and iron concentrations in the xylem sap of transgenic plants increased two-fold compared to control plants. Iron and zinc levels increased significantly in polished and unpolished rice grains to more than 70% of the recommended estimated average requirement (EAR) for iron and 140% of the recommended EAR for zinc in polished rice grains. Furthermore, the transformed lines showed normal phenotypic growth, were tolerant to iron deficiency and aluminum toxicity, and had grain cadmium levels similar to control plants. Together, our results demonstrate that deploying FRD for iron biofortification has no obvious anti-nutritive effects and should be considered as an effective strategy for reducing human iron deficiency anemia. Copyright © 2018 The Authors. Published by Elsevier B.V. All rights reserved.

  8. A Survey of X-Ray Variability in Seyfert 1 Galaxies with XMM-Newton to study the soft excess and the broad Fe lines

    NASA Astrophysics Data System (ADS)

    Ponti, Gabriele

    The nature of the soft excess and the presence of the broad Fe lines is still nowadays highly debated because the different absorption/emission models are degenerate. Spectral variability studies have the potential to break this degeneracy. I will present the results of a spectral variability RMS survey of the 36 brightest type 1 Seyfert galaxies observed by XMM-Newton for more than 30 ks. More than 80 as already measured, on longer timescales, with RXTE (Markowitz et al. 2004). About half of the sample show lower variability in the soft energy band, indicating that the emission from the soft excess is more stable than the one of the continuum. While the other sources show a soft excess that is as variable as the continuum. About half of the sample do not show an excess of variability where the warm absorber component imprints its stronger features, suggesting that for these sources the soft excess is not produced by a relativistic absorbing wind. In a few bright and well exposed sources it has been possible to measure an excess of variability at the energy of the broad component of the Fe K line, in agreement with the broad emission line interpretation. For the sources where more than one observation was available the stability of the shape of the RMS spectrum has been investigated. Moreover, it will be presented the results of the computation of the excess variance of all the radio quiet type 1 AGN of the XMM-Newton database. The relations between variability, black hole mass, accretion rate and luminosity are investigated and their scatter measured.

  9. Search for gravitational redshifted absorption lines in LMXB Serpens X-1

    NASA Astrophysics Data System (ADS)

    Yoneda, Hiroki; Done, Chris; Paerels, Frits; Takahashi, Tadayuki; Watanabe, Shin

    2018-04-01

    The equation of state for ultradense matter can be tested from observations of the ratio of mass to radius of neutron stars. This could be measured precisely from the redshift of a narrow line produced on the surface. X-rays bursts have been intensively searched for such features, but so far without detection. Here instead we search for redshifted lines in the persistent emission, where the accretion flow dominates over the surface emission. We discuss the requirements for narrow lines to be produced, and show that narrow absorption lines from highly ionized iron can potentially be observable in accreting low-mass X-ray binaries (LMXBs; low B field) that have either low spin or low inclination so that Doppler broadening is small. This selects Serpens X-1 as the only potential candidate persistent LMXB due to its low inclination. Including surface models in the broad-band accretion flow model predicts that the absorption line from He-like iron at 6.7 keV should be redshifted to ˜5.1-5.7 keV (10-15 km for 1.4 M⊙) and have an equivalent width of 0.8-8 eV for surface temperatures of 7-10 × 106 K. We use the high-resolution Chandra grating data to give a firm upper limit of 2-3 eV for an absorption line at ˜5 keV. We discuss possible reasons for this lack of detection (the surface temperature and the geometry of the boundary layer etc.). Future instruments with better sensitivity are required in order to explore the existence of such features.

  10. Broad-band beam buncher

    DOEpatents

    Goldberg, David A.; Flood, William S.; Arthur, Allan A.; Voelker, Ferdinand

    1986-01-01

    A broad-band beam buncher is disclosed, comprising an evacuated housing, an electron gun therein for producing an electron beam, a buncher cavity having entrance and exit openings through which the beam is directed, grids across such openings, a source providing a positive DC voltage between the cavity and the electron gun, a drift tube through which the electron beam travels in passing through such cavity, grids across the ends of such drift tube, gaps being provided between the drift tube grids and the entrance and exit grids, a modulator for supplying an ultrahigh frequency modulating signal to the drift tube for producing velocity modulation of the electrons in the beam, a drift space in the housing through which the velocity modulated electron beam travels and in which the beam is bunched, and a discharge opening from such drift tube and having a grid across such opening through which the bunched electron beam is discharged into an accelerator or the like. The buncher cavity and the drift tube may be arranged to constitute an extension of a coaxial transmission line which is employed to deliver the modulating signal from a signal source. The extended transmission line may be terminated in its characteristic impedance to afford a broad-band response and the device as a whole designed to effect broad-band beam coupling, so as to minimize variations of the output across the response band.

  11. Dramatically Variable C IV Mini-Broad Absorption Line System in the Quasar HS 1603+3820

    NASA Astrophysics Data System (ADS)

    Misawa, T.; Eracleous, M.; Charlton, J. C.; Chartas, G.; Kashikawa, N.

    2008-10-01

    We observed the quasar HS 1603+3820 (z_{em} = 2.542, first discovered by Dobrzycki et al. 1996) six times over an interval of 4.2 yrs (1.2 yrs in the quasar rest frame) using the High Dispersion Spectrograph on Subaru telescope. The purpose was to study the mini-broad absorption line (mini-BAL; FWHM ˜ 1,000 km s^{-1}) that is blue-shifted from the quasar by ˜ 9,500 km s^{-1}. We found significant time variability, which supported the physical association of the mini-BAL gas with an outflow from the quasar. We have narrowed down the cause of the variability to two possible scenarios. We also used archival Chandra x-ray data to study the x-ray properties of this quasar. The results constrain the location of the absorbing gas relative to the overall outflow.

  12. Iron deficiency anaemia.

    PubMed

    Lopez, Anthony; Cacoub, Patrice; Macdougall, Iain C; Peyrin-Biroulet, Laurent

    2016-02-27

    Anaemia affects roughly a third of the world's population; half the cases are due to iron deficiency. It is a major and global public health problem that affects maternal and child mortality, physical performance, and referral to health-care professionals. Children aged 0-5 years, women of childbearing age, and pregnant women are particularly at risk. Several chronic diseases are frequently associated with iron deficiency anaemia--notably chronic kidney disease, chronic heart failure, cancer, and inflammatory bowel disease. Measurement of serum ferritin, transferrin saturation, serum soluble transferrin receptors, and the serum soluble transferrin receptors-ferritin index are more accurate than classic red cell indices in the diagnosis of iron deficiency anaemia. In addition to the search for and treatment of the cause of iron deficiency, treatment strategies encompass prevention, including food fortification and iron supplementation. Oral iron is usually recommended as first-line therapy, but the most recent intravenous iron formulations, which have been available for nearly a decade, seem to replenish iron stores safely and effectively. Hepcidin has a key role in iron homoeostasis and could be a future diagnostic and therapeutic target. In this Seminar, we discuss the clinical presentation, epidemiology, pathophysiology, diagnosis, and acute management of iron deficiency anaemia, and outstanding research questions for treatment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. SN 2010ay is a Luminous and Broad-lined Type Ic Supernova within a Low-metallicity Host Galaxy

    NASA Technical Reports Server (NTRS)

    Sanders, N. E.; Soderberg, A. M.; Valenti, S.; Chomiuk, L.; Berger, E.; Smartt, S.; Hurley, K.; Barthelmy, S. D.; Chornock, R.; Foley, R. J.; hide

    2011-01-01

    We report on our serendipitous pre-discovery detection and detailed follow-up of the broad-lined Type Ic supernova SN2010ay at z approx 0.067 imaged by the Pan-STARRS1 3pi survey just approx 4 days after explosion. Combining our photometric observations with those available in the literature, we estimate the explosion date and the peak luminosity of the SN, M(sub R) approximately equals 20.2 mag, significantly brighter than known GRB-SNe and one of the most luminous SNe Ibc ever discovered. We measure the photospheric expansion velocity of the explosion from our spectroscopic follow-up observations, v(sub ph) approximately equals 19.2 X 10 (exp 3) km/s at approx 40 days after explosion. In comparison with other broad-lined SNe, the characteristic velocity of SN2010ay is 2 - 5 X higher and similar to the measurements for GRB-SNe at comparable epochs. Moreover the velocity declines two times slower than other SNe Ic-BL and GRB-SNe. Assuming that the optical emission is powered by radioactive decay, the peak magnitude implies the synthesis of an unusually large mass of Ni-56, M(sub Ni) = 0.9(+0.1/-0.1) solar mass. Our modeling of the light-curve points to a total ejecta mass, M(sub ej) approx 4.7 Solar Mass, and total kinetic energy, E(sub K,51) approximately equals 11. Thus the ratio of M(sub Ni) to M(sub ej) is at least twice as large for SN2010ay than in GRB-SNe and may indicate an additional energy reservoir. We also measure the metallicity (log(O/H) + 12 = 8.19) of the explosion site within the host galaxy using a high S/N optical spectrum. Our abundance measurement places this SN in the low-metallicity regime populated by GRB-SNe, and approx 0.2(0.5) dex lower than that typically measured for the host environments of normal (broad-lined) Ic supernovae. Despite striking similarities to the recent GRB-SN100316D/2010bh, we show that gamma-ray observations rule out an associated GRB with E(sub gamma) approx < 6 X 10(exp 48) erg (25-150 keV). Similarly, our deep

  14. A new transgenic rice line exhibiting enhanced ferric iron reduction and phytosiderophore production confers tolerance to low iron availability in calcareous soil.

    PubMed

    Masuda, Hiroshi; Shimochi, Erika; Hamada, Tatsuro; Senoura, Takeshi; Kobayashi, Takanori; Aung, May Sann; Ishimaru, Yasuhiro; Ogo, Yuko; Nakanishi, Hiromi; Nishizawa, Naoko K

    2017-01-01

    Iron (Fe) deficiency is a critical agricultural problem, especially in calcareous soil, which is distributed worldwide. Rice plants take up Fe(II) from soil through a OsIRT1 transporter (Strategy I-related system) and also take up Fe(III) via a phytosiderophore-based system (Strategy II system). However, rice plants are susceptible to low-Fe conditions because they have low Fe(III) reduction activity and low-level phytosiderophore secretion. Previously, we produced transgenic rice plants expressing a mutationally reconstructed yeast ferric chelate reductase, refre1/372, under the control of the OsIRT1 promoter. This transgenic rice line exhibited higher Fe(III) chelate reductase activity and tolerance to Fe deficiency. In addition, we produced transgenic rice overexpressing the Fe deficiency-inducible transcription factor, OsIRO2, which regulates the expression of various genes involved in the strategy II Fe(III) uptake system, including OsNAS1, OsNAAT1, OsDMAS1, OsYSL15, and TOM1. This transgenic rice exhibited improved phytosiderophore secretion ability and tolerance to Fe deficiency. In the present research, transgenic rice plants that possess both the OsIRT1 promoter-refre1/372 and the 35S promoter-OsIRO2 (RI lines) were produced to enhance both Strategy I Fe(II) reductase ability and Strategy II phytosiderophore productivity. RI lines exhibited enhanced tolerance to Fe-deficient conditions at the early and middle-late stages of growth in calcareous soil, compared to both the non-transgenic line and lines harboring either OsIRT1 promoter-refre1/372 or 35S promoter-OsIRO2 alone. RI lines also exhibited a 9-fold higher yield than the non-transgenic line. Moreover, we successfully produced Fe-deficiency-tolerant Tachisugata rice, which is a high-biomass variety used as fodder. Collectively, our results demonstrate that combined enhancement of two Fe uptake systems in rice is highly effective in conferring tolerance to low Fe availability in calcareous soil.

  15. A model for Cryogenian iron formation

    NASA Astrophysics Data System (ADS)

    Cox, Grant M.; Halverson, Galen P.; Poirier, André; Le Heron, Daniel; Strauss, Justin V.; Stevenson, Ross

    2016-01-01

    The Neoproterozoic Tatonduk (Alaska) and Holowilena (South Australia) iron formations share many characteristics including their broadly coeval (Sturtian) ages, intimate association with glaciogenic sediments, and mineralogy. We show that these shared characteristics extend to their neodymium (εNd) and iron isotope (δ56Fe) systematics. In both regions δ56Fe values display a distinct up-section trend to isotopically heavier values, while εNd values are primitive and similar to non-ferruginous mudstones within these successions. The δ56Fe profiles are consistent with oxidation of ferruginous waters during marine transgression, and the εNd values imply that much of this iron was sourced from the leaching of continental margin sediments largely derived from continental flood basalts. Rare earth element data indicate a secondary hydrothermal source for this iron.

  16. Abiotic stress growth conditions induce different responses in kernel iron concentration across genotypically distinct maize inbred varieties

    PubMed Central

    Kandianis, Catherine B.; Michenfelder, Abigail S.; Simmons, Susan J.; Grusak, Michael A.; Stapleton, Ann E.

    2013-01-01

    The improvement of grain nutrient profiles for essential minerals and vitamins through breeding strategies is a target important for agricultural regions where nutrient poor crops like maize contribute a large proportion of the daily caloric intake. Kernel iron concentration in maize exhibits a broad range. However, the magnitude of genotype by environment (GxE) effects on this trait reduces the efficacy and predictability of selection programs, particularly when challenged with abiotic stress such as water and nitrogen limitations. Selection has also been limited by an inverse correlation between kernel iron concentration and the yield component of kernel size in target environments. Using 25 maize inbred lines for which extensive genome sequence data is publicly available, we evaluated the response of kernel iron density and kernel mass to water and nitrogen limitation in a managed field stress experiment using a factorial design. To further understand GxE interactions we used partition analysis to characterize response of kernel iron and weight to abiotic stressors among all genotypes, and observed two patterns: one characterized by higher kernel iron concentrations in control over stress conditions, and another with higher kernel iron concentration under drought and combined stress conditions. Breeding efforts for this nutritional trait could exploit these complementary responses through combinations of favorable allelic variation from these already well-characterized genetic stocks. PMID:24363659

  17. RED SUPERGIANT STARS AS COSMIC ABUNDANCE PROBES: NLTE EFFECTS IN J-BAND IRON AND TITANIUM LINES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bergemann, Maria; Kudritzki, Rolf-Peter; Lind, Karin

    2012-06-01

    Detailed non-LTE (NLTE) calculations for red supergiant (RSG) stars are presented to investigate the influence of NLTE on the formation of atomic iron and titanium lines in the J band. With their enormous brightness at J band RSG stars are ideal probes of cosmic abundances. Recent LTE studies have found that metallicities accurate to 0.15 dex can be determined from medium-resolution spectroscopy of individual RSGs in galaxies as distant as 10 Mpc. The NLTE results obtained in this investigation support these findings. NLTE abundance corrections for iron are smaller than 0.05 dex for effective temperatures between 3400 K and 4200more » K and 0.1 dex at 4400 K. For titanium the NLTE abundance corrections vary smoothly between -0.4 dex and +0.2 dex as a function of effective temperature. For both elements, the corrections also depend on stellar gravity and metallicity. The physical reasons behind the NLTE corrections and the consequences for extragalactic J-band abundance studies are discussed.« less

  18. Iron K α line of Kerr black holes with Proca hair

    NASA Astrophysics Data System (ADS)

    Zhou, Menglei; Bambi, Cosimo; Herdeiro, Carlos A. R.; Radu, Eugen

    2017-05-01

    We continue our study on the capabilities of present and future x-ray missions to test the nature of astrophysical black hole candidates via x-ray reflection spectroscopy and distinguish Kerr black holes from other solutions of 4-dimensional Einstein's gravity in the presence of a matter field. Here we investigate the case of Kerr black holes with Proca hair [1]. The analysis of a sample of these configurations suggests that even extremely hairy black holes can mimic the iron line profile of the standard Kerr black holes, and, at least for the configurations of our study, we find that current x-ray missions cannot distinguish these objects from Kerr black holes. This contrasts with our previous findings for the case of Kerr black holes with scalar (rather than Proca) hair [2], even though such comparison may be biased by the limited sample. Future x-ray missions can detect the presence of Proca hair, but a theoretical knowledge of the expected intensity profile (currently missing) can be crucial to obtain strong constraints.

  19. Extreme Emission Line Galaxies in CANDELS: Broad-Band Selected, Star-Bursting Dwarf Galaxies at Z greater than 1

    NASA Technical Reports Server (NTRS)

    vanderWel, A.; Straughn, A. N.; Rix, H.-W.; Finkelstein, S. L.; Koekemoer, A. M.; Weiner, B. J.; Wuyts, S.; Bell, E. F.; Faber, S. M.; Trump, J. R.; hide

    2012-01-01

    We identify an abundant population of extreme emission line galaxies (EELGs) at redshift z approx. 1.7 in the Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey (CANDELS) imaging from Hubble Space Telescope/Wide Field Camera 3 (HST/WFC3). 69 EELG candidates are selected by the large contribution of exceptionally bright emission lines to their near-infrared broad-band magnitudes. Supported by spectroscopic confirmation of strong [OIII] emission lines . with rest-frame equivalent widths approx. 1000A in the four candidates that have HST/WFC3 grism observations, we conclude that these objects are galaxies with approx.10(exp 8) Solar Mass in stellar mass, undergoing an enormous starburst phase with M*/M* of only approx. 15 Myr. These bursts may cause outflows that are strong enough to produce cored dark matter profiles in low-mass galaxies. The individual star formation rates and the co-moving number density (3.7x10(exp -4) Mpc(sup -3) can produce in approx.4 Gyr much of the stellar mass density that is presently contained in 10(exp 8) - 10(exp 9) Solar Mass dwarf galaxies. Therefore, our observations provide a strong indication that many or even most of the stars in present-day dwarf galaxies formed in strong, short-lived bursts, mostly at z > 1.

  20. Failed Radiatively Accelerated Dusty Outflow Model of the Broad Line Region in Active Galactic Nuclei. I. Analytical Solution

    NASA Astrophysics Data System (ADS)

    Czerny, B.; Li, Yan-Rong; Hryniewicz, K.; Panda, S.; Wildy, C.; Sniegowska, M.; Wang, J.-M.; Sredzinska, J.; Karas, V.

    2017-09-01

    The physical origin of the broad line region in active galactic nuclei is still unclear despite many years of observational studies. The reason is that the region is unresolved, and the reverberation mapping results imply a complex velocity field. We adopt a theory-motivated approach to identify the principal mechanism responsible for this complex phenomenon. We consider the possibility that the role of dust is essential. We assume that the local radiation pressure acting on the dust in the accretion disk atmosphere launches the outflow of material, but higher above the disk the irradiation from the central parts causes dust evaporation and a subsequent fallback. This failed radiatively accelerated dusty outflow is expected to represent the material forming low ionization lines. In this paper we formulate simple analytical equations to describe the cloud motion, including the evaporation phase. The model is fully described just by the basic parameters of black hole mass, accretion rate, black hole spin, and viewing angle. We study how the spectral line generic profiles correspond to this dynamic. We show that the virial factor calculated from our model strongly depends on the black hole mass in the case of enhanced dust opacity, and thus it then correlates with the line width. This could explain why the virial factor measured in galaxies with pseudobulges differs from that obtained from objects with classical bulges, although the trend predicted by the current version of the model is opposite to the observed trend.

  1. Association mapping of iron deficiency chlorosis loci in soybean (Glycine max L. Merr.) advanced breeding lines.

    PubMed

    Wang, Ju; McClean, Phillip E; Lee, Rian; Goos, R Jay; Helms, Ted

    2008-04-01

    Association mapping is an alternative to mapping in a biparental population. A key to successful association mapping is to avoid spurious associations by controlling for population structure. Confirming the marker/trait association in an independent population is necessary for the implementation of the marker in other genetic studies. Two independent soybean populations consisting of advanced breeding lines representing the diversity within maturity groups 00, 0, and I were screened in multi-site, replicated field trials to discover molecular markers associated with iron deficiency chlorosis (IDC), a major yield-limiting factor in soybean. Lines with extreme phenotypes were initially screened to identify simple sequence repeat (SSR) markers putatively associated with the IDC. Marker data collected from all lines were used to control for population structure and kinship relationships. Single factor analysis of variance (SFA) and mixed linear model (MLM) analyses were used to discover marker/trait associations. The MLM analyses, which include population structure, kinship or both factors, reduced the number of markers significantly associated with IDC by 50% compared with SFA. With the MLM approach, three markers were found to be associated with IDC in the first population. Two of these markers, Satt114 and Satt239, were also found to be associated with IDC in the second confirmation population. For both populations, those lines with the tolerance allele at both these two marker loci had significantly lower IDC scores than lines with one or no tolerant alleles.

  2. Intravenous iron treatments for iron deficiency anemia in inflammatory bowel disease: a budget impact analysis of iron isomaltoside 1000 (Monofer) in the UK.

    PubMed

    Pollock, R F; Muduma, G

    2017-12-01

    Iron deficiency is the leading cause of anemia in patients with inflammatory bowel disease (IBD). Intravenous iron is the first-line treatment for clinically active IBD or previous oral iron intolerance. The aim of the present study was to develop a comparative model of iron deficiency and delivery for iron isomaltoside (IIM), ferric carboxymaltose (FCM), low molecular weight iron dextran (LMWID), and iron sucrose (IS) in the treatment of iron deficiency anemia associated with IBD. Areas covered: A model was developed to evaluate iron delivery characteristics, resource use and costs associated with IIM, FCM, LMWID and IS. Iron deficiency was modeled using dosing tables and retreatments were modeled based on a pooled retrospective analysis. The analyses were conducted over 5 years in patients with IBD with mean bodyweight of 75.4 kg and hemoglobin levels of 10.77 g/dL based on observational data. Expert opinion: The modeling analysis showed that using IIM required 1.2 infusions (per treatment) to correct the mean iron deficit, compared with 1.6, 1.2, and 7.1 with FCM, LMWID and IS, respectively. Costs were estimated to be 2,518 pounds sterling (GBP) per patient with IIM or LMWID, relative to GBP 3,309 with FCM or GBP 14,382 with IS.

  3. Steps Toward Determination of the Size and Structure of the Broad-Line Region in Active Galactic Nuclei XVI: A 13 Year Study of Spectral Variability in NGC 5548

    NASA Technical Reports Server (NTRS)

    Peterson, B. M.; Berlind, P.; Bertram, R.; Bischoff, K.; Bochkarev, N. G.; Burenkov, A. N.; Calkins, M.; Carrasco, L.; Chavushyan, V. H.

    2002-01-01

    We present the final installment of an intensive 13 year study of variations of the optical continuum and broad H beta emission line in the Seyfert 1 galaxy NGC 5548. The database consists of 1530 optical continuum measurements and 1248 H beta measurements. The H beta variations follow the continuum variations closely, with a typical time delay of about 20 days. However, a year-by-year analysis shows that the magnitude of emission-line time delay is correlated with the mean continuum flux. We argue that the data are consistent with the simple model prediction between the size of the broad-line region and the ionizing luminosity, r is proportional to L(sup 1/2)(sub ion). Moreover, the apparently linear nature of the correlation between the H beta response time and the nonstellar optical continuum F(sub opt) arises as a consequence of the changing shape of the continuum as it varies, specifically F(sub opt) is proportional to F(sup 0.56)(sub UV).

  4. Broad-band beam buncher

    DOEpatents

    Goldberg, D.A.; Flood, W.S.; Arthur, A.A.; Voelker, F.

    1984-03-20

    A broad-band beam bunther is disclosed, comprising an evacuated housing, an electron gun therein for producing an electron beam, a buncher cavity having entrance and exit openings through which the beam is directed, grids across such openings, a source providing a positive DC voltage between the cavity and the electron gun, a drift tube through which the electron beam travels in passing through such cavity, grids across the ends of such drift tube, gaps being provided between the drift tube grids and the entrance and exit grids, a modulator for supplying an ultrahigh frequency modulating signal to the drift tube for producing velocity modulation of the electrons in the beam, a drift space in the housing through which the velocity modulated electron beam travels and in which the beam is bunched, and a discharge opening from such drift tube and having a grid across such opening through which the bunched electron beam is discharged into an accelerator or the like. The buncher cavity and the drift tube may be arranged to constitute an extension of a coaxial transmission line which is employed to deliver the modulating signal from a signal source. The extended transmission line may be terminated in its characteristic impedance to afford a broad-

  5. Distinct Mechanisms of Ferritin Delivery to Lysosomes in Iron-Depleted and Iron-Replete Cells ▿

    PubMed Central

    Asano, Takeshi; Komatsu, Masaaki; Yamaguchi-Iwai, Yuko; Ishikawa, Fuyuki; Mizushima, Noboru; Iwai, Kazuhiro

    2011-01-01

    Ferritin is a cytosolic protein that stores excess iron, thereby protecting cells from iron toxicity. Ferritin-stored iron is believed to be utilized when cells become iron deficient; however, the mechanisms underlying the extraction of iron from ferritin have yet to be fully elucidated. Here, we demonstrate that ferritin is degraded in the lysosome under iron-depleted conditions and that the acidic environment of the lysosome is crucial for iron extraction from ferritin and utilization by cells. Ferritin was targeted for degradation in the lysosome even under iron-replete conditions in primary cells; however, the mechanisms underlying lysosomal targeting of ferritin were distinct under depleted and replete conditions. In iron-depleted cells, ferritin was targeted to the lysosome via a mechanism that involved autophagy. In contrast, lysosomal targeting of ferritin in iron-replete cells did not involve autophagy. The autophagy-independent pathway of ferritin delivery to lysosomes was deficient in several cancer-derived cells, and cancer-derived cell lines are more resistant to iron toxicity than primary cells. Collectively, these results suggest that ferritin trafficking may be differentially regulated by cell type and that loss of ferritin delivery to the lysosome under iron-replete conditions may be related to oncogenic cellular transformation. PMID:21444722

  6. Failed Radiatively Accelerated Dusty Outflow Model of the Broad Line Region in Active Galactic Nuclei. I. Analytical Solution

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Czerny, B.; Panda, S.; Wildy, C.

    2017-09-10

    The physical origin of the broad line region in active galactic nuclei is still unclear despite many years of observational studies. The reason is that the region is unresolved, and the reverberation mapping results imply a complex velocity field. We adopt a theory-motivated approach to identify the principal mechanism responsible for this complex phenomenon. We consider the possibility that the role of dust is essential. We assume that the local radiation pressure acting on the dust in the accretion disk atmosphere launches the outflow of material, but higher above the disk the irradiation from the central parts causes dust evaporationmore » and a subsequent fallback. This failed radiatively accelerated dusty outflow is expected to represent the material forming low ionization lines. In this paper we formulate simple analytical equations to describe the cloud motion, including the evaporation phase. The model is fully described just by the basic parameters of black hole mass, accretion rate, black hole spin, and viewing angle. We study how the spectral line generic profiles correspond to this dynamic. We show that the virial factor calculated from our model strongly depends on the black hole mass in the case of enhanced dust opacity, and thus it then correlates with the line width. This could explain why the virial factor measured in galaxies with pseudobulges differs from that obtained from objects with classical bulges, although the trend predicted by the current version of the model is opposite to the observed trend.« less

  7. A GRB and Broad-lined Type Ic Supernova from a Single Central Engine

    NASA Astrophysics Data System (ADS)

    Barnes, Jennifer; Duffell, Paul C.; Liu, Yuqian; Modjaz, Maryam; Bianco, Federica B.; Kasen, Daniel; MacFadyen, Andrew I.

    2018-06-01

    Unusually high velocities (≳0.1c) and correspondingly high kinetic energies have been observed in a subset of Type Ic supernovae (so-called “broad-lined Ic” supernovae; SNe Ic-BL), prompting a search for a central engine model capable of generating such energetic explosions. A clue to the explosion mechanism may lie in the fact that all supernovae that accompany long-duration gamma-ray bursts (GRBs) belong to the SN Ic-BL class. Using a combination of two-dimensional relativistic hydrodynamics and radiation transport calculations, we demonstrate that the central engine responsible for long GRBs can also trigger an SN Ic-BL. We find that a reasonable GRB engine injected into a stripped Wolf–Rayet progenitor produces a relativistic jet with energy ∼1051 erg, as well as an SN whose synthetic light curves and spectra are fully consistent with observed SNe Ic-BL during the photospheric phase. As a result of the jet’s asymmetric energy injection, the SN spectra and light curves depend on viewing angle. The impact of viewing angle on the spectrum is particularly pronounced at early times, while the viewing-angle dependence for the light curves (∼10% variation in bolometric luminosity) persists throughout the photospheric phase.

  8. The diagnostic capability of iron limes

    NASA Astrophysics Data System (ADS)

    Giannini, Teresa; Nisini, Brunella; Antoniucci, Simone; Alcala, Juan; Bacciotti, Francesca; Bonito, Rosaria; Podio, Linda; Stelzer, Beate; Whelan, Emma

    2013-07-01

    We present the VLT/X-Shooter spectrum of two jets from young protostars of different luminosity and mass, ESO-Halpha 574 and Par-Lup 3-4. In the covered spectral range (350-2500 nm) we detected more than 100 [FeII] and [FeIII] lines, which are used to precisely probe the key physical parameters of the gas (electron density and temperature, ionization degree, visual extinction). These quantities have been compared with shock-model predictions, which suggest that only the higher luminosity source (ESO-Ha 574) is able to drive a high-velocity and dissociative shock. The diagnostic capability of Iron, proven on the presented objects, represents a unique tool for the following reasons: 1) the large number of lines in the uv-infrared range makes possible to trace the physical conditions in a very large range of the parameter space; 2) at variance with the diagnostic commonly performed with other species, such as Oxygen, Nitrogen, and Sulphur, no assumption on the relative abundance is needed, since all the parameters are derived from line ratios of the same species; 3) in the unperturbed ISM, Iron is locked on the grain surfaces, while it is released in gas-phase if gas-grain or grain-grain collisions occur within a shock. Therefore the Iron abundance (derivable from ratios of Iron lines with those of other volatile species) is a direct probe of the presence of dust in the jet beam, an information crucial to understand whether jets originate close to the star or in the circumstellar disk.

  9. Extreme Emission Line Galaxies in CANDELS: Broad-Band Selected, Star-Bursting Dwarf Galaxies at Z greater than 1

    NASA Technical Reports Server (NTRS)

    VanDerWel, A.; Straughn, A. N.; Rix, H.-W.; Finkelstein, S. L.; Koekemoer, A. M.; Weiner, B. J.; Wuyts, S.; Bell, E. F.; Faber, S. M.; Trump, J. R.; hide

    2011-01-01

    We identify an abundant population of extreme emission line galaxies at redshift z=1.6 - 1.8 in the Cosmic Assembly Near-IR Deep Extragalactic Legacy Survey (CANDELS) imaging from Hubble Space Telescope/Wide Field Camera 3 (HST/WFC3). 69 candidates are selected by the large contribution of exceptionally bright emission lines to their near-infrared, broad-band fluxes. Supported by spectroscopic confirmation of strong [OIII] emission lines - with equivalent widths approximately 1000A - in the four candidates that have HST/WFC3 grism observations, we conclude that these objects are dwarf galaxies with approximately 10(exp 8) solar mass in stellar mass, undergoing an enormous star-burst phase with M*/M* of only approximately 10 Myr. The star formation activity and the co-moving number density (3.7 x 10(exp -4) Mpc(exp -3)) imply that strong, short-lived bursts play a significant, perhaps even dominant role in the formation and evolution of dwarf galaxies at z greater than 1. The observed star formation activity can produce in less than 5 Gyr the same amount of stellar mass density as is presently contained in dwarf galaxies. Therefore, our observations provide a strong indication that the stellar populations of present-day dwarf galaxies formed mainly in strong, short-lived bursts, mostly at z greater than 1.

  10. Determination of Dietary Iron Requirements by Full Expression of Iron-Containing Enzymes in Various Tissues of Broilers.

    PubMed

    Ma, Xinyan; Liao, Xiudong; Lu, Lin; Li, Sufen; Zhang, Liyang; Luo, Xugang

    2016-11-01

    The current dietary iron requirement (80 mg/kg) of broilers is mainly based on growth, hemoglobin concentration, or hematocrit data obtained in a few early studies; however, expressions of iron-containing enzymes might be more sensitive novel criteria to evaluate dietary iron requirements. The objective of this study was to determine dietary iron requirements of broilers for the full expression of succinate dehydrogenase (SDH), catalase, and cytochrome c oxidase (COX) in various tissues. A total of 336 1-d-old Arbor Acres male chicks were randomly assigned to 1 of 7 treatments with 6 replicates and fed a basal corn and soybean-meal diet (control, containing 67 mg Fe/kg) and the basal diet supplemented with 20, 40, 60, 80, 100, or 120 mg Fe/kg from FeSO 4 ⋅ 7H 2 O for 21 d. Regression analysis was performed to estimate the optimal dietary iron concentration with the use of broken-line or quadratic models. SDH activity in the liver and heart, COX and catalase activity in the liver, Sdh mRNA levels in the liver, and Cox mRNA levels in the liver and heart of broilers were affected (P < 0.027) by supplemental iron concentration, and increased quadratically (P < 0.004) as dietary iron concentration increased. Dietary iron requirements estimated on the basis of fitted broken-line or quadratic-curve models (P < 0.005) of the above indexes were 97-136 mg/kg. SDH activity in the liver and heart, COX and catalase activity in the liver, Sdh mRNA levels in the liver, and Cox mRNA levels in the liver and heart are, to our knowledge, new and sensitive criteria to evaluate the dietary iron requirements of broilers, and the dietary iron requirements would be 97-136 mg/kg to support the full expression of the above iron-containing enzymes in various tissues of broiler chicks from 1 to 21 d of age, which are higher than the current NRC iron requirement. © 2016 American Society for Nutrition.

  11. Gamma-Ray Emission from the Broad-Line Radio Galaxy 3C 111

    NASA Technical Reports Server (NTRS)

    Hartman, Robert C.; Kadler, M.; Tueller, Jack

    2008-01-01

    The broad-line radio galaxy 3C 111 has been suggested as the counterpart of the y-ray source 3EG J0416+3650. While 3C 111 meets most of the criteria for a high-probability identification, like a bright flat-spectrum radio core and a blazar-like broadband SED, in the Third EGRET Catalog, the large positional offset of about 1.5' put 3C 111 outside the 99% probability region for 3EG J0416+3650, making this association questionable. We present a re-analysis of all available archival data for 3C 111 from the EGRET archives, resulting in detection of variable hard-spectrum high-energy gamma-ray emission above 1000 MeV from a position close to the nominal position of 3C 111, in three separate viewing periods (VPs), at a 3sigma level in each. A second variable hard-spectrum source is present nearby. At >100 MeV, one variable soft-spectrum source seems to account for most of the EGRET-detected emission of 3EG J0416+3650. A follow-up Swift UVOT/XRT observation reveals one moderately bright X-ray source in the error box of 3EG J0416+3650, but because of the large EGRET position uncertainty, it is not certain that the X-ray and gamma-ray sources are associated. Another Swift observation near the second (unidentified) hard gamma-ray source detected no X-ray source nearby.

  12. The Relativistic Iron Line Profile in the Seyfert 1 Galaxy IC4329a

    NASA Technical Reports Server (NTRS)

    Done, C.; Madejski, G. M.; Zycki, P. T.

    2000-01-01

    We present simultaneous ASCA and RXTE data on the bright Seyfert 1 galaxy IC4329a. The iron line is significantly broadened, but not to the extent expected from an accretion disk which extends down to the last stable orbit around a black hole. We marginally detect a narrow line component, presumably from the molecular torus, but, even including this gives a line profile from the accretion disk which is significantly narrower that that seen in MCG-6-30-15, and is much more like that seen from the low/hard state galactic black hole candidates. This is consistent with the inner disk being truncated before the last stable orbit, forming a hot flow at small radii as in the ADAF models. However. we cannot rule out the presence of an inner disk which does not contribute to the reflected spectrum. either because of extreme ionisation suppressing the characteristic atomic features of the reflected spectrum or because the X-ray source is intrinsically anisotropic, so it does not illuminate the inner disk. The source was monitored by RXTE every 2 days for 2 months, and these snapshot spectra show that there is intrinsic spectral variability. The data are good enough to disentangle the power law from the reflected continuum and we see that the power law softens as the source brightens. The lack of a corresponding increase in the observed reflected spectrum implies that either the changes in disk inner radial extent/ionization structure are small, or that the variability is actually driven by changes in the seed photons which are decoupled from the hard X-ray mechanism.

  13. Crossing a Broad Gray Line to Help Children

    ERIC Educational Resources Information Center

    Allen, Megan M.

    2015-01-01

    Helping students with mental health issues sometimes presents teachers with the dilemma of following the letter of school rules or doing what is best for the child. One teacher tells her story of crossing such lines, but only in service to children. She also outlines what teachers can and should do to help students who need mental health services.

  14. Investigating the reasons of variability in Si IV and C IV broad absorption line troughs of quasars

    NASA Astrophysics Data System (ADS)

    Stathopoulos, Dimitrios; Lyratzi, Evangelia; Danezis, Emmanuel; Antoniou, Antonios; Tzimeas, Dimitrios

    2017-09-01

    In this paper we analyze the C IV and Si IV broad absorption troughs of two BALQSOs (J101056.69+355833.3, J114548.38+393746.6) to the individual components they consist of. By analyzing a BAL trough to its components we have the advantage to study the variations of the individual absorbing systems in the line of sight and not just the variations of the whole absorption trough or the variations of selected portions of BAL troughs exhibiting changes. We find that the velocity shifts and FWHMs (Full Width at Half Maximum) of the individual components do not vary between an interval of six years. All variable components show changes in the optical depths at line centers which are manifested as variations in the EW (Equivalent Width) of the components. In both BALQSOs, over corresponding velocities, Si IV has higher incidence of variability than C IV. From our analysis, evidence is in favour of different covering fractions between C IV and Si IV. Finally, although most of our results favour the crossing cloud scenario as the cause of variability, there is also strong piece of evidence indicating changing ionization as the source of variability. Thus, a mixed situation where both physical mechanisms contribute to BAL variability is the most possible scenario.

  15. Study on Emission Spectral Lines of Iron, Fe in Laser-Induced Breakdown Spectroscopy (LIBS) on Soil Samples

    NASA Astrophysics Data System (ADS)

    Idris, Nasrullah; Lahna, Kurnia; Fadhli; Ramli, Muliadi

    2017-05-01

    In this work, LIBS technique has been used for detection of heavy metal especially iron, Fe in soil sample. As there are a large number of emission spectral lines due to Fe and other constituents in soil, this study is intended to identify emission spectral lines of Fe and finally to find best fit emission spectral lines for carrying out a qualitative and quantitative analysis. LIBS apparatus used in this work consists of a laser system (Neodymium Yttrium Aluminum Garnet, Nd-YAG: Quanta Ray; LAB SERIES; 1,064 nm; 500 mJ; 8 ns) and an optical multichannel analyzer (OMA) system consisting of a spectrograph (McPherson model 2061; 1,000 mm focal length; f/8.6 Czerny- Turner) and an intensified charge coupled device (ICCD) 1024x256 pixels (Andor I*Star). The soil sample was collected from Banda Aceh city, Aceh, Indonesia. For spectral data acquisition, the soil sample has been prepared by a pressing machine in the form of pellet. The laser beam was focused using a high density lens (f=+150 mm) and irradiated on the surface of the pellet for generating luminous plasma under 1 atmosphere of air surrounding. The plasma emission was collected by an optical fiber and then sent to the optical multichannel analyzer (OMA) system for acquisition of the emission spectra. It was found that there are many Fe emission lines both atomic lines (Fe I) and ionic lines (Fe II) appeared in all detection windows in the wavelength regions, ranging from 200 nm to 1000 nm. The emission lines of Fe with strong intensities occurs together with emission lines due to other atoms such as Mg, Ca, and Si. Thus, the identification of emission lines from Fe is complicated by presence of many other lines due to other major and minor elements in soil. Considering the features of the detected emission lines, several emission spectral lines of Fe I (atomic emission line), especially Fe I 404.58 nm occurring at visible range are potential to be good candidate of analytical lines in relation to detection

  16. Iron K shell line, a probe of low energy cosmic rays in SNRs

    NASA Astrophysics Data System (ADS)

    Koyama, Katsuji; Sato, Tamotsu

    2016-06-01

    Since the discovery of non thermal power-law X-rays at the rim of SN1006 by Koyama et al. (1995), this feature has been established to be evidence of high energy cosmic rays (HECRs). The HECRs are created by a diffuse shock acceleration process. Accordingly low energy cosmic rays (LECRS) must be presented as the injector of this acceleration process. We found for the first time that the K-shell line from neutral iron at 6.4 keV is good tracer of LECRs in SNRs. This paper present the observational facts for LECRs from intermediate aged SNRs, 3C391, Kes79, Kes 78 and W44 in the Scutum Arm region (see figure, Sato et al. 2014, 2015). Two SNRs, 3C391 and W44, exhibit recombining plasma (RP), an unusual structure in the frame work of the standard SNR evolution scenario. Together with the RP, we discuss the origin of LECRs in the SNRs.

  17. Optical frequency locked loop for long-term stabilization of broad-line DFB laser frequency difference

    NASA Astrophysics Data System (ADS)

    Lipka, Michał; Parniak, Michał; Wasilewski, Wojciech

    2017-09-01

    We present an experimental realization of the optical frequency locked loop applied to long-term frequency difference stabilization of broad-line DFB lasers along with a new independent method to characterize relative phase fluctuations of two lasers. The presented design is based on a fast photodiode matched with an integrated phase-frequency detector chip. The locking setup is digitally tunable in real time, insensitive to environmental perturbations and compatible with commercially available laser current control modules. We present a simple model and a quick method to optimize the loop for a given hardware relying exclusively on simple measurements in time domain. Step response of the system as well as phase characteristics closely agree with the theoretical model. Finally, frequency stabilization for offsets within 4-15 GHz working range achieving <0.1 Hz long-term stability of the beat note frequency for 500 s averaging time period is demonstrated. For these measurements we employ an I/Q mixer that allows us to precisely and independently measure the full phase trace of the beat note signal.

  18. Stability of the Broad-line Region Geometry and Dynamics in Arp 151 Over Seven Years

    NASA Astrophysics Data System (ADS)

    Pancoast, A.; Barth, A. J.; Horne, K.; Treu, T.; Brewer, B. J.; Bennert, V. N.; Canalizo, G.; Gates, E. L.; Li, W.; Malkan, M. A.; Sand, D.; Schmidt, T.; Valenti, S.; Woo, J.-H.; Clubb, K. I.; Cooper, M. C.; Crawford, S. M.; Hönig, S. F.; Joner, M. D.; Kandrashoff, M. T.; Lazarova, M.; Nierenberg, A. M.; Romero-Colmenero, E.; Son, D.; Tollerud, E.; Walsh, J. L.; Winkler, H.

    2018-04-01

    The Seyfert 1 galaxy Arp 151 was monitored as part of three reverberation mapping campaigns spanning 2008–2015. We present modeling of these velocity-resolved reverberation mapping data sets using a geometric and dynamical model for the broad-line region (BLR). By modeling each of the three data sets independently, we infer the evolution of the BLR structure in Arp 151 over a total of 7 yr and constrain the systematic uncertainties in nonvarying parameters such as the black hole mass. We find that the BLR geometry of a thick disk viewed close to face-on is stable over this time, although the size of the BLR grows by a factor of ∼2. The dynamics of the BLR are dominated by inflow, and the inferred black hole mass is consistent for the three data sets, despite the increase in BLR size. Combining the inference for the three data sets yields a black hole mass and statistical uncertainty of log10({M}BH}/{M}ȯ ) = {6.82}-0.09+0.09 with a standard deviation in individual measurements of 0.13 dex.

  19. Iron Biofortification and Homeostasis in Transgenic Cassava Roots Expressing the Algal Iron Assimilatory Gene, FEA1

    PubMed Central

    Ihemere, Uzoma E.; Narayanan, Narayanan N.; Sayre, Richard T.

    2012-01-01

    We have engineered the tropical root crop cassava (Manihot esculenta) to express the Chlamydomonas reinhardtii iron assimilatory gene, FEA1, in its storage roots with the objective of enhancing the root nutritional qualities. Iron levels in mature cassava storage roots were increased from 10 to 36 ppm in the highest iron accumulating transgenic lines. These iron levels are sufficient to meet the minimum daily requirement for iron in a 500 g meal. Significantly, the expression of the FEA1 gene in storage roots did not alter iron levels in leaves. Transgenic plants also had normal levels of zinc in leaves and roots consistent with the specific uptake of ferrous iron mediated by the FEA1 protein. Relative to wild-type plants, fibrous roots of FEA1 expressing plants had reduced Fe (III) chelate reductase activity consistent with the more efficient uptake of iron in the transgenic plants. We also show that multiple cassava genes involved in iron homeostasis have altered tissue-specific patterns of expression in leaves, stems, and roots of transgenic plants consistent with increased iron sink strength in transgenic roots. These results are discussed in terms of strategies for the iron biofortification of plants. PMID:22993514

  20. Review on iron and its importance for human health

    PubMed Central

    Abbaspour, Nazanin; Hurrell, Richard; Kelishadi, Roya

    2014-01-01

    It is well-known that deficiency or over exposure to various elements has noticeable effects on human health. The effect of an element is determined by several characteristics, including absorption, metabolism, and degree of interaction with physiological processes. Iron is an essential element for almost all living organisms as it participates in a wide variety of metabolic processes, including oxygen transport, deoxyribonucleic acid (DNA) synthesis, and electron transport. However, as iron can form free radicals, its concentration in body tissues must be tightly regulated because in excessive amounts, it can lead to tissue damage. Disorders of iron metabolism are among the most common diseases of humans and encompass a broad spectrum of diseases with diverse clinical manifestations, ranging from anemia to iron overload, and possibly to neurodegenerative diseases. In this review, we discuss the latest progress in studies of iron metabolism and bioavailability, and our current understanding of human iron requirement and consequences and causes of iron deficiency. Finally, we discuss strategies for prevention of iron deficiency. PMID:24778671

  1. VLBI survey of compact broad absorption line quasars with balnicity index BI = 0

    NASA Astrophysics Data System (ADS)

    Cegłowski, M.; Kunert-Bajraszewska, M.; Roskowiński, C.

    2015-06-01

    We present high-resolution observations, using both the European VLBI Network (EVN) at 1.7 GHz and the Very Long Baseline Array (VLBA) at 5 and 8.4 GHz, to image radio structures of 14 compact sources classified as broad absorption line (BAL) quasars based on the absorption index (AI). All sources but one were resolved, with the majority showing core-jet morphology typical for radio-loud quasars. We discuss in detail the most interesting cases. The high radio luminosities and small linear sizes of the observed objects indicate they are strong young active galactic nuclei. Nevertheless, the distribution of the radio-loudness parameter, log RI, of a larger sample of AI quasars shows that the objects observed by us constitute the most luminous, small subgroup of the AI population. Additionally, we report that for the radio-loudness parameter, the distribution of AI quasars and that for those selected using the traditional balnicity index differ significantly. Strong absorption is connected with lower log RI and thus probably larger viewing angles. Since the AI quasars have on average larger log RI, the orientation can mean that we see them less absorbed. However, we suggest that the orientation is not the only parameter that affects the detected absorption. That the strong absorption is associated with the weak radio emission is equally important and worth exploring.

  2. Gamma-Ray Emision from the Broad-Line Radio Galaxy 3C 111

    NASA Technical Reports Server (NTRS)

    Hartman, Robert C.; Kadler, Matthias; Tueller, Jack

    2008-01-01

    The broad-line radio galaxy 3C 111 has been suggested as the counterpart of the Gamma-ray source 3EGJ0416+3650. While 3C 111 meets most of the criteria for a high-probability identification, like a bright fla t-spectrum radio core and a blazarlike broadband SED, in the Third EG RET Catalog, the large positional offset of about 1.5 degrees put 3C1 11 outside the 99% probability region for 3EG J0416+3650, making this association questionable. We present a re-analysis of all available data for 3C111 from the EGRET archives, resulting in probable detection of high-energy Gamma-ray emission above 1000MeV from a position clo se to the nominal position of 3C 111, in two separate viewing periods (VPs), at a 3sigma level in each. A new source, GROJ0426+3747, appea rs to be present nearby, seen only in the >1000MeV data. For >100MeV, the data are in agreement with only one source (at the original cata log position) accounting for most of the EGRET-detected emission of 3 EGJ0416+3650. A follow-up Swift UVOT/XRT observation reveals one mode rately bright X-ray source in the error box of 3EGJ0416+3650, but bec ause of the large EGRET position uncertainty, it is not certain that the X-ray and Gamma-ray sources are associated. A Swift observation of GROJ0426+3747 detected no X.ray source nearby.

  3. Iron homeostasis and toxicity in retinal degeneration.

    PubMed

    He, Xining; Hahn, Paul; Iacovelli, Jared; Wong, Robert; King, Chih; Bhisitkul, Robert; Massaro-Giordano, Mina; Dunaief, Joshua L

    2007-11-01

    Iron is essential for many metabolic processes but can also cause damage. As a potent generator of hydroxyl radical, the most reactive of the free radicals, iron can cause considerable oxidative stress. Since iron is absorbed through diet but not excreted except through menstruation, total body iron levels buildup with age. Macular iron levels increase with age, in both men and women. This iron has the potential to contribute to retinal degeneration. Here we present an overview of the evidence suggesting that iron may contribute to retinal degenerations. Intraocular iron foreign bodies cause retinal degeneration. Retinal iron buildup resulting from hereditary iron homeostasis disorders aceruloplasminemia, Friedreich's ataxia, and panthothenate kinase-associated neurodegeneration cause retinal degeneration. Mice with targeted mutation of the iron exporter ceruloplasmin have age-dependent retinal iron overload and a resulting retinal degeneration with features of age-related macular degeneration (AMD). Post mortem retinas from patients with AMD have more iron and the iron carrier transferrin than age-matched controls. Over the past 10 years much has been learned about the intricate network of proteins involved in iron handling. Many of these, including transferrin, transferrin receptor, divalent metal transporter-1, ferritin, ferroportin, ceruloplasmin, hephaestin, iron-regulatory protein, and histocompatibility leukocyte antigen class I-like protein involved in iron homeostasis (HFE) have been found in the retina. Some of these proteins have been found in the cornea and lens as well. Levels of the iron carrier transferrin are high in the aqueous and vitreous humors. The functions of these proteins in other tissues, combined with studies on cultured ocular tissues, genetically engineered mice, and eye exams on patients with hereditary iron diseases provide clues regarding their ocular functions. Iron may play a role in a broad range of ocular diseases, including

  4. Iron homeostasis and toxicity in retinal degeneration

    PubMed Central

    He, Xining; Hahn, Paul; Iacovelli, Jared; Wong, Robert; King, Chih; Bhisitkul, Robert; Massaro-Giordano, Mina; Dunaief, Joshua L.

    2007-01-01

    Iron is essential for many metabolic processes but can also cause damage. As a potent generator of hydroxyl radical, the most reactive of the free radicals, iron can cause considerable oxidative stress. Since iron is absorbed through diet but not excreted except through menstruation, total body iron levels build up with age. Macular iron levels increase with age, in both men and women. This iron has the potential to contribute to retinal degeneration. Here we present an overview of the evidence suggesting that iron may contribute to retinal degenerations. Intraocular iron foreign bodies cause retinal degeneration. Retinal iron buildup resulting from hereditary iron homeostasis disorders aceruloplasminemia, Friedreich’s Ataxia, and panthothenate kinase associated neurodegeneration cause retinal degeneration. Mice with targeted mutation of the iron exporter ceruloplasmin have age-dependent retinal iron overload and a resulting retinal degeneration with features of age-related macular degeneration (AMD). Post mortem retinas from patients with AMD have more iron and the iron carrier transferrin than age- matched controls. Over the past ten years much has been learned about the intricate network of proteins involved in iron handling. Many of these, including transferrin, transferrin receptor, divalent metal transporter 1, ferritin, ferroportin, ceruloplasmin, hephaestin, iron regulatory protein, and histocompatibility leukocyte antigen class I-like protein involved in iron homeostasis (HFE) have been found in the retina. Some of these proteins have been found in the cornea and lens as well. Levels of the iron carrier transferrin are high in the aqueous and vitreous humors. The functions of these proteins in other tissues, combined with studies on cultured ocular tissues, genetically engineered mice, and eye exams on patients with hereditary iron diseases provide clues regarding their ocular functions. Iron may play a role in a broad range of ocular diseases, including

  5. ASASSN-16fp (SN 2016coi): a transitional supernova between Type Ic and broad-lined Ic

    NASA Astrophysics Data System (ADS)

    Kumar, Brajesh; Singh, A.; Srivastav, S.; Sahu, D. K.; Anupama, G. C.

    2018-01-01

    We present results based on a well-sampled optical (UBVRI) and ultraviolet (Swift/UVOT) imaging, and low-resolution optical spectroscopic follow-up observations of the nearby Type Ic supernova (SN) ASASSN-16fp (SN 2016coi). The SN was monitored during the photospheric phase (-10 to +33 d with respect to the B-band maximum light). The rise to maximum light and early post-maximum decline of the light curves are slow. The peak absolute magnitude (MV = -17.7 ± 0.2 mag) of ASASSN-16fp is comparable with broad-lined Ic SN 2002ap, SN 2012ap and transitional Ic SN 2004aw but considerably fainter than the gamma-ray burst/X-ray flash associated SNe (e.g. SN 1998bw, 2006aj). Similar to the light curve, the spectral evolution is also slow. ASASSN-16fp shows distinct photospheric phase spectral lines along with the C II features. The expansion velocity of the ejecta near maximum light reached ∼16 000 km s-1 and settled to ∼8000 km s-1, ∼1 month post-maximum. Analytical modelling of the quasi-bolometric light curve of ASASSN-16fp suggests that ∼0.1 M⊙ 56Ni mass was synthesized in the explosion, with a kinetic energy of 6.9^{+1.5}_{-1.3} × 1051 erg and total ejected mass of ∼4.5 ± 0.3 M⊙.

  6. In situ functionalization and PEO coating of iron oxide nanocrystals using seeded emulsion polymerization.

    PubMed

    Kloust, Hauke; Schmidtke, Christian; Feld, Artur; Schotten, Theo; Eggers, Robin; Fittschen, Ursula E A; Schulz, Florian; Pöselt, Elmar; Ostermann, Johannes; Bastús, Neus G; Weller, Horst

    2013-04-16

    Herein we demonstrate that seeded emulsion polymerization is a powerful tool to produce multiply functionalized PEO coated iron oxide nanocrystals. Advantageously, by simple addition of functional surfactants, functional monomers, or functional polymerizable linkers-solely or in combinations thereof-during the seeded emulsion polymerization process, a broad range of in situ functionalized polymer-coated iron oxide nanocrystals were obtained. This was demonstrated by purposeful modulation of the zeta potential of encapsulated iron oxide nanocrystals and conjugation of a dyestuff. Successful functionalization was unequivocally proven by TXRF. Furthermore, the spatial position of the functional groups can be controlled by choosing the appropriate spacers. In conclusion, this methodology is highly amenable for combinatorial strategies and will spur rapid expedited synthesis and purposeful optimization of a broad scope of nanocrystals.

  7. Raman Spectroscopic Characterisation of Australian Banded Iron Formation and Iron Ore

    NASA Astrophysics Data System (ADS)

    Wells, M. A.; Ramanaidou, E. R.

    2012-04-01

    In Australia and world-wide over the past 5-10 years, declining reserves of premium, high-grade (>64% Fe), low-P bearing iron ore, have seen iron ore producers increase their utilisation of lower Fe-grade, higher P/Al/Si ore. In Australia, the channel iron deposits (CID), bedded iron deposits (BID) and, more recently, BIF-derived magnetite iron deposits (MID) have seen increased usage driven mainly by the increased demand from Chinese steel mills (Ramanaidou and Wells, 2011). Efficient exploitation and processing of these lower-grade iron ores requires a detailed understanding of their iron oxide and gangue mineralogy and geochemistry. The common Fe-bearing minerals (e.g., hematite, magnetite, goethite and kenomagnetite) in these deposits, as well as gangue minerals such as quartz and carbonates, are all strongly Raman active (e.g., de Faria et al., 1997). Their distinct Raman spectra enable them to be easily detected and mapped in situ in either unprepared material or samples prepared as polished blocks. In this paper, using representative examples of Australian CID ore, martite-goethite bedded iron deposit (BID) ore and banded iron formation (BIF) examined as polished blocks, we present a range of Raman spectra of the key iron ore minerals, and discuss how Raman spectroscopy can be applied to characterising iron ore mineralogy. Raman imaging micrographs, obtained using a StreamLine Plus Raman imaging system, clearly identified the main Fe-oxide and gangue components in the CID, BID and BIF samples when compared to optical micrographs. Raman analysis enabled the unequivocal identification of diamond in the CID ore as a contaminant from the polishing paste used to prepare the sample, and confirmed the presence of hematite in the BID ore in the form of martite, which can be morphologically similar to magnetite and, thus, difficult to otherwise distinguish. Image analysis of Raman mineral maps could be used to quantify mineral abundance based on the number of 'pixels

  8. Development of Elite BPH-Resistant Wide-Spectrum Restorer Lines for Three and Two Line Hybrid Rice.

    PubMed

    Fan, Fengfeng; Li, Nengwu; Chen, Yunping; Liu, Xingdan; Sun, Heng; Wang, Jie; He, Guangcun; Zhu, Yingguo; Li, Shaoqing

    2017-01-01

    Hybrid rice has contributed significantly to the world food security. Breeding of elite high-yield, strong-resistant broad-spectrum restorer line is an important strategy for hybrid rice in commercial breeding programs. Here, we developed three elite brown planthopper (BPH)-resistant wide-spectrum restorer lines by pyramiding big-panicle gene Gn8.1 , BPH-resistant genes Bph6 and Bph9 , fertility restorer genes Rf3, Rf4, Rf5 , and Rf6 through molecular marker assisted selection. Resistance analysis revealed that the newly developed restorer lines showed stronger BPH-resistance than any of the single-gene donor parent Luoyang-6 and Luoyang-9. Moreover, the three new restorer lines had broad spectrum recovery capabilities for Honglian CMS, Wild abortive CMS and two-line GMS sterile lines, and higher grain yields than that of the recurrent parent 9,311 under nature field conditions. Importantly, the hybrid crosses also showed good performance for grain yield and BPH-resistance. Thus, the development of elite BPH-resistant wide-spectrum restorer lines has a promising future for breeding of broad spectrum BPH-resistant high-yield varieties.

  9. SHORT-TIMESCALE MONITORING OF THE X-RAY, UV, AND BROAD DOUBLE-PEAK EMISSION LINE OF THE NUCLEUS OF NGC 1097

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Schimoia, Jaderson S.; Storchi-Bergmann, Thaisa; Grupe, Dirk

    2015-02-10

    Recent studies have suggested that the short-timescale (≲ 7 days) variability of the broad (∼10,000 km s{sup –1}) double-peaked Hα profile of the LINER nucleus of NGC 1097 could be driven by a variable X-ray emission from a central radiatively inefficient accretion flow. To test this scenario, we have monitored the NGC 1097 nucleus in X-ray and UV continuum with Swift and the Hα flux and profile in the optical spectrum using SOAR and Gemini-South from 2012 August to 2013 February. During the monitoring campaign, the Hα flux remained at a very low level—three times lower than the maximum flux observed in previousmore » campaigns and showing only limited (∼20%) variability. The X-ray variations were small, only ∼13% throughout the campaign, while the UV did not show significant variations. We concluded that the timescale of the Hα profile variation is close to the sampling interval of the optical observations, which results in only a marginal correlation between the X-ray and Hα fluxes. We have caught the active galaxy nucleus in NGC 1097 in a very low activity state, in which the ionizing source was very weak and capable of ionizing just the innermost part of the gas in the disk. Nonetheless, the data presented here still support the picture in which the gas that emits the broad double-peaked Balmer lines is illuminated/ionized by a source of high-energy photons which is located interior to the inner radius of the line-emitting part of the disk.« less

  10. Predicting the Presence of Companions for Stripped-envelope Supernovae: The Case of the Broad-lined Type Ic SN 2002ap

    NASA Astrophysics Data System (ADS)

    Zapartas, E.; de Mink, S. E.; Van Dyk, S. D.; Fox, O. D.; Smith, N.; Bostroem, K. A.; de Koter, A.; Filippenko, A. V.; Izzard, R. G.; Kelly, P. L.; Neijssel, C. J.; Renzo, M.; Ryder, S.

    2017-06-01

    Many young, massive stars are found in close binaries. Using population synthesis simulations we predict the likelihood of a companion star being present when these massive stars end their lives as core-collapse supernovae (SNe). We focus on stripped-envelope SNe, whose progenitors have lost their outer hydrogen and possibly helium layers before explosion. We use these results to interpret new Hubble Space Telescope observations of the site of the broad-lined Type Ic SN 2002ap, 14 years post-explosion. For a subsolar metallicity consistent with SN 2002ap, we expect a main-sequence (MS) companion present in about two thirds of all stripped-envelope SNe and a compact companion (likely a stripped helium star or a white dwarf/neutron star/black hole) in about 5% of cases. About a quarter of progenitors are single at explosion (originating from initially single stars, mergers, or disrupted systems). All of the latter scenarios require a massive progenitor, inconsistent with earlier studies of SN 2002ap. Our new, deeper upper limits exclude the presence of an MS companion star >8-10 {M}⊙ , ruling out about 40% of all stripped-envelope SN channels. The most likely scenario for SN 2002ap includes nonconservative binary interaction of a primary star initially ≲ 23 {M}⊙ . Although unlikely (<1% of the scenarios), we also discuss the possibility of an exotic reverse merger channel for broad-lined Type Ic events. Finally, we explore how our results depend on the metallicity and the model assumptions and discuss how additional searches for companions can constrain the physics that govern the evolution of SN progenitors.

  11. TheoSSA - Model WD Spectra on Demand: The Impact of Ne, Na, Mg, and Iron-group Elements on the Balmer Lines

    NASA Astrophysics Data System (ADS)

    Reindl, N.; Rauch, T.

    2015-06-01

    The registered German Astrophysical Virtual Observatory (GAVO) service TheoSSA provides easy access to synthetic stellar spectra. This GAVO database contains already ten thousands of these, which were calculated with different chemical compositions of the elements H to Ni. In addition to the database, it is possible to calculate individual spectra for hot, compact stars based on the Tübingen NLTE Model-Atmosphere Package (TMAP) via the TMAW service. The TMAW models were, in the pilot phase, restricted to the elements H, He, C, N, and O. Now, TMAW is extended to additionally consider opacities from Ne, Na, and Mg. Soon, TMAW will also be able to include the opacities from the so-called iron-group elements (Ca - Ni). We describe the improvements and show the impact of Ne, Na, Mg, and iron-group elements on the Balmer lines.

  12. Detection of Broad Hα Emission Lines in the Late-Time Spectra of a Hydrogen-Poor Superluminous Supernova

    DOE PAGES

    Yan, Lin; Quimby, R.; Ofek, E.; ...

    2015-11-23

    iPTF13ehe is a hydrogen-poor superluminous supernova (SLSN) at z = 0.3434, with a slow-evolving light curve and spectral features similar to SN2007bi. It rises in 83–148 days to reach a peak bolometric luminosity of ~1.3 × 10 44 erg s -1, then decays slowly at 0.015 mag day -1. The measured ejecta velocity is ~ 13,000 km s -1. The inferred explosion characteristics, such as the ejecta mass (70–220 M ⊙), and the total radiative and kinetic energy (E rad ~ 10 51 erg, E kin ~ 2 × 10 53 erg), are typical of slow-evolving H-poor SLSN events. However,more » the late-time spectrum taken at +251 days (rest, post-peak) reveals a Balmer Hα emission feature with broad and narrow components, which has never been detected before among other H-poor SLSNe. The broad component has a velocity width of ~4500 km s -1 and a ~300 km s -1 blueward shift relative to the narrow component. In this paper, we interpret this broad Hα emission with a luminosity of ~2 × 10 41 erg s -1 as resulting from the interaction between the supernova ejecta and a discrete H-rich shell, located at a distance of ~4 × 10 16 cm from the explosion site. This interaction causes the rest-frame r-band LC to brighten at late times. The fact that the late-time spectra are not completely absorbed by the shock-ionized H-shell implies that its Thomson scattering optical depth is likely ≤1, thus setting upper limits on the shell mass ≤30 M ⊙. Of the existing models, a Pulsational Pair Instability supernova model can naturally explain the observed 30 M ⊙ H-shell, ejected from a progenitor star with an initial mass of (95–150) M ⊙ about 40 years ago. Finally, we estimate that at least ~15% of all SLSNe-I may have late-time Balmer emission lines.« less

  13. Detection of Broad Hα Emission Lines in the Late-time Spectra of a Hydrogen-poor Superluminous Supernova

    NASA Astrophysics Data System (ADS)

    Yan, Lin; Quimby, R.; Ofek, E.; Gal-Yam, A.; Mazzali, P.; Perley, D.; Vreeswijk, P. M.; Leloudas, G.; De Cia, A.; Masci, F.; Cenko, S. B.; Cao, Y.; Kulkarni, S. R.; Nugent, P. E.; Rebbapragada, Umaa D.; Woźniak, P. R.; Yaron, O.

    2015-12-01

    iPTF13ehe is a hydrogen-poor superluminous supernova (SLSN) at z = 0.3434, with a slow-evolving light curve and spectral features similar to SN2007bi. It rises in 83-148 days to reach a peak bolometric luminosity of ˜1.3 × 1044 erg s-1, then decays slowly at 0.015 mag day-1. The measured ejecta velocity is ˜ 13,000 km s-1. The inferred explosion characteristics, such as the ejecta mass (70-220 M⊙), and the total radiative and kinetic energy (Erad ˜ 1051 erg, Ekin ˜ 2 × 1053 erg), are typical of slow-evolving H-poor SLSN events. However, the late-time spectrum taken at +251 days (rest, post-peak) reveals a Balmer Hα emission feature with broad and narrow components, which has never been detected before among other H-poor SLSNe. The broad component has a velocity width of ˜4500 km s-1 and a ˜300 km s-1 blueward shift relative to the narrow component. We interpret this broad Hα emission with a luminosity of ˜2 × 1041 erg s-1 as resulting from the interaction between the supernova ejecta and a discrete H-rich shell, located at a distance of ˜4 × 1016 cm from the explosion site. This interaction causes the rest-frame r-band LC to brighten at late times. The fact that the late-time spectra are not completely absorbed by the shock-ionized H-shell implies that its Thomson scattering optical depth is likely ≤1, thus setting upper limits on the shell mass ≤30 M⊙. Of the existing models, a Pulsational Pair Instability supernova model can naturally explain the observed 30 M⊙ H-shell, ejected from a progenitor star with an initial mass of (95-150) M⊙ about 40 years ago. We estimate that at least ˜15% of all SLSNe-I may have late-time Balmer emission lines.

  14. Iron deficiency and new insights into therapy.

    PubMed

    Low, Michael Sy; Grigoriadis, George

    2017-07-17

    Iron deficiency and iron deficiency anaemia remain prevalent in Australia. The groups at highest risk are pre-menopausal women, socially disadvantaged people and those of Indigenous background. Diagnosing iron deficiency using a full blood examination and iron studies can be difficult and can be further complicated by concomitant inflammation. Results of iron studies should always be interpreted as an overall picture rather than focusing on individual parameters. In difficult clinical scenarios, soluble transferrin receptor assays can be useful. Management of iron deficiency involves identification and treatment of the cause of iron deficiency, as well as effective iron replacement. Clinicians should always take a detailed history and perform a comprehensive physical examination of a patient with iron deficiency. Patients should be monitored even if a likely cause of iron deficiency is identified. Patients who fail to respond to iron replacement or maintain iron status should be referred for further investigation, including endoscopy to exclude internal bleeding. Both enteral and parenteral iron are effective at replacing iron. For most adult patients, we recommend trialling daily oral iron (30-100 mg of elemental iron) as the first-line therapy. Safety and efficacy of intravenous iron infusions have improved with the availability of a newer formulation, ferric carboxymaltose. Patients who fail to respond to oral iron replacement can be safely managed with intravenous iron. Blood transfusion for iron deficiency anaemia should be reserved for life-threatening situations and should always be followed by appropriate iron replacement.

  15. Detailed non-LTE calculations of the iron emission from NGC 1068

    NASA Technical Reports Server (NTRS)

    Band, David L.; Klein, Richard I.; Castor, John I.; Nash, J. K.

    1989-01-01

    The X-ray iron line emission from NGC 1068 observed by the Ginga satellite is modeled using the new multiline, multilevel, non-LTE radiative transport code ALTAIR and a detailed atomic model for Ne-like through stripped iron. The parameter space of the obscured type 1 Seyfert nucleus model for this object is studied. The equivalent width is greater than previously predicted. It is found that detailed radiative transfer can have a significant effect on the observed line flux both for the K alpha line and for the L-shell emission. The ionization of the iron increases with temperature. Therefore the K alpha equivalent width and energy is a function not only of the ionization parameter, but also of the column depth and temperature. For a likely model of NGC 1068 it is found that the iron abundance is about twice solar, but that modifications of this model may permit a smaller abundance.

  16. Intermediate-line Emission in AGNs: The Effect of Prescription of the Gas Density

    NASA Astrophysics Data System (ADS)

    Adhikari, T. P.; Hryniewicz, K.; Różańska, A.; Czerny, B.; Ferland, G. J.

    2018-03-01

    The requirement of an intermediate-line component in the recently observed spectra of several active galactic nuclei (AGNs) points to the possible existence of a physically separate region between the broad-line region (BLR) and narrow-line region (NLR). In this paper we explore the emission from the intermediate-line region (ILR) by using photoionization simulations of the gas clouds distributed radially from the center of the AGN. The gas clouds span distances typical for the BLR, ILR, and NLR, and the appearance of dust at the sublimation radius is fully taken into account in our model. The structure of a single cloud is calculated under the assumption of constant pressure. We show that the slope of the power-law radial profile of the cloud density does not affect the existence of the ILR in major types of AGNs. We found that the low-ionization iron line, Fe II, appears to be highly sensitive to the presence of dust and therefore becomes a potential tracer of dust content in line-emitting regions. We show that the use of a disk-like cloud density profile computed for the upper part of the atmosphere of the accretion disk reproduces the observed properties of the line emissivities. In particular, the distance of the Hβ line inferred from our model agrees with that obtained from reverberation mapping studies in the Sy1 galaxy NGC 5548.

  17. Physical conditions in broad and associated narrow absorption-line systems toward APM 08279+5255

    NASA Astrophysics Data System (ADS)

    Srianand, R.; Petitjean, P.

    2000-05-01

    Results of a careful analysis of the absorption systems with z_abs =~ z_em seen toward the bright, z_em ~ 3.91, gravitationally lensed quasar APM 08279+5255 are presented. Two of the narrow-line systems, at z_abs = 3.8931 and z_abs = 3.9135, show absorptions from singly ionized species with weak or no N v and O vi absorptions at the same redshift. Absorption due to fine structure transitions of C ii and S ii i (excitation energies corresponding to, respectively, 156mu m and 34mu m) are detected at z_abs = 3.8931. Excitation by IR radiation is favored as the column density ratios are consistent with the shape of APM 08279+5255 IR spectrum. The low-ionization state of the system favors a picture where the cloud is closer to the IR source than to the UV source, supporting the idea that the extension of the IR source is larger than ~ 200 pc. The absence of fine structure lines at z_abs = 3.9135 suggests that the gas responsible for this system is farther away from the IR source. Abundances are ~ 0.01 and 1 Zsun at z_abs = 3.913 and 3.8931 and aluminum could be over-abundant with respect to silicon and carbon by at least a factor of two and five. All this suggests that whereas the z_abs = 3.8931 system is probably located within 200 pc from the QSO and ejected at a velocity larger than 1000 km s-1, the z_abs = 3.9135 system is farther away and part of the host-galaxy. Several narrow-line systems have strong absorption lines due to C iv, O vi and N v and very low neutral hydrogen optical depths. This probably implies metallicities Z>= Z_sun although firm conclusion cannot be drawn as the exact value depends strongly on the shape of the ionizing spectrum. The C iv broad absorption has a complex structure with mini-BALs (width <= 1000 km s-1) and narrow components superposed on a continuous absorption of smaller optical depth. The continuous absorption is much stronger in O vi indicating that the corresponding gas-component is of higher ionization than the other components

  18. Characteristics of iron ore sinter with EFB addition

    NASA Astrophysics Data System (ADS)

    Purwanto, H.; Rozhan, A. N.; Mohamad, A. S.; Zakiyuddin, A.

    2018-04-01

    Utilization of EFB-derived biochar in sintering of iron ore has been conducted in this work with regards to the porosity of iron sinter. EFB has been heated up in argon atmosphere to 450°C in order to produce biochar. In the present work, the sintering process was conducted at 1150°C with variations of biochar content from 5% to 10%. In this case, the apparent density for iron sinter shows significant decrease as the biochar addition increase. The porosity of iron sinter showed a gradual increment from 5% to 7.5% and escalated at 10% biochar content. The results of porosity and apparent density were in line with the micrograph of iron sinter.

  19. Decoupling of Iron and Phosphate in the Global Ocean

    NASA Technical Reports Server (NTRS)

    Parekh, Payal

    2003-01-01

    Iron is an essential micronutrient for marine phytoplankton, limiting their growth in high nutrient, low chlorophyll regions of the ocean. I use a hierarchy of ocean circulation and biogeochemistry models to understand controls on global iron distribution. I formulate a mechanistic model of iron cycling which includes scavenging onto sinking particles and complexation with an organic ligand. The iron cycle is coupled to a phosphorus cycling model. Iron's aeolian source is prescribed. In the context of a highly idealized multi-box model scheme, the model can be brought into consistency with the relatively sparse ocean observations of iron in the oceans. This biogeochemical scheme is also implemented in a coarse resolution ocean general circulation model. This model also successfully reproduces the broad regional patterns of iron and phosphorus. In particular, the high macronutrient concentrations of the Southern Ocean result from iron limitation in the model. Due to the potential ability of iron to change the efficiency of the carbon pump in the remote Southern Ocean, I study Southern Ocean surface phosphate response to increased aeolian dust flux. My box model and GCM results suggest that a global ten fold increase in dust flux can support a phosphate drawdown of 0.25-0.5 micromolar.

  20. The Hubble Space Telescope Quasar Absorption Line Key Project: The Unusual Absorption-Line System in the Spectrum of PG 2302+029--Ejected or Intervening?

    NASA Technical Reports Server (NTRS)

    Jannuzi, B. T.; Hartig, G. F.; Kirhakos, S.; Sargent, W. L. W.; Turnshek, D. A.; Weymann, R. J.; Bahcall, J. N.; Bergeron, J.; Boksenberg, A.; Savage, B. D.; hide

    1996-01-01

    We report the discovery of a high-ionization broad absorption line system at a redshift of z(sub abs) = 0.695 in the spectrum of the z(sub em) = 1.052 radio-quiet quasar PG 2302+029. Broad absorption with FWHM from 3000 to 5000 km/s is detected from C iv, N v, and O vi in Hubble Space Telescope (HST) Faint Object Spectrograph spectra of the quasar. A narrow-line system (FWHM approx. 250 km/s) at z(sub abs) = 0.7016 is resolved from the broad blend and includes absorption by Ly alpha and the C iv, N v, and O vi doublets. No absorption by low-ionization metal species (e.g., Si II and Mg II) is detected in the HST or ground-based spectra for either the broad or the narrow system. The centroids of the broad system lines are displaced by approx. 56,000 km/s to the blue of the quasar's broad emission lines. The reddest extent of the broad-line absorption is more than 50,000 km/s from the quasar. The properties of this system are unprecedented, whether it is an intervening or an ejected system.

  1. High-resolution line-shape spectroscopy during a laser pulse based on Dual-Broad-Band-CARS interferometry

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Vereschagin, Konstantin A; Vereschagin, Alexey K; Smirnov, Valery V

    2006-07-31

    A high-resolution spectroscopic method is developed for recording Raman spectra of molecular transitions in transient objects during a laser pulse with a resolution of {approx}0.1 cm{sup -1}. The method is based on CARS spectroscopy using a Fabry-Perot interferometer for spectral analysis of the CARS signal and detecting a circular interferometric pattern on a two-dimensional multichannel photodetector. It is shown that the use of the Dual-Broad-Band-CARS configuration to obtain the CARS process provides the efficient averaging of the spectral-amplitude noise of the CARS signal generated by a laser pulse and, in combination with the angular integration of the two-dimensional interference pattern,more » considerably improves the quality of interferograms. The method was tested upon diagnostics of the transient oxygen-hydrogen flame where information on the shapes of spectral lines of the Q-branch of hydrogen molecules required for measuring temperature was simultaneously obtained and used. (special issue devoted to the 90th anniversary of a.m. prokhorov)« less

  2. Ultraviolet Broad Absorption Features and the Spectral Energy Distribution of the QSO PG 1351+64. 3.1

    NASA Technical Reports Server (NTRS)

    Zheng, W.; Kriss, G. A.; Wang, J. X.; Brotherton, M.; Oegerle, W. R.; Blair, W. P.; Davidsen, A. F.; Green, R. F.; Hutchings, J. B.; Kaiser, M. E.; hide

    2001-01-01

    We present a moderate-resolution (approximately 20 km s(exp -1) spectrum of the mini broad absorption line QSO PG 1351+64 between 915-1180 A, obtained with the Far Ultraviolet Spectroscopic Explorer (FUSE). Additional low-resolution spectra at longer wavelengths were also obtained with the Hubble Space Telescope (HST) and ground-based telescopes. Broad absorption is present on the blue wings of C III (lambda)977, Ly(beta), O VI (lambda)(lambda)1032,1038, Ly(alpha), N V (lambda)(lambda)1238,1242, Si IV (lambda)(lambda)1393,1402, and C IV (lambda)(lambda)1548,1450. The absorption profile can be fitted with five components at velocities of approximately -780, -1049, -1629, -1833, and -3054 km s(exp -1) with respect to the emission-line redshift of z = 0.088. All the absorption components cover a large fraction of the continuum source as well as the broad-line region. The O VI emission feature is very weak, and the O VI/Ly(alpha) flux ratio is 0.08, one of the lowest among low-redshift active galaxies and QSOs. The UV (ultraviolet) continuum shows a significant change in slope near 1050 A in the restframe. The steeper continuum shortward of the Lyman limit extrapolates well to the observed weak X-ray flux level. The absorbers' properties are similar to those of high-redshift broad absorption-line QSOs. The derived total column density of the UV absorbers is on the order of 10(exp 21) cm(exp -2), unlikely to produce significant opacity above 1 keV in the X-ray. Unless there is a separate, high-ionization X-ray absorber, the QSO's weak X-ray flux may be intrinsic. The ionization level of the absorbing components is comparable to that anticipated in the broad-line region, therefore the absorbers may be related to broad-line clouds along the line of sight.

  3. Ultraviolet Broad Absorption Features and the Spectral Energy Distribution of the QSO PG 1351+641. 2.5

    NASA Technical Reports Server (NTRS)

    Zheng, W.; Kriss, G. A.; Wang, J. X.; Brotherton, M.; Oegerle, W. R.; Blair, W. P.; Davidsen, A. F.; Green, R. F.; Hutchings, J. B.; Kaiser, M. E.; hide

    2001-01-01

    We present a moderate-resolution (approximately 20 km/s) spectrum of the broad-absorption line QSO PG 1351+64 between 915-1180 angstroms, obtained with the Far Ultraviolet Spectroscopic Explorer (FUSE). Additional low-resolution spectra at longer wavelengths were also obtained with the Hubble Space Telescope (HST) and ground-based telescopes. Broad absorption is present on the blue wings of C III lambda977, Ly-beta, O VI lambda-lambda-1032,1038, Ly-alpha, N V lambda-lambda-1238,1242, Si IV lambda-lambda-1393,1402, and C IV lambda-lambda-1548,1450. The absorption profile can be fitted with five components at velocities of approximately -780, -1049, -1629, -1833, and -3054 km/s with respect to the emission-line redshift of z = 0.088. All the absorption components cover a large fraction of the continuum source as well as the broad-line region. The O VI emission feature is very weak, and the O VI/Ly-alpha flux ratio is 0.08, one of the lowest among low-redshift active galaxies and QSOs. The ultraviolet continuum shows a significant change in slope near 1050 angstroms in the restframe. The steeper continuum shortward of the Lyman limit extrapolates well to the observed weak X-ray flux level. The absorbers' properties are similar to those of high-redshift broad absorption-line QSOs. The derived total column density of the UV absorbers is on the order of 10(exp 21)/s, unlikely to produce significant opacity above 1 keV in the X-ray. Unless there is a separate, high-ionization X-ray absorber, the QSO's weak X-ray flux may be intrinsic. The ionization level of the absorbing components is comparable to that anticipated in the broad-line region, therefore the absorbers may be related to broad-line clouds along the line of sight.

  4. NuSTAR reveals the Comptonizing corona of the broad-line radio galaxy 3C 382

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ballantyne, D. R.; Bollenbacher, J. M.; Brenneman, L. W.

    Broad-line radio galaxies (BLRGs) are active galactic nuclei that produce powerful, large-scale radio jets, but appear as Seyfert 1 galaxies in their optical spectra. In the X-ray band, BLRGs also appear like Seyfert galaxies, but with flatter spectra and weaker reflection features. One explanation for these properties is that the X-ray continuum is diluted by emission from the jet. Here, we present two NuSTAR observations of the BLRG 3C 382 that show clear evidence that the continuum of this source is dominated by thermal Comptonization, as in Seyfert 1 galaxies. The two observations were separated by over a year andmore » found 3C 382 in different states separated by a factor of 1.7 in flux. The lower flux spectrum has a photon-index of Γ=1.68{sub −0.02}{sup +0.03}, while the photon-index of the higher flux spectrum is Γ=1.78{sub −0.03}{sup +0.02}. Thermal and anisotropic Comptonization models provide an excellent fit to both spectra and show that the coronal plasma cooled from kT{sub e} = 330 ± 30 keV in the low flux data to 231{sub −88}{sup +50} keV in the high flux observation. This cooling behavior is typical of Comptonizing corona in Seyfert galaxies and is distinct from the variations observed in jet-dominated sources. In the high flux observation, simultaneous Swift data are leveraged to obtain a broadband spectral energy distribution and indicates that the corona intercepts ∼10% of the optical and ultraviolet emitting accretion disk. 3C 382 exhibits very weak reflection features, with no detectable relativistic Fe Kα line, that may be best explained by an outflowing corona combined with an ionized inner accretion disk.« less

  5. The iron chelator deferasirox protects mice from mucormycosis through iron starvation

    PubMed Central

    Ibrahim, Ashraf S.; Gebermariam, Teclegiorgis; Fu, Yue; Lin,, Lin; Husseiny, Mohamed I.; French, Samuel W.; Schwartz, Julie; Skory, Christopher D.; Edwards, John E.; Spellberg, Brad J.

    2007-01-01

    Mucormycosis causes mortality in at least 50% of cases despite current first-line therapies. Clinical and animal data indicate that the presence of elevated available serum iron predisposes the host to mucormycosis. Here we demonstrate that deferasirox, an iron chelator recently approved for use in humans by the US FDA, is a highly effective treatment for mucormycosis. Deferasirox effectively chelated iron from Rhizopus oryzae and demonstrated cidal activity in vitro against 28 of 29 clinical isolates of Mucorales at concentrations well below clinically achievable serum levels. When administered to diabetic ketoacidotic or neutropenic mice with mucormycosis, deferasirox significantly improved survival and decreased tissue fungal burden, with an efficacy similar to that of liposomal amphotericin B. Deferasirox treatment also enhanced the host inflammatory response to mucormycosis. Most importantly, deferasirox synergistically improved survival and reduced tissue fungal burden when combined with liposomal amphotericin B. These data support clinical investigation of adjunctive deferasirox therapy to improve the poor outcomes of mucormycosis with current therapy. As iron availability is integral to the pathogenesis of other infections (e.g., tuberculosis, malaria), broader investigation of deferasirox as an antiinfective treatment is warranted. PMID:17786247

  6. Carbonate-sensitive phytotransferrin controls high-affinity iron uptake in diatoms

    NASA Astrophysics Data System (ADS)

    McQuaid, Jeffrey B.; Kustka, Adam B.; Oborník, Miroslav; Horák, Aleš; McCrow, John P.; Karas, Bogumil J.; Zheng, Hong; Kindeberg, Theodor; Andersson, Andreas J.; Barbeau, Katherine A.; Allen, Andrew E.

    2018-03-01

    In vast areas of the ocean, the scarcity of iron controls the growth and productivity of phytoplankton. Although most dissolved iron in the marine environment is complexed with organic molecules, picomolar amounts of labile inorganic iron species (labile iron) are maintained within the euphotic zone and serve as an important source of iron for eukaryotic phytoplankton and particularly for diatoms. Genome-enabled studies of labile iron utilization by diatoms have previously revealed novel iron-responsive transcripts, including the ferric iron-concentrating protein ISIP2A, but the mechanism behind the acquisition of picomolar labile iron remains unknown. Here we show that ISIP2A is a phytotransferrin that independently and convergently evolved carbonate ion-coordinated ferric iron binding. Deletion of ISIP2A disrupts high-affinity iron uptake in the diatom Phaeodactylum tricornutum, and uptake is restored by complementation with human transferrin. ISIP2A is internalized by endocytosis, and manipulation of the seawater carbonic acid system reveals a second-order dependence on the concentrations of labile iron and carbonate ions. In P. tricornutum, the synergistic interaction of labile iron and carbonate ions occurs at environmentally relevant concentrations, revealing that carbonate availability co-limits iron uptake. Phytotransferrin sequences have a broad taxonomic distribution and are abundant in marine environmental genomic datasets, suggesting that acidification-driven declines in the concentration of seawater carbonate ions will have a negative effect on this globally important eukaryotic iron acquisition mechanism.

  7. The Frequency of Intrinsic X-Ray Weakness among Broad Absorption Line Quasars

    NASA Astrophysics Data System (ADS)

    Liu, Hezhen; Luo, B.; Brandt, W. N.; Gallagher, S. C.; Garmire, G. P.

    2018-06-01

    We present combined ≈14–37 ks Chandra observations of seven z = 1.6–2.7 broad absorption line (BAL) quasars selected from the Large Bright Quasar Survey (LBQS). These seven objects are high-ionization BAL (HiBAL) quasars, and they were undetected in the Chandra hard band (2–8 keV) in previous observations. The stacking analyses of previous Chandra observations suggested that these seven objects likely contain some candidates for intrinsically X-ray weak BAL quasars. With the new Chandra observations, six targets are detected. We calculate their effective power-law photon indices and hard-band flux weakness, and find that two objects, LBQS 1203+1530 and LBQS 1442–0011, show soft/steep spectral shapes ({{{Γ }}}eff}={2.2}-0.9+0.9 and {1.9}-0.8+0.9) and significant X-ray weakness in the hard band (by factors of ≈15 and 12). We conclude that the two HiBAL quasars are good candidates for intrinsically X-ray weak BAL quasars. The mid-infrared-to-ultraviolet spectral energy distributions of the two candidates are consistent with those of typical quasars. We constrain the fraction of intrinsically X-ray weak active galactic nuclei (AGNs) among HiBAL quasars to be ≈7%–10% (2/29–3/29), and we estimate it is ≈6%–23% (2/35–8/35) among the general BAL quasar population. Such a fraction is considerably larger than that among non-BAL quasars, and we suggest that intrinsically X-ray weak quasars are preferentially observed as BAL quasars. Intrinsically X-ray weak AGNs likely comprise a small minority of the luminous type 1 AGN population, and they should not affect significantly the completeness of these AGNs found in deep X-ray surveys.

  8. Nutritional improvement of corn pasta-like product with broad bean (Vicia faba) and quinoa (Chenopodium quinoa).

    PubMed

    Giménez, M A; Drago, S R; Bassett, M N; Lobo, M O; Sammán, N C

    2016-05-15

    In this study, the nutritional quality of pasta-like product (spaghetti-type), made with corn (Zea mays) flour enriched with 30% broad bean (Vicia faba) flour and 20% of quinoa (Chenopodium quinoa) flour, was determined. Proximate chemical composition and iron, zinc and dietary fiber were determined. A biological assay was performed to assess the protein value using net protein utilization (NPU), true digestibility (TD) and protein digestibility-corrected amino acid score (PDCAAS). Iron and zinc availability were estimated by measuring dialyzable mineral fraction (%Da) resulting from in vitro gastrointestinal digestion. Nutritionally improved, gluten-free spaghetti (NIS) showed significantly increased NPU and decreased TD compared with a non-enriched control sample. One NIS-portion supplied 10-20% of recommended fiber daily intake. Addition of quinoa flour had a positive effect on the FeDa% as did broad bean flour on ZnDa%. EDTA increased Fe- and ZnDa% in all NIS-products, but it also impaired sensorial quality. Copyright © 2016. Published by Elsevier Ltd.

  9. The fraction and mid-infrared properties of broad absorption line quasars from the Sloan Digital Sky Survey

    NASA Astrophysics Data System (ADS)

    Pu, Xingting

    2014-02-01

    We present the results of a study which uses a sample of 1822 Sloan Digital Sky Survey (SDSS) quasars with reliable Wide-field Infrared Survey Explorer (WISE) detections in the redshift range 1.7≤ z≤4.38 to investigate the mid-infrared fraction of broad absorption line (BAL) quasars. The BAL quasars in the sample include both high-ionization BAL (HiBAL) quasars that show broad absorption from C iv and low-ionization BAL (LoBAL) quasars that show additional broad absorption from Mg ii. The fraction of C iv BAL quasars with nonzero absorption index (AI) is found to be 38.7±1.2 %, in good agreement with that derived for the Two Micron All Sky Survey (2MASS) sample. The C iv BAL quasar fractions remain constant with magnitude in the WISE 3.4 μm (W1) and 4.6 μm (W2) bands, and increase rapidly with decreasing magnitude in the WISE 12 μm (W3) and 22 μm (W4) bands. The nonzero AI fraction of 44.5±2.1 % determined in the WISE W4 band is more likely to represent the intrinsic BAL quasar fraction. No evidence that the fraction is a strong function of redshift is found. At 1.7≤ z≤2.15, the overall mid-infrared LoBAL fraction is and the fractions increase significantly with decreasing magnitude in all four of WISE bands. Moreover, it is found that the mean optical-to-WISE colors of BAL quasars are ≃0.2 mag redder than that of non-BAL quasars, while the traditional (nonzero balnicity) BAL quasars are redder than the nontraditional BAL quasars by ≃0.15 mag, which suggest a continuum of more reddening from non-BAL to nontraditional BAL to traditional BAL. No evidence that nontraditional BALs are a distinct class from traditional BALs is found. Finally, it is shown that the mean optical-to-WISE colors of LoBALs are ≃0.4 mag redder than that of HiBALs at 1.7≤ z≤2.15.

  10. DETECTION OF BROAD Hα EMISSION LINES IN THE LATE-TIME SPECTRA OF A HYDROGEN-POOR SUPERLUMINOUS SUPERNOVA

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Yan, Lin; Masci, F.; Quimby, R.

    2015-12-01

    iPTF13ehe is a hydrogen-poor superluminous supernova (SLSN) at z = 0.3434, with a slow-evolving light curve and spectral features similar to SN2007bi. It rises in 83–148 days to reach a peak bolometric luminosity of ∼1.3 × 10{sup 44} erg s{sup −1}, then decays slowly at 0.015 mag day{sup −1}. The measured ejecta velocity is ∼ 13,000 km s{sup −1}. The inferred explosion characteristics, such as the ejecta mass (70–220 M{sub ⊙}), and the total radiative and kinetic energy (E{sub rad} ∼ 10{sup 51} erg, E{sub kin} ∼ 2 × 10{sup 53} erg), are typical of slow-evolving H-poor SLSN events. However,more » the late-time spectrum taken at +251 days (rest, post-peak) reveals a Balmer Hα emission feature with broad and narrow components, which has never been detected before among other H-poor SLSNe. The broad component has a velocity width of ∼4500 km s{sup −1} and a ∼300 km s{sup −1} blueward shift relative to the narrow component. We interpret this broad Hα emission with a luminosity of ∼2 × 10{sup 41} erg s{sup −1} as resulting from the interaction between the supernova ejecta and a discrete H-rich shell, located at a distance of ∼4 × 10{sup 16} cm from the explosion site. This interaction causes the rest-frame r-band LC to brighten at late times. The fact that the late-time spectra are not completely absorbed by the shock-ionized H-shell implies that its Thomson scattering optical depth is likely ≤1, thus setting upper limits on the shell mass ≤30 M{sub ⊙}. Of the existing models, a Pulsational Pair Instability supernova model can naturally explain the observed 30 M{sub ⊙} H-shell, ejected from a progenitor star with an initial mass of (95–150) M{sub ⊙} about 40 years ago. We estimate that at least ∼15% of all SLSNe-I may have late-time Balmer emission lines.« less

  11. Broad-range real-time PCR assay for the rapid identification of cell-line contaminants and clinically important mollicute species.

    PubMed

    Störmer, Melanie; Vollmer, Tanja; Henrich, Birgit; Kleesiek, Knut; Dreier, Jens

    2009-04-01

    Polymerase chain reaction assays have become widely used methods of confirming the presence of Mollicutes species in clinical samples and cell cultures. We have developed a broad-range real-time PCR assay using the locked nucleic acid technology to detect mollicute species causing human infection and cell line contamination. Primers and probes specifically for the conserved regions of the mycoplasmal tuf gene (encoding elongation factor Tu) were designed. Cell culture supernatants, clinical specimens (vaginal swabs, sputum, cryopreserved heart valve tissues), and reference strains were tested for mollicute contamination as well as to exclude cross-reaction to human nucleic acids and other bacterial species. Nucleic acids were extracted using magnetic separation technology. The coamplification of the human beta2-microglobulin DNA served as an internal control. The PCR assay was highly specific and obtained an analytical sensitivity of one copy per microl sample. The 95% detection limit was calculated to 10 copies per microl sample for Mycoplasma pneumoniae and M. orale. No false-positive results were observed due to cross-reaction of walled bacterial, fungal, and human nucleic acids. To evaluate the PCR, we compared the results to two commercialized test systems. Moreover, in combination with a previously developed broad-range RT-PCR assay for the detection of bacteria in blood products, both mollicute and walled bacterial contamination can be detected simultaneously using multiplex real-time RT-PCR.

  12. Studies of the reactivity of the ferrihydrite surface by iron isotopic exchange and Mossbauer spectroscopy

    USGS Publications Warehouse

    Rea, Brigid A.; Davis, James A.; Waychunas , Glenn A.

    1994-01-01

    Two-line ferrihydrite is an important adsorbent of many toxics in natural and anthropogenic systems; however, the specific structural sites responsible for the high adsorption capacity are not well understood. A combination of chemical and spectroscopic techniques have been employed in this study to gain further insight into the structural nature of sites at the ferrihydrite surface. The kinetics of iron isotopic exchange demonstrated that there are at least two types of iron sites in ferrihydrite. One population of sites, referred to as labile sites, approached iron isotopic equilibrium within 24 hr in 59Fe-NTA solutions, while the second population of sites, referred to as non-labile, exhibited a much slower rate of isotopic exchange. Adsorbed arsenate reduced the degree of exchange by labile sites, indicating that the anion blocked or greatly inhibited the rate of exchange of these sites. Mössbauer spectra were collected from a variety of samples including 56Fe-ferrihydrite samples with 57Fe in labile sites, samples containing 57Fe throughout the structure, and samples with 57Fe in non-labile sites. The spectra showed characteristic broad doublets signifying poor structural order. Refined fits of the spectra indicated that labile sites have larger quadrupole splitting, hence more local distortion, than non-labile sites. In all cases, the spectra demonstrated some degree of asymmetry, indicating a distribution of Fe environments in ferrihydrite. Overall spectral findings, combined with recent EXAFS results (Waychunas et al., 1993), indicate that labile sites likely are more reactive (with respect to iron isotopic exchange) because they have fewer neighboring Fe octahedra and are therefore bound less strongly to the ferrihydrite structure. The labile population of sites probably is composed of end sites of the dioctahedral chain structure of 2-line ferrihydrite, which is a subset of the entire population of surface sites. Mössbauer spectra of samples containing

  13. The effect of gold kiwifruit consumed with an iron fortified breakfast cereal meal on iron status in women with low iron stores: A 16 week randomised controlled intervention study

    PubMed Central

    2010-01-01

    Background Dietary treatment is often recommended as the first line of treatment for women with mild iron deficiency. Although it is well established that ascorbic acid enhances iron absorption, it is less clear whether the consumption of ascorbic acid rich foods (such as kiwifruit) with meals fortified with iron improves iron status. The aim of this study is to investigate whether the consumption of ZESPRI® GOLD kiwifruit (a fruit high in ascorbic acid and carotenoids) with an iron fortified breakfast cereal meal increases iron status in women with low iron stores. Methods/Design Eighty nine healthy women aged 18-44 years with low iron stores (serum ferritin (SF) ≤ 25 μg/L, haemoglobin (Hb) ≥ 115 g/L) living in Auckland, New Zealand were randomised to receive an iron fortified breakfast cereal (16 mg iron per serve) and either two ZESPRI® GOLD kiwifruit or a banana (low ascorbic acid and carotenoid content) to eat at breakfast time every day for 16 weeks. Iron status (SF, Hb, C-reactive protein (CRP) and soluble transferrin receptor (sTfR)), ascorbic acid and carotenoid status were measured at baseline and after 16 weeks. Anthropometric measures, dietary intake, physical activity and blood loss were measured before and after the 16 week intervention. Discussion This randomised controlled intervention study will be the first study to investigate the effect of a dietary based intervention of an iron fortified breakfast cereal meal combined with an ascorbic acid and carotenoid rich fruit on improving iron status in women with low iron stores. Trial registration ACTRN12608000360314 PMID:20102633

  14. Reddening and He i{sup ∗} λ 10830 Absorption Lines in Three Narrow-line Seyfert 1 Galaxies

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Zhang, Shaohua; Zhou, Hongyan; Shi, Xiheng

    We report the detection of heavy reddening and the He i* λ 10830 absorption lines at the active galactic nucleus (AGN) redshift in three narrow-line Seyfert 1 galaxies: SDSS J091848.61+211717.0, SDSS J111354.66+124439.0, and SDSS J122749.13+321458.9. They exhibit very red optical to near-infrared colors, narrow Balmer/Paschen broad emission lines and He i* λ 10830 absorption lines. The ultraviolet-optical-infrared nucleus continua are reddened by the SMC extinction law of E ( B − V ) ∼ 0.74, 1.17, and 1.24 mag for three objects, which are highly consistent with the values obtained from the broad-line Balmer decrements, but larger than those ofmore » narrow emission lines. The reddening analysis suggests that the extinction dust simultaneously obscures the accretion disk, the broad emission-line region, and the hot dust from the inner edge of the torus. It is possible that the dust obscuring the AGN structures is the dusty torus itself. Furthermore, the Cloudy analysis of the He i* λ 10830 absorption lines proposes the distance of the absorption materials to be the extend scale of the torus, which greatly increases probabilities of the obscure and absorption materials being the dusty torus.« less

  15. Hemochromatosis Enhances Tumor Progression via Upregulation of Intracellular Iron in Head and Neck Cancer

    PubMed Central

    Lenarduzzi, Michelle; Hui, Angela B. Y.; Yue, Shijun; Ito, Emma; Shi, Wei; Williams, Justin; Bruce, Jeff; Sakemura-Nakatsugawa, Noriko; Xu, Wei; Schimmer, Aaron; Liu, Fei-Fei

    2013-01-01

    Introduction Despite improvements in treatment strategies for head and neck squamous cell carcinoma (HNSCC), outcomes have not significantly improved; highlighting the importance of identifying novel therapeutic approaches to target this disease. To address this challenge, we proceeded to evaluate the role of iron in HNSCC. Experimental Design Expression levels of iron-related genes were evaluated in HNSCC cell lines using quantitative RT-PCR. Cellular phenotypic effects were assessed using viability (MTS), clonogenic survival, BrdU, and tumor formation assays. The prognostic significance of iron-related proteins was determined using immunohistochemistry. Results In a panel of HNSCC cell lines, hemochromatosis (HFE) was one of the most overexpressed genes involved in iron regulation. In vitro knockdown of HFE in HNSCC cell lines significantly decreased hepcidin (HAMP) expression and intracellular iron level. This in turn, resulted in a significant decrease in HNSCC cell viability, clonogenicity, DNA synthesis, and Wnt signalling. These cellular changes were reversed by re-introducing iron back into HNSCC cells after HFE knockdown, indicating that iron was mediating this phenotype. Concordantly, treating HNSCC cells with an iron chelator, ciclopirox olamine (CPX), significantly reduced viability and clonogenic survival. Finally, patients with high HFE expression experienced a reduced survival compared to patients with low HFE expression. Conclusions Our data identify HFE as potentially novel prognostic marker in HNSCC that promotes tumour progression via HAMP and elevated intracellular iron levels, leading to increased cellular proliferation and tumour formation. Hence, these findings suggest that iron chelators might have a therapeutic role in HNSCC management. PMID:23991213

  16. The effects of metamorphism on iron mineralogy and the iron speciation redox proxy

    NASA Astrophysics Data System (ADS)

    Slotznick, Sarah P.; Eiler, John M.; Fischer, Woodward W.

    2018-03-01

    utilized. The presence of diagenetic iron carbonates in many samples severely affected the proxy even at low grade, engendering an interpretation of ferruginous conditions in all lithologies, but particularly in carbonate-bearing rocks. Increasing metamorphic grades transformed iron in carbonates into iron in silicate minerals, which when combined with a slight increase in the amount of pyrrhotite, drove the proxy toward more oxic and more euxinic conditions. Broad-classes of metamorphic reactions (e.g. decarbonation, silicate formation) occurred at distinct temperatures-pressures in carbonates versus siliciclastics, and could be either abrupt between metamorphic facies or more gradual in nature. Notably, these analyses highlighted the importance of trace iron in phases like calcite, which otherwise might not be included in iron-focused research i.e. ore-system petrogenesis, metamorphic evolution, or normative calculations of mineral abundance. The observations show that iron is mobile and reactive during diagenesis and metamorphism, and these post-depositional processes can readily overprint primary redox information held by iron speciation. However, in principle, additional mineralogical and petrographic approaches can be combined with iron speciation data to help untangle many of these post-depositional processes and arrive at more accurate estimates of paleoenvironmental redox conditions and processes, even for metamorphosed samples.

  17. SPECTRAL OPTICAL MONITORING OF THE NARROW-LINE SEYFERT 1 GALAXY Ark 564

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shapovalova, A. I.; Burenkov, A. N.; Popovic, L. C.

    2012-09-15

    We present the results of a long-term (1999-2010) spectral optical monitoring campaign of the active galactic nucleus (AGN) Ark 564, which shows a strong Fe II line emission in the optical. This AGN is a narrow-line Seyfert 1 (NLS1) galaxy, a group of AGNs with specific spectral characteristics. We analyze the light curves of the permitted H{alpha}, H{beta}, optical Fe II line fluxes, and the continuum flux in order to search for a time lag between them. Additionally, in order to estimate the contribution of iron lines from different multiplets, we fit the H{beta} and Fe II lines with amore » sum of Gaussian components. We find that during the monitoring period the spectral variation (F{sub max}/F{sub min}) of Ark 564 is between 1.5 for H{alpha} and 1.8 for the Fe II lines. The correlation between the Fe II and H{beta} flux variations is of higher significance than that of H{alpha} and H{beta} (whose correlation is almost absent). The permitted-line profiles are Lorentzian-like and do not change shape during the monitoring period. We investigate, in detail, the optical Fe II emission and find different degrees of correlation between the Fe II emission arising from different spectral multiplets and the continuum flux. The relatively weak and different degrees of correlations between permitted lines and continuum fluxes indicate a rather complex source of ionization of the broad-line emission region.« less

  18. A new, sophisticated test of the Binary Black Hole Hypothesis for Quasars with Double-peaked Broad Balmer Lines.

    NASA Astrophysics Data System (ADS)

    Nguyen Duy Doan, Anh; Eracleous, Michael; Runnoe, Jessie; Halpern, Jules P.; Liu, Jia; Mathes, Gavin; Flohic, Helene M. L. G.

    2018-01-01

    Displaced peaks in the Balmer lines of quasars could serve as indirect evidence for the existence of close, bound supermassive black hole binaries (SBHBs) at sub-parsec separations. In this work, we test the SBHB hypothesis for 14 quasars with double-peaked emission lines using their long-term radial velocity curves. We make use of a Markov Chain Monte Carlo method to explore the parameter space efficiently. Compared to previous works, we have relaxed the assumption of circular orbits, adding two parameters (eccentricity and argument of periapsis) to the parameter space. We also account for jitter, i.e., short-term fluctuations in the radial velocity curves due to processes that are intrinsic to an individual broad-line region. We have found that the distribution of jitter about a smooth radial velocity curve resembles a Gaussian. Thus, jitter is equivalent to increasing measurement uncertainty in individual measurements. The resulting posterior distributions show the lower mass limit of the SBHBs to be in the range of 10^8 - 10^11 solar masses. For several objects, the mass limit drops by a few orders of magnitude compared to previous results by Liu et. al. However, we note that solutions corresponding to minimum masses often require very high orbital eccentricity ( > 0.9). We also calculate the orbital decay timescale of the binaries due to gravitational radiation, finding values in the range 10^6 - 10^11 years; these values correspond to the minimum-mass solutions. For one third of our targets, we can confidently disfavor the SBHB hypothesis on the basis that the minimum mass exceeds even the most massive black holes measured so far (2 x 10^10 solar masses). For the remaining objects, we must take into account the plausibility of a variety of parameters (e.g. eccentricity, lifetime, etc.) in our evaluation.

  19. Interaction Between the Broad-Lined Type Ic Supernova 2012ap and Carriers of Diffuse Interstellar Bands

    NASA Technical Reports Server (NTRS)

    Milisavljevic, Dan; Margutti, Raffaella; Crabtree, Kyle N.; Foster, Jonathan B.; Soderberg, Alicia M.; Fesen, Robert A.; Parrent, Jerod T.; Sanders, Nathan E.; Drout, Maria R.; Kamble, Atish; hide

    2014-01-01

    The diffuse interstellar bands (DIBs) are absorption features observed in optical and near-infrared spectra that are thought to be associated with carbon-rich polyatomic molecules in interstellar gas. However, because the central wavelengths of these bands do not correspond with electronic transitions of any known atomic or molecular species, their nature has remained uncertain since their discovery almost a century ago. Here we report on unusually strong DIBs in optical spectra of the broad- lined Type Ic supernova SN2012ap that exhibit changes in equivalent width over short (. 30 days) timescales. The 4428 A and 6283 A DIB features get weaker with time, whereas the 5780 A feature shows a marginal increase. These nonuniform changes suggest that the supernova is interacting with a nearby source of the DIBs and that the DIB carriers possess high ionization potentials, such as small cations or charged fullerenes. We conclude that moderate-resolution spectra of supernovae with DIB absorptions obtained within weeks of outburst could reveal unique information about the mass-loss environment of their progenitor systems and provide new constraints on the properties of DIB carriers.

  20. Dependence of the Broad Absorption Line Quasar Fraction on Radio Luminosity

    NASA Astrophysics Data System (ADS)

    Shankar, Francesco; Dai, Xinyu; Sivakoff, Gregory R.

    2008-11-01

    We find that the fraction of classical broad absorption line quasars (BALQSOs) among the FIRST radio sources in the Sloan Data Release 3, is 20.5+ 7.3-5.9% at the faintest radio powers detected (L1.4 GHz ~ 1032 erg s-1), and rapidly drops to lesssim8% at L1.4 GHz ~ 3 × 1033 erg s-1. Similarly, adopting the broader absorption index (AI) definition of Trump et al., we find the fraction of radio BALQSOs to be 44+ 8.1-7.8%, reducing to 23.1+ 7.3-6.1% at high luminosities. While the high fraction at low radio power is consistent with the recent near-IR estimates by Dai et al., the lower fraction at high radio powers is intriguing and confirms previous claims based on smaller samples. The trend is independent of the redshift range, the optical and radio flux selection limits, or the exact definition of a radio match. We also find that at fixed optical magnitude, the highest bins of radio luminosity are preferentially populated by non-BALQSOs, consistent with the overall trend. We do find, however, that those quasars identified as AI-BALQSOs but not under the classical definition do not show a significant drop in their fraction as a function of radio power, further supporting independent claims that these sources, characterized by lower equivalent width, may represent an independent class from the classical BALQSOs. We find the balnicity index, a measure of the absorption trough in BALQSOs, and the mean maximum wind velocity to be roughly constant at all radio powers. We discuss several plausible physical models which may explain the observed fast drop in the fraction of the classical BALQSOs with increasing radio power, although none is entirely satisfactory. A strictly evolutionary model for the BALQSO and radio emission phases requires a strong fine-tuning to work, while a simple geometric model, although still not capable of explaining polar BALQSOs and the paucity of FRII BALQSOs, is statistically successful in matching the data if part of the apparent radio

  1. DETECTION OF EXTREMELY BROAD WATER EMISSION FROM THE MOLECULAR CLOUD INTERACTING SUPERNOVA REMNANT G349.7+0.2

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rho, J.; Hewitt, J. W.; Boogert, A.

    2015-10-10

    We performed Herschel HIFI, PACS, and SPIRE observations toward the molecular cloud interacting supernova remnant G349.7+0.2. An extremely broad emission line was detected at 557 GHz from the ground state transition 1{sub 10}-1{sub 01} of ortho-water. This water line can be separated into three velocity components with widths of 144, 27, and 4 km s{sup −1}. The 144 km s{sup −1} component is the broadest water line detected to date in the literature. This extremely broad line width shows the importance of probing shock dynamics. PACS observations revealed three additional ortho-water lines, as well as numerous high-J carbon monoxide (CO)more » lines. No para-water lines were detected. The extremely broad water line is indicative of a high velocity shock, which is supported by the observed CO rotational diagram that was reproduced with a J-shock model with a density of 10{sup 4} cm{sup −3} and a shock velocity of 80 km s{sup −1}. Two far-infrared fine-structure lines, [O i] at 145 μm and [C ii] line at 157 μm, are also consistent with the high velocity J-shock model. The extremely broad water line could be simply from short-lived molecules that have not been destroyed in high velocity J-shocks; however, it may be from more complicated geometry such as high-velocity water bullets or a shell expanding in high velocity. We estimate the CO and H{sub 2}O densities, column densities, and temperatures by comparison with RADEX and detailed shock models.« less

  2. Solving the 56Ni Puzzle of Magnetar-powered Broad-lined Type IC Supernovae

    NASA Astrophysics Data System (ADS)

    Wang, Ling-Jun; Han, Yan-Hui; Xu, Dong; Wang, Shan-Qin; Dai, Zi-Gao; Wu, Xue-Feng; Wei, Jian-Yan

    2016-11-01

    Broad-lined Type Ic supernovae (SNe Ic-BL) are of great importance because their association with long-duration gamma-ray bursts (LGRBs) holds the key to deciphering the central engine of LGRBs, which refrains from being unveiled despite decades of investigation. Among the two popularly hypothesized types of central engine, I.e., black holes and strongly magnetized neutron stars (magnetars), there is mounting evidence that the central engine of GRB-associated SNe (GRB-SNe) is rapidly rotating magnetars. Theoretical analysis also suggests that magnetars could be the central engine of SNe Ic-BL. What puzzled the researchers is the fact that light-curve modeling indicates that as much as 0.2{--}0.5 {M}⊙ of 56Ni was synthesized during the explosion of the SNe Ic-BL, which is unfortunately in direct conflict with current state-of-the-art understanding of magnetar-powered 56Ni synthesis. Here we propose a dynamic model of magnetar-powered SNe to take into account the acceleration of the ejecta by the magnetar, as well as the thermalization of the injected energy. Assuming that the SN kinetic energy comes exclusively from the magnetar acceleration, we find that although a major fraction of the rotational energy of the magnetar is to accelerate the SN ejecta, a tiny fraction of this energy deposited as thermal energy of the ejecta is enough to reduce the needed 56Ni to 0.06 M ⊙ for both SN 1997ef and SN 2007ru. We therefore suggest that magnetars could power SNe Ic-BL in aspects both of energetics and of 56Ni synthesis.

  3. Dust inflated accretion disc as the origin of the broad line region in active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Baskin, Alexei; Laor, Ari

    2018-02-01

    The broad line region (BLR) in active galactic nuclei (AGNs) is composed of dense gas (˜1011 cm-3) on sub-pc scale, which absorbs about 30 per cent of the ionizing continuum. The outer size of the BLR is likely set by dust sublimation, and its density by the incident radiation pressure compression (RPC). But, what is the origin of this gas, and what sets its covering factor (CF)? Czerny & Hryniewicz (2011) suggested that the BLR is a failed dusty wind from the outer accretion disc. We explore the expected dust properties, and the implied BLR structure. We find that graphite grains sublimate only at T ≃ 2000 K at the predicted density of ˜1011 cm-3, and therefore large graphite grains (≥0.3 μm) survive down to the observed size of the BLR, RBLR. The dust opacity in the accretion disc atmosphere is ˜50 times larger than previously assumed, and leads to an inflated torus-like structure, with a predicted peak height at RBLR. The illuminated surface of this torus-like structure is a natural place for the BLR. The BLR CF is mostly set by the gas metallicity, the radiative accretion efficiency, a dynamic configuration and ablation by the incident optical-UV continuum. This model predicts that the BLR should extend inwards of RBLR to the disc radius where the surface temperature is ≃2000 K, which occurs at Rin ≃ 0.18RBLR. The value of Rin can be tested by reverberation mapping of the higher ionization lines, predicted by RPC to peak well inside RBLR. The dust inflated disc scenario can also be tested based on the predicted response of RBLR and the CF to changes in the AGN luminosity and accretion rate.

  4. Broad absorption line disappearance and emergence using multiple-epoch spectroscopy from the Sloan Digital Sky Survey

    NASA Astrophysics Data System (ADS)

    McGraw, S. M.; Brandt, W. N.; Grier, C. J.; Filiz Ak, N.; Hall, P. B.; Schneider, D. P.; Anderson, S. F.; Green, P. J.; Hutchinson, T. A.; Macleod, C. L.; Vivek, M.

    2017-08-01

    We investigate broad absorption line (BAL) disappearance and emergence using a 470 BAL-quasar sample over ≤0.10-5.25 rest-frame years with at least three spectroscopic epochs for each quasar from the Sloan Digital Sky Survey. We identify 14 disappearing BALs over ≤1.73-4.62 rest-frame years and 18 emerging BALs over ≤1.46-3.66 rest-frame years associated with the C IV λλ1548,1550 and/or Si IV λλ1393,1402 doublets, and report on their variability behaviour. BAL quasars in our data set exhibit disappearing/emerging C IV BALs at a rate of 2.3^{+0.9}_{-0.7} and 3.0^{+1.0}_{-0.8} per cent, respectively, and the frequency for BAL to non-BAL quasar transitions is 1.7^{+0.8}_{-0.6} per cent. We detect four re-emerging BALs over ≤3.88 rest-frame years on average and three re-disappearing BALs over ≤4.15 rest-frame years on average, the first reported cases of these types. We infer BAL lifetimes along the line of sight to be nominally ≲ 100-1000 yr using disappearing C IV BALs in our sample. Interpretations of (re-)emerging and (re-)disappearing BALs reveal evidence that collectively supports both transverse-motion and ionization-change scenarios to explain BAL variations. We constrain a nominal C IV/Si IV BAL-outflow location of ≲ 100 pc from the central source and a radial size of ≳ 1× 10-7 pc (0.02 au) using the ionization-change scenario, and constrain a nominal outflow location of ≲ 0.5 pc and a transverse size of ˜0.01 pc using the transverse-motion scenario. Our findings are consistent with previous work, and provide evidence in support of BALs tracing compact flow geometries with small filling factors.

  5. NOD promoter-controlled AtIRT1 expression functions synergistically with NAS and FERRITIN genes to increase iron in rice grains.

    PubMed

    Boonyaves, Kulaporn; Gruissem, Wilhelm; Bhullar, Navreet K

    2016-02-01

    Rice is a staple food for over half of the world's population, but it contains only low amounts of bioavailable micronutrients for human nutrition. Consequently, micronutrient deficiency is a widespread health problem among people who depend primarily on rice as their staple food. Iron deficiency anemia is one of the most serious forms of malnutrition. Biofortification of rice grains for increased iron content is an effective strategy to reduce iron deficiency. Unlike other grass species, rice takes up iron as Fe(II) via the IRON REGULATED TRANSPORTER (IRT) in addition to Fe(III)-phytosiderophore chelates. We expressed Arabidopsis IRT1 (AtIRT1) under control of the Medicago sativa EARLY NODULIN 12B promoter in our previously developed high-iron NFP rice lines expressing NICOTIANAMINE SYNTHASE (AtNAS1) and FERRITIN. Transgenic rice lines expressing AtIRT1 alone had significant increases in iron and combined with NAS and FERRITIN increased iron to 9.6 µg/g DW in the polished grains that is 2.2-fold higher as compared to NFP lines. The grains of AtIRT1 lines also accumulated more copper and zinc but not manganese. Our results demonstrate that the concerted expression of AtIRT1, AtNAS1 and PvFERRITIN synergistically increases iron in both polished and unpolished rice grains. AtIRT1 is therefore a valuable transporter for iron biofortification programs when used in combination with other genes encoding iron transporters and/or storage proteins.

  6. TLc-A, the leading nanochelating-based nanochelator, reduces iron overload in vitro and in vivo.

    PubMed

    Kalanaky, Somayeh; Hafizi, Maryam; Safari, Sepideh; Mousavizadeh, Kazem; Kabiri, Mahboubeh; Farsinejad, Alireza; Fakharzadeh, Saideh; Nazaran, Mohammad Hassan

    2016-03-01

    Iron chelation therapy is an effective approach to the treatment of iron overload conditions, in which iron builds up to toxic levels in the body and may cause organ damage. Treatments using deferoxamine, deferasirox and deferiprone have been introduced and despite their disadvantages, they remain the first-line therapeutics in iron chelation therapy. Our study aimed to compare the effectiveness of the iron chelation agent TLc-A, a nano chelator synthetized based on the novel nanochelating technology, with deferoxamine. We found that TLc-A reduced iron overload in Caco2 cell line more efficiently than deferoxamine. In rats with iron overload, very low concentrations of TLc-A lowered serum iron level after only three injections of the nanochelator, while deferoxamine was unable to reduce iron level after the same number of injections. Compared with deferoxamine, TLc-A significantly increased urinary iron excretion and reduced hepatic iron content. The toxicity study showed that the intraperitoneal median lethal dose for TLc-A was at least two times higher than that for deferoxamine. In conclusion, our in vitro and in vivo studies indicate that the novel nano chelator compound, TLc-A, offers superior performance in iron reduction than the commercially available and widely used deferoxamine.

  7. Deferiprone for the treatment of transfusional iron overload in thalassemia.

    PubMed

    Belmont, Ami; Kwiatkowski, Janet L

    2017-06-01

    Transfusional iron overload can lead to hepatic fibrosis, arrhythmias and congestive heart failure and a number of endocrinopathies. Deferiprone is an oral iron chelator approved for use in the United States as a second line agent for the treatment of transfusional iron overload in patients with thalassemia. Areas covered: This article will review the data regarding the efficacy of deferiprone for iron chelation and prevention and reversal of iron related complications, the drug's adverse effect profile, and the use of this drug in combination regimens. Expert commentary: Extensive data support that deferiprone is particularly efficacious at cardiac iron removal and therefore, a chelator regimen that contains deferiprone is generally recommended when there is significant cardiac iron loading and/or in the setting of iron-related cardiac disease. The most concerning side effects of deferiprone are agranulocytosis and milder forms of neutropenia, which require appropriate monitoring and patient/provider education.

  8. Two iron-regulated transporter (IRT) genes showed differential expression in poplar trees under iron or zinc deficiency.

    PubMed

    Huang, Danqiong; Dai, Wenhao

    2015-08-15

    Two iron-regulated transporter (IRT) genes were cloned from the iron chlorosis resistant (PtG) and susceptible (PtY) Populus tremula 'Erecta' lines. Nucleotide sequence analysis showed no significant difference between PtG and PtY. The predicted proteins contain a conserved ZIP domain with 8 transmembrane (TM) regions. A ZIP signature sequence was found in the fourth TM domain. Phylogenetic analysis revealed that PtIRT1 was clustered with tomato and tobacco IRT genes that are highly responsible to iron deficiency. The PtIRT3 gene was clustered with the AtIRT3 gene that was related to zinc and iron transport in plants. Tissue specific expression indicated that PtIRT1 only expressed in the root, while PtIRT3 constitutively expressed in all tested tissues. Under iron deficiency, the expression of PtIRT1 was dramatically increased and a significantly higher transcript level was detected in PtG than in PtY. Iron deficiency also enhanced the expression of PtIRT3 in PtG. On the other hand, zinc deficiency down-regulated the expression of PtIRT1 and PtIRT3 in both PtG and PtY. Zinc accumulated significantly under iron-deficient conditions, whereas the zinc deficiency showed no significant effect on iron accumulation. A yeast complementation test revealed that the PtIRT1 and PtIRT3 genes could restore the iron uptake ability under the iron uptake-deficiency condition. The results will help understand the mechanisms of iron deficiency response in poplar trees and other woody species. Copyright © 2015 Elsevier GmbH. All rights reserved.

  9. Iron and copper release in drinking-water distribution systems.

    PubMed

    Shi, Baoyou; Taylor, James S

    2007-09-01

    A large-scale pilot study was carried out to evaluate the impacts of changes in water source and treatment process on iron and copper release in water distribution systems. Finished surface waters, groundwaters, and desalinated waters were produced with seven different treatment systems and supplied to 18 pipe distribution systems (PDSs). The major water treatment processes included lime softening, ferric sulfate coagulation, reverse osmosis, nanofiltration, and integrated membrane systems. PDSs were constructed from PVC, lined cast iron, unlined cast iron, and galvanized pipes. Copper pipe loops were set up for corrosion monitoring. Results showed that surface water after ferric sulfate coagulation had low alkalinity and high sulfates, and consequently caused the highest iron release. Finished groundwater treated by conventional method produced the lowest iron release but the highest copper release. The iron release of desalinated water was relatively high because of the water's high chloride level and low alkalinity. Both iron and copper release behaviors were influenced by temperature.

  10. FE Line Diagnostics of Multiply Shocked Stellar Atmospheres: The Mira S. Carinae

    NASA Technical Reports Server (NTRS)

    Bookbinder, Jay

    1997-01-01

    Extensive LWP-HI spectra were obtained of the Mira S Car at a rapid time cadence as compared with the shock cycle time of S Car. These spectra were obtained in an attempt to understand the velocity structures in the shocked wind using the fluoresced iron lines. Data analysis of the IUE observations, which included the primary calibration of all of the IUE spectra obtained of S Car, was carried out. In addition, line identifications, flux calculations, background subtractions, and line profile analysis as a function of S Car's pulsational phase were performed. The database incorporated all line identifications as a function of pulsation phase for all IUE LWP-HI observations to date of S Car. At least 45 separate iron line features are identified in the S Car spectrum at one or more phases of the shock cycle, including those due to Fe II (UV 161) which is pumped by three different iron lines; Fe I(UV 44) which is pumped by the Mg II k line. Other strong multiplets that have been identified include UV(1), UV(2), UV(5), UV(32), UV(60), UV(63), UV(161), UV(207), and UV(399). Over 300 weaker lines have also been tentatively identified with Fe line transitions.

  11. Vanishing absorption and blueshifted emission in FeLoBAL quasars

    NASA Astrophysics Data System (ADS)

    Rafiee, Alireza; Pirkola, Patrik; Hall, Patrick B.; Galati, Natalee; Rogerson, Jesse; Ameri, Abtin

    2016-07-01

    We study the dramatic decrease in iron absorption strength in the iron low-ionization broad absorption line quasar SDSS J084133.15+200525.8. We report on the continued weakening of absorption in the prototype of this class of variable broad absorption line quasar, FBQS J140806.2+305448. We also report a third example of this class, SDSS J123103.70+392903.6; unlike the other two examples, it has undergone an increase in observed continuum brightness (at 3000 Å rest frame) as well as a decrease in iron absorption strength. These changes could be caused by absorber transverse motion or by ionization variability. We note that the Mg II and UV Fe II lines in several FeLoBAL quasars are blueshifted by thousands of km s-1 relative to the H β emission line peak. We suggest that such emission arises in the outflowing winds normally seen only in absorption.

  12. GAMMA–GAMMA ABSORPTION IN THE BROAD LINE REGION RADIATION FIELDS OF GAMMA-RAY BLAZARS

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Böttcher, Markus; Els, Paul, E-mail: Markus.Bottcher@nwu.ac.za

    2016-04-20

    The expected level of γγ absorption in the Broad Line Region (BLR) radiation field of γ -ray loud Flat Spectrum Radio Quasars (FSRQs) is evaluated as a function of the location of the γ -ray emission region. This is done self-consistently with parameters inferred from the shape of the spectral energy distribution (SED) in a single-zone leptonic EC-BLR model scenario. We take into account all geometrical effects both in the calculation of the γγ opacity and the normalization of the BLR radiation energy density. As specific examples, we study the FSRQs 3C279 and PKS 1510-089, keeping the BLR radiation energymore » density at the location of the emission region fixed at the values inferred from the SED. We confirm previous findings that the optical depth due to γγ absorption in the BLR radiation field exceeds unity for both 3C279 and PKS 1510-089 for locations of the γ -ray emission region inside the inner boundary of the BLR. It decreases monotonically, with distance from the central engine and drops below unity for locations within the BLR. For locations outside the BLR, the BLR radiation energy density required for the production of GeV γ -rays rapidly increases beyond observational constraints, thus making the EC-BLR mechanism implausible. Therefore, in order to avoid significant γγ absorption by the BLR radiation field, the γ -ray emission region must therefore be located near the outer boundary of the BLR.« less

  13. Energy dependence of polarization across broad deexcitation gamma-ray line profiles

    NASA Astrophysics Data System (ADS)

    Werntz, Carl; Lang, F. L.

    1998-04-01

    The energy profiles of deexcitation gamma-ray lines from recoiling inelastically scattered nuclei exhibit detailed structure. MeV-wide gamma-ray lines from the direction of the Orion nebula have been detected (H. Bloemen, et al., Astr. and Astrophys. L5, 281 (1994).) by COMPTEL whose source is postulated to be cosmic ray carbon and oxygen nuclei shock accelerated near supernova remnants colliding with ambient hydrogen and helium. Even when the heavy ion velocity distributions are isotropic, structure characteristic of the multipolarity of the gamma transition remains (A. M. Bykov et al, Astr. and Astrophys. 607, L37 (1996); B. Kozlovsky et al, Astrophys. J. 484, (1997).). In experiments in which the energy dependent structure of the deexcitation gamma-ray profiles is not resolved, the gammas display a high degree of linear polarization that rapidly changes with gamma-beam angle. We calculate the polarization, both linear and circular, as a function of gamma-ray energy across the laboratory line profiles of C12*(4.44) and O16*(6.13) inelastically excited by protons and alphas. We then investigate the polarization in the surviving structures for isotropic energetic ions colliding with ^1H and ^4He.

  14. Probing the Broad-Line Region and the Accretion Disk in the Lensed Quasars HE 0435-1223, WFI 2033-4723, and HE 2149-2745 Using Gravitational Microlensing

    NASA Astrophysics Data System (ADS)

    Motta, V.; Mediavilla, E.; Rojas, K.; Falco, E. E.; Jiménez-Vicente, J.; Muñoz, J. A.

    2017-02-01

    We use single-epoch spectroscopy of three gravitationally lensed quasars, HE 0435-1223, WFI 2033-4723, and HE 2149-2745, to study their inner structure (broad-line region [BLR] and continuum source). We detect microlensing-induced magnification in the wings of the broad emission lines of two of the systems (HE 0435-1223 and WFI 2033-4723). In the case of WFI 2033-4723, microlensing affects two “bumps” in the spectra that are almost symmetrically arranged on the blue (coincident with an Al III emission line) and red wings of C III]. These match the typical double-peaked profile that follows from disk kinematics. The presence of microlensing in the wings of the emission lines indicates the existence of two different regions in the BLR: a relatively small one with kinematics possibly related to an accretion disk, and another one that is substantially more extended and insensitive to microlensing. There is good agreement between the estimated size of the region affected by microlensing in the emission lines, {r}s={10}-7+15\\sqrt{M/{M}⊙ } lt-day (red wing of C IV in HE 0435-1223) and {r}s={11}-7+28\\sqrt{M/{M}⊙ } lt-day (C III] bumps in WFI 2033-4723), and the sizes inferred from the continuum emission, {r}s={13}-4+5\\sqrt{M/{M}⊙ } lt-day (HE 0435-1223) and {r}s={10}-2+3\\sqrt{M/{M}⊙ } lt-day (WFI 2033-4723). For HE 2149-2745 we measure an accretion disk size {r}s={8}-5+11\\sqrt{M/{M}⊙ } lt-day. The estimates of p, the exponent of the size versus wavelength ({r}s\\propto {λ }p), are 1.2 ± 0.6, 0.8 ± 0.2, and 0.4 ± 0.3 for HE 0435-1223, WFI 2033-4723, and HE 2149-2745, respectively. In conclusion, the continuum microlensing amplitude in the three quasars and chromaticity in WFI 2033-4723 and HE 2149-2745 are below expectations for the thin-disk model. The disks are larger and their temperature gradients are flatter than predicted by this model.

  15. Monte Carlo simulations of the detailed iron absorption line profiles from thermal winds in X-ray binaries

    NASA Astrophysics Data System (ADS)

    Tomaru, Ryota; Done, Chris; Odaka, Hirokazu; Watanabe, Shin; Takahashi, Tadayuki

    2018-05-01

    Blueshifted absorption lines from highly ionized iron are seen in some high inclination X-ray binary systems, indicating the presence of an equatorial disc wind. This launch mechanism is under debate, but thermal driving should be ubiquitous. X-ray irradiation from the central source heats disc surface, forming a wind from the outer disc where the local escape velocity is lower than the sound speed. The mass-loss rate from each part of the disc is determined by the luminosity and spectral shape of the central source. We use these together with an assumed density and velocity structure of the wind to predict the column density and ionization state, then combine this with a Monte Carlo radiation transfer to predict the detailed shape of the absorption (and emission) line profiles. We test this on the persistent wind seen in the bright neutron star binary GX 13+1, with luminosity L/LEdd ˜ 0.5. We approximately include the effect of radiation pressure because of high luminosity, and compute line features. We compare these to the highest resolution data, the Chandra third-order grating spectra, which we show here for the first time. This is the first physical model for the wind in this system, and it succeeds in reproducing many of the features seen in the data, showing that the wind in GX13+1 is most likely a thermal-radiation driven wind. This approach, combined with better streamline structures derived from full radiation hydrodynamic simulations, will allow future calorimeter data to explore the detail wind structure.

  16. Super-Enhancers and Broad H3K4me3 Domains Form Complex Gene Regulatory Circuits Involving Chromatin Interactions.

    PubMed

    Cao, Fan; Fang, Yiwen; Tan, Hong Kee; Goh, Yufen; Choy, Jocelyn Yeen Hui; Koh, Bryan Thean Howe; Hao Tan, Jiong; Bertin, Nicolas; Ramadass, Aroul; Hunter, Ewan; Green, Jayne; Salter, Matthew; Akoulitchev, Alexandre; Wang, Wilson; Chng, Wee Joo; Tenen, Daniel G; Fullwood, Melissa J

    2017-05-19

    Stretched histone regions, such as super-enhancers and broad H3K4me3 domains, are associated with maintenance of cell identity and cancer. We connected super-enhancers and broad H3K4me3 domains in the K562 chronic myelogenous leukemia cell line as well as the MCF-7 breast cancer cell line with chromatin interactions. Super-enhancers and broad H3K4me3 domains showed higher association with chromatin interactions than their typical counterparts. Interestingly, we identified a subset of super-enhancers that overlap with broad H3K4me3 domains and show high association with cancer-associated genes including tumor suppressor genes. Besides cell lines, we could observe chromatin interactions by a Chromosome Conformation Capture (3C)-based method, in primary human samples. Several chromatin interactions involving super-enhancers and broad H3K4me3 domains are constitutive and can be found in both cancer and normal samples. Taken together, these results reveal a new layer of complexity in gene regulation by super-enhancers and broad H3K4me3 domains.

  17. Super-massive binary black holes and emission lines in active galactic nuclei

    NASA Astrophysics Data System (ADS)

    Popović, Luka Č.

    2012-02-01

    It is now agreed that mergers play an essential role in the evolution of galaxies and therefore that mergers of supermassive black holes (SMBHs) must have been common. We see the consequences of past supermassive binary black holes (SMBs) in the light profiles of so-called 'core ellipticals' and a small number of SMBs have been detected. However, the evolution of SMBs is poorly understood. Theory predicts that SMBs should spend a substantial amount of time orbiting at velocities of a few thousand kilometers per second. If the SMBs are surrounded by gas observational effects might be expected from accretion onto one or both of the SMBHs. This could result in a binary Active Galactic Nucleus (AGN) system. Like a single AGN, such a system would emit a broad band electromagnetic spectrum and broad and narrow emission lines. The broad emission spectral lines emitted from AGNs are our main probe of the geometry and physics of the broad line region (BLR) close to the SMBH. There is a group of AGNs that emit very broad and complex line profiles, showing two displaced peaks, one blueshifted and one redshifted from the systemic velocity defined by the narrow lines, or a single such peak. It has been proposed that such line shapes could indicate an SMB system. We discuss here how the presence of an SMB will affect the BLRs of AGNs and what the observational consequences might be. We review previous claims of SMBs based on broad line profiles and find that they may have non-SMB explanations as a consequence of a complex BLR structure. Because of these effects it is very hard to put limits on the number of SMBs from broad line profiles. It is still possible, however, that unusual broad line profiles in combination with other observational effects (line ratios, quasi-periodical oscillations, spectropolarimetry, etc.) could be used for SMBs detection. Some narrow lines (e.g., [O III]) in some AGNs show a double-peaked profile. Such profiles can be caused by streams in the Narrow

  18. Crowdsourcing Broad Absorption Line Properties and Other Features of Quasar Outflow Using Zooniverse Citizen Science Project Platform

    NASA Astrophysics Data System (ADS)

    Crowe, Cassie; Lundgren, Britt; Grier, Catherine

    2018-01-01

    The Sloan Digital Sky Survey (SDSS) regularly publishes vast catalogs of quasars and other astronomical objects. Previously, the SDSS collaboration has used visual inspection to check quasar redshift validity and flag instances of broad absorption lines (BALs). This information helps researchers to easily single out the quasars with BAL properties and study their outflows and other intervening gas clouds. Due to the ever-growing number of new SDSS quasar observations, visual inspections are no longer possible using previous methods. Currently, BAL information is being determined entirely computationally, and the accuracy of that information is not precisely known. This project uses the Zooniverse citizen science platform to visually inspect quasar spectra for BAL properties, to check the accuracy of the current autonomous methods, and to flag multi-phase outflows and find candidates for in-falling gas into the quasar central engine. The layout and format of a Zooniverse project provides an easier way to inspect and record data on each spectrum and share the workload via crowdsourcing. Work done by the SDSS collaboration members is serving as a beta test for a public project upon the official release of the DR14 quasar catalog by SDSS.

  19. Recovering from iron deficiency chlorosis in near-isogenic soybeans: a microarray study.

    PubMed

    O'Rourke, Jamie A; Graham, Michelle A; Vodkin, Lila; Gonzalez, Delkin Orlando; Cianzio, Silvia R; Shoemaker, Randy C

    2007-05-01

    Iron deficiency chlorosis (IDC) in soybeans has proven to be a perennial problem in the calcareous soils of the U.S. upper Midwest. A historically difficult trait to study in fields, the use of hydroponics in a controlled greenhouse environment has provided a mechanism to study genetic variation while limiting environmental complications. IDC susceptible plants growing in calcareous soils and in iron-controlled hydroponic experiments often exhibit a characteristic chlorotic phenotype early in the growing season but are able to re-green later in the season. To examine the changes in gene expression of these plants, near-isogenic lines, iron efficient PI548553 (Clark) and iron inefficient PI547430 (IsoClark), developed for their response to iron deficiency stress [USDA, ARS, National Genetic Resources Program, Germplasm Resources Information Network - GRIN. (Online Database) National Germplasm Resources Laboratory, Beltsville, MD, 2004. Available: http://www.ars.grin.gov/cgi-bin/npgs/html/acc_search.pl?accid=PI+547430. [22] were grown in iron-deficient hydroponic conditions for one week, then transferred to iron sufficient conditions for another week. This induced a phenotypic response mimicking the growth of the plants in the field; initial chlorosis followed by re-greening. RNA was isolated from root tissue and transcript profiles were examined between the two near-isogenic lines using publicly available cDNA microarrays. By alleviating the iron deficiency stress our expectation was that plants would return to baseline expression levels. However, the microarray comparison identified four cDNAs that were under-expressed by a two-fold or greater difference in the iron inefficient plant compared to the iron efficient plant. This differential expression was re-examined and confirmed by real time PCR experimentation. Control experiments showed that these genes are not differentially expressed in plants grown continually under iron rich hydroponic conditions. The

  20. Iron spin transitions in the lower mantle

    NASA Astrophysics Data System (ADS)

    McCammon, C.; Dubrovinsky, L.; Potapkin, V.; Glazyrin, K.; Kantor, A.; Kupenko, I.; Prescher, C.; Sinmyo, R.; Smirnov, G.; Chumakov, A.; Rüffer, R.

    2012-04-01

    Iron has the ability to adopt different electronic configurations (spin states), which can significantly influence mantle properties and dynamics. It is now generally accepted as a result of studies over the past decade that ferrous iron in (Mg,Fe)O undergoes a high-spin to low-spin transition in the mid-part of the lower mantle; however results on (Mg,Fe)(Si,Al)O3 perovskite, the dominant phase of the lower mantle, remain controversial. Identifying spin transitions in (Mg,Fe)(Si,Al)O3 perovskite presents a significant challenge. X-ray emission spectroscopy provides information on the bulk spin number, but cannot separate individual contributions. Nuclear forward scattering measures hyperfine interactions, but is not well suited to complex materials due to the non-uniqueness of fitting models. Energy-domain Mössbauer spectroscopy generally enables an unambiguous resolution of all hyperfine parameters which can be used to infer spin states; however high pressure measurements using conventional radioactive point sources require extremely long counting times. To solve this problem, we have developed an energy-domain synchrotron Mössbauer source that enables rapid measurement of spectra under extreme conditions (both high pressure and high temperature) with a quality generally sufficient to unambiguously deconvolute even highly complex spectra. We have used the newly developed method to measure high quality Mössbauer spectra of different compositions of (Mg,Fe)O and (Mg,Fe)(Si,Al)O3 perovskite at pressures up to 122 GPa and temperatures up to 2400 K. Experiments were carried out at the European Synchrotron Radiation Facility on the nuclear resonance beamline ID18 equipped with a portable laser heating system for diamond anvil cells. Our results confirm previous observations for (Mg,Fe)O that show a broad spin crossover region at high pressures and high temperatures, and show unambiguously that ferric iron in (Mg,Fe)(Si,Al)O3 perovskite remains in the high-spin state

  1. Effective Processing of the Iron Ores

    NASA Astrophysics Data System (ADS)

    Kuskov, Vadim; Kuskova, Yana; Udovitsky, Vladimir

    2017-11-01

    Effective technology for a complex wasteless processing of the iron ores has been designed and includes three main components (plats): comminution plant, briquette plant, pigment plant. The comminution is done per energy effective technology. Using of briquetting for ores clotting enables the costs cut and brings to a higher level of environmental safety of the process. Briquette formation can be done as a regular pressing, as an extrusion. Developed technology allows to produce high quality competitively products for metallurgy industry and red iron oxide pigments. The whole production line impacts the environment in a minimal manner.

  2. Variability of broad and blueshifted component of [OIII]λ5007 in I ZWI

    NASA Astrophysics Data System (ADS)

    Wang, J.; Wei, J. Y.; He, X. T.

    2005-04-01

    Although the existence of asymmetrical profile of [OIII]λ5007 has been discovered for ages, its filiation and physics are poorly understood. Two new spectra of I ZWI taken on November 16, 2001 and on December 3, 2002 were compared with the spectra taken by BG92. Following results are obtained. (1) The certain variations of broad [OIII] during about 10 years separating the observations are identified. The inferred length scale of broad [OIII] emitting region ranges from 0.3 to 3 pc. By assuming a Keplerian motion in line emitting region, the material emitting broad [OIII] is likely to be located at the transient emission line region, between BLR and NLR. (2) We find a positive relation between the FeII emission and flux of Hβ (or continuum). On the other hand, the parameter RFe decreases with ionizing continuum marginally. (3) We detect a low ionized NLR in I ZWI, because of the low flux ratios [OIII]n/Hβn (∼1.7).

  3. Iron metabolism and related genetic diseases: A cleared land, keeping mysteries.

    PubMed

    Brissot, Pierre; Loréal, Olivier

    2016-02-01

    Body iron has a very close relationship with the liver. Physiologically, the liver synthesizes transferrin, in charge of blood iron transport; ceruloplasmin, acting through its ferroxidase activity; and hepcidin, the master regulator of systemic iron. It also stores iron inside ferritin and serves as an iron reservoir, both protecting the cell from free iron toxicity and ensuring iron delivery to the body whenever needed. The liver is first in line for receiving iron from the gut and the spleen, and is, therefore, highly exposed to iron overload when plasma iron is in excess, especially through its high affinity for plasma non-transferrin bound iron. The liver is strongly involved when iron excess is related either to hepcidin deficiency, as in HFE, hemojuvelin, hepcidin, and transferrin receptor 2 related haemochromatosis, or to hepcidin resistance, as in type B ferroportin disease. It is less involved in the usual (type A) form of ferroportin disease which targets primarily the macrophagic system. Hereditary aceruloplasminemia raises important pathophysiological issues in light of its peculiar organ iron distribution. Copyright © 2015 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.

  4. Specialized computer system to diagnose critical lined equipment

    NASA Astrophysics Data System (ADS)

    Yemelyanov, V. A.; Yemelyanova, N. Y.; Morozova, O. A.; Nedelkin, A. A.

    2018-05-01

    The paper presents data on the problem of diagnosing the lining condition at the iron and steel works. The authors propose and describe the structure of the specialized computer system to diagnose critical lined equipment. The relative results of diagnosing lining condition by the basic system and the proposed specialized computer system are presented. To automate evaluation of lining condition and support in making decisions regarding the operation mode of the lined equipment, the specialized software has been developed.

  5. Iron deficiency alters megakaryopoiesis and platelet phenotype independent of thrombopoietin.

    PubMed

    Evstatiev, Rayko; Bukaty, Adam; Jimenez, Kristine; Kulnigg-Dabsch, Stefanie; Surman, Lidia; Schmid, Werner; Eferl, Robert; Lippert, Kathrin; Scheiber-Mojdehkar, Barbara; Kvasnicka, Hans Michael; Khare, Vineeta; Gasche, Christoph

    2014-05-01

    Iron deficiency is a common cause of reactive thrombocytosis, however, the exact pathways have not been revealed. Here we aimed to study the mechanisms behind iron deficiency-induced thrombocytosis. Within few weeks, iron-depleted diet caused iron deficiency in young Sprague-Dawley rats, as reflected by a drop in hemoglobin, mean corpuscular volume, hepatic iron content and hepcidin mRNA in the liver. Thrombocytosis established in parallel. Moreover, platelets produced in iron deficient animals displayed a higher mean platelet volume and increased aggregation. Bone marrow studies revealed subtle alterations that are suggestive of expansion of megakaryocyte progenitors, an increase in megakaryocyte ploidy and accelerated megakaryocyte differentiation. Iron deficiency did not alter the production of hematopoietic growth factors such as thrombopoietin, interleukin 6 or interleukin 11. Megakaryocytic cell lines grown in iron-depleted conditions exhibited reduced proliferation but increased ploidy and cell size. Our data suggest that iron deficiency increases megakaryopoietic differentiation and alters platelet phenotype without changes in megakaryocyte growth factors, specifically TPO. Iron deficiency-induced thrombocytosis may have evolved to maintain or increase the coagulation capacity in conditions with chronic bleeding. Copyright © 2014 Wiley Periodicals, Inc.

  6. Relative coronal abundances derived from X-ray observations 3: The effect of cascades on the relative intensity of Fe (XVII) line fluxes, and a revised iron abundance

    NASA Technical Reports Server (NTRS)

    Walker, A. B. C., Jr.; Rugge, H. R.; Weiss, K.

    1974-01-01

    Permitted lines in the optically thin coronal X-ray spectrum were analyzed to find the distribution of coronal material, as a function of temperature, without special assumptions concerning coronal conditions. The resonance lines of N, O, Ne, Na, Mg, Al, Si, S, and Ar which dominate the quiet coronal spectrum below 25A were observed. Coronal models were constructed and the relative abundances of these elements were determined. The intensity in the lines of the 2p-3d transitions near 15A was used in conjunction with these coronal models, with the assumption of coronal excitation, to determine the Fe XVII abundance. The relative intensities of the 2p-3d Fe XVII lines observed in the corona agreed with theoretical prediction. Using a more complete theoretical model, and higher resolution observations, a revised calculation of iron abundance relative to hydrogen of 0.000026 was made.

  7. Diethylentriaminepenta acetic acid glucose conjugates as a cell permeable iron chelator.

    PubMed

    Mosayebnia, Mona; Shafiee-Ardestani, Mehdi; Pasalar, Parvin; Mashayekhi, Mojgan; Amanlou, Massoud

    2014-01-01

    To find out whether DTPA-DG complex can enhance clearance of intracellular free iron. Diethylenetriaminepentaacetic acid-D-deoxy-glucosamine (DTPA-DG) was synthesized and examined for its activity as a cell-permeable iron chelator in human hepatocellular carcinoma (HEPG2) cell line exposed to high concentration of iron sulfate and compared with deferoxamine (DFO), a prototype iron chelator. The effect of DTPA-DG on cell viability was monitored using the 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide MTT assay as well. There was a significant increase of iron level after iron overload induction in HEPG2 cell culture. DTPA-DG presented a remarkable capacity to iron burden reducing with estimated 50% inhibitory concentration value of 65.77 nM. In fact, glycosyl moiety was gained access of DTPA to intracellular iron deposits through glucose transporter systems. DTPA-DG, more potent than DFO to sequester deposits of free iron with no profound toxic effect. The results suggest the potential of DTPA-DG in chelating iron and permitting its excretion from primary organ storage.

  8. Synchrotron speciation data for zero-valent iron nanoparticles

    EPA Pesticide Factsheets

    This data set encompasses a complete analysis of synchrotron speciation data for 5 iron nanoparticle samples (P1, P2, P3, S1, S2, and metallic iron) to include linear combination fitting results (Table 6 and Figure 9) and ab-initio extended x-ray absorption fine structure spectroscopy fitting (Figure 10 and Table 7).Table 6: Linear combination fitting of the XAS data for the 5 commercial nZVI/ZVI products tested. Species proportions are presented as percentages. Goodness of fit is indicated by the chi^2 value.Figure 9: Normalised Fe K-edge k3-weighted EXAFS of the 5 commercial nZVI/ZVIproducts tested. Dotted lines show the best 4-component linear combination fit ofreference spectra.Figure 10: Fourier transformed radial distribution functions (RDFs) of the five samplesand an iron metal foil. The black lines in Fig. 10 represent the sample data and the reddotted curves represent the non-linear fitting results of the EXAFS data.Table 7: Coordination parameters of Fe in the samples.This dataset is associated with the following publication:Chekli, L., B. Bayatsarmadi, R. Sekine, B. Sarkar, A. Maoz Shen, K. Scheckel , W. Skinner, R. Naidu, H. Shon, E. Lombi, and E. Donner. Analytical Characterisation of Nanoscale Zero-Valent Iron: A Methodological Review. Richard P. Baldwin ANALYTICA CHIMICA ACTA. Elsevier Science Ltd, New York, NY, USA, 903: 13-35, (2016).

  9. The dependence of C IV broad absorption line properties on accompanying Si IV and Al III absorption: relating quasar-wind ionization levels, kinematics, and column densities

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Filiz Ak, N.; Brandt, W. N.; Schneider, D. P.

    2014-08-20

    We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line of sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for Cmore » IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines of sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C IV BALs with no accompanying Si IV or Al III BALs may have only mild or no saturation.« less

  10. A survey on anticancer effects of artemisinin, iron, miconazole, and butyric acid on 5637 (bladder cancer) and 4T1 (Breast cancer) cell lines.

    PubMed

    Shahbazfar, Amir Ali; Zare, Payman; Ranjbaran, Mehrdad; Tayefi-Nasrabadi, Hossein; Fakhri, Omid; Farshi, Yashar; Shadi, Sahar; Khoshkerdar, Afsaneh

    2014-01-01

    Anticancer properties of artemisinin and its derivatives have been shown in many experiments. Addition of butyric acid, miconazole, and iron to this traditional drug has been done in order to enhance its anticancer potency. Cell lines 5637 and 4T1, were cultivated and classified into 13 groups of three each. Different doses of artemisinin with constant doses of iron, miconazole and butyric acid, were added to the cultures. At the end of exposure pathological and enzymatic studies were performed. In four groups treated with different doses of artemisinin and iron, dose-dependent changes were observed. These changes included apoptosis and necrosis with dominance of apoptosis. The supernatant lactate dehydrogenase (LDH) level was increased in a dose-dependent manner, but there was no significant increase in the cell fraction of malonyldialdehyde (MDA) or LDH. In four other groups, which received miconazole, butyric acid and iron in addition to different doses of artemisinin, necrosis was more prominent than apoptosis, and the MDA level did not show any significant change, but LDH was increased. The groups treated with miconazole showed identical changes, with less severity compared to combination therapy groups. In butyric acid-treated groups, the only detectable changes were, mild cell swelling, few apoptosis, and rare necrosis. A combination therapy with artemisinin can be more effective against cancer cells than monotherapy with that. Butyric acid was not effective on cancer cells. Miconazole deviated the nature of cell death from apoptosis to necrosis and it must be used under caution.

  11. Characterizing the Iron Wash fault: A fault line scarp in Utah

    NASA Astrophysics Data System (ADS)

    Kozaci, O.; Ostenaa, D.; Goodman, J.; Zellman, M.; Hoeft, J.; Sowers, J. M.; Retson, T.

    2015-12-01

    The Iron Wash fault (IWF) is an approximately 30 mile-long, NW-SE trending structure, oriented perpendicular to the San Rafael Monocline near Green River in Utah. IWF exhibits well-expressed geomorphic features such as a linear escarpment with consistently north side down displacement. The fault coincides with an abrupt change in San Rafael Monocline dip angle along its eastern margin. The IWF is exposed in incised drainages where Jurassic Navajo sandstone (oldest) and Lower Carmel Formation (old), are juxtaposed against Jurassic Entrada sandstone (younger) and Quaternary alluvium (youngest). To assess the recency of activity of the IWF we performed detailed geomorphic mapping and a paleoseismic trenching investigation. A benched trench was excavated across a Quaternary fluvial terrace remnant across the mapped trace of the IWF. The uppermost gravel units and overlying colluvium are exposed in the trench across the projection of the fault. In addition, we mapped the basal contact of the Quaternary gravel deposit in relation to the adjacent fault exposures in detail to show the geometry of the basal contact near and across the fault. We find no evidence of vertical displacement of these Quaternary gravels. A preliminary U-series date of calcite cementing unfaulted fluvial gravels and OSL dating of a sand lens within the unfaulted fluvial gravels yielded approximately 304,000 years and 78,000 years, respectively. These preliminary results of independent dating methods constrains the timing of last activity of the IWF to greater than 78,000 years before present suggesting that IWF not an active structure. Its distinct geomorphic expression is most likely the result of differential erosion, forming a fault-line scarp.

  12. Iron overload in patients with myelodysplastic syndromes: An updated overview.

    PubMed

    Moukalled, Nour M; El Rassi, Fuad A; Temraz, Sally N; Taher, Ali T

    2018-06-15

    Myelodysplastic syndromes (MDS) encompass a heterogeneous group of clonal hematopoietic stem cell disorders characterized by a broad clinical spectrum related to ineffective hematopoiesis leading to unilineage or multilineage cytopenias, with a high propensity for transformation to acute myeloid leukemia. Iron overload has been recently identified as one of the important conditions complicating the management of these diverse disorders. The accumulation of iron is mainly related to chronic transfusions; however, evidence suggests a possible role for ineffective erythropoiesis and increased intestinal absorption of iron, related to altered hepcidin and growth differentiation factor-15 levels in the development of hemosiderosis in patients with MDS. In addition to its suggested role in the exacerbation of ineffective erythropoiesis, multiple reports have identified a prognostic implication for the development of iron overload in patients with MDS, with an improvement in overall survival after the initiation of iron chelation therapy. This review includes a detailed discussion of iron overload in patients with MDS whether they are undergoing supportive therapy or curative hematopoietic stem cell transplantation, with a focus on the mechanism, diagnosis, and effect on survival as well as the optimal management of this highly variable complication. Cancer 2018. © 2018 American Cancer Society. © 2018 American Cancer Society.

  13. The Diagnostic Potential of Fe Lines Applied to Protostellar Jets

    NASA Astrophysics Data System (ADS)

    Giannini, T.; Nisini, B.; Antoniucci, S.; Alcalá, J. M.; Bacciotti, F.; Bonito, R.; Podio, L.; Stelzer, B.; Whelan, E. T.

    2013-11-01

    We investigate the diagnostic capabilities of iron lines for tracing the physical conditions of shock-excited gas in jets driven by pre-main sequence stars. We have analyzed the 3000-25000 Å, X-shooter spectra of two jets driven by the pre-main sequence stars ESO-Hα 574 and Par-Lup 3-4. Both spectra are very rich in [Fe II] lines over the whole spectral range; in addition, lines from [Fe III] are detected in the ESO-Hα 574 spectrum. Non-local thermal equilibrium codes solving the equations of the statistical equilibrium along with codes for the ionization equilibrium are used to derive the gas excitation conditions of electron temperature and density and fractional ionization. An estimate of the iron gas-phase abundance is provided by comparing the iron lines emissivity with that of neutral oxygen at 6300 Å. The [Fe II] line analysis indicates that the jet driven by ESO-Hα 574 is, on average, colder (T e ~ 9000 K), less dense (n e ~ 2 × 104 cm-3), and more ionized (x e ~ 0.7) than the Par-Lup 3-4 jet (T e ~ 13,000 K, n e ~ 6 × 104 cm-3, x e < 0.4), even if the existence of a higher density component (n e ~ 2 × 105 cm-3) is probed by the [Fe III] and [Fe II] ultra-violet lines. The physical conditions derived from the iron lines are compared with shock models suggesting that the shock at work in ESO-Hα 574 is faster and likely more energetic than the Par-Lup 3-4 shock. This latter feature is confirmed by the high percentage of gas-phase iron measured in ESO-Hα 574 (50%-60% of its solar abundance in comparison with less than 30% in Par-Lup 3-4), which testifies that the ESO-Hα 574 shock is powerful enough to partially destroy the dust present inside the jet. This work demonstrates that a multiline Fe analysis can be effectively used to probe the excitation and ionization conditions of the gas in a jet without any assumption on ionic abundances. The main limitation on the diagnostics resides in the large uncertainties of the atomic data, which, however, can

  14. Diagnosis and treatment of iron-deficiency anaemia in pregnancy and postpartum.

    PubMed

    Breymann, C; Honegger, C; Hösli, I; Surbek, D

    2017-12-01

    Iron deficiency occurs frequently in pregnancy and can be diagnosed by serum ferritin-level measurement (threshold value < 30 μg/L). Screening for iron-deficiency anemia is recommended in every pregnant women, and should be done by serum ferritin-level screening in the first trimester and regular hemoglobin checks at least once per trimester. In the case of iron deficiency with or without anaemia in pregnancy, oral iron therapy should be given as first-line treatment. In the case of severe iron-deficiency anemia, intolerance of oral iron, lack of response to oral iron, or in the case of a clinical need for rapid and efficient treatment of anaemia (e.g., advanced pregnancy), intravenous iron therapy should be administered. In the postpartum period, oral iron therapy should be administered for mild iron-deficiency anemia (haemorrhagic anemia), and intravenous iron therapy for moderately severe-to-severe anemia (Hb < 95 g/L). If there is an indication for intravenous iron therapy in pregnancy or postpartum, iron-containing drugs which have been studied in well-controlled clinical trials in pregnancy and postpartum such as ferric carboxymaltose must be preferred for safety reasons. While anaphylactic reactions are extremely are with non-dextrane products, close surveillance during administration is recommended for all intravenous iron products.

  15. Iron deficiency intravenous substitution in a Swiss academic primary care division: analysis of practices

    PubMed Central

    Varcher, Monica; Zisimopoulou, Sofia; Braillard, Olivia; Favrat, Bernard; Junod Perron, Noëlle

    2016-01-01

    Background Iron deficiency is a common problem in primary care and is usually treated with oral iron substitution. With the recent simplification of intravenous (IV) iron administration (ferric carboxymaltose) and its approval in many countries for iron deficiency, physicians may be inclined to overutilize it as a first-line substitution. Objective The aim of this study was to evaluate iron deficiency management and substitution practices in an academic primary care division 5 years after ferric carboxymaltose was approved for treatment of iron deficiency in Switzerland. Methods All patients treated for iron deficiency during March and April 2012 at the Geneva University Division of Primary Care were identified. Their medical files were analyzed for information, including initial ferritin value, reasons for the investigation of iron levels, suspected etiology, type of treatment initiated, and clinical and biological follow-up. Findings were assessed using an algorithm for iron deficiency management based on a literature review. Results Out of 1,671 patients, 93 were treated for iron deficiency. Median patients’ age was 40 years and 92.5% (n=86) were female. The average ferritin value was 17.2 μg/L (standard deviation 13.3 μg/L). The reasons for the investigation of iron levels were documented in 82% and the suspected etiology for iron deficiency was reported in 67%. Seventy percent of the patients received oral treatment, 14% IV treatment, and 16% both. The reasons for IV treatment as first- and second-line treatment were reported in 57% and 95%, respectively. Clinical and biological follow-up was planned in less than two-thirds of the cases. Conclusion There was no clear overutilization of IV iron substitution. However, several steps of the iron deficiency management were not optimally documented, suggesting shortcuts in clinical reasoning. PMID:27445502

  16. Iron Homeostasis and Nutritional Iron Deficiency123

    PubMed Central

    Theil, Elizabeth C.

    2011-01-01

    Nonheme food ferritin (FTN) iron minerals, nonheme iron complexes, and heme iron contribute to the balance between food iron absorption and body iron homeostasis. Iron absorption depends on membrane transporter proteins DMT1, PCP/HCP1, ferroportin (FPN), TRF2, and matriptase 2. Mutations in DMT1 and matriptase-2 cause iron deficiency; mutations in FPN, HFE, and TRF2 cause iron excess. Intracellular iron homeostasis depends on coordinated regulation of iron trafficking and storage proteins encoded in iron responsive element (IRE)-mRNA. The noncoding IRE-mRNA structures bind protein repressors, IRP1 or 2, during iron deficiency. Integration of the IRE-RNA in translation regulators (near the cap) or turnover elements (after the coding region) increases iron uptake (DMT1/TRF1) or decreases iron storage/efflux (FTN/FPN) when IRP binds. An antioxidant response element in FTN DNA binds Bach1, a heme-sensitive transcription factor that coordinates expression among antioxidant response proteins like FTN, thioredoxin reductase, and quinone reductase. FTN, an antioxidant because Fe2+ and O2 (reactive oxygen species generators) are consumed to make iron mineral, is also a nutritional iron concentrate that is an efficiently absorbed, nonheme source of iron from whole legumes. FTN protein cages contain thousands of mineralized iron atoms and enter cells by receptor-mediated endocytosis, an absorption mechanism distinct from transport of nonheme iron salts (ferrous sulfate), iron chelators (ferric-EDTA), or heme. Recognition of 2 nutritional nonheme iron sources, small and large (FTN), will aid the solution of iron deficiency, a major public health problem, and the development of new policies on iron nutrition. PMID:21346101

  17. THE LICK AGN MONITORING PROJECT 2011: SPECTROSCOPIC CAMPAIGN AND EMISSION-LINE LIGHT CURVES

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Barth, Aaron J.; Bennert, Vardha N.; Canalizo, Gabriela

    2015-04-15

    In the Spring of 2011 we carried out a 2.5 month reverberation mapping campaign using the 3 m Shane telescope at Lick Observatory, monitoring 15 low-redshift Seyfert 1 galaxies. This paper describes the observations, reductions and measurements, and data products from the spectroscopic campaign. The reduced spectra were fitted with a multicomponent model in order to isolate the contributions of various continuum and emission-line components. We present light curves of broad emission lines and the active galactic nucleus (AGN) continuum, and measurements of the broadline widths in mean and rms spectra. For the most highly variable AGNs wemore » also measured broadline widths and velocity centroids from the nightly spectra. In four AGNs exhibiting the highest variability amplitudes, we detect anticorrelations between broad Hβ width and luminosity, demonstrating that the broad-line region “breathes” on short timescales of days to weeks in response to continuum variations. We also find that broad Hβ velocity centroids can undergo substantial changes in response to continuum variations; in NGC 4593, the broad Hβ velocity shifted by ∼250 km s{sup −1} over a 1 month period. This reverberation-induced velocity shift effect is likely to contribute a significant source of confusion noise to binary black hole searches that use multi-epoch quasar spectroscopy to detect binary orbital motion. We also present results from simulations that examine biases that can occur in measurement of broad-line widths from rms spectra due to the contributions of continuum variations and photon-counting noise.« less

  18. The Lick AGN Monitoring Project 2011: Spectroscopic Campaign and Emission-line Light Curves

    NASA Technical Reports Server (NTRS)

    Barth, Aaron J.; Bennert, Vardha N.; Canalizo, Gabriela; Filippenko, Alexei V.; Gates, Elinor L.; Greene, Jenny E..; Li, Weidong; Malkan, Matthew A.; Pancoast, Anna; Sand, David J.; hide

    2016-01-01

    In the Spring of 2011 we carried out a 2.5 month reverberation mapping campaign using the 3 m Shane telescope at Lick Observatory, monitoring 15 low-redshift Seyfert 1 galaxies. This paper describes the observations, reductions and measurements, and data products from the spectroscopic campaign. The reduced spectra were fitted with a multicomponent model in order to isolate the contributions of various continuum and emission-line components. We present light curves of broad emission lines and the active galactic nucleus (AGN) continuum, and measurements of the broadline widths in mean and rms spectra. For the most highly variable AGNs we also measured broad H beta line widths and velocity centroids from the nightly spectra. In four AGNs exhibiting the highest variability amplitudes, we detect anticorrelations between broad H beta width and luminosity, demonstrating that the broad-line region "breathes" on short timescales of days to weeks in response to continuum variations. We also find that broad H beta velocity centroids can undergo substantial changes in response to continuum variations; in NGC 4593, the broad H beta velocity shifted by approximately 250 km s(exp -1) over a 1 month period. This reverberation-induced velocity shift effect is likely to contribute a significant source of confusion noise to binary black hole searches that use multi-epoch quasar spectroscopy to detect binary orbital motion. We also present results from simulations that examine biases that can occur in measurement of broad-line widths from rms spectra due to the contributions of continuum variations and photon-counting noise.

  19. Deferiprone therapy for transfusional iron overload.

    PubMed

    Victor Hoffbrand, A

    2005-06-01

    Iron chelation is needed to prevent damage to the heart, liver and endocrine glands from iron overload in patients with refractory anaemias who receive regular blood transfusions. Desferrioxamine is still the first-line drug, but because of its expense in many countries, and lack of compliance because of difficulty with administration, there is a major need for an orally active (and cheaper) chelating drug. Seventeen years after the first clinical trials deferiprone, which is orally active, has emerged as suitable for patients for whom desferrioxamine is, for one reason or another, inadequate. Many patients are successfully chelated at a dose of deferiprone 75 mg/kg/day. Some patients may need higher doses (up to 100 mg/kg), or combination therapy of deferiprone every day and desferrioxamine on several days each week. Recent data suggest that deferiprone may be superior to desferrioxamine at protecting the heart from iron overload. The side-effects of deferiprone--agranulocytosis, neutropenia, gastrointestinal symptoms, arthropathy, transient changes in liver enzymes, and zinc deficiency--are now well recognized; they result in discontinuation of the drug in only 5-10% of patients. Deferiprone is now licensed in 43 countries for thalassaemia major patients for whom desferrioxamine is inadequate. If results of current trials confirm its superiority at reducing cardiac damage, it may well become the first-line drug for many patients.

  20. Broad NE 8 lambda 774 emission from quasars in the HST-FOS snapshot survey (ABSNAP)

    NASA Technical Reports Server (NTRS)

    Hamann, Fred; Zuo, Lin; Tytler, David

    1995-01-01

    We discuss the strength and frequency of broad Ne VIII lambda 774 emission from quasars measured in the Hubble Space Telescope Faint Object Spectrograph (HST-FOS) snapshot survey (Absnap). Five sources in the survey have suitable redshifts (0.86 less than or equal to Z(sub em) less than or equal to 1.31), signal-to-noise ratios and no Lyman limit absorptions. Three of the five sources have a strong broad emission line near 774 A (rest), and the remaining two sources have a less securely measured line near this wavelength. We identify these lines with Ne VIII lambda 774 based on the measured wavelengths and theoretical estimates of various line fluxes (Hamann et al. 1995a). Secure Ne VIII detections occur in both radio-loud and radio-quiet sources. We tentatively conclude that broad Ne VIII lambda 774 emission is common in quasars, with typical strengths between approximately 25% and approximately 200% of O VI lambda 1034. These Ne VIII lambda 774 measurements imply that the broad emission line regions have a much hotter and more highly ionized component than previously recognized. They also suggest that quasar continua have substantial ionizing flux out to energies greater than 207 eV (greater than 15.2 ryd, lambda less than 60 A). Photoionization calculations using standard incident spectra indicate that the Ne VIII emission requires ionization parameters U greater than or = 5, total column densities N(sub H) greater than or = 10(sub 22)/sq cm and covering factors greater than or = 25%. The temperatures could be as high as approximately 10(exp 5) K. If the gas is instead collisionally ionized, strong Ne VIII would imply equilibrium temperatures in the range approximately 400,000 less than or approximately = T(sub e) less than or approximately = 10(exp 6) K. In either case, the highly ionized Ne VIII emission regions would appear as X-ray 'warm absorbers' if they lie along our line of sight to the X-ray continuum source.

  1. Nitric oxide-mediated modulation of iron regulatory proteins: implication for cellular iron homeostasis.

    PubMed

    Kim, Sangwon; Ponka, Prem

    2002-01-01

    Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) that are located in the 3' untranslated region (UTR) and the 5' UTR of their respective mRNAs. Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin. Moreover, NO(.), a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels and a decrease in ferritin synthesis. We have shown that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO(+) (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA-binding of IRP2, followed by IRP2 degradation, and these changes were associated with a decrease in TfR mRNA levels and a dramatic increase in ferritin synthesis. Moreover, we demonstrated that stimulation of RAW 264.7 cells with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) increased IRP1 binding activity, whereas RNA-binding of IRP2 decreased and was followed by a degradation of this protein. Furthermore, the decrease of IRP2 binding/protein levels was associated with a decrease in TfR mRNA levels and an increase in ferritin synthesis in LPS/IFN-gamma-treated cells, and these changes were prevented by inhibitors of inducible nitric oxide synthase. These results suggest that NO(+)-mediated degradation of IRP2 plays a major role in iron metabolism during inflammation.

  2. The near-infrared broad emission line region of active galactic nuclei - II. The 1-μm continuum

    NASA Astrophysics Data System (ADS)

    Landt, Hermine; Elvis, Martin; Ward, Martin J.; Bentz, Misty C.; Korista, Kirk T.; Karovska, Margarita

    2011-06-01

    We use quasi-simultaneous near-infrared (near-IR) and optical spectroscopy from four observing runs to study the continuum around 1 μm in 23 well-known broad emission line active galactic nuclei (AGN). We show that, after correcting the optical spectra for host galaxy light, the AGN continuum around this wavelength can be approximated by the sum of mainly two emission components, a hot dust blackbody and an accretion disc. The accretion disc spectrum appears to dominate the flux at ˜ 1 μm, which allows us to derive a relation for estimating AGN black hole masses based on the near-IR virial product. This result also means that a near-IR reverberation programme can determine the AGN state independent of simultaneous optical spectroscopy. On average we derive hot dust blackbody temperatures of ˜1400 K, a value close to the sublimation temperature of silicate dust grains, and relatively low hot dust covering factors of ˜7 per cent. Our preliminary variability studies indicate that in most sources, the hot dust emission responds to changes in the accretion disc flux with the expected time lag; however, a few sources show a behaviour that can be attributed to dust destruction.

  3. Spectral Analysis of the Accretion Flow in NGC 1052 with Suzaku

    NASA Technical Reports Server (NTRS)

    Brenneman, L. W.; Weaver, K. A.; Kadler, M.; Tueller, J.; Marscher, A.; Ros, E.; Zensus,A.; Kovalev, Y. Y.; Aller, M.; Aller, H.; hide

    2008-01-01

    We present an analysis of the 101 ks, 2007 Suzaku spectrum of the LINER galaxy NGC 1052. The 0:3..10 keV continuum is well-modeled by a power-law continuum modified by Galactic and intrinsic absorption, and exhibits a soft, thermal emission component below 1 keV. Both a narrow core and a broader component of Fe-Ka emission are robustly detected at 6:4 keV. While the narrow line is consistent with an origin in material distant from the black hole, the broad line is best fit empirically by a model that describes fluorescent emission from the inner accretion disk around a rapidly rotating black hole. We find no direct evidence for Comptonized reflection of the hard X-ray source by the disk above 10 keV, however, which casts doubt on the hypothesis that the broad iron line is produced in a standard accretion disk. We explore other possible scenarios for producing this spectral feature and conclude that the high equivalent width and full width half maximum velocity of the broad iron line (v greater than or equals 0:37c) necessitate an origin within d approx. 8r(sub g) of the hard X-ray source. Based on the confirmed presence of a strong radio jet in this source, the broad iron line may be produced in dense plasma at the base of the jet, implying that emission mechanisms in the central-most portions of active galactic nuclei are more complex than previously thought.

  4. A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium

    PubMed Central

    Slavic, Ksenija; Krishna, Sanjeev; Lahree, Aparajita; Bouyer, Guillaume; Hanson, Kirsten K.; Vera, Iset; Pittman, Jon K.; Staines, Henry M.; Mota, Maria M.

    2016-01-01

    Iron is an essential micronutrient but is also highly toxic. In yeast and plant cells, a key detoxifying mechanism involves iron sequestration into intracellular storage compartments, mediated by members of the vacuolar iron-transporter (VIT) family of proteins. Here we study the VIT homologue from the malaria parasites Plasmodium falciparum (PfVIT) and Plasmodium berghei (PbVIT). PfVIT-mediated iron transport in a yeast heterologous expression system is saturable (Km∼14.7 μM), and selective for Fe2+ over other divalent cations. PbVIT-deficient P. berghei lines (Pbvit−) show a reduction in parasite load in both liver and blood stages of infection in mice. Moreover, Pbvit− parasites have higher levels of labile iron in blood stages and are more sensitive to increased iron levels in liver stages, when compared with wild-type parasites. Our data are consistent with Plasmodium VITs playing a major role in iron detoxification and, thus, normal development of malaria parasites in their mammalian host. PMID:26786069

  5. A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium.

    PubMed

    Slavic, Ksenija; Krishna, Sanjeev; Lahree, Aparajita; Bouyer, Guillaume; Hanson, Kirsten K; Vera, Iset; Pittman, Jon K; Staines, Henry M; Mota, Maria M

    2016-01-20

    Iron is an essential micronutrient but is also highly toxic. In yeast and plant cells, a key detoxifying mechanism involves iron sequestration into intracellular storage compartments, mediated by members of the vacuolar iron-transporter (VIT) family of proteins. Here we study the VIT homologue from the malaria parasites Plasmodium falciparum (PfVIT) and Plasmodium berghei (PbVIT). PfVIT-mediated iron transport in a yeast heterologous expression system is saturable (Km ∼ 14.7 μM), and selective for Fe(2+) over other divalent cations. PbVIT-deficient P. berghei lines (Pbvit(-)) show a reduction in parasite load in both liver and blood stages of infection in mice. Moreover, Pbvit(-) parasites have higher levels of labile iron in blood stages and are more sensitive to increased iron levels in liver stages, when compared with wild-type parasites. Our data are consistent with Plasmodium VITs playing a major role in iron detoxification and, thus, normal development of malaria parasites in their mammalian host.

  6. [EPR study of iron status in human body during intensive physical activity].

    PubMed

    Ibragimova, M I; Chushnikov, A I; Cherepnev, G V; Petukhov, V Iu; Zheglov, E P

    2014-01-01

    The iron metabolism was studied in serum blood samples collected from 26 professional sportsmen undergoing intensive physical exercises using EPR combined with haematological and biochemical laboratory tests. Only 23% of EPR spectra (n = 6) were practically normal while in the rest spectra additional abnormal absorption lines were detected. Presumably, the significant portion of new signals may be caused by different cytochromes. Moreover, the anisotropic signals with g1 approximately equal to 2.02; g2 approximately equal to 1.94 and g3 approximately equal to 1.86 registered in some spectra pointed to the sulfur-iron centers. There was nearly linear correlation between the concentration of Fe3+ in transfferin (Fe(3+)-Tf) obtained from the EPR spectra and the serum iron concentration measured by absorption photometry both for sportsmen and controls (healthy individuals and patients with different diseases). At equal serum iron concentrations the Fe(3+)-Tf level was higher in sportsmen than that in controls. The Pearson correlation coefficient (r) for Fe(3+)-Tf and serum iron values was equal to 0.89 in sportsmen versus r = 0.97 in controls. Additional new lines in serum EPR spectra of professional sportsmen prove the suitability of EPR assay for scheduled medical exams since routinebiochemical and haematological tests are insufficient to discover all abnormalities in iron metabolism under intensive physical exercises.

  7. Lithium suppression of tau induces brain iron accumulation and neurodegeneration.

    PubMed

    Lei, P; Ayton, S; Appukuttan, A T; Moon, S; Duce, J A; Volitakis, I; Cherny, R; Wood, S J; Greenough, M; Berger, G; Pantelis, C; McGorry, P; Yung, A; Finkelstein, D I; Bush, A I

    2017-03-01

    Lithium is a first-line therapy for bipolar affective disorder. However, various adverse effects, including a Parkinson-like hand tremor, often limit its use. The understanding of the neurobiological basis of these side effects is still very limited. Nigral iron elevation is also a feature of Parkinsonian degeneration that may be related to soluble tau reduction. We found that magnetic resonance imaging T 2 relaxation time changes in subjects commenced on lithium therapy were consistent with iron elevation. In mice, lithium treatment lowers brain tau levels and increases nigral and cortical iron elevation that is closely associated with neurodegeneration, cognitive loss and parkinsonian features. In neuronal cultures lithium attenuates iron efflux by lowering tau protein that traffics amyloid precursor protein to facilitate iron efflux. Thus, tau- and amyloid protein precursor-knockout mice were protected against lithium-induced iron elevation and neurotoxicity. These findings challenge the appropriateness of lithium as a potential treatment for disorders where brain iron is elevated (for example, Alzheimer's disease), and may explain lithium-associated motor symptoms in susceptible patients.

  8. Nasca Lines, Peru

    NASA Image and Video Library

    2001-10-22

    The Nasca Lines are located in the Pampa region of Peru, the desolate plain of the Peruvian coast 400 km south of Lima. The Lines were first spotted when commercial airlines began flying across the Peruvian desert in the 1920's. Passengers reported seeing 'primitive landing strips' on the ground below. The Lines were made by removing the iron-oxide coated pebbles which cover the surface of the desert. When the gravel is removed, they contrast with the light color underneath. In this way the lines were drawn as furrows of a lighter color. On the pampa, south of the Nasca Lines, archaeologists have now uncovered the lost city of the line-builders, Cahuachi. It was built nearly two thousand years ago and was mysteriously abandoned 500 years later. This ASTER sub-image covers an area of 14 x 18 km, was acquired on December 22, 2000, and is located at 14.7 degrees south latitude and 75.1 degrees west longitude. http://photojournal.jpl.nasa.gov/catalog/PIA11097

  9. The role of ferric carboxymaltose in the treatment of iron deficiency anemia in patients with gastrointestinal disease.

    PubMed

    Koduru, Pramoda; Abraham, Bincy P

    2016-01-01

    Iron deficiency anemia (IDA) is the most common form of nutritional anemia worldwide. Iron plays a pivotal role in vital functioning of almost every organ system. IDA affects both physical and psychological functioning of humans. Oral iron is considered as first-line therapy for the treatment of IDA due to low cost, good safety profile and ease of administration. However, the absorption of oral iron is affected by several factors and incidence of gastrointestinal side effects can lead to lack of adherence to therapy as well as poor efficacy. This has led to the emergence of intravenous iron therapy which is clearly superior to oral iron with higher increment of hemoglobin levels and rapid replenishment of iron stores. Ferric carboxymaltose (FCM) is a novel non-dextran intravenous iron form which has been approved for use in patients with iron deficiency who have had inadequate response to oral iron therapy, intolerance to oral iron, or nondialysis-dependent chronic kidney disease. The safety and efficacy of using FCM for the treatment of IDA has been demonstrated in several clinical trials. One dose can provide a large amount of iron and has a very short infusion time. It should be considered as first-line therapy in patients with active inflammation like inflammatory bowel disease when gastrointestinal absorption of oral iron may be compromised. It should also be given to patients who have inadequate response to oral iron therapy. It has been shown to be noninferior to other intravenous iron formulations with a good safety profile and produced fewer anaphylactic reactions.

  10. Prion protein modulates glucose homeostasis by altering intracellular iron.

    PubMed

    Ashok, Ajay; Singh, Neena

    2018-04-26

    The prion protein (PrP C ), a mainly neuronal protein, is known to modulate glucose homeostasis in mouse models. We explored the underlying mechanism in mouse models and the human pancreatic β-cell line 1.1B4. We report expression of PrP C on mouse pancreatic β-cells, where it promoted uptake of iron through divalent-metal-transporters. Accordingly, pancreatic iron stores in PrP knockout mice (PrP -/- ) were significantly lower than wild type (PrP +/+ ) controls. Silencing of PrP C in 1.1B4 cells resulted in significant depletion of intracellular (IC) iron, and remarkably, upregulation of glucose transporter GLUT2 and insulin. Iron overloading, on the other hand, resulted in downregulation of GLUT2 and insulin in a PrP C -dependent manner. Similar observations were noted in the brain, liver, and neuroretina of iron overloaded PrP +/+ but not PrP -/- mice, indicating PrP C -mediated modulation of insulin and glucose homeostasis through iron. Peripheral challenge with glucose and insulin revealed blunting of the response in iron-overloaded PrP +/+ relative to PrP -/- mice, suggesting that PrP C -mediated modulation of IC iron influences both secretion and sensitivity of peripheral organs to insulin. These observations have implications for Alzheimer's disease and diabetic retinopathy, known complications of type-2-diabetes associated with brain and ocular iron-dyshomeostasis.

  11. Evidence for the equality of the solar photospheric and coronal abundance of iron

    NASA Technical Reports Server (NTRS)

    Phillips, K. J. H.; Pike, C. D.; Lang, J.; Zarro, D. M.; Fludra, A.; Watanabe, T.; Takahashi, M.

    1995-01-01

    The Fe K-alpha and K-beta X-ray lines (wavelengths 1.94 and 1.76 A) in the solar X-ray spectrum are formed by fluoroescence of photospheric iron atoms, and the ratio of the intensity of either to the He-like iron (Fe XXV) resonance line at 1.85 A is a function of the photospheric-to-coronal abundance of iron. The temperature dependence of this ratio is weak as long as the flare temperature T(sub e) greater than or approximately equal to 15 x 10(exp 6)K. Comparison of the theoretical value of this intensity ratio with observations from crystal spectrometers on Yohkoh, Solar Maximum Mission (SMM) and P78-1 are consistent with the photospheric abundance of Fe being equal to the coronal.

  12. Iron and oxygen isotope fractionation during iron UV photo-oxidation: Implications for early Earth and Mars

    NASA Astrophysics Data System (ADS)

    Nie, Nicole X.; Dauphas, Nicolas; Greenwood, Richard C.

    2017-01-01

    Banded iron formations (BIFs) contain appreciable amounts of ferric iron (Fe3+). The mechanism by which ferrous iron (Fe2+) was oxidized into Fe3+ in an atmosphere that was globally anoxic is highly debated. Of the three scenarios that have been proposed to explain BIF formation, photo-oxidation by UV photons is the only one that does not involve life (the other two are oxidation by O2 produced by photosynthesis, and anoxygenic photosynthesis whereby Fe2+ is directly used as electron donor in place of water). We experimentally investigated iron and oxygen isotope fractionation imparted by iron photo-oxidation at a pH of 7.3. The iron isotope fractionation between precipitated Fe3+-bearing lepidocrocite and dissolved Fe2+ follows a Rayleigh distillation with an instantaneous 56Fe/54Fe fractionation factor of + 1.2 ‰. Such enrichment in the heavy isotopes of iron is consistent with the values measured in BIFs. We also investigated the nature of the mass-fractionation law that governs iron isotope fractionation in the photo-oxidation experiments (i.e., the slope of the δ56Fe-δ57Fe relationship). The experimental run products follow a mass-dependent law corresponding to the high-T equilibrium limit. The fact that a ∼3.8 Gyr old BIF sample (IF-G) from Isua (Greenland) falls on the same fractionation line confirms that iron photo-oxidation in the surface layers of the oceans was a viable pathway to BIF formation in the Archean, when the atmosphere was largely transparent to UV photons. Our experiments allow us to estimate the quantum yield of the photo-oxidation process (∼0.07 iron atom oxidized per photon absorbed). This yield is used to model iron oxidation on early Mars. As the photo-oxidation proceeds, the aqueous medium becomes more acidic, which slows down the reaction by changing the speciation of iron to species that are less efficient at absorbing UV-photons. Iron photo-oxidation in centimeter to meter-deep water ponds would take months to years to

  13. Variation and inheritance of iron reductase activity in the roots of common bean (Phaseolus vulgaris L.) and association with seed iron accumulation QTL.

    PubMed

    Blair, Matthew W; Knewtson, Sharon Jb; Astudillo, Carolina; Li, Chee-Ming; Fernandez, Andrea C; Grusak, Michael A

    2010-10-05

    Iron deficiency anemia is a global problem which often affects women and children of developing countries. Strategy I plants, such as common bean (Phaseolus vulgaris L.) take up iron through a process that involves an iron reduction mechanism in their roots; this reduction is required to convert ferric iron to ferrous iron. Root absorbed iron is critical for the iron nutrition of the plant, and for the delivery of iron to the shoot and ultimately the seeds. The objectives of this study were to determine the variability and inheritance for iron reductase activity in a range of genotypes and in a low × high seed iron cross (DOR364 x G19833), to identify quantitative trait loci (QTL) for this trait, and to assess possible associations with seed iron levels. The experiments were carried out with hydroponically grown plants provided different amounts of iron varying between 0 and 20 μM Fe(III)-EDDHA. The parents, DOR364 and G19833, plus 13 other cultivated or wild beans, were found to differ in iron reductase activity. Based on these initial experiments, two growth conditions (iron limited and iron sufficient) were selected as treatments for evaluating the DOR364 × G19833 recombinant inbred lines. A single major QTL was found for iron reductase activity under iron-limited conditions (1 μM Fe) on linkage group b02 and another major QTL was found under iron sufficient conditions (15 μM Fe) on linkage group b11. Associations between the b11 QTL were found with several QTL for seed iron. Genes conditioning iron reductase activity in iron sufficient bean plants appear to be associated with genes contributing to seed iron accumulation. Markers for bean iron reductase (FRO) homologues were found with in silico mapping based on common bean synteny with soybean and Medicago truncatula on b06 and b07; however, neither locus aligned with the QTL for iron reductase activity. In summary, the QTL for iron reductase activity under iron limited conditions may be useful in

  14. Nustar Reveals an Intrinsically X-ray Weak Broad Absorption Line Quasar in the Ultraluminous Infrared Galaxy Markarian 231

    NASA Technical Reports Server (NTRS)

    Teng, Stacy H.; Brandt. W. N.; Harrison, F. A.; Luo, B.; Alexander, D. M.; Bauer, F. E.; Boggs, S. E.; Christensen, F. E.; Comastri, A.; Craig, W. W.; hide

    2014-01-01

    We present high-energy (3-30 keV) NuSTAR observations of the nearest quasar, the ultraluminous infrared galaxy (ULIRG) Markarian 231 (Mrk 231), supplemented with new and simultaneous low-energy (0.5-8 keV) data from Chandra. The source was detected, though at much fainter levels than previously reported, likely due to contamination in the large apertures of previous non-focusing hard X-ray telescopes. The full band (0.5-30 keV) X-ray spectrum suggests the active galactic nucleus (AGN) in Mrk 231 is absorbed by a patchy and Compton-thin N(sub H) approx. 1.2(sup +0.3) sub-0.3) x 10(exp 23) / sq cm) column. The intrinsic X-ray luminosity L(sub 0.5-30 Kev) approx. 1.0 x 10(exp 43) erg /s) is extremely weak relative to the bolometric luminosity where the 2-10 keV to bolometric luminosity ratio is approx. 0.03% compared to the typical values of 2-15%. Additionally, Mrk 231 has a low X-ray-to-optical power law slope alpha(sub 0X) approx. -1.7. It is a local example of a low-ionization broad absorption line (LoBAL) quasar that is intrinsically X-ray weak. The weak ionizing continuum may explain the lack of mid-infrared [O IV], [Ne V], and [Ne VI] fine-structure emission lines which are present in sources with otherwise similar AGN properties. We argue that the intrinsic X-ray weakness may be a result of the super-Eddington accretion occurring in the nucleus of this ULIRG, and may also be naturally related to the powerful wind event seen in Mrk 231, a merger remnant escaping from its dusty cocoon.

  15. Measurements of Anisotropy in Non-LTE Low-Density, Iron-Vanadium Plasmas

    NASA Astrophysics Data System (ADS)

    Jarrott, L. C.; Foord, M. E.; Heeter, R. F.; Liedahl, D. A.; Barrios, M. A.; Brown, G. V.; Gray, W.; Marley, E. V.; Mauche, C. W.; Widmann, K.; Schneider, M. B.

    2016-10-01

    We report on Non-LTE anisotropy experiments carried out on the Omega Laser Facility at the Laboratory for Laser Energetics, Rochester NY. In these experiments, a 50/50 mixture of iron and vanadium, 2000A thick and 250um in diameter is contained within a beryllium tamper, 10um thick and 1000um in diameter. Each side of the beryllium tamper is then irradiated using 52 of the 60 Omega beams with an intensity of 3e14 W/cm2 over 3ns in duration. Iron-Vanadium line ratios indicate a plasma temperature of greater than 2 keV was produced. The geometrical aspect ratio ranged from 0.8 to 4.0; allowing for the characterization of optical-depth-dependent anisotropy in the iron-vanadium line emission. Results of this characterization and its comparison with modeling will be presented. This work performed under the auspices of U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DE-AC52-07NA27344.

  16. Iron Abundance in the Prototype PG 1159 Star, GW Vir Pulsator PG 1159-035, and Related Objects

    NASA Technical Reports Server (NTRS)

    Werner, K.; Rauch, T.; Kruk, J. W.; Kurucz, R. L.

    2011-01-01

    We performed an iron abundance determination of the hot, hydrogen deficient post-AGB star PG 1159-035. which is the prototype of the PG 1159 spectral class and the GW Vir pulsators, and of two related objects (PG 1520+525, PG 1144+005), based on the first detection of Fe VIII lines in stellar photospheres. In another PG 1159 star. PG 1424+535. we detect Fe VII lines. In all four stars, each within T(sub eff) = 110,000-150,000 K, we find a solar iron abundance. This result agrees with our recent abundance analysis of the hottest PG 1159 stars (T(sub eff) = 150,000-200,000 K) that exhibit Fe x lines. On the whole, we find that the PG 1159 stars are not significantly iron deficient, in contrast to previous notions.

  17. Galvanic Corrosion of Lead by Iron (Oxyhydr)Oxides: Potential Impacts on Drinking Water Quality.

    PubMed

    Trueman, Benjamin F; Sweet, Gregory A; Harding, Matthew D; Estabrook, Hayden; Bishop, D Paul; Gagnon, Graham A

    2017-06-20

    Lead exposure via drinking water remains a significant public health risk; this study explored the potential effects of upstream iron corrosion on lead mobility in water distribution systems. Specifically, galvanic corrosion of lead by iron (oxyhydr)oxides was investigated. Coupling an iron mineral cathode with metallic lead in a galvanic cell increased lead release by 531 μg L -1 on average-a 9-fold increase over uniform corrosion in the absence of iron. Cathodes were composed of spark plasma sintered Fe 3 O 4 or α-Fe 2 O 3 or field-extracted Fe 3 O 4 and α-FeOOH. Orthophosphate immobilized oxidized lead as insoluble hydroxypyromorphite, while humic acid enhanced lead mobility. Addition of a humic isolate increased lead release due to uniform corrosion by 81 μg L -1 and-upon coupling lead to a mineral cathode-release due to galvanic corrosion by 990 μg L -1 . Elevated lead in the presence of humic acid appeared to be driven by complexation, with 208 Pb and UV 254 size-exclusion chromatograms exhibiting strong correlation under these conditions (R 2 average = 0.87). A significant iron corrosion effect was consistent with field data: lead levels after lead service line replacement were greater by factors of 2.3-4.7 at sites supplied by unlined cast iron distribution mains compared with the alternative, lined ductile iron.

  18. The hydro- and multi-isotope geochemistry of iron-rich ground waters emerging at the southern Baltic Sea coast line

    NASA Astrophysics Data System (ADS)

    Lipka, Marko; Wu, Zijun; Escher, Peter; Struck, Ulrich; Dellwig, Olaf; Schafmeister, Maria; Böttcher*, Michael E.

    2013-04-01

    preferentially desorbed from the aqueous solution. The changes in the stream composition lead to the formation of iron(oxyhyr)oxide precipitates in the stream bed before the waters pass to underground drainage into a subterranean mixing zone with brackish BS waters. These ochrous precipitates act as a sink for dissolved phosphate and minor calcium. P : Fe ratios and Ca : Fe ratios are about 0.08 and 0.2, respectively, which are caused by P adsorption and a mixture with minor CaCO3 and/or Ca-phosphate. The investigation reveals that the surface precipitation on the beach leads to the formation of SGD essentially free of dissolved iron and strongly depleted in phosphate. Similar iron phases may also be an important part of the subterranean estuary supposed at that coast line, where retention of nutrients and heavy metals by iron(oxyhydr)oxides could influence the release of nutrients into the coastal ecosystem. Fe- and P-rich surface precipitates, however, are transported in suspension into the Baltic Sea during wind-driven flood events. Acknowledgements: This work was partly supported by the BONUS+ project AMBER and the Leibniz IOW.

  19. Neural network to diagnose lining condition

    NASA Astrophysics Data System (ADS)

    Yemelyanov, V. A.; Yemelyanova, N. Y.; Nedelkin, A. A.; Zarudnaya, M. V.

    2018-03-01

    The paper presents data on the problem of diagnosing the lining condition at the iron and steel works. The authors describe the neural network structure and software that are designed and developed to determine the lining burnout zones. The simulation results of the proposed neural networks are presented. The authors note the low learning and classification errors of the proposed neural networks. To realize the proposed neural network, the specialized software has been developed.

  20. Analysis of the ironline from 4U 1728-34 with NuSTAR and Swift

    NASA Astrophysics Data System (ADS)

    Sleator, Clio; Tomsick, John; King, Ashley L.; Miller, Jon M.; Boggs, Steven E.

    2016-01-01

    We report on a simultaneous NuSTAR and Swift observation of the neutron star low-mass X-ray binary 4U 1728-34. We detected and removed four Type 1 X-ray bursts during the observation in order to study the persistent emission. The continuum spectrum is hard and well described by a black body and cutoff power law. Residuals between 6-8 keV indicate strong evidence of a broad Fe Kα line. By modeling the spectrum with a relativistically blurred reflection model, we find an upper limit for the inner disk radius Rin ≤ 1.77 ISCO. From this upper limit, we find that RNS ≤ 20 km, assuming M=1.4M⊙ and a=0.15 (where a=cJ/GM2 is calculated from the previously measured burst oscillation frequency). We discuss how this limit could be improved for neutron star LMXBs in the future.

  1. Considerations and challenges in defining optimal iron utilization in hemodialysis.

    PubMed

    Charytan, David M; Pai, Amy Barton; Chan, Christopher T; Coyne, Daniel W; Hung, Adriana M; Kovesdy, Csaba P; Fishbane, Steven

    2015-06-01

    Trials raising concerns about erythropoiesis-stimulating agents, revisions to their labeling, and changes to practice guidelines and dialysis payment systems have provided strong stimuli to decrease erythropoiesis-stimulating agent use and increase intravenous iron administration in recent years. These factors have been associated with a rise in iron utilization, particularly among hemodialysis patients, and an unprecedented increase in serum ferritin concentrations. The mean serum ferritin concentration among United States dialysis patients in 2013 exceeded 800 ng/ml, with 18% of patients exceeding 1200 ng/ml. Although these changes are broad based, the wisdom of these practices is uncertain. Herein, we examine influences on and trends in intravenous iron utilization and assess the clinical trial, epidemiologic, and experimental evidence relevant to its safety and efficacy in the setting of maintenance dialysis. These data suggest a potential for harm from increasing use of parenteral iron in dialysis-dependent patients. In the absence of well powered, randomized clinical trials, available evidence will remain inadequate for making reliable conclusions about the effect of a ubiquitous therapy on mortality or other outcomes of importance to dialysis patients. Nephrology stakeholders have an urgent obligation to initiate well designed investigations of intravenous iron in order to ensure the safety of the dialysis population. Copyright © 2015 by the American Society of Nephrology.

  2. Properties of Narrow line Seyfert 1 galaxies

    NASA Astrophysics Data System (ADS)

    Rakshit, Suvendu; Stalin, Chelliah Subramonian; Chand, Hum; Zhang, Xue-Guang

    2018-04-01

    Narrow line Seyfert 1 (NLSy1) galaxies constitute a class of active galactic nuclei characterized by the full width at half maximum (FWHM) of the Hα broad emission line <2000 km s-1 and the flux ratio of [O III] to Hα <3. Their properties are not well understood since only a few NLSy1 galaxies were known earlier. We have studied various properties of NLSy1 galaxies using an enlarged sample and compared them with the conventional broad-line Seyfert 1 (BLSy1) galaxies. Both the sample of sources have z˜ 0.8 and their optical spectra from SDSS-DR12 that are used to derive various physical parameters have a median signal to noise (S/N) ratio >10 pixel-1. A strong correlation between the Hα and Hα emission lines is found both in the FWHM and flux. The nuclear continuum luminosity is found to be strongly correlated with the luminosity of Hα, Hα and [O III] emission lines. The black hole mass in NLSy1 galaxies is lower compared to their broad line counterparts. Compared to BLSy1 galaxies, NLSy1 galaxies have a stronger FeII emission and a higher Eddington ratio that place them in the extreme upper right corner of the R4570 - λEdd diagram. The distribution of the radio-loudness parameter (R) in NLSy1 galaxies drops rapidly at R>10 compared to the BLSy1 galaxies that have powerful radio jets. The soft X-ray photon index in NLSy1 galaxies is on average higher (2.9 ± 0.9) than BLSy1 galaxies (2.4 ± 0.8). It is anti-correlated with the Hα width but correlated with the FeII strength. NLSy1 galaxies on average have a lower amplitude of optical variability compared to their broad lines counterparts. These results suggest Eddington ratio as the main parameter that drives optical variability in these sources.

  3. Gallium-based anti-infectives: targeting microbial iron-uptake mechanisms.

    PubMed

    Kelson, Andrew B; Carnevali, Maia; Truong-Le, Vu

    2013-10-01

    Microbes have evolved elaborate iron-acquisition systems to sequester iron from the host environment using siderophores and heme uptake systems. Gallium(III) is structurally similar to iron(III), except that it cannot be reduced under physiological conditions, therefore gallium has the potential to serve as an iron analog, and thus an anti-microbial. Because Ga(III) can bind to virtually any complex that binds Fe(III), simple gallium salts as well as more complex siderophores and hemes are potential carriers to deliver Ga(III) to the microbes. These gallium complexes represent a new class of anti-infectives that is different in mechanism of action from conventional antibiotics. Simple gallium salts such as gallium nitrate, maltolate, and simple gallium siderophore complexes such as gallium citrate have shown good antibacterial activities. The most studied complex has been gallium citrate, which exhibits broad activity against many Gram negative bacteria at ∼1-5μg/ml MICs, strong biofilm activity, low drug resistance, and efficacy in vivo. Using the structural features of specific siderophore and heme made by pathogenic bacteria and fungi, researchers have begun to evaluate new gallium complexes to target key pathogens. This review will summarize potential iron-acquisition system targets and recent research on gallium-based anti-infectives. Copyright © 2013 Elsevier Ltd. All rights reserved.

  4. Iron

    MedlinePlus

    ... too little iron, you may develop iron deficiency anemia. Causes of low iron levels include blood loss, poor diet, or an inability to absorb enough iron from foods. People at higher risk of having too little iron are young children and women who are pregnant or have periods. ...

  5. Integrating Microarray Analysis and the Soybean Genome to Understand the Soybean's Iron Deficiency Response

    USDA-ARS?s Scientific Manuscript database

    Transcriptional profiles of soybean (Glycine max, L. Merr) near isogenic lines Clark (PI548553, iron efficient) and IsoClark (PI547430, iron inefficient) were analyzed and compared using the Affymetrix® GeneChip® Soybean Genome Array. A comparison of plants grown under Fe-sufficient and Fe-limited ...

  6. Iron and alloys of iron. [lunar resources

    NASA Technical Reports Server (NTRS)

    Sastri, Sankar

    1992-01-01

    All lunar soil contains iron in the metallic form, mostly as an iron-nickel alloy in concentrations of a few tenths of 1 percent. Some of this free iron can be easily separated by magnetic means. It is estimated that the magnetic separation of 100,000 tons of lunar soil would yield 150-200 tons of iron. Agglutinates contain metallic iron which could be extracted by melting and made into powder metallurgy products. The characteristics and potential uses of the pure-iron and iron-alloy lunar products are discussed. Processes for working iron that might be used in a nonterrestrial facility are also addressed.

  7. Broad-Enrich: functional interpretation of large sets of broad genomic regions.

    PubMed

    Cavalcante, Raymond G; Lee, Chee; Welch, Ryan P; Patil, Snehal; Weymouth, Terry; Scott, Laura J; Sartor, Maureen A

    2014-09-01

    Functional enrichment testing facilitates the interpretation of Chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq) data in terms of pathways and other biological contexts. Previous methods developed and used to test for key gene sets affected in ChIP-seq experiments treat peaks as points, and are based on the number of peaks associated with a gene or a binary score for each gene. These approaches work well for transcription factors, but histone modifications often occur over broad domains, and across multiple genes. To incorporate the unique properties of broad domains into functional enrichment testing, we developed Broad-Enrich, a method that uses the proportion of each gene's locus covered by a peak. We show that our method has a well-calibrated false-positive rate, performing well with ChIP-seq data having broad domains compared with alternative approaches. We illustrate Broad-Enrich with 55 ENCODE ChIP-seq datasets using different methods to define gene loci. Broad-Enrich can also be applied to other datasets consisting of broad genomic domains such as copy number variations. http://broad-enrich.med.umich.edu for Web version and R package. Supplementary data are available at Bioinformatics online. © The Author 2014. Published by Oxford University Press.

  8. How fast do quasar emission lines vary? First results from a program to monitor the Balmer lines of the Palomar-Green Quasars

    NASA Technical Reports Server (NTRS)

    Maoz, Dan; Smith, Paul S.; Jannuzi, Buell T.; Kaspi, Shai; Netzer, Hagai

    1994-01-01

    We have monitored spectrophotometrically a subsample (28) of the Palomar-Green Bright Quasar Sample for 2 years in order to test for correlations between continuum and emission-line variations and to determine the timescales relevant to mapping the broad-line regions of high-luminosity active galactic nuclei (AGNs). Half of the quasars showed optical continuum variations with amplitudes in the range 20-75%. The rise and fall time for the continuum variations is typically 0.5-2 years. In most of the objects with continuum variations, we detect correlated variations in the broad H-alpha and H-beta emission lines. The amplitude of the line variations is usually 2-4 times smaller than the optical continuum fluctuations. We present light curves and analyze spectra for six of the variable quasars with 1000-10,000 A luminosity in the range 0.3-4 x 10(exp 45) ergs/s. In four of these objects the lines respond to the continuum variations with a lag that is smaller than or comparable to our typical sampling interval (a few months). Although continued monitoring is required to confirm these results and increase their accuracy, the present evidence indicates that quasars with the above luminosities have broad-line regions smaller than about 1 1t-yr. Two of the quasars monitored show no detectable line variations despite relatively large-amplitude continuum changes. This could be a stronger manifestation of the low-amplitude line-response phenomenon we observe in the other quasars.

  9. Broadly tunable picosecond ir source

    DOEpatents

    Campillo, A.J.; Hyer, R.C.; Shapiro, S.L.

    1980-04-23

    A picosecond traveling-wave parametric device capable of controlled spectral bandwidth and wavelength in the infrared is reported. Intense 1.064 ..mu..m picosecond pulses (1) pass through a 4.5 cm long LiNbO/sub 3/ optical parametric oscillator crystal (2) set at its degeneracy angle. A broad band emerges, and a simple grating (3) and mirror (4) arrangement is used to inject a selected narrow-band into a 2 cm long LiNbO/sub 3/ optical parametric amplifier crystal (5) along a second pump line. Typical input energies at 1.064 ..mu..m along both pump lines are 6 to 8 mJ for the oscillator and 10 mJ for the amplifier. This yields 1 mJ of tunable output in the range 1.98 to 2.38 ..mu..m which when down-converted in a 1 cm long CdSe crystal mixer (6) gives 2 ..mu..J of tunable radiation over the 14.8 to 18.5 ..mu..m region. The bandwidth and wavelength of both the 2 and 16 ..mu..m radiation output are controlled solely by the diffraction grating.

  10. Broadly tunable picosecond IR source

    DOEpatents

    Campillo, Anthony J.; Hyer, Ronald C.; Shapiro, Stanley J.

    1982-01-01

    A picosecond traveling-wave parametric device capable of controlled spectral bandwidth and wavelength in the infrared is reported. Intense 1.064 .mu.m picosecond pulses (1) pass through a 4.5 cm long LiNbO.sub.3 optical parametric oscillator crystal (2) set at its degeneracy angle. A broad band emerges, and a simple grating (3) and mirror (4) arrangement is used to inject a selected narrow-band into a 2 cm long LiNbO.sub.3 optical parametric amplifier crystal (5) along a second pump line. Typical input energies at 1.064 .mu.m along both pump lines are 6-8 mJ for the oscillator and 10 mJ for the amplifier. This yields 1 mJ of tunable output in the range 1.98 to 2.38 .mu.m which when down-converted in a 1 cm long CdSe crystal mixer (6) gives 2 .mu.J of tunable radiation over the 14.8 to 18.5 .mu.m region. The bandwidth and wavelength of both the 2 and 16 .mu.m radiation output are controlled solely by the diffraction grating.

  11. In-line interferometer for broadband near-field scanning optical spectroscopy.

    PubMed

    Brauer, Jens; Zhan, Jinxin; Chimeh, Abbas; Korte, Anke; Lienau, Christoph; Gross, Petra

    2017-06-26

    We present and investigate a novel approach towards broad-bandwidth near-field scanning optical spectroscopy based on an in-line interferometer for homodyne mixing of the near field and a reference field. In scattering-type scanning near-field optical spectroscopy, the near-field signal is usually obscured by a large amount of unwanted background scattering from the probe shaft and the sample. Here we increase the light reflected from the sample by a semi-transparent gold layer and use it as a broad-bandwidth, phase-stable reference field to amplify the near-field signal in the visible and near-infrared spectral range. We experimentally demonstrate that this efficiently suppresses the unwanted background signal in monochromatic near-field measurements. For rapid acquisition of complete broad-bandwidth spectra we employ a monochromator and a fast line camera. Using this fast acquisition of spectra and the in-line interferometer we demonstrate the measurement of pure near-field spectra. The experimental observations are quantitatively explained by analytical expressions for the measured optical signals, based on Fourier decomposition of background and near field. The theoretical model and in-line interferometer together form an important step towards broad-bandwidth near-field scanning optical spectroscopy.

  12. Iron excretion in iron dextran-overloaded mice

    PubMed Central

    Musumeci, Marco; Maccari, Sonia; Massimi, Alessia; Stati, Tonino; Sestili, Paola; Corritore, Elisa; Pastorelli, Augusto; Stacchini, Paolo; Marano, Giuseppe; Catalano, Liviana

    2014-01-01

    Background Iron homeostasis in humans is tightly regulated by mechanisms aimed to conserve iron for reutilisation, with a negligible role played by excretory mechanisms. In a previous study we found that mice have an astonishing ability to tolerate very high doses of parenterally administered iron dextran. Whether this ability is linked to the existence of an excretory pathway remains to be ascertained. Materials and methods Iron overload was generated by intraperitoneal injections of iron dextran (1 g/kg) administered once a week for 8 weeks in two different mouse strains (C57bl/6 and B6D2F1). Urinary and faecal iron excretion was assessed by inductively coupling plasma-mass spectrometry, whereas cardiac and liver architecture was evaluated by echocardiography and histological methods. For both strains, 24-hour faeces and urine samples were collected and iron concentration was determined on days 0, 1 and 2 after iron administration. Results In iron-overloaded C57bl/6 mice, the faecal iron concentration increased by 218% and 157% on days 1 and 2, respectively (p<0.01). The iron excreted represented a loss of 14% of total iron administered. Similar but smaller changes was also found in B6D2F1 mice. Conversely, we found no significant changes in the concentration of iron in the urine in either of the strains of mice. In both strains, histological examination showed accumulation of iron in the liver and heart which tended to decrease over time. Conclusions This study indicates that mice have a mechanism for removal of excess body iron and provides insights into the possible mechanisms of excretion. PMID:24960657

  13. Non-transferrin bound iron: a key role in iron overload and iron toxicity.

    PubMed

    Brissot, Pierre; Ropert, Martine; Le Lan, Caroline; Loréal, Olivier

    2012-03-01

    Besides transferrin iron, which represents the normal form of circulating iron, non-transferrin bound iron (NTBI) has been identified in the plasma of patients with various pathological conditions in which transferrin saturation is significantly elevated. To show that: i) NTBI is present not only during chronic iron overload disorders (hemochromatosis, transfusional iron overload) but also in miscellaneous diseases which are not primarily iron overloaded conditions; ii) this iron species represents a potentially toxic iron form due to its high propensity to induce reactive oxygen species and is responsible for cellular damage not only at the plasma membrane level but also towards different intracellular organelles; iii) the NTBI concept may be expanded to include intracytosolic iron forms which are not linked to ferritin, the major storage protein which exerts, at the cellular level, the same type of protective effect towards the intracellular environment as transferrin in the plasma. Plasma NTBI and especially labile plasma iron determinations represent a new important biological tool since elimination of this toxic iron species is a major therapeutic goal. The NTBI approach represents an important mechanistic concept for explaining cellular iron excess and toxicity and provides new important biochemical diagnostic tools. This article is part of a Special Issue entitled Transferrins: Molecular mechanisms of iron transport and disorders. Copyright © 2011 Elsevier B.V. All rights reserved.

  14. An economic evaluation of intravenous versus oral iron supplementation in people on haemodialysis.

    PubMed

    Wong, Germaine; Howard, Kirsten; Hodson, Elisabeth; Irving, Michelle; Craig, Jonathan C

    2013-02-01

    Iron supplementation can be administered either intravenously or orally in patients with chronic kidney disease (CKD) and iron deficiency anaemia, but practice varies widely. The aim of this study was to estimate the health care costs and benefits of parenteral iron compared with oral iron in haemodialysis patients receiving erythropoiesis-stimulating agents (ESAs). Using broad health care funder perspective, a probabilistic Markov model was constructed to compare the cost-effectiveness and cost-utility of parenteral iron therapy versus oral iron for the management of haemodialysis patients with relative iron deficiency. A series of one-way, multi-way and probabilistic sensitivity analyses were conducted to assess the robustness of the model structure and the extent in which the model's assumptions were sensitive to the uncertainties within the input variables. Compared with oral iron, the incremental cost-effectiveness ratios (ICERs) for parenteral iron were $74,760 per life year saved and $34,660 per quality-adjusted life year (QALY) gained. A series of one-way sensitivity analyses show that the ICER is most sensitive to the probability of achieving haemoglobin (Hb) targets using supplemental iron with a consequential decrease in the standard ESA doses and the relative increased risk in all-cause mortality associated with low Hb levels (Hb < 9.0 g/dL). If the willingness-to-pay threshold was set at $50,000/QALY, the proportions of simulations that showed parenteral iron was cost-effective compared with oral iron were over 90%. Assuming that there is an overall increased mortality risk associated with very low Hb level (<9.0 g/dL), using parenteral iron to achieve an Hb target between 9.5 and 12 g/L is cost-effective compared with oral iron therapy among haemodialysis patients with relative iron deficiency.

  15. A Rice Phenolic Efflux Transporter Is Essential for Solubilizing Precipitated Apoplasmic Iron in the Plant Stele*

    PubMed Central

    Ishimaru, Yasuhiro; Kakei, Yusuke; Shimo, Hugo; Bashir, Khurram; Sato, Yutaka; Sato, Yuki; Uozumi, Nobuyuki; Nakanishi, Hiromi; Nishizawa, Naoko K.

    2011-01-01

    Iron deficiency is one of the major agricultural problems, as 30% of the arable land of the world is too alkaline for optimal crop production, rendering plants short of available iron despite its abundance. To take up apoplasmic precipitated iron, plants secrete phenolics such as protocatechuic acid (PCA) and caffeic acid. The molecular pathways and genes of iron uptake strategies are already characterized, whereas the molecular mechanisms of phenolics synthesis and secretion have not been clarified, and no phenolics efflux transporters have been identified in plants yet. Here we describe the identification of a phenolics efflux transporter in rice. We identified a cadmium-accumulating rice mutant in which the amount of PCA and caffeic acid in the xylem sap was dramatically reduced and hence named it phenolics efflux zero 1 (pez1). PEZ1 localized to the plasma membrane and transported PCA when expressed in Xenopus laevis oocytes. PEZ1 localized mainly in the stele of roots. In the roots of pez1, precipitated apoplasmic iron increased. The growth of PEZ1 overexpression lines was severely restricted, and these lines accumulated more iron as a result of the high solubilization of precipitated apoplasmic iron in the stele. We show that PEZ1 is responsible for an increase of PCA concentration in the xylem sap and is essential for the utilization of apoplasmic precipitated iron in the stele. PMID:21602276

  16. Flat field concave holographic grating with broad spectral region and moderately high resolution.

    PubMed

    Wu, Jian Fen; Chen, Yong Yan; Wang, Tai Sheng

    2012-02-01

    In order to deal with the conflicts between broad spectral region and high resolution in compact spectrometers based on a flat field concave holographic grating and line array CCD, we present a simple and practical method to design a flat field concave holographic grating that is capable of imaging a broad spectral region at a moderately high resolution. First, we discuss the principle of realizing a broad spectral region and moderately high resolution. Second, we provide the practical method to realize our ideas, in which Namioka grating theory, a genetic algorithm, and ZEMAX are used to reach this purpose. Finally, a near-normal-incidence example modeled in ZEMAX is shown to verify our ideas. The results show that our work probably has a general applicability in compact spectrometers with a broad spectral region and moderately high resolution.

  17. X-ray and gamma-ray line production by nonthermal ions

    NASA Technical Reports Server (NTRS)

    Bussard, R. W.; Omidvar, K.; Ramaty, R.

    1977-01-01

    X-ray production was calculated at approximately 6.8 keV by the 2p to 1s transition in fast hydrogen- and helium-like iron ions, following both electron capture to excited levels and collisional excitation. A refinement of the OBK approximation was used to obtain an improved charge exchange cross section. This, and the corresponding ionization cross section were used to determine equilibrium charge fractions for iron ions as functions of their energy. The effective X-ray line production cross section was found to be sharply peaked in energy at about 8 to 12 MeV/amu. Because fast ions of similar energies can also excite nuclear levels, the ratio of selected strong gamma ray line emissivities to the X-ray line emissivity was also calculated. Limits set by this method on the intensity of gamma ray line emission from the galactic center and the radio galaxy Centaurus A are generally lower than those reported in the literature.

  18. A Monte Carlo Approach to Magnetar-powered Transients. II. Broad-lined Type Ic Supernovae Not Associated with GRBs

    NASA Astrophysics Data System (ADS)

    Wang, L. J.; Cano, Z.; Wang, S. Q.; Zheng, W. K.; Liu, L. D.; Deng, J. S.; Yu, H.; Dai, Z. G.; Han, Y. H.; Xu, D.; Qiu, Y. L.; Wei, J. Y.; Li, B.; Song, L. M.

    2017-12-01

    Broad-lined type Ic supernovae (SNe Ic-BL) are a subclass of rare core-collapse SNe whose energy source is debated in the literature. Recently, a series of investigations on SNe Ic-BL with the magnetar (plus 56Ni) model were carried out. Evidence for magnetar formation was found for the well-observed SNe Ic-BL 1998bw and 2002ap. In this paper, we systematically study a large sample of SNe Ic-BL not associated with gamma-ray bursts (GRBs). We use photospheric velocity data determined in a homogeneous way. We find that the magnetar+56Ni model provides a good description of the light curves and velocity evolution of our sample of SNe Ic-BL, although some SNe (not all) can also be described by the pure-magnetar model or by the two-component pure-56Ni model (three out of 12 are unlikely to be explained by two-component model). In the magnetar+56Ni model, the amount of 56Ni required to explain their luminosity is significantly reduced, and the derived initial explosion energy is, in general, in accordance with neutrino heating. Some correlations between different physical parameters are evaluated, and their implications regarding magnetic field amplification and the total energy reservoir are discussed.

  19. The Broad-Lined Type Ic SN 2012ap and the Nature of Relativistic Supernovae Lacking a Gamma-Ray Burst Detection

    NASA Technical Reports Server (NTRS)

    Milisavljevic, D.; Margutti, R.; Parrent, J. T.; Soderberg, A. M.; Fesen, R. A.; Mazzali, P.; Maeda, K.; Sanders, N. E.; Cenko, S. B.; Silverman, J. M.

    2014-01-01

    We present ultraviolet, optical, and near-infrared observations of SN2012ap, a broad-lined Type Ic supernova in the galaxy NGC 1729 that produced a relativistic and rapidly decelerating outflow without a gamma-ray burst signature. Photometry and spectroscopy follow the flux evolution from -13 to +272 days past the B-band maximum of -17.4 +/- 0.5 mag. The spectra are dominated by Fe II, O I, and Ca II absorption lines at ejecta velocities of v approx. 20,000 km s(exp. -1) that change slowly over time. Other spectral absorption lines are consistent with contributions from photospheric He I, and hydrogen may also be present at higher velocities (v approx. greater than 27,000 km s(exp. -1)). We use these observations to estimate explosion properties and derive a total ejecta mass of 2.7 Solar mass, a kinetic energy of 1.0×1052 erg, and a (56)Ni mass of 0.1-0.2 Solar mass. Nebular spectra (t > 200 d) exhibit an asymmetric double-peaked [O I] lambda lambda 6300, 6364 emission profile that we associate with absorption in the supernova interior, although toroidal ejecta geometry is an alternative explanation. SN2012ap joins SN2009bb as another exceptional supernova that shows evidence for a central engine (e.g., black-hole accretion or magnetar) capable of launching a non-negligible portion of ejecta to relativistic velocities without a coincident gamma-ray burst detection. Defining attributes of their progenitor systems may be related to notable properties including above-average environmental metallicities of Z approx. greater than Solar Z, moderate to high levels of host-galaxy extinction (E(B -V ) > 0.4 mag), detection of high-velocity helium at early epochs, and a high relative flux ratio of [Ca II]/[O I] > 1 at nebular epochs. These events support the notion that jet activity at various energy scales may be present in a wide range of supernovae.

  20. Steps toward determination of the size and structure of the broad-line region in active galactic nuclei. 8: An intensive HST, IUE, and ground-based study of NGC 5548

    NASA Technical Reports Server (NTRS)

    Korista, K.; Alloin, D.; Barr, P.; Clavel, J.; Cohen, R. D.; Crenshaw, D. M.; Evans, I. N.; Horne, K.; Koratkar, A. P.; Kriss, G. A.

    1994-01-01

    We present the data and initial results from a combined HST/IUE/ground-based spectroscopic monitoring campaign on the Seyfert 1 galaxy NGC 5548 that was undertaken in order to address questions that require both higher temporal resolution and higher signal-to-noise ratios than were obtained in our previous multiwavelength monitoring of this galaxy in 1988-89. IUE spectra were obtained once every two days for a period of 74 days beginning on 14 March 1993. During the last 39 days of this campaign, spectroscopic observations were also made with the HST Faint Object Spectrograph (FOS) on a daily basis. Ground-based observations, consisting of 165 optical spectra and 77 photometric observations (both CCD imaging and aperture photometry), are reported for the period 1992 October to 1993 September, although much of the data are concentrated around the time of the satellite-based program. These data constitute a fifth year of intensive optical monitoring of this galaxy. In this contribution, we describe the acquisition and reduction of all of the satellite and ground-based data obtained in this program. We describe in detail various photometric problems with the FOS and explain how we identified and corrected for various anomalies. During the HST portion of the monitoring campaign, the 1350 A continuum flux is found to have varied by nearly a factor of two. In other wavebands, the continuum shows nearly identical behavior, except that the amplitude of variability is larger at shorter wavelengths, and the continuum light curves appear to show more short time-scale variability at shorter wavelengths. The broad emission lines also vary in flux, with amplitudes that are slightly smaller than the UV continuum variations and with a small time delay relative to the UV continuum. On the basis of simple time-series analysis of the UV and optical continuum and emission line light curves, we find (1) that the ultraviolet and optical continuum variations are virtually simultaneous

  1. Constraining possible variations of the fine structure constant in strong gravitational fields with the Kα iron line

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Bambi, Cosimo, E-mail: bambi@fudan.edu.cn

    2014-03-01

    In extensions of general relativity and in theories aiming at unifying gravity with the forces of the Standard Model, the value of the ''fundamental constants'' is often determined by the vacuum expectation value of new fields, which may thus change in different backgrounds. Variations of fundamental constants with respect to the values measured today in laboratories on Earth are expected to be more evident on cosmological timescales and/or in strong gravitational fields. In this paper, I show that the analysis of the Kα iron line observed in the X-ray spectrum of black holes can potentially be used to probe themore » fine structure constant α in gravitational potentials relative to Earth of Δφ ≈ 0.1. At present, systematic effects not fully under control prevent to get robust and stringent bounds on possible variations of the value of α with this technique, but the fact that current data can be fitted with models based on standard physics already rules out variations of the fine structure constant larger than some percent.« less

  2. Macroporous Carbon Supported Zerovalent Iron for Remediation of Trichloroethylene

    DOE PAGES

    Lawrinenko, Michael; Wang, Zhuangji; Horton, Robert; ...

    2016-12-26

    Groundwater contamination with chlorinated hydrocarbons has become a widespread problem that threatens water quality and human health. Permeable reactive barriers (PRBs), which employ zerovalent iron, are effective for remediation; however, a need exists to reduce the economic and environmental costs associated with constructing PRBs. Here, we present a method to produce zerovalent iron supported on macroporous carbon using only lignin and magnetite. Biochar- ZVI (BC-ZVI) produced by this method exhibits a broad pore size distribution with micrometer sized ZVI phases dispersed throughout a carbon matrix. X-ray diffraction revealed that pyrolysis at 900 °C of a 50/50 lignin$-$magnetite mixture resulted inmore » almost complete reduction of magnetite to ZVI and that compression molding promotes iron reduction in pyrolysis due to mixing of starting materials. High temperature pyrolysis of lignin yields some graphite in BC-ZVI due to reduction of carbonaceous gases on iron oxides. TCE was removed from water as it passed through a column packed with BC-ZVI at flow rates representative of average and high groundwater flow. Lastly, one-dimensional convection$-$dispersion modeling revealed that adsorption by biochar influences TCE transport and that BC-ZVI facilitated removal of TCE from contaminated water by both adsorption and degradation.« less

  3. Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton

    PubMed Central

    Botebol, Hugo; Lesuisse, Emmanuel; Šuták, Robert; Six, Christophe; Lozano, Jean-Claude; Schatt, Philippe; Vergé, Valérie; Kirilovsky, Amos; Morrissey, Joe; Léger, Thibaut; Camadro, Jean-Michel; Gueneugues, Audrey; Bowler, Chris; Blain, Stéphane; Bouget, François-Yves

    2015-01-01

    In large regions of the open ocean, iron is a limiting resource for phytoplankton. The reduction of iron quota and the recycling of internal iron pools are among the diverse strategies that phytoplankton have evolved to allow them to grow under chronically low ambient iron levels. Phytoplankton species also have evolved strategies to cope with sporadic iron supply such as long-term storage of iron in ferritin. In the picophytoplanktonic species Ostreococcus we report evidence from observations both in the field and in laboratory cultures that ferritin and the main iron-binding proteins involved in photosynthesis and nitrate assimilation pathways show opposite diurnal expression patterns, with ferritin being maximally expressed during the night. Biochemical and physiological experiments using a ferritin knock-out line subsequently revealed that this protein plays a central role in the diel regulation of iron uptake and recycling and that this regulation of iron homeostasis is essential for cell survival under iron limitation. PMID:26553998

  4. Central role for ferritin in the day/night regulation of iron homeostasis in marine phytoplankton.

    PubMed

    Botebol, Hugo; Lesuisse, Emmanuel; Šuták, Robert; Six, Christophe; Lozano, Jean-Claude; Schatt, Philippe; Vergé, Valérie; Kirilovsky, Amos; Morrissey, Joe; Léger, Thibaut; Camadro, Jean-Michel; Gueneugues, Audrey; Bowler, Chris; Blain, Stéphane; Bouget, François-Yves

    2015-11-24

    In large regions of the open ocean, iron is a limiting resource for phytoplankton. The reduction of iron quota and the recycling of internal iron pools are among the diverse strategies that phytoplankton have evolved to allow them to grow under chronically low ambient iron levels. Phytoplankton species also have evolved strategies to cope with sporadic iron supply such as long-term storage of iron in ferritin. In the picophytoplanktonic species Ostreococcus we report evidence from observations both in the field and in laboratory cultures that ferritin and the main iron-binding proteins involved in photosynthesis and nitrate assimilation pathways show opposite diurnal expression patterns, with ferritin being maximally expressed during the night. Biochemical and physiological experiments using a ferritin knock-out line subsequently revealed that this protein plays a central role in the diel regulation of iron uptake and recycling and that this regulation of iron homeostasis is essential for cell survival under iron limitation.

  5. Genetic diversity and selection of common bean lines based on technological quality and biofortification.

    PubMed

    Steckling, S de M; Ribeiro, N D; Arns, F D; Mezzomo, H C; Possobom, M T D F

    2017-03-22

    The development of common bean cultivars with high technological quality that are biofortified with minerals, is required to meet the demand for food with health benefits. The objectives of this study were to evaluate whether common bean genotypes differ in terms of technological and mineral biofortification traits, to study the correlations between these characters, to analyze the genetic dissimilarity of common bean genotypes, and to select superior lines for these traits. For this, 14 common bean genotypes were evaluated in experiments conducted in three growing seasons in the Rio Grande do Sul State, Brazil. A significant genotype x environment interaction was observed for technological quality (mass of 100 grains and cooking time) and biofortification traits (concentration of potassium, phosphorus, calcium, iron, zinc, and copper). Positive correlation estimates were obtained between phosphorus and potassium (r = 0.575), iron and zinc (r = 0.641), copper and iron (r = 0.729), and copper and phosphorus (r = 0.533). In the main component cluster analysis, four groups of genotypes were formed. The following lines are recommended for selection: LP 11-363 for fast-cooking, CNFC 11 948 for high iron concentration, and LEC 03-14 for high potassium, phosphorus, and calcium concentrations in grains. Common bean lines with high phosphorus and iron concentrations in grains can be indirectly selected based on higher potassium, copper, and zinc concentrations. Controlled crossings between LP 11-363 x CNFC 11 948 and LP 11-363 x LEC 03-14 are recommended to obtain segregating lines that are fast-cooking and biofortified with minerals.

  6. Integrating microarray analysis and the soybean genome to understand the soybeans iron deficiency response

    PubMed Central

    2009-01-01

    Background Soybeans grown in the upper Midwestern United States often suffer from iron deficiency chlorosis, which results in yield loss at the end of the season. To better understand the effect of iron availability on soybean yield, we identified genes in two near isogenic lines with changes in expression patterns when plants were grown in iron sufficient and iron deficient conditions. Results Transcriptional profiles of soybean (Glycine max, L. Merr) near isogenic lines Clark (PI548553, iron efficient) and IsoClark (PI547430, iron inefficient) grown under Fe-sufficient and Fe-limited conditions were analyzed and compared using the Affymetrix® GeneChip® Soybean Genome Array. There were 835 candidate genes in the Clark (PI548553) genotype and 200 candidate genes in the IsoClark (PI547430) genotype putatively involved in soybean's iron stress response. Of these candidate genes, fifty-eight genes in the Clark genotype were identified with a genetic location within known iron efficiency QTL and 21 in the IsoClark genotype. The arrays also identified 170 single feature polymorphisms (SFPs) specific to either Clark or IsoClark. A sliding window analysis of the microarray data and the 7X genome assembly coupled with an iterative model of the data showed the candidate genes are clustered in the genome. An analysis of 5' untranslated regions in the promoter of candidate genes identified 11 conserved motifs in 248 differentially expressed genes, all from the Clark genotype, representing 129 clusters identified earlier, confirming the cluster analysis results. Conclusion These analyses have identified the first genes with expression patterns that are affected by iron stress and are located within QTL specific to iron deficiency stress. The genetic location and promoter motif analysis results support the hypothesis that the differentially expressed genes are co-regulated. The combined results of all analyses lead us to postulate iron inefficiency in soybean is a result of a

  7. Ironic effects of emotion suppression when recounting distressing memories.

    PubMed

    Dalgleish, Tim; Yiend, Jenny; Schweizer, Susanne; Dunn, Barnaby D

    2009-10-01

    Theories of ironic mental control posit that under conditions in which effortful control is compromised, for example, in laboratory manipulations of mental load or in those suffering from clinical levels of negative affect, attempts to suppress negative emotions can lead to a paradoxical increase in such feelings, relative to conditions in which no suppression is attempted. In line with this, we showed that high negative affect participants, when asked to suppress (downregulate) their negative feelings while writing about a distressing personal memory, exhibited an ironically greater increase in negative emotions compared with a no-instruction condition, in contrast to low negative affect controls who were able to suppress their emotions. Comparable ironic effects were not associated with instructions to experience emotions. This first demonstration of ironic effects of emotion suppression in response to personal material in those with emotional problems sheds light into how certain emotion regulation strategies may maintain and exacerbate such conditions.

  8. Diagnosis and treatment of iron deficiency anemia during pregnancy and the postpartum period: Iron deficiency anemia working group consensus report

    PubMed Central

    Api, Olus; Breyman, Christian; Çetiner, Mustafa; Demir, Cansun; Ecder, Tevfik

    2015-01-01

    According to the World Health Organization (WHO), anemia is the most common disease, affecting >1.5 billion people worldwide. Furthermore, iron deficiency anemia (IDA) accounts for 50% of cases of anemia. IDA is common during pregnancy and the postpartum period, and can lead to serious maternal and fetal complications. The aim of this report was to present the experiences of a multidisciplinary expert group, and to establish reference guidelines for the optimal diagnosis and treatment of IDA during pregnancy and the postpartum period. Studies and guidelines on the diagnosis and treatment of IDA published in Turkish and international journals were reviewed. Conclusive recommendations were made by an expert panel aiming for a scientific consensus. Measurement of serum ferritin has the highest sensitivity and specificity for diagnosis of IDA unless there is a concurrent inflammatory condition. The lower threshold value for hemoglobin (Hb) in pregnant women is <11 g/dL during the 1st and 3rd trimesters, and <10.5 g/dL during the 2nd trimester. In postpartum period a Hb concentration <10 g/dL indicates clinically significant anemia. Oral iron therapy is given as the first-line treatment for IDA. Although current data are limited, intravenous (IV) iron therapy is an alternative therapeutic option in patients who do not respond to oral iron therapy, have adverse reactions, do not comply with oral iron treatment, have a very low Hb concentration, and require rapid iron repletion. IV iron preparations can be safely used for the treatment of IDA during pregnancy and the postpartum period, and are more beneficial than oral iron preparations in specific indications. PMID:28913064

  9. Revealing sources and chemical identity of iron ligands across the California Current System

    NASA Astrophysics Data System (ADS)

    Boiteau, R.; Repeta, D.; Fitzsimmons, J. N.; Parker, C.; Twining, B. S.; Baines, S.

    2016-02-01

    The California Current System is one of the most productive regions of the ocean, fueled by the upwelling of nutrient rich water. Differences in the supply of micronutrient iron to surface waters along the coast lead to a mosaic of iron-replete and iron-limited conditions across the region, affecting primary production and community composition. Most of the iron in this region is supplied by upwelling of iron from the benthic boundary layer that is complexed by strong organic ligands. However, the source, identity, and bioavailability of these ligands are unknown. Here, we used novel hyphenated chromatography mass spectrometry approaches to structurally characterize organic ligands across the region. With these methods, iron ligands are detected with liquid chromatography coupled to inductively coupled plasma mass spectrometry (LC-ICPMS), and then their mass and fragmentation spectra are determined by high resolution electrospray ionization mass spectrometry (LC-ESIMS). Iron isotopic exchange was used to compare the relative binding strengths of different ligands. Our survey revealed a broad range of ligands from multiple sources. Benthic boundary layers and anoxic sediments were sources of structurally amorphous weak ligands, likely organic degradation products, as well as siderophores, strong iron binding molecules that facilitate iron acquisition. In the euphotic zone, marine microbes and zooplankton grazing produced a wide distribution of other compounds that included known and novel siderophores. This work demonstrates that the chemical nature of ligands from different sources varies substantially and has important implications for iron biogeochemical cycling and availability to members of the microbial community.

  10. Stability and broad-sense heritaibility of mineral content in potato: copper and sulfur

    USDA-ARS?s Scientific Manuscript database

    Potato breeding lines and varieties in two separate trials were evaluated for copper and sulfur content by wet ashing and Inductively Coupled Argon Plasma Emission Spectrophotometer analysis. Stability and broad-sense heritability were determined. Copper contents ranged among genotypes between 2.0...

  11. Zooplankton Gut Passage Mobilizes Lithogenic Iron for Ocean Productivity.

    PubMed

    Schmidt, Katrin; Schlosser, Christian; Atkinson, Angus; Fielding, Sophie; Venables, Hugh J; Waluda, Claire M; Achterberg, Eric P

    2016-10-10

    Iron is an essential nutrient for phytoplankton, but low concentrations limit primary production and associated atmospheric carbon drawdown in large parts of the world's oceans [1, 2]. Lithogenic particles deriving from aeolian dust deposition, glacial runoff, or river discharges can form an important source if the attached iron becomes dissolved and therefore bioavailable [3-5]. Acidic digestion by zooplankton is a potential mechanism for iron mobilization [6], but evidence is lacking. Here we show that Antarctic krill sampled near glacial outlets at the island of South Georgia (Southern Ocean) ingest large amounts of lithogenic particles and contain 3-fold higher iron concentrations in their muscle than specimens from offshore, which confirms mineral dissolution in their guts. About 90% of the lithogenic and biogenic iron ingested by krill is passed into their fecal pellets, which contain ∼5-fold higher proportions of labile (reactive) iron than intact diatoms. The mobilized iron can be released in dissolved form directly from krill or via multiple pathways involving microbes, other zooplankton, and krill predators. This can deliver substantial amounts of bioavailable iron and contribute to the fertilization of coastal waters and the ocean beyond. In line with our findings, phytoplankton blooms downstream of South Georgia are more intensive and longer lasting during years with high krill abundance on-shelf. Thus, krill crop phytoplankton but boost new production via their nutrient supply. Understanding and quantifying iron mobilization by zooplankton is essential to predict ocean productivity in a warming climate where lithogenic iron inputs from deserts, glaciers, and rivers are increasing [7-10]. Copyright © 2016 Elsevier Ltd. All rights reserved.

  12. The Narrow-Line Region of Narrow-Line Seyfert 1 Galaxies

    NASA Astrophysics Data System (ADS)

    Rodríguez-Ardila, A.; Binette, Luc; Pastoriza, Miriani G.; Donzelli, Carlos J.

    2000-08-01

    This work studies the optical emission-line properties and physical conditions of the narrow-line region (NLR) of seven narrow-line Seyfert 1 galaxies (NLS1's) for which high signal-to-noise ratio spectroscopic observations were available. The resolution is 340 km s-1 (at Hα) over the wavelength interval 3700-9500 Å, enabling us to separate the broad and narrow components of the permitted emission lines. Our results show that the flux carried out by the narrow component of Hβ is, on average, 50% of the total line flux. As a result, the [O III] λ5007/Hβ ratio emitted in the NLR varies from 1 to 5, instead of the universally adopted value of 10. This has strong implications for the required spectral energy distribution that ionizes the NLR gas. Photoionization models that consider a NLR composed of a combination of matter-bounded and ionization-bounded clouds are successful at explaining the low [O III] λ5007/Hβ ratio and the weakness of low-ionization lines of NLS1's. Variation of the relative proportion of these two type of clouds nicely reproduces the dispersion of narrow-line ratios found among the NLS1 sample. Assuming similar physical model parameters of both NLS1's and the normal Seyfert 1 galaxy NGC 5548, we show that the observed differences of emission-line ratios between these two groups of galaxies can be explained, to a first approximation, in terms of the shape of the input ionizing continuum. Narrow emission-line ratios of NLS1's are better reproduced by a steep power-law continuum in the EUV-soft X-ray region, with spectral index α~-2. Flatter spectral indices (α~-1.5) match the observed line ratios of NGC 5548 but are unable to provide a good match to the NLS1 ratios. This result is consistent with ROSAT observations of NLS1's, which show that these objects are characterized by steeper power-law indices than those of Seyfert 1 galaxies with strong broad optical lines. Based on observations made at CASLEO. Complejo Astronómico El Leoncito

  13. Nanophase iron phosphate, iron arsenate, iron vanadate, and iron molybdate minerals synthesized within the protein cage of ferritin.

    PubMed

    Polanams, Jup; Ray, Alisha D; Watt, Richard K

    2005-05-02

    Nanoparticles of iron phosphate, iron arsenate, iron molybdate, and iron vanadate were synthesized within the 8 nm interior of ferritin. The synthesis involved reacting Fe(II) with ferritin in a buffered solution at pH 7.4 in the presence of phosphate, arsenate, vanadate, or molybdate. O2 was used as the oxidant to deposit the Fe(III) mineral inside ferritin. The rate of iron incorporation into ferritin was stimulated when oxo-anions were present. The simultaneous deposition of both iron and the oxo-anion was confirmed by elemental analysis and energy-dispersive X-ray analysis. The ferritin samples containing iron and one of the oxo-anions possessed different UV/vis spectra depending on the anion used during mineral formation. TEM analysis showed mineral cores with approximately 8 nm mineral particles consistent with the formation of mineral phases inside ferritin.

  14. Intravenous iron-dextran: studies on unsaturated iron-binding capacity

    PubMed Central

    Cox, J. S. G.; Moss, G. F.; Bremner, I.; Reason, Janet

    1968-01-01

    A method is described for measuring the plasma unsaturated iron-binding capacity in the presence of very high concentrations of iron as iron-dextran. The procedure utilizes 59Fe to label the apotransferrin with subsequent separation of ionic iron from transferrin-bound iron on an ion exchange or Sephadex G.25 column. The unsaturated iron-binding capacity has been measured in rabbits and dogs after intravenous injection of iron-dextran and in human subjects after total dose infusion of iron-dextran. No evidence of saturation of the unsaturated iron-binding capacity was found even when the plasma iron values were greater than 40,000 μg Fe/100 ml. PMID:5697365

  15. In vitro cytotoxicity analysis of doxorubicin-loaded/superparamagnetic iron oxide colloidal nanoassemblies on MCF7 and NIH3T3 cell lines

    PubMed Central

    Tomankova, Katerina; Polakova, Katerina; Pizova, Klara; Binder, Svatopluk; Havrdova, Marketa; Kolarova, Mary; Kriegova, Eva; Zapletalova, Jana; Malina, Lukas; Horakova, Jana; Malohlava, Jakub; Kolokithas-Ntoukas, Argiris; Bakandritsos, Aristides; Kolarova, Hana; Zboril, Radek

    2015-01-01

    One of the promising strategies for improvement of cancer treatment is based on magnetic drug delivery systems, thus avoiding side effects of standard chemotherapies. Superparamagnetic iron oxide (SPIO) nanoparticles have ideal properties to become a targeted magnetic drug delivery contrast probes, named theranostics. We worked with SPIO condensed colloidal nanocrystal clusters (MagAlg) prepared through a new soft biomineralization route in the presence of alginate as the polymeric shell and loaded with doxorubicin (DOX). The aim of this work was to study the in vitro cytotoxicity of these new MagAlg–DOX systems on mouse fibroblast and breast carcinoma cell lines. For proper analysis and understanding of cell behavior after administration of MagAlg–DOX compared with free DOX, a complex set of in vitro tests, including production of reactive oxygen species, comet assay, cell cycle determination, gene expression, and cellular uptake, were utilized. It was found that the cytotoxic effect of MagAlg–DOX system is delayed compared to free DOX in both cell lines. This was attributed to the different mechanism of internalization of DOX and MagAlg–DOX into the cells, together with the fact that the drug is strongly bound on the drug nanocarriers. We discovered that nanoparticles can attenuate or even inhibit the effect of DOX, particularly in the tumor MCF7 cell line. This is a first comprehensive study on the cytotoxic effect of DOX-loaded SPIO compared with free DOX on healthy and cancer cell lines, as well as on the induced changes in gene expression. PMID:25673990

  16. Cytotoxic consequences of Halloysite nanotube/iron oxide nanocomposite and iron oxide nanoparticles upon interaction with bacterial, non-cancerous and cancerous cells.

    PubMed

    Abhinayaa, R; Jeevitha, G; Mangalaraj, D; Ponpandian, N; Vidhya, Kalieswaran; Angayarkanni, Jayaraman

    2018-05-19

    Cytotoxic effects of iron oxide (Fe 3 O 4 ) nanoparticles and Halloysite nanotube/iron oxide (HNT/Fe 3 O 4 ) nanocomposite are compared based on their interaction with Gram-negative bacteria Escherichia coli and Gram-positive bacteria Bacillus subtilis. Similarly, the action of these two nanomaterials on non-cancerous Vero cell lines and human lung cancerous (A-549) cell lines are compared. The cytotoxicity studies on Fe 3 O 4 nanoparticles and HNT/Fe 3 O 4 nanocomposite showed difference in the rate of killing of bacterial cells. This is reflected in differential cell growth, cell membrane integrity loss, lactate dehydrogenase (LDH) release and reactive oxygen species (ROS) production. These factors are measured over a range of concentrations of Fe 3 O 4 nanoparticles and HNT/Fe 3 O 4 nanocomposite and at specified time intervals, to test if there is any statistically significant difference between the toxicity of the two nanomaterials. Between the two nanomaterials, HNT/Fe 3 O 4 nanocomposite is found to be less toxic to bacterial cells than Fe 3 O 4 nanoparticles. HNT, when attached to the Fe 3 O 4 nanoparticles, changes their surface characteristics and suppresses their inherent toxicity on bacteria. In the study on the effect on cell lines, Fe 3 O 4 nanoparticles and HNT/Fe 3 O 4 nanocomposite are both seen to be biocompatible with Vero cell lines. However, HNT/Fe 3 O 4 nanocomposite showed more cytotoxicity than Fe 3 O 4 nanoparticles on A-549 cell lines. Copyright © 2018 Elsevier B.V. All rights reserved.

  17. Ferritin accumulation under iron scarcity in Drosophila iron cells.

    PubMed

    Mehta, A; Deshpande, A; Bettedi, L; Missirlis, F

    2009-10-01

    Ferritins are highly stable, multi-subunit protein complexes with iron-binding capacities that reach 4500 iron atoms per ferritin molecule. The strict dependence of cellular physiology on an adequate supply of iron cofactors has likely been a key driving force in the evolution of ferritins as iron storage molecules. The insect intestine has long been known to contain cells that are responsive to dietary iron levels and a specialized group of "iron cells" that always accumulate iron-loaded ferritin, even when no supplementary iron is added to the diet. Here, we further characterize ferritin localization in Drosophila melanogaster larvae raised under iron-enriched and iron-depleted conditions. High dietary iron intake results in ferritin accumulation in the anterior midgut, but also in garland (wreath) cells and in pericardial cells, which together filter the circulating hemolymph. Ferritin is also abundant in the brain, where levels remain unaltered following dietary iron chelation, a treatment that depletes ferritin from the aforementioned tissues. We attribute the stability of ferritin levels in the brain to the function of the blood-brain barrier that may shield this organ from systemic iron fluctuations. Most intriguingly, our dietary manipulations demonstrably iron-depleted the iron cells without a concomitant reduction in their production of ferritin. Therefore, insect iron cells may constitute an exception from the evolutionary norm with respect to iron-dependent ferritin regulation. It will be of interest to decipher both the physiological purpose served and the mechanism employed to untie ferritin regulation from cellular iron levels in this cell type.

  18. FLARE-LIKE VARIABILITY OF THE Mg II {lambda}2800 EMISSION LINE IN THE {gamma}-RAY BLAZAR 3C 454.3

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Leon-Tavares, J.; Chavushyan, V.; Patino-Alvarez, V.

    2013-02-01

    We report the detection of a statistically significant flare-like event in the Mg II {lambda}2800 emission line of 3C 454.3 during the outburst of autumn 2010. The highest levels of emission line flux recorded over the monitoring period (2008-2011) coincide with a superluminal jet component traversing through the radio core. This finding crucially links the broad emission line fluctuations to the non-thermal continuum emission produced by relativistically moving material in the jet and hence to the presence of broad-line region clouds surrounding the radio core. If the radio core were located at several parsecs from the central black hole, thenmore » our results would suggest the presence of broad-line region material outside the inner parsec where the canonical broad-line region is envisaged to be located. We briefly discuss the implications of broad emission line material ionized by non-thermal continuum in the context of virial black hole mass estimates and gamma-ray production mechanisms.« less

  19. Unveiling the X-ray/UV properties of AGN winds using Broad and mini-Broad Absorption Line Quasars

    NASA Astrophysics Data System (ADS)

    Giustini, M.

    2015-07-01

    BAL/mini-BALs are observed in the UV spectra of ˜ 20-30% of optically selected AGN as broad absorption troughs blueshifted by several thousands km/s, indicative of powerful nuclear winds. They could be representative of the average AGN if their winds cover only 20-30% of the continuum source, and/or represent an evolutionary state analogous to the high-soft state of BHB, when the jet emission is quenched and strong X-ray absorbing equatorial disk winds are virtually ubiquitous. High-quality, possibly time-resolved X-ray/UV studies are crucial to assess the global amount and 'character' of absorption in BAL/mini-BAL QSOs and to constrain the physical mechanism responsible for the launch and acceleration of their winds, therefore placing them in the broader context of AGN geometry and evolution. I will review here the known X-ray properties of BAL/mini-BAL QSOs, and present new results from a comprehensive X-ray spectral analysis of all the Palomar-Green BAL/mini-BAL QSOs with available XMM-Newton observations, for a total of 51 pointings of 14 different sources. These will include the most recent results from a high-quality simultaneous XMM/HST observational campaign on the mini-BAL QSO PG 1126-041, that unveiled with stunning details the X-ray/UV connection in action in an AGN disk wind through correlated X-ray/UV absorption variability.

  20. Deferasirox is a powerful NF-κB inhibitor in myelodysplastic cells and in leukemia cell lines acting independently from cell iron deprivation by chelation and reactive oxygen species scavenging

    PubMed Central

    Messa, Emanuela; Carturan, Sonia; Maffè, Chiara; Pautasso, Marisa; Bracco, Enrico; Roetto, Antonella; Messa, Francesca; Arruga, Francesca; Defilippi, Ilaria; Rosso, Valentina; Zanone, Chiara; Rotolo, Antonia; Greco, Elisabetta; Pellegrino, Rosa M.; Alberti, Daniele; Saglio, Giuseppe; Cilloni, Daniela

    2010-01-01

    Background Usefulness of iron chelation therapy in myelodysplastic patients is still under debate but many authors suggest its possible role in improving survival of low-risk myelodysplastic patients. Several reports have described an unexpected effect of iron chelators, such as an improvement in hemoglobin levels, in patients affected by myelodysplastic syndromes. Furthermore, the novel chelator deferasirox induces a similar improvement more rapidly. Nuclear factor-κB is a key regulator of many cellular processes and its impaired activity has been described in different myeloid malignancies including myelodysplastic syndromes. Design and Methods We evaluated deferasirox activity on nuclear factor-κB in myelodysplastic syndromes as a possible mechanism involved in hemoglobin improvement during in vivo treatment. Forty peripheral blood samples collected from myelodysplastic syndrome patients were incubated with 50 μM deferasirox for 18h. Results Nuclear factor-κB activity dramatically decreased in samples showing high basal activity as well as in cell lines, whereas no similar behavior was observed with other iron chelators despite a similar reduction in reactive oxygen species levels. Additionally, ferric hydroxyquinoline incubation did not decrease deferasirox activity in K562 cells suggesting the mechanism of action of the drug is independent from cell iron deprivation by chelation. Finally, incubation with both etoposide and deferasirox induced an increase in K562 apoptotic rate. Conclusions Nuclear factor-κB inhibition by deferasirox is not seen from other chelators and is iron and reactive oxygen species scavenging independent. This could explain the hemoglobin improvement after in vivo treatment, such that our hypothesis needs to be validated in further prospective studies. PMID:20534700

  1. Iron oxide surfaces

    NASA Astrophysics Data System (ADS)

    Parkinson, Gareth S.

    2016-03-01

    The current status of knowledge regarding the surfaces of the iron oxides, magnetite (Fe3O4), maghemite (γ-Fe2O3), haematite (α-Fe2O3), and wüstite (Fe1-xO) is reviewed. The paper starts with a summary of applications where iron oxide surfaces play a major role, including corrosion, catalysis, spintronics, magnetic nanoparticles (MNPs), biomedicine, photoelectrochemical water splitting and groundwater remediation. The bulk structure and properties are then briefly presented; each compound is based on a close-packed anion lattice, with a different distribution and oxidation state of the Fe cations in interstitial sites. The bulk defect chemistry is dominated by cation vacancies and interstitials (not oxygen vacancies) and this provides the context to understand iron oxide surfaces, which represent the front line in reduction and oxidation processes. Fe diffuses in and out from the bulk in response to the O2 chemical potential, forming sometimes complex intermediate phases at the surface. For example, α-Fe2O3 adopts Fe3O4-like surfaces in reducing conditions, and Fe3O4 adopts Fe1-xO-like structures in further reducing conditions still. It is argued that known bulk defect structures are an excellent starting point in building models for iron oxide surfaces. The atomic-scale structure of the low-index surfaces of iron oxides is the major focus of this review. Fe3O4 is the most studied iron oxide in surface science, primarily because its stability range corresponds nicely to the ultra-high vacuum environment. It is also an electrical conductor, which makes it straightforward to study with the most commonly used surface science methods such as photoemission spectroscopies (XPS, UPS) and scanning tunneling microscopy (STM). The impact of the surfaces on the measurement of bulk properties such as magnetism, the Verwey transition and the (predicted) half-metallicity is discussed. The best understood iron oxide surface at present is probably Fe3O4(100); the structure is

  2. Trace Metal Associations with Manganese-Rich Surface Coatings of Lead Service Lines

    EPA Science Inventory

    Analysis of lead service line samples from U. S. Environmental Protection Agency’s long-term research program to evaluate control and metal release from domestic drinking water service lines has revealed that Manganese-rich solids also contain Iron and sometimes Aluminum have fre...

  3. The Evolution of Quasar C IV and Si IV Broad Absorption Lines over Multi-year Timescales

    NASA Astrophysics Data System (ADS)

    Gibson, Robert R.; Brandt, W. N.; Gallagher, S. C.; Hewett, Paul C.; Schneider, Donald P.

    2010-04-01

    We investigate the variability of C IV λ1549 broad absorption line (BAL) troughs over rest-frame timescales of up to ≈7 yr in 14 quasars at redshifts z >~ 2.1. For nine sources at sufficiently high redshift, we also compare the C IV and Si IV λ1400 absorption variation. We compare shorter and longer term variability using spectra from up to four different epochs per source and find complex patterns of variation in the sample overall. The scatter in the change of absorption equivalent width (EW), ΔEW, increases with the time between observations. BALs do not, in general, strengthen or weaken monotonically, and variation observed over shorter (lsimmonths) timescales is not predictive of multi-year variation. We find no evidence for asymmetry in the distribution of ΔEW that would indicate that BALs form and decay on different timescales, and we constrain the typical BAL lifetime to be gsim30 yr. The BAL absorption for one source, LBQS 0022+0150, has weakened and may now be classified as a mini-BAL. Another source, 1235+1453, shows evidence of variable, blue continuum emission that is relatively unabsorbed by the BAL outflow. C IV and Si IV BAL shape changes are related in at least some sources. Given their high velocities, BAL outflows apparently traverse large spatial regions and may interact with parsec-scale structures such as an obscuring torus. Assuming BAL outflows are launched from a rotating accretion disk, notable azimuthal symmetry is required in the outflow to explain the relatively small changes observed in velocity structure over times up to 7 yr.

  4. Observations of neutral iron emission in twilight spectra

    NASA Technical Reports Server (NTRS)

    Tepley, C. A.; Meriwether, J. W., Jr.; Walker, J. C. G.; Mathews, J. D.

    1981-01-01

    A method is presented for the analysis of twilight airglow spectra that may be contaminated by atmospheric continuum emission of unknown brightness. The necessity of correcting for this continuum emission when measuring weak airglow features in twilight is illustrated by application of the method to the neutral iron line at 3860 A.

  5. Line identifications, line strengths, and continuum flux measurements in the ultraviolet spectrum of Arcturus

    NASA Technical Reports Server (NTRS)

    Carpenter, K. G.; Wing, R. F.; Stencel, R. E.

    1985-01-01

    The ultraviolet spectrum of Arcturus has been observed at high resolution with the IUE satellite. Line identifications, mean absolute 'continuum' flux measurements, integrated absolute emission-line fluxes, and measurements of selected absorption line strengths are presented for the 2250-2930 A region. In the 1150-2000 A region, identifications are given primarily on the basis of low-resolution spectra. Chromospheric emission lines have been identified with low-excitation species including H I, C I, C II, O I, Mg I, Mg II, Al II, Si I, Si II, S I, and Fe II; there is no evidence for lines of C IV, N V, or other species requiring high temperatures. A search for molecular absorption features in the 2500-2930 A interval has led to several tentative identifications, but only OH could be established as definitely present. Iron lines strongly dominate the identifications in the 2250-2930 A region, Fe II accounting for about 86 percent of the emission features and Fe I for 43 percent of the identified absorption features.

  6. INTERIOR VIEW OF SECOND FLOOR STAIR HALL. SHOWING THE IRON ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    INTERIOR VIEW OF SECOND FLOOR STAIR HALL. SHOWING THE IRON STAIR RAILS AND NEWEL POSTS WITH INCISED LINES. NOTE THE TONGUE-AND-GROOVE WOOD FLOORING. VIEW FACING EAST. - Hickam Field, Officers' Housing Type L, 702 Julian Avenue, Honolulu, Honolulu County, HI

  7. Iron deficiency and iron deficiency anaemia in women.

    PubMed

    Percy, Laura; Mansour, Diana; Fraser, Ian

    2017-04-01

    Iron deficiency (ID) is the most common micronutrient deficiency worldwide with >20% of women experiencing it during their reproductive lives. Hepcidin, a peptide hormone mostly produced by the liver, controls the absorption and regulation of iron. Understanding iron metabolism is pivotal in the successful management of ID and iron deficiency anaemia (IDA) using oral preparations, parenteral iron or blood transfusion. Oral preparations vary in their iron content and can result in gastrointestinal side effects. Parenteral iron is indicated when there are compliance/tolerance issues with oral iron, comorbidities which may affect absorption or ongoing iron losses that exceed absorptive capacity. It may also be the preferred option when rapid iron repletion is required to prevent physiological decompensation or given preoperatively for non-deferrable surgery. As gynaecologists, we focus on managing women's heavy menstrual bleeding (HMB) and assume that primary care clinicians are treating the associated ID/IDA. We now need to take the lead in diagnosing, managing and initiating treatment for ID/IDA and treating HMB simultaneously. This dual management will significantly improve their quality of life. In this chapter we will summarise the importance of iron in cellular functioning, describe how to diagnose ID/IDA and help clinicians choose between the available treatment options. Copyright © 2016. Published by Elsevier Ltd.

  8. 46 CFR 56.60-10 - Cast iron and malleable iron.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Cast iron and malleable iron. 56.60-10 Section 56.60-10... APPURTENANCES Materials § 56.60-10 Cast iron and malleable iron. (a) The low ductility of cast iron and... avoided. Cast iron and malleable iron components shall not be used at temperatures above 450 °F. Cast iron...

  9. Non-LTE line-blanketed model atmospheres of hot stars. 2: Hot, metal-rich white dwarfs

    NASA Technical Reports Server (NTRS)

    Lanz, T.; Hubeny, I.

    1995-01-01

    We present several model atmospheres for a typical hot metal-rich DA white dwarf, T(sub eff) = 60,000 K, log g = 7.5. We consider pure hydrogen models, as well as models with various abundances of two typical 'trace' elements-carbon and iron. We calculte a number of Local Thermodynamic Equilibrium (LTE) and non-LTE models, taking into account the effect of numerous lines of these elements on the atmospheric structure. We demostrate that while the non-LTE effects are notvery significant for pure hydrogen models, except for describing correctly the central emission in H-alpha they are essential for predicting correctly the ionization balance of metals, such as carbon and iron. Previously reported discrepancies in LTE abundances determinations using C III and C IV lines are easily explained by non-LTE effects. We show that if the iron abundance is larger than 10(exp -5), the iron line opacity has to be considered not only for the spectrum synthesis, but also in the model construction itself. For such metal abundances, non-LTE metal line-blanketed models are needed for detailed abundance studies of hot, metal-rich white dwarfs. We also discuss the predicted Extreme Ultraviolet (EUV) spectrum and show that it is very sensitive to metal abundances, as well as to non-LTE effects.

  10. Planning what not to eat: ironic effects of implementation intentions negating unhealthy habits.

    PubMed

    Adriaanse, Marieke A; van Oosten, Johanna M F; de Ridder, Denise T D; de Wit, John B F; Evers, Catharine

    2011-01-01

    The present studies tested the effectiveness of implementation intentions with an "if [situation], then not [habitual response]" structure. Based on ironic process theory and the literature on the processing of negations, it was expected that these "negation implementation intentions" would, ironically, strengthen the habit (situation-response association) one aims to break. In line with the hypotheses, forming negation implementation intentions resulted in cognitive ironic rebound effects as well as behavioral ironic rebound effects compared to an intention only condition or a replacement implementation intention. Additionally, it was found that negation implementation intentions are most likely to result in ironic rebound effects when the habit to be negated is strong. Although implementation intentions are generally highly effective in facilitating behavior change even when this involves breaking unwanted habits, the present research suggests that they are ineffective when they have a negating structure.

  11. Higher iron bioavailability of a human-like collagen iron complex.

    PubMed

    Zhu, Chenhui; Yang, Fan; Fan, Daidi; Wang, Ya; Yu, Yuanyuan

    2017-07-01

    Iron deficiency remains a public health problem around the world due to low iron intake and/or bioavailability. FeSO 4 , ferrous succinate, and ferrous glycinate chelate are rich in iron but have poor bioavailability. To solve the problem of iron deficiency, following previous research studies, a thiolated human-like collagen-ironcomplex supplement with a high iron content was prepared in an anaerobic workstation. In addition, cell viability tests were evaluated after conducting an MTT assay, and a quantitative analysis of the thiolated human-like collagen-iron digesta samples was performed using the SDS-PAGE method coupled with gel filtration chromatography. The iron bioavailability was assessed using Caco-2 cell monolayers and iron-deficiency anemia mice models. The results showed that (1) one mole of thiolated human-like collagen-iron possessed approximately 35.34 moles of iron; (2) thiolated human-like collagen-iron did not exhibit cytotoxity and (3) thiolated human-like collagen- iron digesta samples had higher bioavailability than other iron supplements, including FeSO 4 , ferrous succinate, ferrous glycine chelate and thiolated human-like collagen-Fe iron. Finally, the iron bioavailability was significantly enhanced by vitamin C. These results indicated that thiolated human-like collagen-iron is a promising iron supplement for use in the future.

  12. Optical Follow-Up Observations of PTF10qts, a Luminous Broad-Lined Type Ic Supernova Found by the Palomar Transient Factory

    NASA Technical Reports Server (NTRS)

    Walker, E. S.; Mazzali, P. A.; Pian, E.; Hurley, K.; Arcavi, I.; Cenko, S. B.; Gal-Yam, A.; Horesh, A.; Kasliwal, M.; Poznanski, D.; hide

    2014-01-01

    We present optical photometry and spectroscopy of the broad-lined Type Ic supernova (SN Ic-BL) PTF10qts, which was discovered as part of the Palomar Transient Factory. The supernova was located in a dwarf galaxy of magnitude r = 21.1 at a redshift z = 0.0907.We find that the R-band light curve is a poor proxy for bolometric data and use photometric and spectroscopic data to construct and constrain the bolometric light curve. The derived bolometric magnitude at maximum light is Mbol = -18.51 +/- 0.2 mag, comparable to that of SN1998bw (Mbol = -18.7 mag) which was associated with a gamma-ray burst (GRB). PTF10qts is one of the most luminous SN Ic-BL observed without an accompanying GRB. We estimate the physical parameters of the explosion using data from our programme of follow-up observations, finding that it produced a larger mass of radioactive nickel compared to other SNeIc-BL with similar inferred ejecta masses and kinetic energies. The progenitor of the event was likely a approximately 20 solar mass star.

  13. Evidence that stainable bone marrow iron following parenteral iron therapy does not correlate with serum iron studies and may not represent readily available storage iron.

    PubMed

    Thomason, Ronald W; Almiski, Muhamad S

    2009-04-01

    We recently reported that parenteral iron therapy is associated with a characteristic pattern of iron staining on bone marrow aspirate smears. We now present clinical information from 6 patients who received parenteral iron and, at one or more points in follow-up, were found to have low or borderline low serum ferritin levels and/or serum iron levels, even though marrow aspirate smears revealed abundant stainable iron in the pattern characteristic of prior parenteral iron therapy. We conclude that stainable iron seen in this pattern does not correlate with serum iron studies and may not represent functionally available storage iron. This pattern of iron staining should not be used as evidence to withhold further iron therapy in patients who otherwise continue to have features of iron deficiency anemia.

  14. Removal of iron and manganese using biological roughing up flow filtration technology.

    PubMed

    Pacini, Virginia Alejandra; María Ingallinella, Ana; Sanguinetti, Graciela

    2005-11-01

    The removal of iron and manganese from groundwater using biological treatment methods is almost unknown in Latin America. Biological systems used in Europe are based on the process of double rapid biofiltration during which dissolved oxygen and pH need to be strictly controlled in order to limit abiotic iron oxidation. The performance of roughing filter technology in a biological treatment process for the removal of iron and manganese, without the use of chemical agents and under natural pH conditions was studied. Two pilot plants, using two different natural groundwaters, were operated with the following treatment line: aeration, up flow roughing filtration and final filtration (either slow or rapid). Iron and manganese removal efficiencies were found to be between 85% and 95%. The high solid retention capability of the roughing filter means that it is possible to remove iron and manganese simultaneously by biotic and abiotic mechanisms. This system combines simple, low-cost operation and maintenance with high iron and manganese removal efficiencies, thus constituting a technology which is particularly suited to small waterworks.

  15. Colloidal synthesis of biocompatible iron disulphide nanocrystals.

    PubMed

    Santos-Cruz, J; Nuñez-Anita, R E; Mayén-Hernández, S A; Martínez-Alvarez, O; Acosta-Torres, L S; de la Fuente-Hernández, J; Campos-González, E; Vega-González, M; Arenas-Arrocena, M C

    2018-08-01

    The aim of this research was to synthesis biocompatible iron disulphide nanocrystals at different reaction temperatures using the colloidal synthesis methodology. Synthesis was conducted at the 220-240 °C range of reaction temperatures at intervals of 5 °C in an inert argon atmosphere. The toxicity of iron disulphide nanocrystals was evaluated in vitro using mouse fibroblast cell line. Two complementary assays were conducted: the first to evaluate cell viability of the fibroblast via an MTT assay and the second to determine the preservation of fibroblast nuclei integrity through DAPI staining, which labels nuclear DNA in fluorescence microscopes. Through TEM and HRTEM, we observed a cubic morphology of pyrite iron disulphide nanocrystals ranging in sizes 25-50 nm (225 °C), 50-70 nm (230 °C) and >70 nm (235 °C). Through X-ray diffraction, we observed a mixture of pyrite and pyrrohotite in the samples synthesized at 225 °C and 240 °C, showing the best photocatalytic activity at 80% and 65%, respectively, for the degradation of methylene blue after 120 minutes. In all experimental groups, iron disulphide nanocrystals were biocompatible, i.e. no statistically significant differences were observed between experimental groups as shown in a one-way ANOVA and Tukey's test. Based on all of these results, we recommend non-cytotoxic semiconductor iron sulphide nanocrystals for biomedical applications.

  16. Searching for Variability of NV Intrinsic Narrow Absorption Line Systems

    NASA Astrophysics Data System (ADS)

    Rodruck, Michael; Charlton, Jane; Ganguly, Rajib

    2018-01-01

    The majority of quasar absorption line systems with NV detected are found within the associated region (within 5000 km/s of the quasar redshift) and many/most are believed to be related to the quasar accretion disk wind or outflows. The most definite evidence that these NV absorbers are "intrinsic" is partial covering of the quasar continuum source and/or broad line region. Over 75 quasars containing NV narrow absorption lines have observations obtained at different times with the Keck/HIRES and the VLT/UVES spectrographs at high resolution. The interval between these observations range from months to a decade in the quasar rest frame. While variability is common for intrinsic broad and mini-broad absorption lines, intrinsic narrow absorption lines have been found to be less likely to vary, though systematic studies with large, high quality datasets have been limited. The variability timescales are useful for deriving gas densities and thus the distances from the central engines. This is important in mapping the quasar surroundings, understanding the accretion disk wind mechanism, and assessing the effect the wind has on the galaxy surroundings. We report on the results of a systematic study of variability of NV NALs, exploiting the overlap of targets for observations in the archives of Keck and VLT, and discuss the consequences for interpretation of the origin of intrinsic narrow absorption lines.

  17. Broad-line radio galaxies observed with Fermi-LAT: The origin of the GeV γ-ray emission

    DOE PAGES

    Kataoka, J.; Stawarz, Ł.; Takahashi, Y.; ...

    2011-09-22

    Here, we report on a detailed investigation of the γ-ray emission from 18 broad-line radio galaxies (BLRGs) based on two years of Fermi Large Area Telescope data. We confirm the previously reported detections of 3C 120 and 3C 111 in the GeV photon energy range; a detailed look at the temporal characteristics of the observed γ-ray emission reveals in addition possible flux variability in both sources. No statistically significant γ-ray detection of the other BLRGs was found, however, in the considered data set. Though the sample size studied is small, what appears to differentiate 3C 111 and 3C 120 frommore » the BLRGs not yet detected in γ-rays is the particularly strong nuclear radio flux. This finding, together with the indications of the γ-ray flux variability and a number of other arguments presented, indicates that the GeV emission of BLRGs is most likely dominated by the beamed radiation of relativistic jets observed at intermediate viewing angles. In this paper we also analyzed a comparison sample of high-accretion-rate Seyfert 1 galaxies, which can be considered radio-quiet counterparts of BLRGs, and found that none were detected in γ-rays. A simple phenomenological hybrid model applied for the broadband emission of the discussed radio-loud and radio-quiet type 1 active galaxies suggests that the relative contribution of the nuclear jets to the accreting matter is ≥ 1% on average for BLRGs, whereas it is ≤ 0.1% for Seyfert 1 galaxies.« less

  18. Superluminous Transients at AGN Centers from Interaction between Black Hole Disk Winds and Broad-line Region Clouds

    NASA Astrophysics Data System (ADS)

    Moriya, Takashi J.; Tanaka, Masaomi; Morokuma, Tomoki; Ohsuga, Ken

    2017-07-01

    We propose that superluminous transients that appear at central regions of active galactic nuclei (AGNs) such as CSS100217:102913+404220 (CSS100217) and PS16dtm, which reach near- or super-Eddington luminosities of the central black holes, are powered by the interaction between accretion-disk winds and clouds in broad-line regions (BLRs) surrounding them. If the disk luminosity temporarily increases by, e.g., limit-cycle oscillations, leading to a powerful radiatively driven wind, strong shock waves propagate in the BLR. Because the dense clouds in the AGN BLRs typically have similar densities to those found in SNe IIn, strong radiative shocks emerge and efficiently convert the ejecta kinetic energy to radiation. As a result, transients similar to SNe IIn can be observed at AGN central regions. Since a typical black hole disk-wind velocity is ≃0.1c, where c is the speed of light, the ejecta kinetic energy is expected to be ≃1052 erg when ≃1 M ⊙ is ejected. This kinetic energy is transformed to radiation energy in a timescale for the wind to sweep up a similar mass to itself in the BLR, which is a few hundred days. Therefore, both luminosities (˜1044 erg s-1) and timescales (˜100 days) of the superluminous transients from AGN central regions match those expected in our interaction model. If CSS100217 and PS16dtm are related to the AGN activities triggered by limit-cycle oscillations, they become bright again in coming years or decades.

  19. A chemical potentiator of copper-accumulation used to investigate the iron-regulons of Saccharomyces cerevisiae.

    PubMed

    Foster, Andrew W; Dainty, Samantha J; Patterson, Carl J; Pohl, Ehmke; Blackburn, Hannah; Wilson, Clare; Hess, Corinna R; Rutherford, Julian C; Quaranta, Laura; Corran, Andy; Robinson, Nigel J

    2014-07-01

    The extreme resistance of Saccharomyces cerevisiae to copper is overcome by 2-(6-benzyl-2-pyridyl)quinazoline (BPQ), providing a chemical-biology tool which has been exploited in two lines of discovery. First, BPQ is shown to form a red (BPQ)2 Cu(I) complex and promote Ctr1-independent copper-accumulation in whole cells and in mitochondria isolated from treated cells. Multiple phenotypes, including loss of aconitase activity, are consistent with copper-BPQ mediated damage to mitochondrial iron-sulphur clusters. Thus, a biochemical basis of copper-toxicity in S. cerevisiae is analogous to other organisms. Second, iron regulons controlled by Aft1/2, Cth2 and Yap5 that respond to mitochondrial iron-sulphur cluster status are modulated by copper-BPQ causing iron hyper-accumulation via upregulated iron-import. Comparison of copper-BPQ treated, untreated and copper-only treated wild-type and fra2Δ by RNA-seq has uncovered a new candidate Aft1 target-gene (LSO1) and paralogous non-target (LSO2), plus nine putative Cth2 target-transcripts. Two lines of evidence confirm that Fra2 dominates basal repression of the Aft1/2 regulons in iron-replete cultures. Fra2-independent control of these regulons is also observed but CTH2 itself appears to be atypically Fra2-dependent. However, control of Cth2-target transcripts which is independent of CTH2 transcript abundance or of Fra2, is also quantified. Use of copper-BPQ supports a substantial contribution of metabolite repression to iron-regulation. © 2014 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

  20. Dietary iron intake, iron status, and gestational diabetes.

    PubMed

    Zhang, Cuilin; Rawal, Shristi

    2017-12-01

    Pregnant women are particularly vulnerable to iron deficiency and related adverse pregnancy outcomes and, as such, are routinely recommended for iron supplementation. Emerging evidence from both animal and population-based studies, however, has raised potential concerns because significant associations have been observed between greater iron stores and disturbances in glucose metabolism, including increased risk of type 2 diabetes among nonpregnant individuals. Yet, the evidence is uncertain regarding the role of iron in the development of gestational diabetes mellitus (GDM), a common pregnancy complication which has short-term and long-term adverse health ramifications for both women and their children. In this review, we critically and systematically evaluate available data examining the risk of GDM associated with dietary iron, iron supplementation, and iron status as measured by blood concentrations of several indicators. We also discuss major methodologic concerns regarding the available epidemiologic studies on iron and GDM. © 2017 American Society for Nutrition.

  1. The Irony of Iron – Biogenic Iron Oxides as an Iron Source to the Ocean

    PubMed Central

    Emerson, David

    2016-01-01

    Primary productivity in at least a third of the sunlit open ocean is thought to be iron-limited. Primary sources of dissolved iron (dFe) to the ocean are hydrothermal venting, flux from the sediments along continental margins, and airborne dust. This article provides a general review of sources of hydrothermal and sedimentary iron to the ocean, and speculates upon the role that iron-cycling microbes play in controlling iron dynamics from these sources. Special attention is paid to iron-oxidizing bacteria (FeOB) that live by oxidizing iron and producing biogenic iron oxides as waste products. The presence and ubiquity of FeOB both at hydrothermal systems and in sediments is only beginning to be appreciated. The biogenic oxides they produce have unique properties that could contribute significantly to the dynamics of dFe in the ocean. Changes in the physical and chemical characteristics of the ocean due to climate change and ocean acidification will undoubtedly impact the microbial iron cycle. A better understanding of the contemporary role of microbes in the iron cycle will help in predicting how these changes could ultimately influence marine primary productivity. PMID:26779157

  2. Rhenium-osmium concentration and isotope systematics in group IIAB iron meteorites

    USGS Publications Warehouse

    Morgan, J.W.; Horan, M.F.; Walker, R.J.; Grossman, J.N.

    1995-01-01

    Rhenium and osmium abundances, and osmium isotopic compositions were measured by negative thermal ionization mass spectrometry in thirty samples, including replicates, of five IIA and eight IIB iron meteorites. Log plots of Os vs. Re abundances for IIA and IIB irons describe straight lines that approximately converge on Lombard, which has the lowest Re and Os abundances and highest 187Re/188Os measured in a IIA iron to date. The linear IIA trend may be exactly reproduced by fractional crystallization, but is not well fitted using variable partition coefficients. The IIB iron trend, however, cannot be entirely explained by simple fractional crystallization. One explanation is that small amounts of Re and Os were added to the asteroid core during the final stages of crystallization. Another possibility is that diffusional enrichment of Os may have occurred in samples most depleted in Re and Os. -from Authors

  3. An XMM-Newton Study of the Bright Narrow-Line Seyfert 1 Galaxy Arakelian 564

    NASA Technical Reports Server (NTRS)

    Brandt, Niel

    2004-01-01

    We report on two XMM-Newton observations of the bright Narrow-Line Seyfert 1 galaxy Ark 564 taken one year apart (2000 June and 2001 June). The 0.6-10 keV continuum is well described by a soft blackbody component (kT - 140-150 eV) plus a steep power law (Gamma - 2.50-2.55). No significant spectral changes are observed between the two observations, although the X-ray flux in the second observation is - 40-50 per cent lower. In both observations we detect a significant absorption edge at a rest-frame energy of - 0.73 keV, corresponding to 0 VII. The presence of the absorption feature is confirmed by a simultaneous Chandra grating observation in 2000 June, although the best-fitting edge threshold is at a slightly lower energy in the Chandra data, possibly because of a different parameterization of the underlying X-ray continuum. We find tentative evidence for a broad iron emission line in the 2000 June observation. The results from an analysis of the power spectral density (PSD) function are also presented. The present XMM-Newton data support the idea that the PSD shows two breaks, although the location of the high-frequency break requires further constraints.

  4. The role of iron in neurodegenerative disorders: insights and opportunities with synchrotron light

    PubMed Central

    Collingwood, Joanna F.; Davidson, Mark R.

    2014-01-01

    There is evidence for iron dysregulation in many forms of disease, including a broad spectrum of neurodegenerative disorders. In order to advance our understanding of the pathophysiological role of iron, it is helpful to be able to determine in detail the distribution of iron as it relates to metabolites, proteins, cells, and tissues, the chemical state and local environment of iron, and its relationship with other metal elements. Synchrotron light sources, providing primarily X-ray beams accompanied by access to longer wavelengths such as infra-red, are an outstanding tool for multi-modal non-destructive analysis of iron in these systems. The micro- and nano-focused X-ray beams that are generated at synchrotron facilities enable measurement of iron and other transition metal elements to be performed with outstanding analytic sensitivity and specificity. Recent developments have increased the scope for methods such as X-ray fluorescence mapping to be used quantitatively rather than semi-quantitatively. Burgeoning interest, coupled with technical advances and beamline development at synchrotron facilities, has led to substantial improvements in resources and methodologies in the field over the past decade. In this paper we will consider how the field has evolved with regard to the study of iron in proteins, cells, and brain tissue, and identify challenges in sample preparation and analysis. Selected examples will be used to illustrate the contribution, and future potential, of synchrotron X-ray analysis for the characterization of iron in model systems exhibiting iron dysregulation, and for human cases of neurodegenerative disorders including Alzheimer’s disease, Parkinson’s disease, Friedreich’s ataxia, and amyotrophic lateral sclerosis. PMID:25191270

  5. Spectroscopic Diagnostics of Solar Magnetic Flux Ropes Using Iron Forbidden Line

    NASA Astrophysics Data System (ADS)

    Cheng, X.; Ding, M. D.

    2016-05-01

    In this Letter, we present Interface Region Imaging Spectrograph Fe xxi 1354.08 Å forbidden line emission of two magnetic flux ropes (MFRs) that caused two fast coronal mass ejections with velocities of ≥1000 km s-1 and strong flares (X1.6 and M6.5) on 2014 September 10 and 2015 June 22, respectively. The extreme-ultraviolet images at the 131 and 94 Å passbands provided by the Atmospheric Imaging Assembly on board Solar Dynamics Observatory reveal that both MFRs initially appear as suspended hot channel-like structures. Interestingly, part of the MFRs is also visible in the Fe xxi 1354.08 forbidden line, even prior to the eruption, e.g., for the SOL2014-09-10 event. However, the line emission is very weak and that only appears at a few locations but not the whole structure of the MFRs. This implies that the MFRs could be comprised of different threads with different temperatures and densities, based on the fact that the formation of the Fe xxi forbidden line requires a critical temperature (˜11.5 MK) and density. Moreover, the line shows a non-thermal broadening and a blueshift in the early phase. It suggests that magnetic reconnection at that time has initiated; it not only heats the MFR and, at the same time, produces a non-thermal broadening of the Fe xxi line but also produces the poloidal flux, leading to the ascension of the MFRs.

  6. Effects of calcium on hepatocyte iron uptake from transferrin, iron-pyrophosphate and iron-ascorbate.

    PubMed

    Nilsen, T

    1991-10-16

    Calcium stimulates hepatocyte iron uptake from transferrin, ferric-iron-pyrophosphate and ferrous-iron-ascorbate. Maximal stimulation of iron uptake is observed at 1-1.5 mM of extra-cellular calcium and the effect is reversible and immediate. Neither the receptor affinity for transferrin, nor the total amounts of transferrin associated with the cells or the rate of transferrin endocytosis are significantly affected by calcium. In the presence of calcium the rate of iron uptake of non-transferrin bound iron increases abruptly at approximate 17 degrees C and 27 degrees C and as assessed by Arrhenius plots, the activation energy is reduced in a calcium dependent manner at approx. 27 degrees C. At a similar temperature, i.e., between 25 degrees C and 28 degrees C, calcium increases the rates of cellular iron uptake from transferrin in a way that is not reflected in the rate of transferrin endocytosis. By the results of this study it is concluded that calcium increases iron transport across the plasma membrane by a mechanism dependent on membrane fluidity.

  7. Low haemoglobin density for detecting iron deficiency across a large population, including pregnancy.

    PubMed

    Crispin, P; Sinclair, F; Andriolo, K

    2016-08-01

    Low haemoglobin density (LHD%) from Coulter counters has been suggested as a means to detect iron deficiency. Its performance in a broad population group, including pregnancy, has not been evaluated. A retrospective study of adult and paediatric (under 12 years old) patient samples referred for blood counts and iron studies between October 2013 and March 2015. Receiver operator characteristic (ROC) curves were constructed to evaluate the performance of LHD% adults, children, and in the antenatal subgroup. Using a strict definition for iron deficiency, compared with a selected normal cohort, LHD% had a ROC area under the curve (AUC) of 0.90 (0.89-0.91), but in an unselected cohort, the AUC fell to 0.74 (0.73-0.75) with a sensitivity of 74% and specificity of 60% at a cut-off value of 5.9%. In the paediatric cohort, the AUC was 0.79(0.73-0.85), giving a sensitivity and specificity of 75% and 68%, respectively. LHD% did not effectively identify iron deficiency in pregnancy with an AUC of 0.60 (0.54-0.65) and was no better than MCV at detecting iron deficiency. LHD% detects iron deficiency in adult and paediatric populations, but not in the antenatal setting, and does not appear superior to MCV. © 2016 John Wiley & Sons Ltd.

  8. Response to parenteral iron therapy distinguish unexplained refractory iron deficiency anemia from iron-refractory iron deficiency anemia.

    PubMed

    Akin, M; Sarbay, H; Guler, S; Balci, Y I; Polat, A

    2016-04-01

    We evaluated that response to parenteral iron therapy could be helpful in distinguishing the types of iron deficiency anemia. This study analyzed responses to IV iron sucrose therapy of 15 children with unexplained refractory iron deficiency anemia (URIDA). We compared the results at diagnosis, 6 weeks and 6 months after the therapy. Results were compared with responses of 11 patients' results with iron-refractory iron deficiency anemia (IRIDA) from our previous study. Six weeks after the start of treatment, ferritin, MCV, MCH and Hb values were in normal range in 10 patients. The increase in Hb, MCH, MCV, and ferritin values ranged 2.6-3.5 g/dL, 1.7-4.2 pg, 2-9 fL, and 13-25 ng/mL, respectively. In five patients, Hb, MCH, and MCV mean (range) values [11.2 g/dL (11-12.2), 24.5 pg (24-25.6), and 67 fL (65-70)] were nearly normal but ferritin mean (range) values [9.8 ng/mL (8-11)] were below normal. Six weeks after the start of treatment, Hb, MCH, MCV and ferritin values of patients with IRIDA were increased. The increase in Hb, MCH, MCV, and ferritin values ranged 0.8-2.7 g/dL, 1.7-4.2 pg, 2-9 fL, and 13-25 ng/mL, respectively. IRIDA is only partially responsive to parenteral iron supplementation. In conclusion, this study demonstrated that the response to intravenous iron therapy for the URIDA cases improved blood parameters more effectively than hereditary IRIDA. Response to parenteral iron therapy would be helpful to distinguish unexplained refractory IDA from hereditary IRIDA for clinicians who do not have access to hepcidin or TMPRS6 mutation analysis. © 2016 John Wiley & Sons Ltd.

  9. Effects of Escherichia coli challenge and transport stress on hematology and serum chemistry values of three genetic lines of turkeys.

    PubMed

    Huff, G R; Huff, W E; Rath, N C; Anthony, N B; Nestor, K E

    2008-11-01

    Three lines of turkeys were compared for response to an Escherichia coli challenge followed by transport stress (transport). The turkey lines were a slow-growing line selected for increased egg production (egg line), a fast-growing line selected for increased 16-wk BW (F line), and a commercial line (Comm line). Birds were challenged at 14 wk of age with an air sac injection of 5,000 to 10,000 cfu of E. coli. At 8 d postchallenge, birds were subjected to a transport stress procedure that included 12 h of holding time in a transport vehicle. The following morning all birds (n = 10 to 19 birds/line) were bled. Whole blood was analyzed using the Cell-Dyn 3500 blood analysis system (Abbott Diagnostics), and serum chemistry was measured using the Express Plus analyzer (Ciba-Corning Diagnostics Corp.). Transport significantly decreased the levels of hematocrit, hemoglobin, mean cell volume, mean corpuscular hemoglobin, glucose, triglycerides, cholesterol, phosphorus, iron, albumin, and alkaline phosphatase (AP) and increased the levels of uric acid, blood urea nitrogen, alanine aminotransferase, aspartate aminotransferase, and creatine kinase. Line differences were variable, but the levels of both iron and AP were least in the fastest-growing Comm line birds and greatest in the slowest-growing egg-line birds with intermediate values in the F line. Iron and AP were also the only parameters influenced by sex, with males having greater levels of both compared with females. The creatine kinase levels were more than 6-fold greater in transported Comm line birds, and iron levels of transported Comm males were 3-fold less than controls. Previously, the growth rate of these lines was positively correlated with increased heterophil to lymphocyte ratios and susceptibility to colibacillosis. The differences seen in the Comm line for these commonly measured blood parameters suggest that they may be useful for profiling flocks to determine their response to transport stress and feed

  10. The Effect Of Local Coal And Smelting Sponge Iron On Iron Content Of Pig Iron

    NASA Astrophysics Data System (ADS)

    Oediyani, Soesaptri; Juwita Sari, Pramita; Hadi P, Djoko

    2018-03-01

    The new regulation on mineral resources was announced by Ministry of Energy and Mineral resources (ESDM) of Indonesia at 2014 which it called Permen ESDM No 1/2014. Therefore, this research was conducted to add the value of local iron ores by using smelting technology. The objective of the research is to produce pig iron that meet the requirement of the new regulation of mineral resources such as 90% Fe. First, iron ores and coal mixed together with lime as a flux, then smelted in a Electric Arc Furnace at 1800°C. The process variables are (1; 1.25; 1.5; 1.75; 2.0) and the composition of coal (0.8%, 1.6%, 3.0%). The type of coal that used in this research was bituminous coal from Kalimantan and also the iron ores from Kalimantan. The products of the smelting technology are Pig iron and slag. Both pig iron and slag then analyzed by SEM-EDS to measure the iron content. The result shows that the maximum iron content on pig iron is about 95.04% meanwhile the minimum iron content on slag is about 3.66%. This result achieved at 1.6% coal and 2.0.

  11. Molecular control of vertebrate iron homeostasis by iron regulatory proteins

    PubMed Central

    Wallander, Michelle L.; Leibold, Elizabeth A.; Eisenstein, Richard S.

    2008-01-01

    Both deficiencies and excesses of iron represent major public health problems throughout the world. Understanding the cellular and organismal processes controlling iron homeostasis is critical for identifying iron-related diseases and in advancing the clinical treatments for such disorders of iron metabolism. Iron regulatory proteins (IRPs) 1 and 2 are key regulators of vertebrate iron metabolism. These RNA binding proteins post-transcriptionally control the stability or translation of mRNAs encoding proteins involved in iron homeostasis thereby controlling the uptake, utilization, storage or export of iron. Recent evidence provides insight into how IRPs selectively control the translation or stability of target mRNAs, how IRP RNA binding activity is controlled by iron-dependent and iron-independent effectors, and the pathological consequences of dysregulation of the IRP system. PMID:16872694

  12. Microbial Biosignatures in High Iron Thermal Springs

    NASA Astrophysics Data System (ADS)

    Parenteau, M. N.; Embaye, T.; Jahnke, L. L.; Cady, S. L.

    2003-12-01

    The emerging anoxic source waters at Chocolate Pots hot springs in Yellowstone National Park contain 2.6 to 11.2 mg/L Fe(II) and are 51-54° C and pH 5.5-6.0. These waters flow down the accumulating iron deposits and over three major phototrophic mat communities: Synechococcus/Chloroflexus at 51-54° C, Pseudanabaena at 51-54° C, and a narrow Oscillatoria at 36-45° C. We are assessing the contribution of the phototrophs to biosignature formation in this high iron system. These biosignatures can be used to assess the biological contribution to ancient iron deposits on Earth (e.g. Precambrian Banded Iron Formations) and, potentially, to those found on Mars. Most studies to date have focused on chemotrophic iron-oxidizing communities; however, recent research has demonstrated that phototrophs have a significant physiological impact on these iron thermal springs (Pierson et al. 1999, Pierson and Parenteau 2000, and Trouwborst et al., 2003). We completed a survey of the microfossils, biominerals, biofabrics, and lipid biomarkers in the phototrophic mats and stromatolitic iron deposits using scanning and transmission electron microscopy (SEM and TEM), energy dispersive spectrometry (EDS), powder X-ray diffraction (XRD), and gas chromatography-mass spectroscopy (GC-MS). The Synechococcus/Chloroflexus mat was heavily encrusted with iron silicates while the narrow Oscillatoria mat was encrusted primarily with iron oxides. Encrustation of the cells increased with depth in the mats. Amorphous 2-line ferrihydrite is the primary precipitate in the spring and the only iron oxide mineral associated with the mats. Goethite, hematite, and siderite were detected in dry sediment samples on the face of the main iron deposit. Analysis of polar lipid fatty acid methyl esters (FAME) generated a suite of lipid biomarkers. The Synechococcus/Chloroflexus mat contained two mono-unsaturated isomers of n-C18:1 with smaller amounts of polyunsaturated n-C18:2, characteristic of cyanobacteria

  13. Sodium D-line emission from Io - Comparison of observed and theoretical line profiles

    NASA Technical Reports Server (NTRS)

    Carlson, R. W.; Matson, D. L.; Johnson, T. V.; Bergstralh, J. T.

    1978-01-01

    High-resolution spectra of the D-line profiles have been obtained for Io's sodium emission cloud. These lines, which are produced through resonance scattering of sunlight, are broad and asymmetric and can be used to infer source and dynamical properties of the sodium cloud. In this paper we compare line profile data with theoretical line shapes computed for several assumed initial velocity distributions corresponding to various source mechanisms. We also examine the consequences of source distributions which are nonuniform over the surface of Io. It is found that the experimental data are compatible with escape of sodium atoms from the leading hemisphere of Io and with velocity distributions characteristic of sputtering processes. Thermal escape and simple models of plasma sweeping are found to be incompatible with the observations.

  14. Iron regulatory proteins and their role in controlling iron metabolism.

    PubMed

    Kühn, Lukas C

    2015-02-01

    Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and 2 (IRP1 and IRP2) play a central role in this regulation. Foremost, IRPs regulate ferritin H and ferritin L translation and thus iron storage, as well as transferrin receptor 1 (TfR1) mRNA stability, thereby adjusting receptor expression and iron uptake via receptor-mediated endocytosis of iron-loaded transferrin. In addition splice variants of iron transporters for import and export at the plasma-membrane, divalent metal transporter 1 (DMT1) and ferroportin are regulated by IRPs. These mechanisms have probably evolved to maintain the cytoplasmic labile iron pool (LIP) at an appropriate level. In certain tissues, the regulation exerted by IRPs influences iron homeostasis and utilization of the entire organism. In intestine, the control of ferritin expression limits intestinal iron absorption and, thus, whole body iron levels. In bone marrow, erythroid heme biosynthesis is coordinated with iron availability through IRP-mediated translational control of erythroid 5-aminolevulinate synthase mRNA. Moreover, the translational control of HIF2α mRNA in kidney by IRP1 coordinates erythropoietin synthesis with iron and oxygen supply. Besides IRPs, body iron absorption is negatively regulated by hepcidin. This peptide hormone, synthesized and secreted by the liver in response to high serum iron, downregulates ferroportin at the protein level and thereby limits iron absorption from the diet. Hepcidin will not be discussed in further detail here.

  15. Iron alters cell survival in a mitochondria-dependent pathway in ovarian cancer cells

    PubMed Central

    Bauckman, Kyle; Haller, Edward; Taran, Nicholas; Rockfield, Stephanie; Ruiz-Rivera, Abigail; Nanjundan, Meera

    2015-01-01

    The role of iron in the development of cancer remains unclear. We previously reported that iron reduces cell survival in a Ras/mitogen-activated protein kinase (MAPK)-dependent manner in ovarian cells; however, the underlying downstream pathway leading to reduced survival was unclear. Although levels of intracellular iron, ferritin/CD71 protein and reactive oxygen species did not correlate with iron-induced cell survival changes, we identified mitochondrial damage (via TEM) and reduced expression of outer mitochondrial membrane proteins (translocase of outer membrane: TOM20 and TOM70) in cell lines sensitive to iron. Interestingly, Ru360 (an inhibitor of the mitochondrial calcium uniporter) reversed mitochondrial changes and restored cell survival in HEY ovarian carcinoma cells treated with iron. Further, cells treated with Ru360 and iron also had reduced autophagic punctae with increased lysosomal numbers, implying cross-talk between these compartments. Mitochondrial changes were dependent on activation of the Ras/MAPK pathway since treatment with a MAPK inhibitor restored expression of TOM20/TOM70 proteins. Although glutathione antioxidant levels were reduced in HEY treated with iron, extracellular glutamate levels were unaltered. Strikingly, oxalomalate (inhibitor of aconitase, involved in glutamate production) reversed iron-induced responses in a similar manner to Ru360. Collectively, our results implicate iron in modulating cell survival in a mitochondria-dependent manner in ovarian cancer cells. PMID:25697096

  16. Spatial Modeling of Iron Transformations Within Artificial Soil Aggregates

    NASA Astrophysics Data System (ADS)

    Kausch, M.; Meile, C.; Pallud, C.

    2008-12-01

    processes for assessing bulk iron cycling. As HFOs are ubiquitous in soils, such process-level understanding of aggregate-scale iron dynamics has broad implications for the prediction of the subsurface fate of nutrients and contaminants that interact strongly with HFO surfaces.

  17. [Norfloxacin: a broad-spectrum quinolone for superficial eye infections].

    PubMed

    Grosset, J

    1990-09-01

    Norfloxacin is a synthetic antibiotic belonging to the fluoroquinolone class. At present, an oral formulation is available and indicated for the treatment of urinary tract infections. Because of the properties of norfloxacin, a 0.3% norfloxacin ophtalmic solution may be used by ophtalmologists. The molecular target of norfloxacin is DNA gyrase that regulates DNA replication. Norfloxacin is a broad spectrum antibiotic. A flurin atome in position 6 is responsible for the broad spectrum of activity as compared with the first generation quinolones. MICs of norfloxacin against Haemophilus influenzae, Neisseria gonorrhoeae, Staphylococcus aureus, Pseudomonas aeruginosa, and enterbacteriaceae are low or intermediate. Norfloxacin is a bactericidal drug of which MBCs are equivalent to or twice as high as MICs against the majority of organisms. The proportion of norfloxacin resistant strains is limited and, at present, no plasmid resistance has been observed. This explains the activity of norfloxacin against clinical isolates whose drug resistance is plasmid-mediated. Norfloxacin resistance is chromosomic, but the mutation rate is low. There is no cross-resistance between quinolones and other classes of drug, with the exception of drug resistance related to changes in the bacterial outer membrane proteins. A low decrease in norfloxacin susceptibility is observed in case of resistance to first generation quinolones. The above-mentioned properties make norfloxacin in ophtalmic solution a first line drug for treatment of superficial ocular infections and a second line drug for treatment of infections due to organisms resistant to other drugs.

  18. Consuming Iron Biofortified Beans Increases Iron Status in Rwandan Women after 128 Days in a Randomized Controlled Feeding Trial.

    PubMed

    Haas, Jere D; Luna, Sarah V; Lung'aho, Mercy G; Wenger, Michael J; Murray-Kolb, Laura E; Beebe, Stephen; Gahutu, Jean-Bosco; Egli, Ines M

    2016-08-01

    Food-based strategies to reduce nutritional iron deficiency have not been universally successful. Biofortification has the potential to become a sustainable, inexpensive, and effective solution. This randomized controlled trial was conducted to determine the efficacy of iron-biofortified beans (Fe-Beans) to improve iron status in Rwandan women. A total of 195 women (aged 18-27 y) with serum ferritin <20 μg/L were randomly assigned to receive either Fe-Beans, with 86 mg Fe/kg, or standard unfortified beans (Control-Beans), with 50 mg Fe/kg, 2 times/d for 128 d in Huye, Rwanda. Iron status was assessed by hemoglobin, serum ferritin, soluble transferrin receptor (sTfR), and body iron (BI); inflammation was assessed by serum C-reactive protein (CRP) and serum α1-acid glycoprotein (AGP). Anthropometric measurements were performed at baseline and at end line. Random weekly serial sampling was used to collect blood during the middle 8 wk of the feeding trial. Mixed-effects regression analysis with repeated measurements was used to evaluate the effect of Fe-Beans compared with Control-Beans on iron biomarkers throughout the course of the study. At baseline, 86% of subjects were iron-deficient (serum ferritin <15 μg/L) and 37% were anemic (hemoglobin <120 g/L). Both groups consumed an average of 336 g wet beans/d. The Fe-Beans group consumed 14.5 ± 1.6 mg Fe/d from biofortified beans, whereas the Control-Beans group consumed 8.6 ± 0.8 mg Fe/d from standard beans (P < 0.05). Repeated-measures analyses showed significant time-by-treatment interactions for hemoglobin, log serum ferritin, and BI (P < 0.05). The Fe-Beans group had significantly greater increases in hemoglobin (3.8 g/L), log serum ferritin (0.1 log μg/L), and BI (0.5 mg/kg) than did controls after 128 d. For every 1 g Fe consumed from beans over the 128 study days, there was a significant 4.2-g/L increase in hemoglobin (P < 0.05). The consumption of iron-biofortified beans significantly improved iron status

  19. Overexpression of native ferritin gene MusaFer1 enhances iron content and oxidative stress tolerance in transgenic banana plants

    PubMed Central

    Yadav, Karuna; Patel, Prashanti; Srivastava, Ashish Kumar

    2017-01-01

    Iron is an indispensable element for plant growth and defense and hence it is essential to improve the plant’s ability to accumulate iron. Besides, it is also an important aspect for human health. In view of this, we attempted to increase the iron content in banana cultivar Rasthali using MusaFer1 as a candidate gene. Initially, the expression of all five genes of the MusaFer family (MusaFer1-5) was quantified under iron-excess and -deficient conditions. The supplementation of 250 and 350 μM iron enhanced expression of all MusaFer genes; however, MusaFer1 was increased maximally by 2- and 4- fold in leaves and roots respectively. Under iron deficient condition, all five MusaFer genes were downregulated, indicating their iron dependent regulation. In MusaFer1 overexpressing lines, iron content was increased by 2- and 3-fold in leaves and roots respectively, as compared with that of untransformed lines. The increased iron was mainly localized in the epidermal regions of petiole. The analysis of MusaFer1 promoter indicated that it might control the expression of iron metabolism related genes and also other genes of MusaFer family. MusaFer1 overexpression led to downregulated expression of MusaFer3, MusaFer4 and MusaFer5 in transgenic leaves which might be associated with the plant’s compensatory mechanism in response to iron flux. Other iron metabolism genes like Ferric reductase (FRO), transporters (IRT, VIT and YSL) and chelators (NAS, DMAS and NAAT) were also differentially expressed in transgenic leaf and root, suggesting the multifaceted impact of MusaFer1 towards iron uptake and organ distribution. Additionally, MusaFer1 overexpression increased plant tolerance against methyl viologen and excess iron which was quantified in terms of photosynthetic efficiency and malondialdehyde content. Thus, the study not only broadens our understanding about iron metabolism but also highlights MusaFer1 as a suitable candidate gene for iron fortification in banana. PMID

  20. Biosynthesis of a broad-spectrum nicotianamine-like metallophore in Staphylococcus aureus.

    PubMed

    Ghssein, Ghassan; Brutesco, Catherine; Ouerdane, Laurent; Fojcik, Clémentine; Izaute, Amélie; Wang, Shuanglong; Hajjar, Christine; Lobinski, Ryszard; Lemaire, David; Richaud, Pierre; Voulhoux, Romé; Espaillat, Akbar; Cava, Felipe; Pignol, David; Borezée-Durant, Elise; Arnoux, Pascal

    2016-05-27

    Metal acquisition is a vital microbial process in metal-scarce environments, such as inside a host. Using metabolomic exploration, targeted mutagenesis, and biochemical analysis, we discovered an operon in Staphylococcus aureus that encodes the different functions required for the biosynthesis and trafficking of a broad-spectrum metallophore related to plant nicotianamine (here called staphylopine). The biosynthesis of staphylopine reveals the association of three enzyme activities: a histidine racemase, an enzyme distantly related to nicotianamine synthase, and a staphylopine dehydrogenase belonging to the DUF2338 family. Staphylopine is involved in nickel, cobalt, zinc, copper, and iron acquisition, depending on the growth conditions. This biosynthetic pathway is conserved across other pathogens, thus underscoring the importance of this metal acquisition strategy in infection. Copyright © 2016, American Association for the Advancement of Science.

  1. 76 FR 68523 - Utah Southern Railroad Company, LLC-Change in Operators Exemption-Iron Bull Railroad Company, LLC

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-04

    ... Railroad Company, LLC--Change in Operators Exemption--Iron Bull Railroad Company, LLC Utah Southern... to change operators from Iron Bull Railroad Company (IBRC) to USRC on a rail line known as the... an operating agreement with PIC. This change in operators is exempt under 49 CFR 1150.31(a)(3).\\1\\ \\1...

  2. DETERMINATION OF FERRITIN AND HEMOSIDERIN IRON IN PATIENTS WITH NORMAL IRON STORES AND IRON OVERLOAD BY SERUM FERRITIN KINETICS

    PubMed Central

    SAITO, HIROSHI; TOMITA, AKIHIRO; OHASHI, HARUHIKO; MAEDA, HIDEAKI; HAYASHI, HISAO; NAOE, TOMOKI

    2012-01-01

    ABSTRACT We attempted to clarify the storage iron metabolism from the change in the serum ferritin level. We assumed that the nonlinear decrease in serum ferritin was caused by serum ferritin increase in iron mobilization. Under this assumption, we determined both ferritin and hemosiderin iron levels by computer-assisted simulation of the row of decreasing assay-dots of serum ferritin in 11 patients with normal iron stores free of both iron deficiency and iron overload; chronic hepatitis C (CHC) and iron deficiency anemia after treatment, and 11 patients with iron overload; hereditary hemochromatosis (HH) and transfusion-dependent anemias (TD). We determined the iron removal rates of 20 and 17 mg/day by administering mean doses of deferasirox at 631 and 616 mg/day in 2 TD during the period of balance of iron addition and removal as indicated by the serum ferritin returned to the previous level. The ferritin-per-hemosiderin ratio was almost the same in both HH and CHC. This matched the localized hepatic hemosiderin deposition in CHC with normal iron stores. We detected the ferritin increased by utilizing the hemosiderin iron in iron removal and the ferritin reduced by transforming ferritin into hemosiderin in iron additions. The iron storing capacity of hemosiderin was limitless, while that of ferritin was suppressed when ferritin iron exceeded around 5 grams. We confirmed the pathway of iron from hemosiderin to ferritin in iron mobilization, and that from ferritin to hemosiderin in iron deposition. Thus, serum ferritin kinetics enabled us to be the first to clinically clarify storage iron metabolism. PMID:22515110

  3. MR characterization of hepatic storage iron in transfusional iron overload.

    PubMed

    Tang, Haiying; Jensen, Jens H; Sammet, Christina L; Sheth, Sujit; Swaminathan, Srirama V; Hultman, Kristi; Kim, Daniel; Wu, Ed X; Brown, Truman R; Brittenham, Gary M

    2014-02-01

    To quantify the two principal forms of hepatic storage iron, diffuse, soluble iron (primarily ferritin), and aggregated, insoluble iron (primarily hemosiderin) using a new MRI method in patients with transfusional iron overload. Six healthy volunteers and 20 patients with transfusion-dependent thalassemia syndromes and iron overload were examined. Ferritin- and hemosiderin-like iron were determined based on the measurement of two distinct relaxation parameters: the "reduced" transverse relaxation rate, RR2 , and the "aggregation index," A, using three sets of Carr-Purcell-Meiboom-Gill (CPMG) datasets with different interecho spacings. Agarose phantoms, simulating the relaxation and susceptibility properties of tissue with different concentrations of dispersed (ferritin-like) and aggregated (hemosiderin-like) iron, were used for validation. Both phantom and in vivo human data confirmed that transverse relaxation components associated with the dispersed and aggregated iron could be separated using the two-parameter (RR2 , A) method. The MRI-determined total hepatic storage iron was highly correlated (r = 0.95) with measurements derived from biopsy or biosusceptometry. As total hepatic storage iron increased, the proportion stored as aggregated iron became greater. This method provides a new means for noninvasive MRI determination of the partition of hepatic storage iron between ferritin and hemosiderin in iron overload disorders. Copyright © 2013 Wiley Periodicals, Inc.

  4. A clumpy stellar wind and luminosity-dependent cyclotron line revealed by the first Suzaku observation of the high-mass X-ray binary 4U 1538–522

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hemphill, Paul B.; Rothschild, Richard E.; Markowitz, Alex

    2014-09-01

    We present results from the first Suzaku observation of the high-mass X-ray binary 4U 1538–522. The broadband spectral coverage of Suzaku allows for a detailed spectral analysis, characterizing the cyclotron resonance scattering feature at 23.0 ± 0.4 keV and the ironline at 6.426 ± 0.008 keV, as well as placing limits on the strengths of the ironline and the iron K edge. We track the evolution of the spectral parameters both in time and in luminosity, notably finding a significant positive correlation between cyclotron line energy and luminosity. A dip and spike in the light curvemore » is shown to be associated with an order-of-magnitude increase in column density along the line of sight, as well as significant variation in the underlying continuum, implying the accretion of a overdense region of a clumpy stellar wind. We also present a phase-resolved analysis, with most spectral parameters of interest showing significant variation with phase. Notably, both the cyclotron line energy and the ironline intensity vary significantly with phase, with the iron line intensity significantly out of phase with the pulse profile. We discuss the implications of these findings in the context of recent work in the areas of accretion column physics and cyclotron resonance scattering feature formation.« less

  5. A physical parameter method for the design of broad-band X-ray imaging systems to do coronal plasma diagnostics

    NASA Technical Reports Server (NTRS)

    Kahler, S.; Krieger, A. S.

    1978-01-01

    The technique commonly used for the analysis of data from broad-band X-ray imaging systems for plasma diagnostics is the filter ratio method. This requires the use of two or more broad-band filters to derive temperatures and line-of-sight emission integrals or emission measure distributions as a function of temperature. Here an alternative analytical approach is proposed in which the temperature response of the imaging system is matched to the physical parameter being investigated. The temperature response of a system designed to measure the total radiated power along the line of sight of any coronal structure is calculated. Other examples are discussed.

  6. [Iron concentration and acceptation of yoghurt prepared in casting iron pots (iron migration and acceptation of yogurt)].

    PubMed

    Quintaes, Késia Diego; Almeyda Haj-Isa, Niurka M; Morgano, Marcelo Antônio

    2005-12-01

    Food fortification is an interesting strategy to treat and prevent iron anemia. This study aims to quantify the iron in yoghurt, with gelatin and sugar and without, prepared in iron and glass containers. Sensorial test was use to evaluate the acceptance and preference of the both products. The yoghurt was prepared in containers of iron and glass with UHT milk, powder milk and natural industrialized yoghurt. After fermentation, half of the product received addition of sugar and strawberry flavor gelatin. The collected samples get the total iron quantified by ICP OES. Sensorial analysis involving 105 consumers was use to determine the acceptance and preference of the products. 0,018 and 0,882mg of iron per 100g added in the natural yoghurt prepared in the glass and in the iron pots, respectively. The yoghurt with gelatin presented 0,037 and 1,302mg of iron per 100g when prepared in the glass and in the iron pots, respectively. The preference was low for the yoghurt prepared in the iron pot (29,5%), but when added strawberry gelatin it was about 51,5%. The yoghurt prepared in iron pots, is easily home made and adds important amount of iron. Add gelatin and sugar can favored its consumption.

  7. Nickel-iron battery system safety

    NASA Technical Reports Server (NTRS)

    Saltat, R. C.

    1984-01-01

    The generated flow rates of gaseous hydrogen and gaseous oxygen from an electrical vehicle nickel-iron battery system were determined and used to evaluate the flame quenching capabilities of several candidate devices to prevent flame propagation within batteries having central watering/venting systems. The battery generated hydrogen and oxygen gases were measured for a complete charge and discharge cycle. The data correlates well with accepted theory during strong overcharge conditions indicating that the measurements are valid for other portions of the cycle. Tests confirm that the gas mixture in the cells is always flammable regardless of the battery status. The literature indicated that a conventional flame arrestor would not be effective over the broad spectrum of gassing conditions presented by a nickel-iron battery. Four different types of protective devices were evaluated. A foam-metal arrestor design was successful in quenching gaseous hydrogen and gaseous oxygen flames, however; the application of this flame arrestor to individual cell or module protection in a battery is problematic. A possible rearrangement of the watering/venting system to accept the partial protection of simple one-way valves is presented which, in combination with the successful foam-metal arrestor as main vent protection, could result in a significant improvement in battery protection.

  8. Sorption of arsenic to biogenic iron (oxyhydr)oxides produced in circumneutral environments

    NASA Astrophysics Data System (ADS)

    Sowers, Tyler D.; Harrington, James M.; Polizzotto, Matthew L.; Duckworth, Owen W.

    2017-02-01

    Arsenic (As) is a widespread and problematic pollutant that can be derived from natural or anthropogenic sources. Iron (oxyhydr)oxides readily sorb As and thus play critical roles in As cycling in terrestrial environments; however, little is known about the affinity and mechanism of As sorption by biogenic iron (oxyhydr)oxides formed in circumneutral environments. To investigate this, we conducted sorption isotherm and kinetics experiments to compare As(V) and As(III) sorption to synthetic 2-line ferrihydrite and iron biominerals harvested from the hyporheic zone of an uncontaminated creek. Inductively coupled plasma mass spectrometry (ICP-MS) was used to quantify both As(V) and As(III), and X-ray absorption spectroscopy (XAS) was utilized to obtain As and Fe K-edge spectra for As(V) and As(III) sorbed to environmentally collected and laboratory produced Fe(III) minerals. All environmental Fe(III) biominerals were determined to be structurally similar to 2-line ferrihydrite. However, environmental Fe(III) biominerals have a surface area normalized affinity for As(V) and for As(III) that is greater than or equivalent to synthetic 2-line ferrihydrite. Whereas the extent of sorption was similar for As(III) on all minerals, As(V) sorption to environmental Fe(III) biominerals was approximately three times higher than what was observed for synthetic 2-line ferrihydrite. Structural modeling of EXAFS spectra revealed that the same surface complexation structure was formed by As(V) and by As(III) on environmental Fe(III) biominerals and ferrihydrite. These results suggest that, despite similarities in binding mechanisms, Fe(III) biominerals may be more reactive sorbents that synthetic surrogates often used to model environmental reactivity.

  9. Orbital-selective pairing and superconductivity in iron selenides

    NASA Astrophysics Data System (ADS)

    Nica, Emilian M.; Yu, Rong; Si, Qimiao

    2017-12-01

    An important challenge in condensed matter physics is understanding iron-based superconductors. Among these systems, the iron selenides hold the record for highest superconducting transition temperature and pose especially striking puzzles regarding the nature of superconductivity. The pairing state of the alkaline iron selenides appears to be of d-wave type based on the observation of a resonance mode in neutron scattering, while it seems to be of s-wave type from the nodeless gaps observed everywhere on the Fermi surface. Here we propose an orbital-selective pairing state, dubbed sτ3, as a natural explanation of these disparate properties. The pairing function, containing a matrix τ3 in the basis of 3d-electron orbitals, does not commute with the kinetic part of the Hamiltonian. This dictates the existence of both intraband and interband pairing terms in the band basis. A spin resonance arises from a d-wave-type sign change in the intraband pairing component, whereas the quasiparticle excitation is fully gapped on the FS due to an s-wave-like form factor associated with the addition in quadrature of the intraband and interband pairing terms. We demonstrate that this pairing state is energetically favored when the electron correlation effects are orbitally selective. More generally, our results illustrate how the multiband nature of correlated electrons affords unusual types of superconducting states, thereby shedding new light not only on the iron-based materials but also on a broad range of other unconventional superconductors such as heavy fermion and organic systems.

  10. The prion-ZIP connection: From cousins to partners in iron uptake

    PubMed Central

    Singh, Neena; Asthana, Abhishek; Baksi, Shounak; Desai, Vilok; Haldar, Swati; Hari, Sahi; Tripathi, Ajai K

    2015-01-01

    ABSTRACT Converging observations from disparate lines of inquiry are beginning to clarify the cause of brain iron dyshomeostasis in sporadic Creutzfeldt-Jakob disease (sCJD), a neurodegenerative condition associated with the conversion of prion protein (PrPC), a plasma membrane glycoprotein, from α-helical to a β-sheet rich PrP-scrapie (PrPSc) isoform. Biochemical evidence indicates that PrPC facilitates cellular iron uptake by functioning as a membrane-bound ferrireductase (FR), an activity necessary for the transport of iron across biological membranes through metal transporters. An entirely different experimental approach reveals an evolutionary link between PrPC and the Zrt, Irt-like protein (ZIP) family, a group of proteins involved in the transport of zinc, iron, and manganese across the plasma membrane. Close physical proximity of PrPC with certain members of the ZIP family on the plasma membrane and increased uptake of extracellular iron by cells that co-express PrPC and ZIP14 suggest that PrPC functions as a FR partner for certain members of this family. The connection between PrPC and ZIP proteins therefore extends beyond common ancestry to that of functional cooperation. Here, we summarize evidence supporting the facilitative role of PrPC in cellular iron uptake, and implications of this activity on iron metabolism in sCJD brains. PMID:26689487

  11. NON-LOCAL THERMODYNAMICAL EQUILIBRIUM EFFECTS ON THE IRON ABUNDANCE OF ASYMPTOTIC GIANT BRANCH STARS IN 47 TUCANAE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Lapenna, E.; Mucciarelli, A.; Lanzoni, B.

    2014-12-20

    We present the iron abundance of 24 asymptotic giant branch (AGB) stars, members of the globular cluster 47 Tucanae, obtained with high-resolution spectra collected with the FEROS spectrograph at the MPG/ESO 2.2 m Telescope. We find that the iron abundances derived from neutral lines (with a mean value [Fe I/H] =–0.94 ± 0.01, σ = 0.08 dex) are systematically lower than those derived from single ionized lines ([Fe II/H] =–0.83 ± 0.01, σ = 0.05 dex). Only the latter are in agreement with those obtained for a sample of red giant branch (RGB) cluster stars, for which the Fe I andmore » Fe II lines provide the same iron abundance. This finding suggests that non-local thermodynamical equilibrium (NLTE) effects driven by overionization mechanisms are present in the atmosphere of AGB stars and significantly affect the Fe I lines while leaving Fe II features unaltered. On the other hand, the very good ionization equilibrium found for RGB stars indicates that these NLTE effects may depend on the evolutionary stage. We discuss the impact of this finding on both the chemical analysis of AGB stars and on the search for evolved blue stragglers.« less

  12. Cast Iron in The 19th Century Building Equipment

    NASA Astrophysics Data System (ADS)

    Kwasek, Michał; Piwek, Aleksander

    2017-10-01

    Cast iron is a material, characteristics of which enable to receive extremely artistic elements. It maintains good strength properties at the same time. That combination of these seemingly contrary traits makes it a commodity that was widely used in the 19th century industry and architecture. These usages were not only as decorative elements, technical and structural ones. The production of new household utilities started, which made people’s lives more comfortable. Cast iron allowed for fast and cheap production while maintaining high aesthetic qualities. Useful elements, which often were ornamental parts of buildings were created. The aim of the article is to characterise elements of interior equipment of the 19th century building that are made of cast iron. As it appears from performed bibliography, archival and field studies, the ways of exploitation are very broad. Some were mounted into the building; the others were a mobile equipment. As it occurred they were most commonly used as functional items. Cast iron was used to produce the minor elements, which were only parts of the bigger wooden or stone items. Notwithstanding, there were also bigger ones casted as a whole, and frequently ones that were assembled from many elements. Nowadays, elements of an interior feature are one of the subjects of study during the restoration work of the buildings. They can provide important information about the building and the way people lived and are considered as the essential part of historical objects.

  13. Vivianite as an important iron phosphate precipitate in sewage treatment plants.

    PubMed

    Wilfert, P; Mandalidis, A; Dugulan, A I; Goubitz, K; Korving, L; Temmink, H; Witkamp, G J; Van Loosdrecht, M C M

    2016-11-01

    Iron is an important element for modern sewage treatment, inter alia to remove phosphorus from sewage. However, phosphorus recovery from iron phosphorus containing sewage sludge, without incineration, is not yet economical. We believe, increasing the knowledge about iron-phosphorus speciation in sewage sludge can help to identify new routes for phosphorus recovery. Surplus and digested sludge of two sewage treatment plants was investigated. The plants relied either solely on iron based phosphorus removal or on biological phosphorus removal supported by iron dosing. Mössbauer spectroscopy showed that vivianite and pyrite were the dominating iron compounds in the surplus and anaerobically digested sludge solids in both plants. Mössbauer spectroscopy and XRD suggested that vivianite bound phosphorus made up between 10 and 30% (in the plant relying mainly on biological removal) and between 40 and 50% of total phosphorus (in the plant that relies on iron based phosphorus removal). Furthermore, Mössbauer spectroscopy indicated that none of the samples contained a significant amount of Fe(III), even though aerated treatment stages existed and although besides Fe(II) also Fe(III) was dosed. We hypothesize that chemical/microbial Fe(III) reduction in the treatment lines is relatively quick and triggers vivianite formation. Once formed, vivianite may endure oxygenated treatment zones due to slow oxidation kinetics and due to oxygen diffusion limitations into sludge flocs. These results indicate that vivianite is the major iron phosphorus compound in sewage treatment plants with moderate iron dosing. We hypothesize that vivianite is dominating in most plants where iron is dosed for phosphorus removal which could offer new routes for phosphorus recovery. Copyright © 2016 Elsevier Ltd. All rights reserved.

  14. Industry experience in promoting weekly iron-folic acid supplementation in the Philippines.

    PubMed

    Garcia, Josel; Datol-Barrett, Eva; Dizon, Maynilad

    2005-12-01

    After participating in a pilot project under a government-industry partnership to promote the adoption of weekly iron-folic acid supplementation among women of reproductive age in the Philippines in 1998, United Laboratories (UNILAB), the Philippines' largest private pharmaceutical company, decided in April 2002 to launch a weekly iron-folic acid supplement for pregnant and non-pregnant women under the brand name Femina. The business objective set for the Femina brand was to build the category of preventive iron-folic acid supplements in line with the Philippine Department of Health's advocacy on weekly supplementation as an alternate to daily dosing to reduce the prevalence of anemia in the country. The brand was supported with an integrated mix of traditional advertising media with complementary direct-to-consumer educational programs that aimed to create awareness of iron-deficiency anemia, its causes and effects, and the role of weekly intake of iron-folic acid in preventing the condition. Aggressive marketing support for 1 year was successful in creating awareness among the target women. Significant lessons derived from consumers identified opportunity areas that can be further addressed in developing advocacy programs on weekly iron supplementation implemented on a nationwide scale in the future.

  15. Broad-band properties of the CfA Seyfert galaxies. III - Ultraviolet variability

    NASA Technical Reports Server (NTRS)

    Edelson, R. A.; Pike, G. F.; Krolik, J. H.

    1990-01-01

    A total of 657 archived IUE spectra are used to study the UV variability properties of six members of the CfA Seyfert I galaxy sample. All show strong evidence for continuum and line variations and a tendency for less luminous objects to be more strongly variable. Most objects show a clear correlation at zero lag between UV spectral index and luminosity, evidence that the variable component is an accretion disk around a black hole which is systematically smaller in less luminous sources. No correlation is seen between the continuum luminosity and equivalent width of the C IV, Mg II, and semiforbidden C III emission lines when the entire sample is examined, but a clear anticorrelation is present when only repeated observations of individual objects are considered. This is due to a combination of light-travel time effects in the broad-line region and the nonlinear responses of lines to continuum fluctuations.

  16. Superluminous Transients at AGN Centers from Interaction between Black Hole Disk Winds and Broad-line Region Clouds

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Moriya, Takashi J.; Tanaka, Masaomi; Ohsuga, Ken

    We propose that superluminous transients that appear at central regions of active galactic nuclei (AGNs) such as CSS100217:102913+404220 (CSS100217) and PS16dtm, which reach near- or super-Eddington luminosities of the central black holes, are powered by the interaction between accretion-disk winds and clouds in broad-line regions (BLRs) surrounding them. If the disk luminosity temporarily increases by, e.g., limit–cycle oscillations, leading to a powerful radiatively driven wind, strong shock waves propagate in the BLR. Because the dense clouds in the AGN BLRs typically have similar densities to those found in SNe IIn, strong radiative shocks emerge and efficiently convert the ejecta kineticmore » energy to radiation. As a result, transients similar to SNe IIn can be observed at AGN central regions. Since a typical black hole disk-wind velocity is ≃0.1 c , where c is the speed of light, the ejecta kinetic energy is expected to be ≃10{sup 52} erg when ≃1 M {sub ⊙} is ejected. This kinetic energy is transformed to radiation energy in a timescale for the wind to sweep up a similar mass to itself in the BLR, which is a few hundred days. Therefore, both luminosities (∼10{sup 44} erg s{sup −1}) and timescales (∼100 days) of the superluminous transients from AGN central regions match those expected in our interaction model. If CSS100217 and PS16dtm are related to the AGN activities triggered by limit–cycle oscillations, they become bright again in coming years or decades.« less

  17. Iron state in iron nanoparticles with and without zirconium

    NASA Astrophysics Data System (ADS)

    Filippov, V. P.; Khasanov, A. M.; Lauer, Yu. A.

    2017-11-01

    Mössbauer and X-ray methods are used for investigations of structure, stability and characteristics of pure-iron grain and two iron-zirconium alloys such as Fe + 5 wt.% Zr and Fe + 10 wt.% Zr. The used powder was ground for 24 h in a SPEX Model 8000 mill shaker. Complex nanoparticles are found, which change their properties under milling. Mössbauer spectral parameters are obtained for investigated materials. Milling results in formation of nanosized particles with two states of iron atoms: one main part is pure α-Fe and another part of iron atoms displaced in grain boundaries or defective zones in which hyperfine magnetic splitting decrease to ˜ 30.0 T. In alloys with Zr three iron states are formed in each alloy, main part of iron is in the form of α-Fe and another two states depend on the concentration of Zr and represent iron in grain boundaries with Zr atoms in nearest neighbor. The changing of iron states is discussed.

  18. Electron scattering wings on lines in interacting supernovae

    NASA Astrophysics Data System (ADS)

    Huang, Chenliang; Chevalier, Roger A.

    2018-03-01

    We consider the effect of electron scattering on lines emitted as a result of supernova interaction with a circumstellar medium, assuming that the scattering occurs in ionized gas in the pre-shock circumstellar medium. The single scattering case gives the broad component in the limit of low optical depth, showing a velocity full width half-maximum that is close to the thermal velocities of electrons. The line shape is approximately exponential at low velocities and steepens at higher velocities. At higher optical depths, the line profile remains exponential at low velocities, but wings strengthen with increasing optical depth. In addition to the line width, the ratio of narrow to broad (scattered) line strength is a possible diagnostic of the gas. The results depend on the density profile of the circumstellar gas, especially if the scattering and photon creation occur in different regions. We apply the scattering model to a number of supernovae, including Type IIn and Type Ia-circumstellar medium (CSM) events. The asymmetry to the red found in some cases can be explained by scattering in a fast wind region that is indicated by observations.

  19. Studying Irony Detection Beyond Ironic Criticism: Let's Include Ironic Praise

    PubMed Central

    Bruntsch, Richard; Ruch, Willibald

    2017-01-01

    Studies of irony detection have commonly used ironic criticisms (i.e., mock positive evaluation of negative circumstances) as stimulus materials. Another basic type of verbal irony, ironic praise (i.e., mock negative evaluation of positive circumstances) is largely absent from studies on individuals' aptitude to detect verbal irony. However, it can be argued that ironic praise needs to be considered in order to investigate the detection of irony in the variety of its facets. To explore whether the detection ironic praise has a benefit beyond ironic criticism, three studies were conducted. In Study 1, an instrument (Test of Verbal Irony Detection Aptitude; TOVIDA) was constructed and its factorial structure was tested using N = 311 subjects. The TOVIDA contains 26 scenario-based items and contains two scales for the detection of ironic criticism vs. ironic praise. To validate the measurement method, the two scales of the TOVIDA were experimentally evaluated with N = 154 subjects in Study 2. In Study 3, N = 183 subjects were tested to explore personality and ability correlates of the two TOVIDA scales. Results indicate that the co-variance between the ironic TOVIDA items was organized by two inter-correlated but distinct factors: one representing ironic praise detection aptitude and one representing ironic criticism detection aptitude. Experimental validation showed that the TOVIDA items truly contain irony and that item scores reflect irony detection. Trait bad mood and benevolent humor (as a facet of the sense of humor) were found as joint correlates for both ironic criticism and ironic praise detection scores. In contrast, intelligence, trait cheerfulness, and corrective humor were found as unique correlates of ironic praise detection scores, even when statistically controlling for the aptitude to detect ironic criticism. Our results indicate that the aptitude to detect ironic praise can be seen as distinct from the aptitude to detect ironic criticism. Generating

  20. METABOLISM OF IRON STORES

    PubMed Central

    SAITO, HIROSHI

    2014-01-01

    ABSTRACT Remarkable progress was recently achieved in the studies on molecular regulators of iron metabolism. Among the main regulators, storage iron, iron absorption, erythropoiesis and hepcidin interact in keeping iron homeostasis. Diseases with gene-mutations resulting in iron overload, iron deficiency, and local iron deposition have been introduced in relation to the regulators of storage iron metabolism. On the other hand, the research on storage iron metabolism has not advanced since the pioneering research by Shoden in 1953. However, we recently developed a new method for determining ferritin iron and hemosiderin iron by computer-assisted serum ferritin kinetics. Serum ferritin increase or decrease curves were measured in patients with normal storage iron levels (chronic hepatitis C and iron deficiency anemia treated by intravenous iron injection), and iron overload (hereditary hemochromatosis and transfusion dependent anemia). We thereby confirmed the existence of two iron pathways where iron flows followed the numbered order (1) labile iron, (2) ferritin and (3) hemosiderin in iron deposition and mobilization among many previously proposed but mostly unproven routes. We also demonstrated the increasing and decreasing phases of ferritin iron and hemosiderin iron in iron deposition and mobilization. The author first demonstrated here the change in proportion between pre-existing ferritin iron and new ferritin iron synthesized by removing iron from hemosiderin in the course of iron removal. In addition, the author disclosed the cause of underestimation of storage iron turnover rate which had been reported by previous investigators in estimating storage iron turnover rate of normal subjects. PMID:25741033

  1. No Compton Reflection In a Chandra/RXTE Observation of Mkn 509: Implications for the Fe-K Line Emission From Accreting X-Ray Sources

    NASA Technical Reports Server (NTRS)

    Yaqoob, Tahir; Padmanabhan, Urmila; Kraemer, Steven B.; Crenshaw, D. Michael; Mckernan, Barry; George, Ian M.; Turner, T. Jane; White, Nicholas E. (Technical Monitor)

    2002-01-01

    We report the results of simultaneous Chandra and RXTE observations of the Seyfert 1 galaxy Mkn 509. We deconvolve the broad and narrow Fe-K emission-line components for which we measure rest-frame equivalent widths of 119+/-18 eV and 57+/-13 eV respectively. The broad line has a FWHM of 57,600((sup 14,400)(sub -21,000)) km/s and the narrow line is unresolved, with an upper limit on the FWHM of 4,940 km/s. Both components must originate in cool matter since we measure rest-frame center energies of 6.36((sup +0.13)(sub -0.12)) keV and 6.42+/-0.01 keV for the broad and narrow line respectively. This rules out He-like and H-like Fe for the origin of both the broad and narrow lines. If, as is widely accepted, the broad Fe-K line originates in Thomson-thick matter (such as an accretion disk), then one expects to observe spectral curvature above approximately 10 keV, (commensurate with the observed broad line), characteristic of the Compton-reflection continuum. However our data sets very stringent limits on deviations of the observed continuum from a power law. Light travel-time delays cannot be invoked to explain anomalies in the relative strengths of the broad Ferry line and Compton-reflection continuum since they are supposed to originate in the same physical location. We are forced to conclude that both the broad and narrow Fe-K lines had to originate in Thomson-thin matter during our observation. This result, for a single observation of just one source, means that our understanding of Fe K line emission and Compton reflection from accreting X-ray sources in general needs to be re-examined. For example, if an irradiated accretion disk existed in Mkn 509 at the time of the observations, the lack of spectral curvature above approximately 10 keV suggests two possibilities. Either the disk was Thomson-thick and highly ionized, having negligible Fe-K line emission and photoelectric absorption or the disk was Thomson-thin producing some or all of the broad Fe-K line

  2. Role of nitric oxide in cellular iron metabolism.

    PubMed

    Kim, Sangwon; Ponka, Prem

    2003-03-01

    Iron regulatory proteins (IRP1 and IRP2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements (IREs) which are located in the 3' untranslated region (UTR) and the 5' UTR of their respective mRNAs. Cellular iron levels affect binding of IRPs to IREs and consequently expression of TfR and ferritin. Moreover, NO*, a redox species of nitric oxide that interacts primarily with iron, can activate IRP1 RNA-binding activity resulting in an increase in TfR mRNA levels. We have shown that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO+ (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA-binding of IRP2, followed by IRP2 degradation, and these changes were associated with a decrease in TfR mRNA levels. Moreover, we demonstrated that stimulation of RAW 264.7 cells with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) increased IRP1 binding activity, whereas RNA-binding of IRP2 decreased and was followed by a degradation of this protein. Furthermore, the decrease of IRP2 binding/protein levels was associated with a decrease in TfR mRNA levels in LPS/IFN-gamma-treated cells, and these changes were prevented by inhibitors of inducible nitric oxide synthase. These results suggest that NO+-mediated degradation of IRP2 plays a major role in iron metabolism during inflammation.

  3. Imaging measurements of atomic iron concentration with laser-induced fluorescence in a nanoparticle synthesis flame reactor

    NASA Astrophysics Data System (ADS)

    Hecht, C.; Kronemayer, H.; Dreier, T.; Wiggers, H.; Schulz, C.

    2009-01-01

    The iron-atom concentration distribution as well as the gas-phase temperature was measured via laser-induced fluorescence (LIF) during iron-oxide nanoparticle synthesis in a low-pressure hydrogen/oxygen/argon flame reactor using ironpentacarbonyl (Fe(CO)5) as precursor. Temperature measurements based on multi-line NO-LIF imaging are used to correct for temperature-dependent ground-state populations. The concentration measurement is calibrated based on line-of-sight absorption measurements. The influence of the precursor on the flame is observed at precursor concentrations larger than 70 ppm as the flame front moves closer to the burner surface with increasing Fe(CO)5 concentration.

  4. New developments and controversies in iron metabolism and iron chelation therapy

    PubMed Central

    Kontoghiorghe, Christina N; Kontoghiorghes, George J

    2016-01-01

    Iron is essential for all organisms including microbial, cancer and human cells. More than a quarter of the human population is affected by abnormalities of iron metabolism, mainly from iron deficiency and iron overload. Iron also plays an important role in free radical pathology and oxidative damage which is observed in almost all major diseases, cancer and ageing. New developments include the complete treatment of iron overload and reduction of morbidity and mortality in thalassaemia using deferiprone and selected deferiprone/deferoxamine combinations and also the use of the maltol iron complex in the treatment of iron deficiency anaemia. There is also a prospect of using deferiprone as a universal antioxidant in non iron overloaded diseases such as neurodegenerative, cardiovascular, renal, infectious diseases and cancer. New regulatory molecules of iron metabolism such as endogenous and dietary chelating molecules, hepcidin, mitochondrial ferritin and their role in health and disease is under evaluation. Similarly, new mechanisms of iron deposition, removal, distribution and toxicity have been identified using new techniques such as magnetic resonance imaging increasing our understanding of iron metabolic processes and the targeted treatment of related diseases. The uniform distribution of iron in iron overload between organs and within each organ is no longer valid. Several other controversies such as the toxicity impact of non transferrin bound iron vs injected iron, the excess levels of iron in tissues causing toxicity and the role of chelation on iron absorption need further investigation. Commercial interests of pharmaceutical companies and connections to leading journals are playing a crucial role in shaping worldwide medical opinion on drug sales and use but also patients’ therapeutic outcome and safety. Major controversies include the selection criteria and risk/benefit assessment in the use of deferasirox in thalassaemia and more so in idiopathic

  5. Deferasirox for managing iron overload in people with thalassaemia.

    PubMed

    Meerpohl, Joerg J; Antes, Gerd; Rücker, Gerta; Fleeman, Nigel; Motschall, Edith; Niemeyer, Charlotte M; Bassler, Dirk

    2012-02-15

    the phase III trial, similar or superior efficacy for surrogate parameters of ferritin and liver iron concentration could only be achieved in the highly iron-overloaded subgroup at a mean ratio of 1 mg of deferasirox to 1.8 mg of deferoxamine corresponding to a mean dose of 28.2 mg/d and 51.6 mg/d respectively. Data on safety at the presumably required doses for effective chelation therapy are limited. Patient satisfaction was significantly better with deferasirox, while rate of discontinuations was similar for both drugs. Deferasirox offers an important alternative line of treatment for people with thalassaemia and secondary iron overload. Based on the available data, deferasirox does not seem to be superior to deferoxamine at the usually recommended ratio of 1 mg of deferasirox to 2 mg of deferoxamine. However, similar efficacy seems to be achievable depending on the dose and ratio of deferasirox compared to deferoxamine. Whether this will result in similar efficacy in the long run and will translate to similar benefits as has been shown for deferoxamine, needs to be confirmed. Data on safety, particularly on rare toxicities and long-term safety, are still limited.Therefore, we think that deferasirox should be offered as an alternative to all patients with thalassaemia who either show intolerance to deferoxamine or poor compliance with deferoxamine. In our opinion, data are still too limited to support the general recommendation of deferasirox as first-line treatment instead of deferoxamine. If a strong preference for deferasirox is expressed, it could be offered as first-line option to individual patients after a detailed discussion of the potential benefits and risks.

  6. "Bridge #6 Rock Creek: Castiron 48" pipe lines to ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    "Bridge #6 - Rock Creek: Cast-iron 48" pipe lines to Gravity - 1859." Construction photo of Pennsylvania Avenue Bridge, 1859. Photograph courtesy Washington Aqueduct Division, U.S. Army Corps of Engineers - Pennsylvania Avenue Bridge, Spanning Rock Creek & Potomac Parkway, Washington, District of Columbia, DC

  7. The recommendation of line-balancing improvement on MCM product line 1 using genetics algorithm and moodie young at XYZ Company, Co.

    NASA Astrophysics Data System (ADS)

    Sriwana, I. K.; Marie, I. A.; Mangala, D.

    2017-12-01

    Kencana Gemilang, Co. is one electronics industry engaging in the manufacture sector. This company manufactures and assembles household electronic products, such as rice cooker, fan, iron, blender, etc. The company deals with an issue of underachievement of an established production target on MCM products line 1. This study aimed to calculate line efficiencies, delay times, and initial line smoothness indexes. The research was carried out by means of depicting a precedence diagram and gathering time data of each work element followed by examination and calculation of standard time as well as line balancing using methods of Moodie Young and Generics Algorithm. Based on results of calculation, better line balancing than the existing initial conditions, i.e. improvement in the line efficiency by 18.39%, deterioration in balanced delay by 28.39%, and deterioration of a smoothness index by 23.85% was obtained.

  8. Iron deficiency and iron excess damage mitochondria and mitochondrial DNA in rats

    PubMed Central

    Walter, Patrick B.; Knutson, Mitchell D.; Paler-Martinez, Andres; Lee, Sonia; Xu, Yu; Viteri, Fernando E.; Ames, Bruce N.

    2002-01-01

    Approximately two billion people, mainly women and children, are iron deficient. Two studies examined the effects of iron deficiency and supplementation on rats. In study 1, mitochondrial functional parameters and mitochondrial DNA (mtDNA) damage were assayed in iron-deficient (≤5 μg/day) and iron-normal (800 μg/day) rats and in both groups after daily high-iron supplementation (8,000 μg/day) for 34 days. This dose is equivalent to the daily dose commonly given to iron-deficient humans. Iron-deficient rats had lower liver mitochondrial respiratory control ratios and increased levels of oxidants in polymorphonuclear-leukocytes, as assayed by dichlorofluorescein (P < 0.05). Rhodamine 123 fluorescence of polymorphonuclear-leukocytes also increased (P < 0.05). Lowered respiratory control ratios were found in daily high-iron-supplemented rats regardless of the previous iron status (P < 0.05). mtDNA damage was observed in both iron-deficient rats and rats receiving daily high-iron supplementation, compared with iron-normal rats (P < 0.05). Study 2 compared iron-deficient rats given high doses of iron (8,000 μg) either daily or every third day and found that rats given iron supplements every third day had less mtDNA damage on the second and third day after the last dose compared to daily high iron doses. Both inadequate and excessive iron (10 × nutritional need) cause significant mitochondrial malfunction. Although excess iron has been known to cause oxidative damage, the observation of oxidant-induced damage to mitochondria from iron deficiency has been unrecognized previously. Untreated iron deficiency, as well as excessive-iron supplementation, are deleterious and emphasize the importance of maintaining optimal iron intake. PMID:11854522

  9. Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease.

    PubMed

    Neves, Joana; Leitz, Dominik; Kraut, Simone; Brandenberger, Christina; Agrawal, Raman; Weissmann, Norbert; Mühlfeld, Christian; Mall, Marcus A; Altamura, Sandro; Muckenthaler, Martina U

    2017-06-01

    Emerging evidence suggests that pulmonary iron accumulation is implicated in a spectrum of chronic lung diseases. However, the mechanism(s) involved in pulmonary iron deposition and its role in the in vivo pathogenesis of lung diseases remains unknown. Here we show that a point mutation in the murine ferroportin gene, which causes hereditary hemochromatosis type 4 (Slc40a1 C326S ), increases iron levels in alveolar macrophages, epithelial cells lining the conducting airways and lung parenchyma, and in vascular smooth muscle cells. Pulmonary iron overload is associated with oxidative stress, restrictive lung disease with decreased total lung capacity and reduced blood oxygen saturation in homozygous Slc40a1 C326S/C326S mice compared to wild-type controls. These findings implicate iron in lung pathology, which is so far not considered a classical iron-related disorder. Copyright © 2017 The Authors. Published by Elsevier B.V. All rights reserved.

  10. Aspergillus fumigatus protein phosphatase PpzA is involved in iron assimilation, secondary metabolite production, and virulence.

    PubMed

    Manfiolli, Adriana Oliveira; de Castro, Patrícia Alves; Dos Reis, Thaila Fernanda; Dolan, Stephen; Doyle, Sean; Jones, Gary; Riaño Pachón, Diego M; Ulaş, Mevlüt; Noble, Luke M; Mattern, Derek J; Brakhage, Axel A; Valiante, Vito; Silva-Rocha, Rafael; Bayram, Ozgur; Goldman, Gustavo H

    2017-12-01

    Metal restriction imposed by mammalian hosts during an infection is a common mechanism of defence to reduce or avoid the pathogen infection. Metals are essential for organism survival due to its involvement in several biological processes. Aspergillus fumigatus causes invasive aspergillosis, a disease that typically manifests in immunocompromised patients. A. fumigatus PpzA, the catalytic subunit of protein phosphatase Z (PPZ), has been recently identified as associated with iron assimilation. A. fumigatus has 2 high-affinity mechanisms of iron acquisition during infection: reductive iron assimilation and siderophore-mediated iron uptake. It has been shown that siderophore production is important for A. fumigatus virulence, differently to the reductive iron uptake system. Transcriptomic and proteomic comparisons between ∆ppzA and wild-type strains under iron starvation showed that PpzA has a broad influence on genes involved in secondary metabolism. Liquid chromatography-mass spectrometry under standard and iron starvation conditions confirmed that the ΔppzA mutant had reduced production of pyripyropene A, fumagillin, fumiquinazoline A, triacetyl-fusarinine C, and helvolic acid. The ΔppzA was shown to be avirulent in a neutropenic murine model of invasive pulmonary aspergillosis. PpzA plays an important role at the interface between iron starvation, regulation of SM production, and pathogenicity in A. fumigatus. © 2017 John Wiley & Sons Ltd.

  11. Zinc deficiency-induced iron accumulation, a consequence of alterations in iron regulatory protein-binding activity, iron transporters, and iron storage proteins.

    PubMed

    Niles, Brad J; Clegg, Michael S; Hanna, Lynn A; Chou, Susan S; Momma, Tony Y; Hong, Heeok; Keen, Carl L

    2008-02-22

    One consequence of zinc deficiency is an elevation in cell and tissue iron concentrations. To examine the mechanism(s) underlying this phenomenon, Swiss 3T3 cells were cultured in zinc-deficient (D, 0.5 microM zinc), zinc-supplemented (S, 50 microM zinc), or control (C, 4 microM zinc) media. After 24 h of culture, cells in the D group were characterized by a 50% decrease in intracellular zinc and a 35% increase in intracellular iron relative to cells in the S and C groups. The increase in cellular iron was associated with increased transferrin receptor 1 protein and mRNA levels and increased ferritin light chain expression. The divalent metal transporter 1(+)iron-responsive element isoform mRNA was decreased during zinc deficiency-induced iron accumulation. Examination of zinc-deficient cells revealed increased binding of iron regulatory protein 2 (IRP2) and decreased binding of IRP1 to a consensus iron-responsive element. The increased IRP2-binding activity in zinc-deficient cells coincided with an increased level of IRP2 protein. The accumulation of IRP2 protein was independent of zinc deficiency-induced intracellular nitric oxide production but was attenuated by the addition of the antioxidant N-acetylcysteine or ascorbate to the D medium. These data support the concept that zinc deficiency can result in alterations in iron transporter, storage, and regulatory proteins, which facilitate iron accumulation.

  12. SIX YEARS OF FERMI-LAT AND MULTI-WAVELENGTH MONITORING OF THE BROAD-LINE RADIO GALAXY 3C 120: JET DISSIPATION AT SUB-PARSEC SCALES FROM THE CENTRAL ENGINE

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Tanaka, Y. T.; Doi, A.; Inoue, Y.

    2015-01-30

    We present multi-wavelength monitoring results for the broad-line radio galaxy 3C 120 in the MeV/GeV, sub-millimeter, and 43 GHz bands over 6 yr. Over the past 2 yr, the Fermi-Large Area Telescope sporadically detected 3C 120 with high significance and the 230 GHz data also suggest an enhanced activity of the source. After the MeV/GeV detection from 3C 120 in MJD 56240–56300, 43 GHz Very Long Baseline Array (VLBA) monitoring revealed a brightening of the radio core, followed by the ejection of a superluminal knot. Since we observed the γ-ray and VLBA phenomena in temporal proximity to each other, itmore » is naturally assumed that they are physically connected. This assumption was further supported by the subsequent observation that the 43 GHz core brightened again after a γ-ray flare occurred around MJD 56560. We can then infer that the MeV/GeV emission took place inside an unresolved 43 GHz core of 3C 120 and that the jet dissipation occurred at sub-parsec distances from the central black hole (BH), if we take the distance of the 43 GHz core from the central BH as ∼0.5 pc, as previously estimated from the time lag between X-ray dips and knot ejections. Based on our constraints on the relative locations of the emission regions and energetic arguments, we conclude that the γ rays are more favorably produced via the synchrotron self-Compton process, rather than inverse Compton scattering of external photons coming from the broad line region or hot dusty torus. We also derived the electron distribution and magnetic field by modeling the simultaneous broadband spectrum.« less

  13. SIX YEARS OF FERMI-LAT AND MULTI-WAVELENGTH MONITORING OF THE BROAD-LINE RADIO GALAXY 3C 120: JET DISSIPATION AT SUB-PARSEC SCALES FROM THE CENTRAL ENGINE

    DOE PAGES

    Tanaka, Y. T.; Doi, A.; Inoue, Y.; ...

    2015-01-23

    In this paper, we present multi-wavelength monitoring results for the broad-line radio galaxy 3C 120 in the MeV/GeV, sub-millimeter, and 43 GHz bands over 6 yr. Over the past 2 yr, the Fermi-Large Area Telescope sporadically detected 3C 120 with high significance and the 230 GHz data also suggest an enhanced activity of the source. After the MeV/GeV detection from 3C 120 in MJD 56240–56300, 43 GHz Very Long Baseline Array (VLBA) monitoring revealed a brightening of the radio core, followed by the ejection of a superluminal knot. Since we observed the γ-ray and VLBA phenomena in temporal proximity tomore » each other, it is naturally assumed that they are physically connected. This assumption was further supported by the subsequent observation that the 43 GHz core brightened again after a γ-ray flare occurred around MJD 56560. We can then infer that the MeV/GeV emission took place inside an unresolved 43 GHz core of 3C 120 and that the jet dissipation occurred at sub-parsec distances from the central black hole (BH), if we take the distance of the 43 GHz core from the central BH as ~0.5 pc, as previously estimated from the time lag between X-ray dips and knot ejections. Based on our constraints on the relative locations of the emission regions and energetic arguments, we conclude that the γ rays are more favorably produced via the synchrotron self-Compton process, rather than inverse Compton scattering of external photons coming from the broad line region or hot dusty torus. Finally, we also derived the electron distribution and magnetic field by modeling the simultaneous broadband spectrum.« less

  14. Out of Balance—Systemic Iron Homeostasis in Iron-Related Disorders

    PubMed Central

    Steinbicker, Andrea U.; Muckenthaler, Martina U.

    2013-01-01

    Iron is an essential element in our daily diet. Most iron is required for the de novo synthesis of red blood cells, where it plays a critical role in oxygen binding to hemoglobin. Thus, iron deficiency causes anemia, a major public health burden worldwide. On the other extreme, iron accumulation in critical organs such as liver, heart, and pancreas causes organ dysfunction due to the generation of oxidative stress. Therefore, systemic iron levels must be tightly balanced. Here we focus on the regulatory role of the hepcidin/ferroportin circuitry as the major regulator of systemic iron homeostasis. We discuss how regulatory cues (e.g., iron, inflammation, or hypoxia) affect the hepcidin response and how impairment of the hepcidin/ferroportin regulatory system causes disorders of iron metabolism. PMID:23917168

  15. Mammalian iron metabolism and its control by iron regulatory proteins☆

    PubMed Central

    Anderson, Cole P.; Shen, Lacy; Eisenstein, Richard S.; Leibold, Elizabeth A.

    2013-01-01

    Cellular iron homeostasis is maintained by iron regulatory proteins 1 and 2 (IRP1 and IRP2). IRPs bind to iron-responsive elements (IREs) located in the untranslated regions of mRNAs encoding protein involved in iron uptake, storage, utilization and export. Over the past decade, significant progress has been made in understanding how IRPs are regulated by iron-dependent and iron-independent mechanisms and the pathological consequences of IRP2 deficiency in mice. The identification of novel IREs involved in diverse cellular pathways has revealed that the IRP–IRE network extends to processes other than iron homeostasis. A mechanistic understanding of IRP regulation will likely yield important insights into the basis of disorders of iron metabolism. This article is part of a Special Issue entitled: Cell Biology of Metals. PMID:22610083

  16. Iron-binding haemerythrin RING ubiquitin ligases regulate plant iron responses and accumulation

    PubMed Central

    Kobayashi, Takanori; Nagasaka, Seiji; Senoura, Takeshi; Itai, Reiko Nakanishi; Nakanishi, Hiromi; Nishizawa, Naoko K.

    2013-01-01

    Iron is essential for most living organisms. Plants transcriptionally induce genes involved in iron acquisition under conditions of low iron availability, but the nature of the deficiency signal and its sensors are unknown. Here we report the identification of new iron regulators in rice, designated Oryza sativa Haemerythrin motif-containing Really Interesting New Gene (RING)- and Zinc-finger protein 1 (OsHRZ1) and OsHRZ2. OsHRZ1, OsHRZ2 and their Arabidopsis homologue BRUTUS bind iron and zinc, and possess ubiquitination activity. OsHRZ1 and OsHRZ2 are susceptible to degradation in roots irrespective of iron conditions. OsHRZ-knockdown plants exhibit substantial tolerance to iron deficiency, and accumulate more iron in their shoots and grains irrespective of soil iron conditions. The expression of iron deficiency-inducible genes involved in iron utilization is enhanced in OsHRZ-knockdown plants, mostly under iron-sufficient conditions. These results suggest that OsHRZ1 and OsHRZ2 are iron-binding sensors that negatively regulate iron acquisition under conditions of iron sufficiency. PMID:24253678

  17. Ferritin iron minerals are chelator targets, antioxidants, and coated, dietary iron.

    PubMed

    Theil, Elizabeth C

    2010-08-01

    Cellular ferritin is central for iron balance during transfusions therapies; serum ferritin is a small fraction of body ferritin, albeit a convenient reporter. Iron overload induces extra ferritin protein synthesis but the protein is overfilled with the extra iron that damages ferritin, with conversion to toxic hemosiderin. Three new approaches that manipulate ferritin to address excess iron, hemosiderin, and associated oxidative damage in Cooley's Anemia and other iron overload conditions are faster removal of ferritin iron with chelators guided to ferritin gated pores by peptides; more ferritin protein synthesis using ferritin mRNA activators, by metal complexes that target mRNA 3D structures; and determining if endocytotic absorption of iron from legumes, which is mostly ferritin, is regulated during iron overload to prevent excess iron entry while providing protein. More of a focus on ferritin features, including protein cage structure, iron mineral, regulatable mRNA, and specific gut absorption properties, will achieve the three novel experimental goals for managing iron homeostasis with transfusion therapies.

  18. Siderophore-mediated iron trafficking in humans is regulated by iron

    PubMed Central

    Liu, Zhuoming; Lanford, Robert; Mueller, Sebastian; Gerhard, Glenn S.; Luscieti, Sara; Sanchez, Mayka; Devireddy, L.

    2013-01-01

    Siderophores are best known as small iron binding molecules that facilitate microbial iron transport. In our previous study we identified a siderophore-like molecule in mammalian cells and found that its biogenesis is evolutionarily conserved. A member of the short chain dehydrogenase family of reductases, 3-OH butyrate dehydrogenase (BDH2) catalyzes a rate-limiting step in the biogenesis of the mammalian siderophore. We have shown that depletion of the mammalian siderophore by inhibiting expression of bdh2 results in abnormal accumulation of cellular iron and mitochondrial iron deficiency. These observations suggest that the mammalian siderophore is a critical regulator of cellular iron homeostasis and facilitates mitochondrial iron import. By utilizing bioinformatics, we identified an iron-responsive element (IRE; a stem-loop structure that regulates genes expression post-transcriptionally upon binding to iron regulatory proteins or IRPs) in the 3′-untranslated region (3′-UTR) of the human BDH2 (hBDH2) gene. In cultured cells as well as in patient samples we now demonstrate that the IRE confers iron-dependent regulation on hBDH2 and binds IRPs in RNA electrophoretic mobility shift assays. In addition, we show that the hBDH2 IRE associates with IRPs in cells and that abrogation of IRPs by RNAi eliminates the iron-dependent regulation of hBDH2 mRNA. The key physiologic implication is that iron-mediated post-transcriptional regulation of hBDH2 controls mitochondrial iron homeostasis in human cells. These observations provide a new and an unanticipated mechanism by which iron regulates its intracellular trafficking. PMID:22527885

  19. Iron-sulfur-carbon relationships in organic-carbon-rich sequences I: Cretaceous Western Interior seaway

    USGS Publications Warehouse

    Dean, W.E.; Arthur, M.A.

    1989-01-01

    Cretaceous marine strata deposited in shallow to intermediate depths in the Western Interior seaway of North America show considerable variation in organic-carbon enrichment and degree of pyrite formation. The extreme range of paleoceanographic and depositional conditions that occurred in this seaway provide a unique opportunity to examine the effects of iron-, carbon-, and sulfur-limitation on pyrite formation in one region over about 30 my. Ternary diagrams of the system Fe-S-OC, together with some measure of the reactivity of organic matter (pyrolysis hydrogen index), provide a rapid means of recognizing iron-, carbon-, and sulfur-limitation on pyrite formation in a series of samples from a single lithologic unit. Iron limitation is indicated by a concentration of data along a line of constant S/Fe ratio on a Fe-S-OC ternary diagram. Carbon limitation is indicated by a concentration of data along a line of constant S/OC ratio. Sulfur-limitation is suggested by the lack of a systematic Fe-S-OC relationship and residual organic matter that is high in abundance and reactivity. -from Authors

  20. Iron overdose

    MedlinePlus

    ... 1222) from anywhere in the United States. Poisonous Ingredient Iron can be harmful in large amounts. Where Found Iron is an ingredient in many mineral and vitamin supplements. Iron supplements ...

  1. Product line management in oncology: a Canadian experience.

    PubMed

    Wodinsky, H B; Egan, D; Markel, F

    1988-01-01

    More competition for finite resources and increasing regulation have led many hospitals to consider a strategic reorganization. Recently, one common reorganization strategy has been"product line management." Product line management can be broadly defined in terms of centralized program management, planning, and marketing strategies. In Canada, while strategic driving forces may be different, a product line management alternative has arisen in one of the most potentially complex product lines, cancer services. This article compares and contrasts the theoretical model for product line management development, with special reference to cancer services, to the experience of one Canadian medical center and cancer center.

  2. Debye–Waller coefficient of heavily deformed nanocrystalline iron

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Scardi, P.; Rebuffi, L.; Abdellatief, M.

    2017-02-17

    Synchrotron radiation X-ray diffraction (XRD) patterns from an extensively ball-milled iron alloy powder were collected at 100, 200 and 300 K. The results were analysed together with those using extended X-ray absorption fine structure, measured on the same sample at liquid nitrogen temperature (77 K) and at room temperature (300 K), to assess the contribution of static disorder to the Debye–Waller coefficient (B iso). Both techniques give an increase of ~20% with respect to bulk reference iron, a noticeably smaller difference than reported by most of the literature for similar systems. Besides good quality XRD patterns, proper consideration of themore » temperature diffuse scattering seems to be the key to accurate values of the Debye–Waller coefficient. Molecular dynamics simulations of nanocrystalline iron aggregates, mapped on the evidence provided by XRD in terms of domain size distribution, shed light on the origin of the observedB isoincrease. The main contribution to the static disorder is given by the grain boundary, while line and point defects have a much smaller effect.« less

  3. Characterization of iron uptake from transferrin by murine endothelial cells.

    PubMed

    Hallmann, R; Savigni, D L; Morgan, E H; Baker, E

    2000-01-01

    Iron is required by the brain for normal function, however, the mechanisms by which it crosses the blood-brain barrier (BBB) are poorly understood. The uptake and efflux of transferrin (Tf) and Fe by murine brain-derived (bEND3) and lymph node-derived (m1END1) endothelial cell lines was compared. The effects of iron chelators, metabolic inhibitors and the cellular activators, lipopolysaccharide (LPS) and tumour necrosis factor-alpha (TNF-alpha), on Tf and Fe uptake were investigated. Cells were incubated with 59Fe-125I-Tf; Fe uptake was shown to increase linearly over time for both cell lines, while Tf uptake reached a plateau within 2 h. Both Tf and Fe uptake were saturable. bEND3 cells were shown to have half as many Tf receptors as m1END1 cells, but the mean cycling times of a Tf molecule were the same. Tf and Fe efflux from the cells were measured over time, revealing that after 2 h only 25% of the Tf but 80% of the Fe remained associated with the cells. Of 7 iron chelators, only deferriprone (L1) markedly decreased Tf uptake. However, Fe uptake was reduced by more than 50% by L1, pyridoxal isonicotinoyl hydrazone (PIH) and desferrithiocin (DFT). The cellular activators TNF-alpha or LPS had little effect on Tf turnover, but they accelerated Fe uptake in both endothelial cell types. Phenylarsenoxide (PhAsO) and N-ethyl maleimide (NEM), inhibitors of Tf endocytosis, reduced both Tf and Fe uptake in both cell lines, while bafilomycin A1, an inhibitor of endosomal acidification, reduced Fe uptake but did not affect Tf uptake. The results suggest that Tf and Fe uptake by both bEND3 and m1END1 is via receptor-mediated endocytosis with release of Fe from Tf within the cell and recycling of apo-Tf. On the basis of Tf- and Fe-metabolism both cell lines are similar and therefore well suited for use in in vitro models for Fe transport across the BBB.

  4. Iron release from the Lucky Iron Fish®: safety considerations.

    PubMed

    Armstrong, Gavin R; Dewey, Cate E; Summerlee, Alastair Js

    2017-01-01

    The principal objective was to explore in greater detail safety issues with regard to the use of the Lucky Iron Fish® (fish) as a treatment for iron deficiency and iron deficiency anaemia in women in rural Cambodia. Experiments were done to determine: (1) purity of the iron in the fish by mass spectroscopy; (2) release of iron and contaminants released during boiling in water using inductive-ly-coupled plasma optical emission spectroscopy; (3) the impact of cooking time, acidity and number of fish in acidified water and two types of Khmer soups; and (4) drinkability of the water after boiling with different num-bers of fish. The fish is composed primarily of ferrous iron with less than 12% non-ferrous iron. Contaminants were either not detectable or levels were below the acceptable standards set by the World Health Organization. The length of time boiling the fish and the acidity of the water increased iron release but even with 5 fish boiled for 60 minutes, iron levels only approached levels where side effects are observed. Boiling one fish in water did not affect the perception of colour, smell or taste of the water but boiling in water with two or more fish resulted in the water being unpalatable which further limits the potential for iron toxicity from using the fish. The results suggest that the Lucky Iron Fish™ may be a safe treatment for iron deficiency.

  5. New insights into iron deficiency and iron deficiency anemia.

    PubMed

    Camaschella, Clara

    2017-07-01

    Recent advances in iron metabolism have stimulated new interest in iron deficiency (ID) and its anemia (IDA), common conditions worldwide. Absolute ID/IDA, i.e. the decrease of total body iron, is easily diagnosed based on decreased levels of serum ferritin and transferrin saturation. Relative lack of iron in specific organs/tissues, and IDA in the context of inflammatory disorders, are diagnosed based on arbitrary cut offs of ferritin and transferrin saturation and/or marker combination (as the soluble transferrin receptor/ferritin index) in an appropriate clinical context. Most ID patients are candidate to traditional treatment with oral iron salts, while high hepcidin levels block their absorption in inflammatory disorders. New iron preparations and new treatment modalities are available: high-dose intravenous iron compounds are becoming popular and indications to their use are increasing, although long-term side effects remain to be evaluated. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Involvement of hepcidin in iron metabolism dysregulation in Gaucher disease.

    PubMed

    Lefebvre, Thibaud; Reihani, Niloofar; Daher, Raed; de Villemeur, Thierry Billette; Belmatoug, Nadia; Rose, Christian; Colin-Aronovicz, Yves; Puy, Hervé; Le Van Kim, Caroline; Franco, Mélanie; Karim, Zoubida

    2018-04-01

    Gaucher disease (GD) is an inherited deficiency of glucocerebrosidase leading to accumulation of glucosylceramide in tissues such as the spleen, liver, and bone marrow. The resulting lipid-laden macrophages lead to the appearance of "Gaucher cells". Anemia associated with an unexplained hyperferritinemia is a frequent finding in GD, but whether this pathogenesis is related to an iron metabolism disorder has remained unclear. To investigate this issue, we explored the iron status of a large cohort of 90 type I GD patients, including 66 patients treated with enzyme replacement therapy. Ten of the patients treated with enzyme replacement were followed up before and during treatment. Serum levels of hepcidin, the iron regulatory peptide, remained within the physiological range, while the transferrin saturation was slightly decreased in children. Inflammation-independent hyperferritinemia was found in 65% of the patients, and Perl's staining of the spleen and marrow smear revealed iron accumulation in Gaucher cells. Treated patients exhibited reduced hyperferritinemia, increased transferrin saturation and transiently increased systemic hepcidin. In addition, the hepcidin and ferritin correlation was markedly improved, and, in most patients, the hemoglobin level was normalized. To further explore eventual iron sequestration in macrophages, we produce a Gaucher cells model by treating the J774 macrophage cell line with a glucocerebrosidase inhibitor and showed induced local hepcidin and membrane retrieval of the iron exporter, ferroportin. These data reveal the involvement of Gaucher cells in abnormal iron sequestration, which may explain the mechanism of hyperferritinemia in GD patients. Local hepcidin-ferroportin interaction was involved in this pathogenesis. Copyright© 2018 Ferrata Storti Foundation.

  7. Studying disorders of vertebrate iron and heme metabolism using zebrafish

    PubMed Central

    van der Vorm, Lisa N.; Paw, Barry H.

    2017-01-01

    Iron is a crucial component of heme- and iron-sulfur clusters, involved in vital cellular functions such as oxygen transport, DNA synthesis, and respiration. Both excess and insufficient levels of iron and heme-precursors cause human disease, such as iron-deficiency anemia, hemochromatosis, and porphyrias. Hence, their levels must be tightly regulated, requiring a complex network of transporters and feedback mechanisms. The use of zebrafish to study these pathways and the underlying genetics offers many advantages, among others their optical transparency, ex-vivo development and high genetic and physiological conservations. This chapter first reviews well-established methods, such as large-scale mutagenesis screens that have led to the initial identification of a series of iron and heme transporters and the generation of a variety of mutant lines. Other widely used techniques are based on injection of RNA, including complementary morpholino knockdown and gene overexpression. In addition, we highlight several recently developed approaches, most notably endonuclease-based gene knockouts such as TALENs or the CRISPR/Cas9 system that have been used to study how loss of function can induce human disease phenocopies in zebrafish. Rescue by chemical complementation with iron-based compounds or small molecules can subsequently be used to confirm causality of the genetic defect for the observed phenotype. All together, zebrafish have proven to be – and will continue to serve as an ideal model to advance our understanding of the pathogenesis of human iron and heme-related diseases and to develop novel therapies to treat these conditions. PMID:28129844

  8. Oral iron supplements for children in malaria-endemic areas

    PubMed Central

    Neuberger, Ami; Okebe, Joseph; Yahav, Dafna; Paul, Mical

    2016-01-01

    , Development and Evaluation (GRADE) approach. We performed a fixed-effect meta-analysis for all outcomes and random-effects meta-analysis for hematological outcomes, and adjusted analyses for cluster RCTs. We based the subgroup analyses for anaemia at baseline, age, and malaria prevention or management services on trial-level data. Main results Thirty-five trials (31,955 children) met the inclusion criteria. Overall, iron does not cause an excess of clinical malaria (risk ratio (RR) 0.93, 95% confidence intervals (CI) 0.87 to 1.00; 14 trials, 7168 children, high quality evidence). Iron probably does not cause an excess of clinical malaria in both populations where anaemia is common and those in which anaemia is uncommon. In areas where there are prevention and management services for malaria, iron (with or without folic acid) may reduce clinical malaria (RR 0.91, 95% CI 0.84 to 0.97; seven trials, 5586 participants, low quality evidence), while in areas where such services are unavailable, iron (with or without folic acid) may increase the incidence of malaria, although the lower CIs indicate no difference (RR 1.16, 95% CI 1.02 to 1.31; nine trials, 19,086 participants, low quality evidence). Iron supplementation does not cause an excess of severe malaria (RR 0.90, 95% CI 0.81 to 0.98; 6 trials, 3421 children, high quality evidence). We did not observe any differences for deaths (control event rate 1%, low quality evidence). Iron and antimalarial treatment reduced clinical malaria (RR 0.54, 95% CI 0.43 to 0.67; three trials, 728 children, high quality evidence). Overall, iron resulted in fewer anaemic children at follow up, and the end average change in haemoglobin from base line was higher with iron. Authors' conclusions Iron treatment does not increase the risk of clinical malaria when regular malaria prevention or management services are provided. Where resources are limited, iron can be administered without screening for anaemia or for iron deficiency, as long as malaria

  9. Reducing iron deficiency anemia in Bolivian school children: calcium and iron combined versus iron supplementation alone.

    PubMed

    Miranda, Melissa; Olivares, Manuel; Brito, Alex; Pizarro, Fernando

    2014-01-01

    The aim of this study was to determine the effect of combined calcium and iron versus single iron supplementation on iron status in Bolivian schoolchildren. Children ages 6 to 10 y old (N = 195), were randomly assigned to receive either 700 mg Ca (as calcium carbonate) plus 30 mg Fe (as ferrous sulfate) (Ca + Fe group) or 30 mg Fe (as ferrous sulfate) (Fe group). The doses were administered daily, from Monday to Friday, between meals at school over 3 mo. Iron status was assessed at baseline and after intervention. Additionally, overall nutritional status was assessed by anthropometry and an estimation of dietary intake. At baseline, the prevalence of anemia in the Ca + Fe group and the Fe group were 15% and 21.5%, respectively. After 3 mo follow-up, the prevalence of iron deficiency anemia dropped significantly (P < 0.001) to 3% in both groups (χ(2) = NS). Iron dietary intake was within recommended levels, but calcium intake only covered 39% of the Recommended Daily Intake. Combined calcium and iron supplementation is equally as effective as single iron supplementation in reducing the prevalence of iron deficiency anemia in Bolivian school children. Copyright © 2014 Elsevier Inc. All rights reserved.

  10. Thermodynamic studies of iron chelation with doxycycline in acidic medium

    NASA Astrophysics Data System (ADS)

    Javed, Javeria; Zahir, Erum

    2017-06-01

    Doxycycline (DOX) is a broad-spectrum tetracycline antibiotic synthetically derived from oxytetracycline. The complex formation of this drug with iron(III) was studied using spectrophotometry. The thermodynamic parameters of the systems were calculated using the changes in the absorption spectra which occur due to hydrogen bond or complex formation. Thermodynamic parameters of the formation of iron(III) complex with doxycycline (Δ H, Δ G, Δ S, and stability constants) were determined spectrophotometrically at a wavelength corresponding to absorption maximum (374.5 nm) at three different temperatures (22, 35, and 45°C). The obtained data show that the complex has metal to ligand molar ratio of 1: 2 at pH 2-3. The stability constants were calculated to be 13.99 × 106, 7.06 × 105, and 1.29 × 106 by mole ratio method at 22, 35, and 45°C, respectively.

  11. Relative Bioavailability of Iron in Bangladeshi Traditional Meals Prepared with Iron-Fortified Lentil Dal

    PubMed Central

    Podder, Rajib; M. DellaValle, Diane; T. Tyler, Robert; P. Glahn, Raymond; Tako, Elad; Vandenberg, Albert

    2018-01-01

    Due to low Fe bioavailability and low consumption per meal, lentil must be fortified to contribute significant bioavailable Fe in the Bangladeshi diet. Moreover, since red lentil is dehulled prior to consumption, an opportunity exists at this point to fortify lentil with Fe. Thus, in the present study, lentil was Fe-fortified (using a fortificant Fe concentration of 2800 µg g−1) and used in 30 traditional Bangladeshi meals with broad differences in concentrations of iron, phytic acid (PA), and relative Fe bioavailability (RFeB%). Fortification with NaFeEDTA increased the iron concentration in lentil from 60 to 439 µg g−1 and resulted in a 79% increase in the amount of available Fe as estimated by Caco-2 cell ferritin formation. Phytic acid levels were reduced from 6.2 to 4.6 mg g−1 when fortified lentil was added, thereby reducing the PA:Fe molar ratio from 8.8 to 0.9. This effect was presumably due to dephytinization of fortified lentil during the fortification process. A significant (p ≤ 0.01) Pearson correlation was observed between Fe concentration and RFeB% and between RFeB% and PA:Fe molar ratio in meals with fortified lentil, but not for the meal with unfortified lentil. In conclusion, fortified lentil can contribute significant bioavailable Fe to populations at risk of Fe deficiency. PMID:29543712

  12. Relative Bioavailability of Iron in Bangladeshi Traditional Meals Prepared with Iron-Fortified Lentil Dal.

    PubMed

    Podder, Rajib; M DellaValle, Diane; T Tyler, Robert; P Glahn, Raymond; Tako, Elad; Vandenberg, Albert

    2018-03-15

    Due to low Fe bioavailability and low consumption per meal, lentil must be fortified to contribute significant bioavailable Fe in the Bangladeshi diet. Moreover, since red lentil is dehulled prior to consumption, an opportunity exists at this point to fortify lentil with Fe. Thus, in the present study, lentil was Fe-fortified (using a fortificant Fe concentration of 2800 µg g -1 ) and used in 30 traditional Bangladeshi meals with broad differences in concentrations of iron, phytic acid (PA), and relative Fe bioavailability (RFeB%). Fortification with NaFeEDTA increased the iron concentration in lentil from 60 to 439 µg g -1 and resulted in a 79% increase in the amount of available Fe as estimated by Caco-2 cell ferritin formation. Phytic acid levels were reduced from 6.2 to 4.6 mg g -1 when fortified lentil was added, thereby reducing the PA:Fe molar ratio from 8.8 to 0.9. This effect was presumably due to dephytinization of fortified lentil during the fortification process. A significant ( p ≤ 0.01) Pearson correlation was observed between Fe concentration and RFeB% and between RFeB% and PA:Fe molar ratio in meals with fortified lentil, but not for the meal with unfortified lentil. In conclusion, fortified lentil can contribute significant bioavailable Fe to populations at risk of Fe deficiency.

  13. Alginate-Iron Speciation and Its Effect on In Vitro Cellular Iron Metabolism

    PubMed Central

    Horniblow, Richard D.; Dowle, Miriam; Iqbal, Tariq H.; Latunde-Dada, Gladys O.; Palmer, Richard E.

    2015-01-01

    Alginates are a class of biopolymers with known iron binding properties which are routinely used in the fabrication of iron-oxide nanoparticles. In addition, alginates have been implicated in influencing human iron absorption. However, the synthesis of iron oxide nanoparticles employs non-physiological pH conditions and whether nanoparticle formation in vivo is responsible for influencing cellular iron metabolism is unclear. Thus the aims of this study were to determine how alginate and iron interact at gastric-comparable pH conditions and how this influences iron metabolism. Employing a range of spectroscopic techniques under physiological conditions alginate-iron complexation was confirmed and, in conjunction with aberration corrected scanning transmission electron microscopy, nanoparticles were observed. The results infer a nucleation-type model of iron binding whereby alginate is templating the condensation of iron-hydroxide complexes to form iron oxide centred nanoparticles. The interaction of alginate and iron at a cellular level was found to decrease cellular iron acquisition by 37% (p < 0.05) and in combination with confocal microscopy the alginate inhibits cellular iron transport through extracellular iron chelation with the resulting complexes not internalised. These results infer alginate as being useful in the chelation of excess iron, especially in the context of inflammatory bowel disease and colorectal cancer where excess unabsorbed luminal iron is thought to be a driver of disease. PMID:26378798

  14. [Old and new iron parameters in iron metabolism and diagnostics].

    PubMed

    Graf, Lukas; Herklotz, Roberto; Huber, Andreas R; Korte, Wolfgang

    2008-09-01

    Iron is an element which is essential to life but also potentially toxic. Therefore, clever mechanisms exist in the human body for uptake, transport and storage of iron. Hepcidin, which seems to be the master protein for regulation of intestinal iron absorption, is known for a short time. The expression of hepcidin is not only influenced by iron levels but also by mediators of inflammation and growth factors of erythropoiesis. Hence hepcidin plays also a crucial role in the development of anemia of chronic disease and iron overload due to ineffective erythropoiesis. Serum ferritin is a reliable parameter to estimate the storage iron. It is an acute phase protein which is elevated during infections and inflammations, though. In these situations, measurement of soluble transferrin receptors is a useful tool to differentiate between iron deficiency and anemia of chronic disease. Newer parameters as erythrocyte zink protoporphyrin or percentage of hypochromic erythrocytes (%HYPO) are suited to detect a functional iron deficiency. Early diagnosis of iron overload is essential to prevent organ damage. Serum ferritin and transferrin are useful parameters to screen for iron overload. If no clear reason for a secondary iron overload can be found, the search for a hereditary haemochromatosis is recommended. Most of these hereditary haemochromatoses are a result of mutations in the HFE gene (homozygous state for Cys282Tyr or compound heterozygosity for Cys282Tyr/ His63Asp) which can be detected by PCR technique. Liver biopsy is still the gold standard for quantification of storage iron. However, a method of increasing importance for quantification of iron overload is magnetic resonance imaging with new approaches as for example T2*.

  15. Nitrate-dependent iron oxidation limits iron transport in anoxic ocean regions

    NASA Astrophysics Data System (ADS)

    Scholz, Florian; Löscher, Carolin R.; Fiskal, Annika; Sommer, Stefan; Hensen, Christian; Lomnitz, Ulrike; Wuttig, Kathrin; Göttlicher, Jörg; Kossel, Elke; Steininger, Ralph; Canfield, Donald E.

    2016-11-01

    Iron is an essential element for life on Earth and limits primary production in large parts of the ocean. Oxygen-free continental margin sediments represent an important source of bioavailable iron to the ocean, yet little of the iron released from the seabed reaches the productive sea surface. Even in the anoxic water of oxygen minimum zones, where iron solubility should be enhanced, most of the iron is rapidly re-precipitated. To constrain the mechanism(s) of iron removal in anoxic ocean regions we explored the sediment and water in the oxygen minimum zone off Peru. During our sampling campaign the water column featured two distinct redox boundaries separating oxic from nitrate-reducing (i.e., nitrogenous) water and nitrogenous from weakly sulfidic water. The sulfidic water mass in contact with the shelf sediment contained elevated iron concentrations >300 nM. At the boundary between sulfidic and nitrogenous conditions, iron concentrations dropped sharply to <20 nM coincident with a maximum in particulate iron concentration. Within the iron gradient, we found an increased expression of the key functional marker gene for nitrate reduction (narG). Part of this upregulation was related to the activity of known iron-oxidizing bacteria. Collectively, our data suggest that iron oxidation and removal is induced by nitrate-reducing microbes, either enzymatically through anaerobic iron oxidation or by providing nitrite for an abiotic reaction. Given the important role that iron plays in nitrogen fixation, photosynthesis and respiration, nitrate-dependent iron oxidation likely represents a key-link between the marine biogeochemical cycles of nitrogen, oxygen and carbon.

  16. Deviation from Boltzmann distribution in excited energy levels of singly-ionized iron in an argon glow discharge plasma for atomic emission spectrometry

    NASA Astrophysics Data System (ADS)

    Zhang, Lei; Kashiwakura, Shunsuke; Wagatsuma, Kazuaki

    2012-01-01

    A Boltzmann plot for many iron ionic lines having excitation energies of 4.7-9.1 eV was investigated in an argon glow discharge plasma when the discharge parameters, such as the voltage/current and the gas pressure, were varied. A Grimm-style radiation source was employed in a DC voltage range of 400-800 V at argon pressures of 400-930 Pa. The plot did not follow a linear relationship over a wide range of the excitation energy, but it yielded a normal Boltzmann distribution in the range of 4.7-5.8 eV and a large overpopulation in higher-lying excitation levels of iron ion. A probable reason for this phenomenon is that excitations for higher excited energy levels of iron ion would be predominantly caused by non-thermal collisions with argon species, the internal energy of which is received by iron atoms for the ionization. Particular intense ionic lines, which gave a maximum peak of the Boltzmann plot, were observed at an excitation energy of ca. 7.7 eV. They were the Fe II 257.297-nm and the Fe II 258.111-nm lines, derived from the 3d54s4p 6P excited levels. The 3d54s4p 6P excited levels can be highly populated through a resonance charge transfer from the ground state of argon ion, because of good matching in the excitation energy as well as the conservation of the total spin before and after the collision. An enhancement factor of the emission intensity for various Fe II lines could be obtained from a deviation from the normal Boltzmann plot, which comprised the emission lines of 4.7-5.8 eV. It would roughly correspond to a contribution of the charge transfer excitation to the excited levels of iron ion, suggesting that the charge-transfer collision could elevate the number density of the corresponding excited levels by a factor of ca.104. The Boltzmann plots give important information on the reason why a variety of iron ionic lines can be emitted from glow discharge plasmas.

  17. Black reefs: iron-induced phase shifts on coral reefs

    PubMed Central

    Kelly, Linda Wegley; Barott, Katie L; Dinsdale, Elizabeth; Friedlander, Alan M; Nosrat, Bahador; Obura, David; Sala, Enric; Sandin, Stuart A; Smith, Jennifer E; Vermeij, Mark J A; Williams, Gareth J; Willner, Dana; Rohwer, Forest

    2012-01-01

    The Line Islands are calcium carbonate coral reef platforms located in iron-poor regions of the central Pacific. Natural terrestrial run-off of iron is non-existent and aerial deposition is extremely low. However, a number of ship groundings have occurred on these atolls. The reefs surrounding the shipwreck debris are characterized by high benthic cover of turf algae, macroalgae, cyanobacterial mats and corallimorphs, as well as particulate-laden, cloudy water. These sites also have very low coral and crustose coralline algal cover and are call black reefs because of the dark-colored benthic community and reduced clarity of the overlying water column. Here we use a combination of benthic surveys, chemistry, metagenomics and microcosms to investigate if and how shipwrecks initiate and maintain black reefs. Comparative surveys show that the live coral cover was reduced from 40 to 60% to <10% on black reefs on Millennium, Tabuaeran and Kingman. These three sites are relatively large (>0.75 km2). The phase shift occurs rapidly; the Kingman black reef formed within 3 years of the ship grounding. Iron concentrations in algae tissue from the Millennium black reef site were six times higher than in algae collected from reference sites. Metagenomic sequencing of the Millennium Atoll black reef-associated microbial community was enriched in iron-associated virulence genes and known pathogens. Microcosm experiments showed that corals were killed by black reef rubble through microbial activity. Together these results demonstrate that shipwrecks and their associated iron pose significant threats to coral reefs in iron-limited regions. PMID:21881615

  18. Black reefs: iron-induced phase shifts on coral reefs.

    PubMed

    Kelly, Linda Wegley; Barott, Katie L; Dinsdale, Elizabeth; Friedlander, Alan M; Nosrat, Bahador; Obura, David; Sala, Enric; Sandin, Stuart A; Smith, Jennifer E; Vermeij, Mark J A; Williams, Gareth J; Willner, Dana; Rohwer, Forest

    2012-03-01

    The Line Islands are calcium carbonate coral reef platforms located in iron-poor regions of the central Pacific. Natural terrestrial run-off of iron is non-existent and aerial deposition is extremely low. However, a number of ship groundings have occurred on these atolls. The reefs surrounding the shipwreck debris are characterized by high benthic cover of turf algae, macroalgae, cyanobacterial mats and corallimorphs, as well as particulate-laden, cloudy water. These sites also have very low coral and crustose coralline algal cover and are call black reefs because of the dark-colored benthic community and reduced clarity of the overlying water column. Here we use a combination of benthic surveys, chemistry, metagenomics and microcosms to investigate if and how shipwrecks initiate and maintain black reefs. Comparative surveys show that the live coral cover was reduced from 40 to 60% to <10% on black reefs on Millennium, Tabuaeran and Kingman. These three sites are relatively large (>0.75 km(2)). The phase shift occurs rapidly; the Kingman black reef formed within 3 years of the ship grounding. Iron concentrations in algae tissue from the Millennium black reef site were six times higher than in algae collected from reference sites. Metagenomic sequencing of the Millennium Atoll black reef-associated microbial community was enriched in iron-associated virulence genes and known pathogens. Microcosm experiments showed that corals were killed by black reef rubble through microbial activity. Together these results demonstrate that shipwrecks and their associated iron pose significant threats to coral reefs in iron-limited regions.

  19. The Broad Way

    ERIC Educational Resources Information Center

    Butler, Kevin

    2008-01-01

    In the world of corporate philanthropy, there are those who give to educational causes, and this article describes one such philanthropist, Eli Broad, who shares his take on schools in America. Broad is in a category unto himself not only because of the amount of money he has given--more than $280 million since 1999--but also for his unique…

  20. Iron Chelation

    MedlinePlus

    ... fortified cereals and eggs. What is Iron Chelation Therapy? Drugs called iron chelators remove extra iron from ... form that must be dissolved in juice or water and taken (by mouth) once a day. Most ...

  1. Broad Halpha Wing Formation in the Planetary Nebula IC 4997.

    PubMed

    Lee; Hyung

    2000-02-10

    The young and compact planetary nebula IC 4997 is known to exhibit very broad wings with a width exceeding 5000 km s-1 around Halpha. We propose that the broad wings are formed through Rayleigh-Raman scattering that involves atomic hydrogen, by which Lybeta photons with a velocity width of a few 102 km s-1 are converted to optical photons and fill the Halpha broad wing region. The conversion efficiency reaches 0.6 near the line center, where the scattering optical depth is much larger than 1, and rapidly decreases in the far wings. Assuming that close to the central star there exists an unresolved inner compact core of high density, nH approximately 109-1010 cm-3, we use the photoionization code "CLOUDY" to show that sufficient Lybeta photons for scattering are produced. Using a top-hat-incident profile for the Lybeta flux and a scattering region with a H i column density NHi=2x1020 cm-2 and a substantial covering factor, we perform a profile-fitting analysis in order to obtain a satisfactory fit to the observed flux. We briefly discuss the astrophysical implications of the Rayleigh-Raman processes in planetary nebulae and other emission objects.

  2. Organometallic iron complexes as potential cancer therapeutics.

    PubMed

    Mojžišová, Gabriela; Mojžiš, Ján; Vašková, Janka

    2014-01-01

    Metal-containing drugs have long been used for medicinal purposes in more or less empirical way. The potential of these anticancer agents has only been fully realised and explored since the discovery of the biological activity of cisplatin. Cisplatin and carboplatin have been two of the most successful anti-cancer agents ever developed, and are currently used to treat ovarian, lung and testicular cancers. They share certain side effects, so their clinical use is severely limited by dose-limiting toxicity. Inherent or acquired resistance is a second problem often associated with platinum-based drugs, with further limits of their clinical use. These problems have prompted chemists to employ different strategies in development of the new metal-based anticancer agents with different mechanisms of action. There are various metal complexes still under development and investigation for the future cancer treatment use. In the search for novel bio-organometallic molecules, iron containing anti-tumoral agents are enjoying an increasing interest and appear very promising as the potential drug candidates. Iron, as an essential cofactor in a number of enzymes and physiological processes, may be less toxic than non essential metals, such as platinum. Up to now, some of iron complexes have been tested as cytotoxic agents and found to be endowed with an antitumor activity in several in vitro tests (on cultured cancer cell lines) and few in vivo experiments (e. g. on Ehrlich's ascites carcinoma). Although the precise molecular mechanism is yet to be defined, a number of observations suggest that the reactive oxygen species can play important role in iron-induced cytotoxicty. This review covers some relevant examples of research on the novel iron complexes.

  3. Iron bromide vapor laser

    NASA Astrophysics Data System (ADS)

    Sukhanov, V. B.; Shiyanov, D. V.; Trigub, M. V.; Dimaki, V. A.; Evtushenko, G. S.

    2016-03-01

    We have studied the characteristics of a pulsed gas-discharge laser on iron bromide vapor generating radiation with a wavelength of 452.9 nm at a pulse repetition frequency (PRF) of 5-30 kHz. The maximum output power amounted to 10 mW at a PRF within 5-15 kHz for a voltage of 20-25 kV applied to electrodes of the discharge tube. Addition of HBr to the medium produced leveling of the radial profile of emission. Initial weak lasing at a wavelength of 868.9 nm was observed for the first time, which ceased with buildup of the main 452.9-nm line.

  4. Self-assembled Targeting of Cancer Cells by Iron(III)-doped, Silica Nanoparticles.

    PubMed

    Mitchell, K K Pohaku; Sandoval, S; Cortes-Mateos, M J; Alfaro, J G; Kummel, A C; Trogler, W C

    2014-12-07

    Iron(III)-doped silica nanoshells are shown to possess an in vitro cell-receptor mediated targeting functionality for endocytosis. Compared to plain silica nanoparticles, iron enriched ones are shown to be target-specific, a property that makes them potentially better vehicles for applications, such as drug delivery and tumor imaging, by making them more selective and thereby reducing the nanoparticle dose. Iron(III) in the nanoshells can interact with endogenous transferrin, a serum protein found in mammalian cell culture media, which subsequently promotes transport of the nanoshells into cells by the transferrin receptor-mediated endocytosis pathway. The enhanced uptake of the iron(III)-doped nanoshells relative to undoped silica nanoshells by a transferrin receptor-mediated pathway was established using fluorescence and confocal microscopy in an epithelial breast cancer cell line. This process was also confirmed using fluorescence activated cell sorting (FACS) measurements that show competitive blocking of nanoparticle uptake by added holo-transferrin.

  5. Salivary proline-rich protein may reduce tannin-iron chelation: a systematic narrative review.

    PubMed

    Delimont, Nicole M; Rosenkranz, Sara K; Haub, Mark D; Lindshield, Brian L

    2017-01-01

    Tannins are often cited for antinutritional effects, including chelation of non-heme iron. Despite this, studies exploring non-heme iron bioavailability inhibition with long-term consumption have reported mixed results. Salivary proline-rich proteins (PRPs) may mediate tannin-antinutritional effects on non-heme iron bioavailability. To review evidence regarding biochemical binding mechanisms and affinity states between PRPs and tannins, as well as effects of PRPs on non-heme iron bioavailability with tannin consumption in vivo. Narrative systematic review and meta-analysis. Common themes in biochemical modeling and affinity studies were collated for summary and synthesis; data were extracted from in vivo experiments for meta-analysis. Thirty-two studies were included in analysis. Common themes that positively influenced tannin-PRP binding included specificity of tannin-PRP binding, PRP and tannin stereochemistry. Hydrolyzable tannins have different affinities than condensed tannins when binding to PRPs. In vivo, hepatic iron stores and non-heme iron absorption are not significantly affected by tannin consumption ( d  = -0.64-1.84; -2.7-0.13 respectively), and PRP expression may increase non-heme iron bioavailability with tannin consumption. In vitro modeling suggests that tannins favor PRP binding over iron chelation throughout digestion. Hydrolyzable tannins are not representative of tannin impact on non-heme iron bioavailability in food tannins because of their unique structural properties and PRP affinities. With tannin consumption, PRP production is increased, and may be an initial line of defense against tannin-non-heme iron chelation in vivo . More research is needed to compare competitive binding of tannin-PRP to tannin-non-heme iron complexes, and elucidate PRPs' role in adaption to non-heme iron bioavailability in vivo.

  6. On the Evolution of the Inner Disk Radius with Flux in the Neutron Star Low-mass X-Ray Binary Serpens X-1

    NASA Technical Reports Server (NTRS)

    Chiang, Chia - Ying; Morgan, Robert A.; Cackett, Edward M.; Miller, Jon M.; Bhattacharyya, Sudip; Strohmayer, Tod E.

    2016-01-01

    We analyze the latest Suzaku observation of the bright neutron star (NS) low-mass X-ray binary Serpens X-1 taken in 2013 October and 2014 April. The observation was taken using the burst mode and only suffered mild pile-up effects. A broad iron line is clearly detected in the X-ray spectrum. We test different models and find that the iron line is asymmetric and best interpreted by relativistic reflection. The relativistically broadened iron line is generally believed to originate from the innermost regions of the accretion disk, where strong gravity causes a series of special and general relativistic effects. The iron line profile indicates an inner radius of approx. 8 R(sub G), which gives an upper limit on the size of the NS. The asymmetric iron line has been observed in a number of previous observations, which gives several inner radius measurements at different flux states. We find that the inner radius of Serpens X-1 does not evolve significantly over the range of L/L(sub Edd) approx. 0.4-0.6, and the lack of flux dependence of the inner radius implies that the accretion disk may be truncated outside of the innermost stable circular orbit by the boundary layer, rather than the stellar magnetic field.

  7. Evaluating Possible Heating Mechanisms Using the Transition Region Line Profiles of Late-Type Stars

    NASA Technical Reports Server (NTRS)

    Wood, Brian E.; Linsky, Jeffrey L.; Ayres, Thomas R.

    1997-01-01

    Our analysis of high-resolution Goddard High-Resolution Spectrograph (GHRS) spectra of late-type stars shows that the Si IV and C IV lines formed near 10(exp 5) K can be decomposed into the sum of two Gaussians, a broad component and a narrow component. We find that the flux contribution of the broad components is correlated with both the C IV and X-ray surface fluxes. For main-sequence stars, the widths of the narrow components suggest subsonic nonthermal velocities, and there appears to be a tight correlation between these nonthermal velocities and stellar surface gravity [xi(sub nc) varies as g(sup (-.68 +/-.07))]. For evolved stars with lower surface gravities, the nonthermal velocities suggested by the narrow components are at or just above the sound speed. Nonthermal velocities computed from the widths of the broad components are always highly supersonic. We propose that the broad components are diagnostics for microflare heating. Turbulent dissipation and Alfven waves are both viable candidates for the narrow component heating mechanism. A solar analog for the broad components might be the 'explosive events' detected by the High-Resolution Telescope and Spectrograph (HRTS) experiment. The broad component we observe for the Si IV lambda 1394 line of alpha Cen A, a star that is nearly identical to the Sun, has a FWHM of 109 +/- 10 km/s and is blueshifted by 9 +/- 3 km/s relative to the narrow component. Both of these properties are consistent with the properties of the solar explosive events. However, the alpha Cen A broad component accounts for 25% +/- 4% of the total Si IV line flux, while solar explosive events are currently thought to account for no more than 5% of the Sun's total transition region emission. This discrepancy must be resolved before the connection between broad components and explosive events can be positively established. In addition to our analysis of the Si IV and C IV lines of many stars, we also provide a more thorough analysis of all

  8. Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro.

    PubMed

    Messner, Donald J; Robinson, Todd; Kowdley, Kris V

    2017-04-01

    Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in T51B cells, a non-neoplastic rat liver epithelial cell line. Purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with iron overload (IC 50 values near 10 μM, P < 0.05). Inhibition of iron-induced tumor promotion (seen upon treatment with 200 μM ferric ammonium citrate ± curcumin/turmeric for 16 wk in culture; subsequently assayed by soft agar colony formation) was nearly complete at 20 μM of total curcuminoids (P < 0.05), a concentration predicted to only partially chelate the added iron. Surprisingly, lower curcumin concentrations (10 μM) increased tumor promotion (P < 0.01). Curcuminoids delivered as a standardized turmeric extract were taken up better by cells, had a longer half-life, and appeared more effective in blocking tumor promotion (P < 0.01), suggesting enhanced curcuminoid delivery to cells in culture. The primary finding that curcuminoids can inhibit tumor promotion caused by iron in T51B cells is tempered by evidence for an underlying increase in neoplastic transformation at lower concentrations.

  9. Curcumin and Turmeric Modulate the Tumor-Promoting Effects of Iron In Vitro

    PubMed Central

    Messner, Donald J.; Robinson, Todd; Kowdley, Kris V.

    2018-01-01

    Free or loosely chelated iron has tumor-promoting properties in vitro. Curcumin, a polyphenol derived from the food spice turmeric (Curcuma longa), is a potent antioxidant that binds iron. The primary aim of this study was to investigate whether curcuminoids prevent tumor-promoting effects of iron in T51B cells, a non-neoplastic rat liver epithelial cell line. Purified curcuminoids (curcumin) or a standardized turmeric extract similarly reduced oxidative stress and cytotoxicity associated with iron overload (IC50 values near 10 μM, P < 0.05). Inhibition of iron-induced tumor promotion (seen upon treatment with 200 μM ferric ammonium citrate ± curcumin/turmeric for 16 wk in culture; subsequently assayed by soft agar colony formation) was nearly complete at 20 μM of total curcuminoids (P < 0.05), a concentration predicted to only partially chelate the added iron. Surprisingly, lower curcumin concentrations (10 μM) increased tumor promotion (P < 0.01). Curcuminoids delivered as a standardized turmeric extract were taken up better by cells, had a longer half-life, and appeared more effective in blocking tumor promotion (P < 0.01), suggesting enhanced curcuminoid delivery to cells in culture. The primary finding that curcuminoids can inhibit tumor promotion caused by iron in T51B cells is tempered by evidence for an underlying increase in neoplastic transformation at lower concentrations. PMID:28129008

  10. Magnetic Resonance Characterization of Hepatic Storage Iron in Transfusional Iron Overload

    PubMed Central

    Tang, Haiying; Jensen, Jens H.; Sammet, Christina L.; Sheth, Sujit; Swaminathan, Srirama V.; Hultman, Kristi; Kim, Daniel; Wu, Ed X.; Brown, Truman R.; Brittenham, Gary M.

    2013-01-01

    Purpose To quantify the two principal forms of hepatic storage iron, diffuse, soluble iron (primarily ferritin), and aggregated, insoluble iron (primarily hemosiderin) using a new MRI method in patients with transfusional iron overload. Materials and Methods Six healthy volunteers and twenty patients with transfusion-dependent thalassemia syndromes and iron overload were examined. Ferritin- and hemosiderin-like iron were determined based on the measurement of two distinct relaxation parameters: the “reduced” transverse relaxation rate, RR2 and the “aggregation index,” A, using three sets of Carr-Purcell-Meiboom-Gill (CPMG) datasets with different interecho spacings. Agarose phantoms, simulating the relaxation and susceptibility properties of tissue with different concentrations of dispersed (ferritin-like) and aggregated (hemosiderin-like) iron, were employed for validation. Results Both phantom and in vivo human data confirmed that transverse relaxation components associated with the dispersed and aggregated iron could be separated using the two-parameter (RR2, A) method. The MRI-determined total hepatic storage iron was highly correlated (r = 0.95) with measurements derived from biopsy or biosusceptometry. As total hepatic storage iron increased, the proportion stored as aggregated iron became greater. Conclusion This method provides a new means for non-invasive MRI determination of the partition of hepatic storage iron between ferritin and hemosiderin in iron overload disorders. PMID:23720394

  11. Efficacy of iron fortification compared to iron supplementation among Vietnamese schoolchildren

    PubMed Central

    Thi Le, Huong; Brouwer, Inge D; Burema, Jan; Nguyen, Khan Cong; Kok, Frans J

    2006-01-01

    The effect of iron fortification is generally assumed to be less than iron supplementation; however, the magnitude of difference in effects is not known. The present study aims to compare the efficacy of these two strategies on anaemia and iron status. After screening on low Hb, 425 anaemic children in six primary schools in Tam Nong district of Phu Tho province were included in a randomized, placebo-controlled trial comparing two groups receiving iron fortified instant noodles or iron supplementation for 6 months and a control group, with children in all groups having been dewormed. Blood samples were collected before and after intervention for haemoglobin, serum ferritin (SF), serum transferrin receptor (TfR), C-reactive protein (CRP), and haemoglobinopathies analysis. Regression analysis was used to assess the effect of iron fortification and iron supplementation on haemoglobin concentration, SF, TfR, body iron, and anaemic status as outcome variables. The improvement of haemoglobin, SF, and body iron level in the group receiving iron fortification was 42% (2.6 g/L versus 6.2 g/L), 20% (23.5 μg/L versus 117.3 μg/L), and 31.3% (1.4 mg/kg versus 4.4 mg/kg) of that in the iron supplementation group. The prevalence of anaemia dropped to 15.1% in the control group, with an additional reduction of anaemia of 8.5% in the iron supplementation group. The additional reduction due to iron fortification was 5.4%, which amounts to well over 50% of the impact of supplementation. In conclusion, the efficacy of iron fortification based on reduction of prevalence of anaemia, and on the change in haemoglobin level, is about half of the maximum impact of supplementation in case of optimal compliance. Thus, in a population of anaemic children with mild iron deficiency, iron fortification should be the preferred strategy to combat anaemia. PMID:17147795

  12. Efficacy of iron fortification compared to iron supplementation among Vietnamese schoolchildren.

    PubMed

    Thi Le, Huong; Brouwer, Inge D; Burema, Jan; Nguyen, Khan Cong; Kok, Frans J

    2006-12-05

    The effect of iron fortification is generally assumed to be less than iron supplementation; however, the magnitude of difference in effects is not known. The present study aims to compare the efficacy of these two strategies on anaemia and iron status. After screening on low Hb, 425 anaemic children in six primary schools in Tam Nong district of Phu Tho province were included in a randomized, placebo-controlled trial comparing two groups receiving iron fortified instant noodles or iron supplementation for 6 months and a control group, with children in all groups having been dewormed. Blood samples were collected before and after intervention for haemoglobin, serum ferritin (SF), serum transferrin receptor (TfR), C-reactive protein (CRP), and haemoglobinopathies analysis. Regression analysis was used to assess the effect of iron fortification and iron supplementation on haemoglobin concentration, SF, TfR, body iron, and anaemic status as outcome variables. The improvement of haemoglobin, SF, and body iron level in the group receiving iron fortification was 42% (2.6 g/L versus 6.2 g/L), 20% (23.5 microg/L versus 117.3 microg/L), and 31.3% (1.4 mg/kg versus 4.4 mg/kg) of that in the iron supplementation group. The prevalence of anaemia dropped to 15.1% in the control group, with an additional reduction of anaemia of 8.5% in the iron supplementation group. The additional reduction due to iron fortification was 5.4%, which amounts to well over 50% of the impact of supplementation. In conclusion, the efficacy of iron fortification based on reduction of prevalence of anaemia, and on the change in haemoglobin level, is about half of the maximum impact of supplementation in case of optimal compliance. Thus, in a population of anaemic children with mild iron deficiency, iron fortification should be the preferred strategy to combat anaemia.

  13. High efficiency iron electrode and additives for use in rechargeable iron-based batteries

    DOEpatents

    Narayan, Sri R.; Prakash, G. K. Surya; Aniszfeld, Robert; Manohar, Aswin; Malkhandi, Souradip; Yang, Bo

    2017-02-21

    An iron electrode and a method of manufacturing an iron electrode for use in an iron-based rechargeable battery are disclosed. In one embodiment, the iron electrode includes carbonyl iron powder and one of a metal sulfide additive or metal oxide additive selected from the group of metals consisting of bismuth, lead, mercury, indium, gallium, and tin for suppressing hydrogen evolution at the iron electrode during charging of the iron-based rechargeable battery. An iron-air rechargeable battery including an iron electrode comprising carbonyl iron is also disclosed, as is an iron-air battery wherein at least one of the iron electrode and the electrolyte includes an organosulfur additive.

  14. The actin-binding protein profilin 2 is a novel regulator of iron homeostasis.

    PubMed

    Luscieti, Sara; Galy, Bruno; Gutierrez, Lucia; Reinke, Michael; Couso, Jorge; Shvartsman, Maya; Di Pascale, Antonio; Witke, Walter; Hentze, Matthias W; Pilo Boyl, Pietro; Sanchez, Mayka

    2017-10-26

    Cellular iron homeostasis is controlled by the iron regulatory proteins (IRPs) 1 and 2 that bind cis -regulatory iron-responsive elements (IRE) on target messenger RNAs (mRNA). We identified profilin 2 ( Pfn2 ) mRNA, which encodes an actin-binding protein involved in endocytosis and neurotransmitter release, as a novel IRP-interacting transcript, and studied its role in iron metabolism. A combination of electrophoretic mobility shift assay experiments and bioinformatic analyses led to the identification of an atypical and conserved IRE in the 3' untranslated region of Pfn2 mRNA. Pfn2 mRNA levels were significantly reduced in duodenal samples from mice with intestinal IRP ablation, suggesting that IRPs exert a positive effect on Pfn2 mRNA expression in vivo. Overexpression of Pfn2 in HeLa and Hepa1-6 cells reduced their metabolically active iron pool. Importantly, Pfn2-deficient mice showed iron accumulation in discrete areas of the brain (olfactory bulb, hippocampus, and midbrain) and reduction of the hepatic iron store without anemia. Despite low liver iron levels, hepatic hepcidin expression remained high, likely because of compensatory activation of hepcidin by mild inflammation. Splenic ferroportin was increased probably to sustain hematopoiesis. Overall, our results indicate that Pfn2 expression is controlled by the IRPs in vivo and that Pfn2 contributes to maintaining iron homeostasis in cell lines and mice. © 2017 by The American Society of Hematology.

  15. Weak hard X-ray emission from broad absorption line quasars: evidence for intrinsic X-ray weakness

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Luo, B.; Brandt, W. N.; Scott, A. E.

    We report NuSTAR observations of a sample of six X-ray weak broad absorption line (BAL) quasars. These targets, at z = 0.148-1.223, are among the optically brightest and most luminous BAL quasars known at z < 1.3. However, their rest-frame ≈2 keV luminosities are 14 to >330 times weaker than expected for typical quasars. Our results from a pilot NuSTAR study of two low-redshift BAL quasars, a Chandra stacking analysis of a sample of high-redshift BAL quasars, and a NuSTAR spectral analysis of the local BAL quasar Mrk 231 have already suggested the existence of intrinsically X-ray weak BAL quasars,more » i.e., quasars not emitting X-rays at the level expected from their optical/UV emission. The aim of the current program is to extend the search for such extraordinary objects. Three of the six new targets are weakly detected by NuSTAR with ≲ 45 counts in the 3-24 keV band, and the other three are not detected. The hard X-ray (8-24 keV) weakness observed by NuSTAR requires Compton-thick absorption if these objects have nominal underlying X-ray emission. However, a soft stacked effective photon index (Γ{sub eff} ≈ 1.8) for this sample disfavors Compton-thick absorption in general. The uniform hard X-ray weakness observed by NuSTAR for this and the pilot samples selected with <10 keV weakness also suggests that the X-ray weakness is intrinsic in at least some of the targets. We conclude that the NuSTAR observations have likely discovered a significant population (≳ 33%) of intrinsically X-ray weak objects among the BAL quasars with significantly weak <10 keV emission. We suggest that intrinsically X-ray weak quasars might be preferentially observed as BAL quasars.« less

  16. 49 CFR 192.489 - Remedial measures: Cast iron and ductile iron pipelines.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... for Corrosion Control § 192.489 Remedial measures: Cast iron and ductile iron pipelines. (a) General graphitization. Each segment of cast iron or ductile iron pipe on which general graphitization is found to a... 49 Transportation 3 2011-10-01 2011-10-01 false Remedial measures: Cast iron and ductile iron...

  17. 49 CFR 192.489 - Remedial measures: Cast iron and ductile iron pipelines.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... for Corrosion Control § 192.489 Remedial measures: Cast iron and ductile iron pipelines. (a) General graphitization. Each segment of cast iron or ductile iron pipe on which general graphitization is found to a... 49 Transportation 3 2010-10-01 2010-10-01 false Remedial measures: Cast iron and ductile iron...

  18. A survey of X-ray line emission from the supernova remnant Puppis A

    NASA Technical Reports Server (NTRS)

    Winkler, P. F.; Clark, G. W.; Markert, T. H.; Kalata, K.; Schnopper, H. W.; Canizares, C. R.

    1981-01-01

    Initial results from the first high-resolution study of the X-ray spectrum of a supernova remnant are reported. The spectrum of Puppis A between 500 and 1100 eV has been surveyed with the Focal Plane Crystal Spectrometer on the Einstein Observatory and the flux in eight lines and three line blends from various transitions of highly ionized nitrogen, oxygen, neon, and iron has been measured. The spectrum resembles that of active regions in the solar corona, but the neon lines seem enhanced relative to the oxygen lines, and both are enhanced relative to iron. The observed line strengths serve as diagnostics of the physical conditions in the emitting material. Without a priori assumptions, the ionization temperatures of O (2.2 million K) and Ne (4 million K) and the dominant ionization stage of Fe (Fe XVII) are deduced. Isothermal equilibrium plasmas or homogeneous nonequilibrium plasmas as descriptions of the source are ruled out. It is concluded that Puppis A must contain plasma over a temperature range 2-million to 5-million K with an intervening absorption column of 4 x 10 to the 21st/sq cm.

  19. Effects of interferon-gamma and lipopolysaccharide on macrophage iron metabolism are mediated by nitric oxide-induced degradation of iron regulatory protein 2.

    PubMed

    Kim, S; Ponka, P

    2000-03-03

    Iron regulatory proteins (IRP-1 and IRP-2) control the synthesis of transferrin receptors (TfR) and ferritin by binding to iron-responsive elements, which are located in the 3'-untranslated region and the 5'-untranslated region of their respective mRNAs. Cellular iron levels affect binding of IRPs to iron-responsive elements and consequently expression of TfR and ferritin. Moreover, NO(*), a redox species of nitric oxide that interacts primarily with iron, can activate IRP-1 RNA binding activity resulting in an increase in TfR mRNA levels. Recently we found that treatment of RAW 264.7 cells (a murine macrophage cell line) with NO(+) (nitrosonium ion, which causes S-nitrosylation of thiol groups) resulted in a rapid decrease in RNA binding of IRP-2 followed by IRP-2 degradation, and these changes were associated with a decrease in TfR mRNA levels (Kim, S., and Ponka, P. (1999) J. Biol. Chem. 274, 33035-33042). In this study, we demonstrated that stimulation of RAW 264.7 cells with lipopolysaccharide (LPS) and interferon-gamma (IFN-gamma) increased IRP-1 binding activity, whereas RNA binding of IRP-2 decreased and was followed by a degradation of this protein. Moreover, the decrease of IRP-2 binding/protein levels was associated with a decrease in TfR mRNA levels in LPS/IFN-gamma-treated cells, and these changes were prevented by inhibitors of inducible nitric oxide synthase. Furthermore, LPS/IFN-gamma-stimulated RAW 264.7 cells showed increased rates of ferritin synthesis. These results suggest that NO(+)-mediated degradation of IRP-2 plays a major role in iron metabolism during inflammation.

  20. Results of the First American Prospective Study of Intravenous Iron in Oral Iron-Intolerant Iron-Deficient Gravidas.

    PubMed

    Auerbach, Michael; James, Stephanie E; Nicoletti, Melissa; Lenowitz, Steven; London, Nicola; Bahrain, Huzefa F; Derman, Richard; Smith, Samuel

    2017-12-01

    Anemia affects up to 42% of gravidas. Neonatal iron deficiency is associated with low birth weight, delayed growth and development, and increased cognitive and behavioral abnormalities. While oral iron is convenient, up to 70% report significant gastrointestinal toxicity. Intravenous iron formulations allowing replacement in one visit with favorable side-effect profiles decrease rates of anemia with improved hemoglobin responses and maternal fetal outcomes. Seventy-four oral iron-intolerant, second- and third-trimester iron-deficient gravidas were questioned for oral iron intolerance and treated with intravenous iron. All received 1000 mg of low-molecular-weight iron dextran in 250 mL normal saline. Fifteen minutes after a test dose, the remainder was infused over the balance of 1 hour. Subjects were called at 1, 2, and 7 days to assess delayed reactions. Four weeks postinfusion or postpartum, hemoglobin levels and iron parameters were measured. Paired t test was used for hemoglobin and iron; 58/73 women were questioned about interval growth and development of their babies. Seventy-three of 74 enrolled subjects completed treatment. Sixty had paired pre- and posttreatment data. The mean pre- and posthemoglobin concentrations were 9.7 and 10.8 g/dL (P < .00001), transferrin saturations 11.7% and 22.6% (P = .0003), and ferritins 14.5 and 126.3 ng/mL, respectively (P < .000001). Six experienced minor infusion reactions. All resolved. Data for 58 infants were available; one was low on its growth charts for 11 months. The remaining 57 were normal. None were diagnosed with iron deficiency anemia. Intravenous iron has less toxicity and is more effective, supporting moving it closer to frontline therapy. Copyright © 2017 Elsevier Inc. All rights reserved.